Structural optimization of flexible components under dynamic loading within a multibody system approach: a comparative evaluation of optimization methods based on a 2-dof robot application.

in Proceedings of the 10th World Congress on Structural and Multidisciplinary Optimization: Orlanda (USA), 19-24 mai 2013 (2013, May)

This paper is dedicated to a comparative evaluation between two methods of optimization to realize the structural optimization of flexible components in mechanical systems modeled as multibody systems. A ... [more ▼]

This paper is dedicated to a comparative evaluation between two methods of optimization to realize the structural optimization of flexible components in mechanical systems modeled as multibody systems. A nonlinear finite element method based formalism is considered for the dynamic simulation of the flexible multibody system. The first method is the Equivalent Static Load method which enables to transform a dynamic response optimization problem into a set of static response optimization problems. The second method treats directly the dynamic optimization problem in an integrated manner where the optimization process is carried out directly based on the time response coming from the multibody system approach. However, the first method proposed by Kang, Park and Arora was developed under the assumption that the multibody system is described using a floating frame of reference. Therefore, in order to carry on the comparison using a unique multibody system approach, a method is first proposed to derive the equivalent static loads when using a nonlinear finite element method based formalism. The comparative evaluation is then carried out on the simple academic example of the mass minimization of a two-arm robot subject to tracking deviation constraints. Conclusions are finally drawn for future work and stringent comparison. [less ▲]

Structural Optimization of the Blanc Pain Flood Control Gate

in Bulletin scientifique de l'UTCB (2003)

Structural organization of mitochondrial human complex I: role of the ND4 and ND5 mitochondria-encoded subunits and interaction with prohibitin

in Biochemical Journal (2004), 383(Part 3), 491-499

Mitochondria-encoded ND (NADH dehydrogenase) subunits, as components of the hydrophobic part of complex I, are essential for NADH:ubiquinone oxidoreductase activity. Mutations or lack of expression of ... [more ▼]

Mitochondria-encoded ND (NADH dehydrogenase) subunits, as components of the hydrophobic part of complex I, are essential for NADH:ubiquinone oxidoreductase activity. Mutations or lack of expression of these subunits have significant pathogenic consequences in humans. However, the way these events affect complex I assembly is poorly documented. To understand the effects of particular mutations in ND subunits on complex I assembly, we studied four human cell lines: ND4 non-expressing cells, ND5 non-expressing cells, and rhodegrees cells that do not express any ND subunits, in comparison with normal complex I control cells. In control cells. all the seven analysed nuclear-encoded complex I subunits Were found to be attached to the mitochondrial inner membrane, except for the 24 kDa subunit, which was nearly equally partitioned between the membranes and the matrix. Absence of a single ND subunit, or even all the seven ND subunits, caused no major changes in the nuclear-encoded complex I subunit content of mitochondria. However, in cells lacking ND4 or ND5, very low amounts of 24 kDa subunit were found associated with the membranes, whereas most of the other nuclear-encoded subunits remained attached. In contrast, membrane association of most of the nuclear subunits was significantly reduced in the absence of all seven ND proteins. Immunopurification detected several subcomplexes. One of these, containing the 23, 30 and 49 kDa subunits, also contained prohibitin. This is the first description of prohibitin interaction with complex I subunits and suggests that this protein might play a role in the assembly or degradation of mitochondrial complex I. [less ▲]

Structural Path Analysis and Multiplier Decomposition within a Social Accounting Matrix Framework

in Economic Journal (1984), 94

Structural Polymorphism Of Two Cpp: An Important Parameter Of Activity

in Biochimica et Biophysica Acta-Biomembranes (2008), 1778(5), 1197-205

Despite numerous investigations, the important structural features of Cell Penetrating Peptides (CPPs) remain unclear as demonstrated by the difficulties encountered in designing new molecules. In this ... [more ▼]

Despite numerous investigations, the important structural features of Cell Penetrating Peptides (CPPs) remain unclear as demonstrated by the difficulties encountered in designing new molecules. In this study, we focused our interest on Penetratin and Transportan and several of their variants. Penetratin W48F and Penetratin W48F/W56F exhibit a reduced and a complete lack of cellular uptake, respectively; TP07 and TP10 present a similar cellular uptake as Transportan and TP08, TP13 and TP15 display no or weak internalization capacity. We applied the algorithmic method named PepLook to analyze the peptide polymorphism. The study reveals common conformational characteristics for the CPPs and their permeable variants: they all are polymorphic. Negative, non permeable, mutants share the opposite feature since they are monomorphic. Finally, we support the hypothesis that structural polymorphism may be crucial since it provides peptides with the possibility of adapting their conformation to medium hydrophobicity and or to partner diversity. [less ▲]

Structural properties of bounded languages with respect to multiplication by a constant

in Actes des Journées Montoises d'Informatique Théorique (2006)

We consider the preservation of recognizability of a set of integers after multiplication by a constant for numeration systems built over a bounded language. As a corollary we show that any nonnegative ... [more ▼]

We consider the preservation of recognizability of a set of integers after multiplication by a constant for numeration systems built over a bounded language. As a corollary we show that any nonnegative integer can be written as a sum of binomial coefficients with some prescribed properties. [less ▲]

Structural shape optimization and convex programming methods

Conference given outside the academic context (1995)

Structural Similarities and Evolutionary Relationships in Chloride-Dependent Alpha-Amylases

in Gene (2000), 253(1), 95-105

The alpha-amylase sequences contained in databanks were screened for the presence of amino acid residues Arg195, Asn298 and Arg/Lys337 forming the chloride-binding site of several specialized alpha ... [more ▼]

The alpha-amylase sequences contained in databanks were screened for the presence of amino acid residues Arg195, Asn298 and Arg/Lys337 forming the chloride-binding site of several specialized alpha-amylases allosterically activated by this anion. This search provides 38 alpha-amylases potentially binding a chloride ion. All belong to animals, including mammals, birds, insects, acari, nematodes, molluscs, crustaceans and are also found in three extremophilic Gram-negative bacteria. An evolutionary distance tree based on complete amino acid sequences was constructed, revealing four distinct clusters of species. On the basis of multiple sequence alignment and homology modeling, invariable structural elements were defined, corresponding to the active site, the substrate binding site, the accessory binding sites, the Ca(2+) and Cl(-) binding sites, a protease-like catalytic triad and disulfide bonds. The sequence variations within functional elements allowed engineering strategies to be proposed, aimed at identifying and modifying the specificity, activity and stability of chloride-dependent alpha-amylases. [less ▲]

Structural studies of the surface of virus-infected cells

in Progress in Medical Virology (1980), 26

A structural study of natural olivine-type phosphates

Poster (2010)