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See detailMODIFYING PHYSICAL ENVIRONMENT TO BE APPROPRIATE FOR CHILDREN
Jidovtseff, Boris ULg; Delvaux, Anne ULg; Mornard, Manhattan ULg

in Book of abstracts AISEP 2015 (2015, July)

Our experience confirms that adapting physical environments is critical for providing appropriate physical activity for 3 to 8 years old children.. Moreover, the pedagogy has to favour success, discovery ... [more ▼]

Our experience confirms that adapting physical environments is critical for providing appropriate physical activity for 3 to 8 years old children.. Moreover, the pedagogy has to favour success, discovery and a fun environment. This work illustrates what can be achieved and provides clear guidance for developing centres to support the promotion of physical activity in early childhood. [less ▲]

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See detailUn modo attutito d’esistere: Note su Sbarbaro traduttore dal francese
Benzoni, Pietro ULg

in Ferreri, Davide (Ed.) Camillo Sbarbaro in versi e in prosa (2009)

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See detailA modular approach dedicated to dam-break and dam-breaching modelling
Stilmant, Frédéric ULg; Dewals, Benjamin ULg; Erpicum, Sébastien ULg et al

in Advances in Hydroinformatics (2015)

The paper presents an integrated tool for dam-break hazard modelling. It is based on a two-dimensional, depth-averaged hydraulic model that uses a conservative and shock-capturing finite volume scheme on ... [more ▼]

The paper presents an integrated tool for dam-break hazard modelling. It is based on a two-dimensional, depth-averaged hydraulic model that uses a conservative and shock-capturing finite volume scheme on a Cartesian grid. The hydraulic model is designed so that different zones within the computation domain can be modelled with different spatial resolutions and/or different model enhancements (e.g. pressurised flows, sediment transport, etc.). The two-dimensional model can be coupled with lumped models that compute the water stage in reservoirs and the outflow discharge through hydraulic structures, in case of normal operating, failure of a valve or breaching processes. These features make hydraulic modelling versatile and computationally efficient. They enable the definition of different failure scenarios, which is of prominent importance given the uncertainty of such a phenomenon. If several hydraulic structures are involved, the procedure takes the behaviour of each structure into account. The sensitivity of the results with respect to the interactions between the flow and the terrain (roughness coefficient, collapse of buildings, breaching process) can be analysed. The results of the hydraulic model are handled thanks to a graphical user interface that provides one-, two- and three-dimensional views and animations of the unsteady flow-field and enables the understanding and verification of the results. Danger maps are generated based on the results of one or more ‘worst-case’ scenarios. In case of a complete risk analysis, the danger maps are combined with data on the exposure and vulnerability of elements at risk for the computation of the corresponding damage. [less ▲]

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See detailA modular approach to quality of life assessment in paediatric oncology
Fonseca, Marta; Missotten, Pierre ULg; Etienne, Anne-Marie ULg et al

in Psychology & Health (2009), 24(Supp 1), 175

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See detailA Modular Approach To Study Protein Adsorption on Surface Modified Hydroxyapatite
Ozhukil Kollath, Vinayaraj ULg; Van den Broeck, Freya; Fehér, Krisztina et al

in Chemistry : A European Journal (2015), 21(29), 10497-10505

Biocompatible inorganic nano- and microcarriers can be suitable candidates for protein delivery. This study demonstrates facile methods of functionalization by using nanoscale linker molecules to change ... [more ▼]

Biocompatible inorganic nano- and microcarriers can be suitable candidates for protein delivery. This study demonstrates facile methods of functionalization by using nanoscale linker molecules to change the protein adsorption capacity of hydroxyapatite (HA) powder. The adsorption capacity of bovine serum albumin as a model protein has been studied with respect to the surface modifications. The selected linker molecules (lysine, arginine, and phosphoserine) can influence the adsorption capacity by changing the electrostatic nature of the HA surface. Qualitative and quantitative analyses of linker-molecule interactions with the HA surface have been performed by using NMR spectroscopy, zeta-potential measurements, X-ray photoelectron spectroscopy, and thermogravimetric analyses. Additionally, correlations to theoretical isotherm models have been calculated with respect to Langmuir and Freundlich isotherms. Lysine and arginine increased the protein adsorption, whereas phosphoserine reduced the protein adsorption. The results show that the adsorption capacity can be controlled with different functionalization, depending on the protein–carrier selections under consideration. The scientific knowledge acquired from this study can be applied in various biotechnological applications that involve biomolecule–inorganic material interfaces. [less ▲]

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See detailModular assembly of RanBP2-type zinc finger domains to target single- stranded RNA
O'Connell, M.R.; Vandevenne, Marylène ULg; Nguyen, C.D. et al

in Angewandte Chemie International Edition (2012)

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See detailModular bimorph mirrors for adaptive optics
Rodrigues, Goncalo; Bastaits, Renaud; Roose, Stéphane ULg et al

in Optical Engineering : The Journal of the Society of Photo-Optical Instrumentation Engineers (2009), 3(48),

This paper examines the possibility of constructing deformable mirrors for adaptive optics with a large number of degrees of freedom from silicon wafers with bimorph piezoelectric actuation. The mirror ... [more ▼]

This paper examines the possibility of constructing deformable mirrors for adaptive optics with a large number of degrees of freedom from silicon wafers with bimorph piezoelectric actuation. The mirror may be used on its own, or as a segment of a larger mirror. The typical size of one segment is 100to200mm ; the production process relies on silicon wafers and thick film piezoelectric material deposition technology; it is able to lead to an actuation pitch of the order of 5mm , and the manufacturing costs appear to grow only slowly with the number of degrees of freedom in the adaptive optics. [less ▲]

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See detailModular changes of cis-regulatory elements from two functional Pit1 genes in the duplicated genome of Cyprinus carpio.
Kausel, G.; Salazar, M.; Castro, L. et al

in Journal of Cellular Biochemistry (2006), 99(3), 905-21

The pituitary-specific transcription factor Pit1 is involved in its own regulation and in a network of transcriptional regulation of hypothalamo-hypophyseal factors including prolactin (PRL) and growth ... [more ▼]

The pituitary-specific transcription factor Pit1 is involved in its own regulation and in a network of transcriptional regulation of hypothalamo-hypophyseal factors including prolactin (PRL) and growth hormone (GH). In the ectotherm teleost Cyprinus carpio, Pit1 plays an important role in regulation of the adaptive response to seasonal environmental changes. Two Pit1 genes exist in carp, a tetraploid vertebrate and transcripts of both genes were detected by RT-PCR analysis. Powerful comparative analyses of the 5'-flanking regions revealed copy specific changes comprising modular functional units in the naturally evolved promoters. These include the precise replacement of four nucleotides around the transcription start site embedded in completely conserved regions extending upstream of the TATA-box, an additional transcription factor binding site in the 5'-UTR of gene-I and, instead, duplication of a 9 bp element in gene-II. Binding of nuclear factors was assessed by electro mobility shift assays using extracts from rat pituitary cells and carp pituitary. Binding was confirmed at one conserved Pit1, one conserved CREB and one consensus MTF1. Interestingly, two functional Pit1 sites and one putative MTF1 binding site are unique to the Pit1 gene-I. In situ hybridization experiments revealed that the expression of gene-I in winter carp was significantly stronger than that of gene-II. Our data suggest that the specific control elements identified in the proximal regulatory region are physiologically relevant for the function of the duplicated Pit1 genes in carp and highlight modular changes in the architecture of two Pit1 genes that evolved for at least 12 MYA in the same organism. [less ▲]

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See detailModular Design of the Bi(multi?) functional penicillin-binding proteins
Englebert, Serge; El Kharroubi, Aboubaker; Piras, Graziella et al

in De pedro; Höltje, J. V.; Loffelhardt, W. (Eds.) Bacterial Growth & Lysis Metabolism and Structure of the Bacterial Sacculus (1993)

Proceedings of a symposium held in Mallorca, Spain in April 1992. The goal of the meeting was to assess the present state of knowledge on the structure and physiology of the bacterium murien sacculus, and ... [more ▼]

Proceedings of a symposium held in Mallorca, Spain in April 1992. The goal of the meeting was to assess the present state of knowledge on the structure and physiology of the bacterium murien sacculus, and develop new hypotheses and strategies to promote further development of the field. The contributions reflect broadly different approaches. Papers discuss structure and chemistry, biosynthesis and maturation, regulation and control of cell wall hydrolases, penicillin interactive proteins, morphogenesis and septum formation, and cell growth. Annotation c. Book News, Inc., Portland, OR (booknews.com) [less ▲]

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See detailModular Design of the Enterococcus Hirae Muramidase-2 and Streptococcus Faecalis Autolysin
Joris, Bernard ULg; Englebert, Serge; Chu, Chien-Peng et al

in FEMS Microbiology Letters (1992), 91(3), 257-264

The mature forms of the extracellular muramidase-2 of Enterococcus hirae and Streptococcus faecalis autolysin have very similar primary structures. Each consists of an active-site-containing N-terminal ... [more ▼]

The mature forms of the extracellular muramidase-2 of Enterococcus hirae and Streptococcus faecalis autolysin have very similar primary structures. Each consists of an active-site-containing N-terminal domain fused to a multiple-repeat C-terminal domain. Polypeptide segments occurring at equivalent places in these two bacterial wall lytic enzymes have homologues in two phage lysozymes and in three functionally unrelated proteins, illustrating the principle that protein molecules frequently are constructed from modules that are linked in a single polypeptide chain. [less ▲]

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See detailModular Diversification of the Locomotor System in Damselfishes (Pomacentridae)
Aguilar-Medrano, Rosalia; Frederich, Bruno ULg; Barber, Paul H.

in Journal of Morphology (2016)

As fish move and interact with their aquatic environment by swimming, small morphological variations of the locomotor system can have profound implications on fitness. Damselfishes (Pomacentridae) have ... [more ▼]

As fish move and interact with their aquatic environment by swimming, small morphological variations of the locomotor system can have profound implications on fitness. Damselfishes (Pomacentridae) have inhabited coral reef ecosystems for more than 50 million years. As such, habitat preferences and behavior could significantly constrain the morphology and evolvability of the locomotor system. To test this hypothesis, we used phylogenetic comparative methods on morphometric, ecological and behavioral data. While body elongation represented the primary source of variation in the locomotor system of damselfishes, results also showed a diverse suite of morphological combinations between extreme morphologies. Results show clear associations between behavior, habitat preferences, and morphology, suggesting ecological constraints on shape diversification of the locomotor system. In addition, results indicate that the three modules of the locomotor system are weakly correlated, resulting in versatile and independent characters. These results suggest that Pomacentridae is shape may result from the interaction between (1) integrated parts of morphological variation that main- tain overall swimming ability and (2) relatively independent parts of the morphology that facilitate adaptation and diversification. [less ▲]

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See detailModular mechatronic modelling for wind turbine generating systems based on an integrated finite element approach
Chen, Qiongzhong ULg; Jetteur, Philippe; Bruls, Olivier ULg

in Proceedings of the First Joint International Conference on Multibody System Dynamics (2010, May)

Wind energy is nowadays the fastest-growing energy source in the world, which has been attracting a lot of research interest in wind turbine generator systems. This paper concerns the modelling and ... [more ▼]

Wind energy is nowadays the fastest-growing energy source in the world, which has been attracting a lot of research interest in wind turbine generator systems. This paper concerns the modelling and simulation of wind turbine generating systems using the flexible multibody simulation software SAMCEF/MECANO. Firstly, it introduces the formulation of an extension of the generalized-alpha method, which is integrated into the flexible multibody dynamics solver for strongly-coupled simulation of mechatronic systems, and then emphasizes on the doubly-fed induction generator (DFIG) and the controller models, which are developed as modular components of the wind turbine package. The mechatronic systems are simulated upon this strongly-coupled approach and simulation results show the validity of the newly-developed solver and the models. The interest of this work is to analyze the control-generator-structure interactions in a wind turbine. The general aim is to develop a computer-aided tool for customization, fast-prototyping and optimal design of wind turbine systems based on the dynamic simulation of the overall system. [less ▲]

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See detailModular modelling of combined AC and DC systems in dynamic simulations
Aristidou, Petros ULg; Papangelis, Lampros ULg; Guillaud, Xavier et al

in Proc. of IEEE PES 2015 PowerTech conference (2015, June)

A formulation is proposed in which an AC-DC system is modeled as a combination of AC grids, DC grids, injectors, AC two-ports and AC/DC converters, respectively. This modular modelling facilitates the ... [more ▼]

A formulation is proposed in which an AC-DC system is modeled as a combination of AC grids, DC grids, injectors, AC two-ports and AC/DC converters, respectively. This modular modelling facilitates the dynamic simulation of future complex AC/DC systems. Furthermore, it can be exploited by the solver, which performs less operations on components with lower dynamic activity, and offers parallel processing of the time simulation. This approach is illustrated on a test system in which a multi-terminal DC grid connects two asynchronous AC systems, allows frequency support between them, and acts as emergency control against AC voltage instability. [less ▲]

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See detailA Modular Multi-camera Framework for Team Sport Tracking
Hayet, Jean-Bernard; Mathes, Thomas; Czyz, Jacek et al

Conference (2005)

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See detailModular mutagenesis of a TIM-barrel enzyme: the crystal structure of a chimeric E. coli TIM having the eighth beta alpha-unit replaced by the equivalent unit of chicken TIM
Kishan, Radha; Zeelen, Ph. Johan; Noble, Martin E.M. et al

in Protein Engineering (1994), 7(8), 945-51

The crystal structure of a hybrid Escherichia coli triosephosphate isomerase (TIM) has been determined at 2.8 A resolution. The hybrid TIM (ETIM8CHI) was constructed by replacing the eighth beta alpha ... [more ▼]

The crystal structure of a hybrid Escherichia coli triosephosphate isomerase (TIM) has been determined at 2.8 A resolution. The hybrid TIM (ETIM8CHI) was constructed by replacing the eighth beta alpha-unit of E. coli TIM with the equivalent unit of chicken TIM. This replacement involves 10 sequence changes. One of the changes concerns the mutation of a buried alanine (Ala232 in strand 8) into a phenylalanine. The ETIM8CHI structure shows that the A232F sequence change can be incorporated by a side-chain rotation of Phe224 (in helix 7). No cavities or strained dihedrals are observed in ETIM8CHI in the region near position 232, which is in agreement with the observation that ETIM8CHI and E.coli TIM have similar stabilities. The largest CA (C-alpha atom) movements, approximately 3 A, are seen for the C-terminal end of helix 8 (associated with the outward rotation of Phe224) and for the residues in the loop after helix 1 (associated with sequence changes in helix 8). From the structure it is not clear why the kcat of ETIM8CHI is 10 times lower than in wild type E.coli TIM. [less ▲]

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See detailModular Structure, Local Flexibility and Cold-Activity of a Novel Chitobiase from a Psychrophilic Antarctic Bacterium
Lonhienne, T.; Zoidakis, J.; Vorgias, C. E. et al

in Journal of Molecular Biology (2001), 310(2), 291-7

The gene archb encoding for the cell-bound chitobiase from the Antarctic Gram-positive bacterium Arthrobacter sp. TAD20 was cloned and expressed in Escherichia coli in a soluble form. The mature ... [more ▼]

The gene archb encoding for the cell-bound chitobiase from the Antarctic Gram-positive bacterium Arthrobacter sp. TAD20 was cloned and expressed in Escherichia coli in a soluble form. The mature chitobiase ArChb possesses four functionally independent domains: a catalytic domain stabilized by Ca(2+), a galactose-binding domain and an immunoglobulin-like domain followed by a cell-wall anchorage signal, typical of cell-surface proteins from Gram-positive bacteria. Binding of saccharides was analyzed by differential scanning calorimetry, allowing to distinguish unequivocally the catalytic domain from the galactose-binding domain and to study binding specificities. The results suggest that ArChb could play a role in bacterium attachment to natural hosts. Kinetic parameters of ArChb demonstrate perfect adaptation to catalysis at low temperatures, as shown by a low activation energy associated with unusually low K(m) and high k(cat) values. Thermodependence of these parameters indicates that discrete amino acid substitutions in the catalytic center have optimized the thermodynamic properties of weak interactions involved in substrate binding at low temperatures. Microcalorimetry also reveals that heat-lability, a general trait of psychrophilic enzymes, only affects the active site domain of ArChb. [less ▲]

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See detailModularity of mind and the role of incentive motivation in representing novelty
Anselme, Patrick ULg

in Animal Cognition (2012), 15(4), 443-459

Animal and human brains contain a myriad of mental representations that have to be successfully tracked within fractions of a second in a large number of situations. This retrieval process is hard to ... [more ▼]

Animal and human brains contain a myriad of mental representations that have to be successfully tracked within fractions of a second in a large number of situations. This retrieval process is hard to explain without postulating the massive modularity of cognition. Assuming that the mind is massively modular, it is then necessary to understand how cognitive modules can efficiently represent dynamic environments – in which some modules may have to deal with change-induced novelty and uncertainty. Novelty of a stimulus is a problem for a module when unknown, significant stimuli do not satisfy the module’s processing criteria – or domain specificity – and cannot therefore be included in its database. It is suggested that the brain mechanisms of incentive motivation, recruited when faced with novelty and uncertainty, induce transient variations in the domain specificity of cognitive modules in order to allow them to process information they were not prepared to learn. It is hypothesised that the behavioural transitions leading from exploratory activity to habit formation are correlated with (and possibly caused by) the organism’s ability to counter novelty-induced uncertainty. [less ▲]

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See detailModulated misfit structure of the thermoelectric [Bi0.84CaO 2]2[CoO2]1.69 cobalt oxide
Muguerra, H.; Grebille, D.; Guilmeau, E. et al

in Inorganic Chemistry (2008), 47(7), 2464-2471

The structure of the thermoelectric lamellar misfit cobalt oxide [Bi 0.84CaO2]2[CoO2]1.69 has been refined using single crystal X-ray diffraction data. Using the four dimensional superspace formalism for ... [more ▼]

The structure of the thermoelectric lamellar misfit cobalt oxide [Bi 0.84CaO2]2[CoO2]1.69 has been refined using single crystal X-ray diffraction data. Using the four dimensional superspace formalism for aperiodic structures, the superspace group is confirmed P2/m(0δ1/2) (a1 = 4.9069(4), b1 = 4.7135(7), b2 = 2.8256(4), c1 = 14.668(5) Å, β1 = 93.32(1)°). The modulated displacements and site occupancies have been refined and are both compatible with the misfit character of the structure, and with a longitudinal modulation of the Bi-O layers of the structure. This modulation is similar to the corresponding one in the related Sr phase [Bi0.87SrO2]2[CoO2]1.82, but now oriented in the orthogonal direction. Because its incommensurate wavelength is locked with the aperiodicity of the misfit structure, it is possible to distinguish between the modulation parameters induced by the accommodation of both subsystems and those related to the longitudinal modulation of the Bi-O layers. In this original structure, two independent aperiodic phenomena coexist in an single crystallographic direction. A particular attention has been paid to the structural configuration of the CoO2 layer, in relation with other similar phases. The thermoelectric properties are probably directly related to the specific distortion of the compressed layer, but the different measured values for the Seebeck coefficient cannot be related to a significant modification of the CoO6 octahedra. © 2008 American Chemical Society. [less ▲]

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See detailModulated X-ray emission of the magnetic O8.5V-star Tr16-22
Nazé, Yaël ULg; Wade, Gregg A.; Petit, Véronique

in Astronomy and Astrophysics (2014), 569

Using an extensive X-ray dataset, we analyzed the X-ray emission of the massive O-star Tr16-22, which was recently found to be magnetic. Its bright X-ray emission is found to be modulated with a ~54 d ... [more ▼]

Using an extensive X-ray dataset, we analyzed the X-ray emission of the massive O-star Tr16-22, which was recently found to be magnetic. Its bright X-ray emission is found to be modulated with a ~54 d period. This timescale should represent the rotational timescale of the star, as it does for other magnetic massive stars. In parallel, new spectropolarimetric data confirm the published magnetic detection. Based on observations collected with the ESA science mission XMM-Newton, Chandra, and ESO-FORS2 instrument.Tables 1-3 are available in electronic form at <A href="http://www.aanda.org/10.1051/0004-6361/201424416/olm">http://www.aanda.org</A> [less ▲]

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