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See detailLIGAND-INDEPENDENT IDENTIFICATION OF ORPHAN GPCR ARRESTIN BINDING
Dupuis, Nadine ULiege; Gilissen, Julie ULiege; Derj, Anouar ULiege et al

Poster (2014, June 05)

Detailed reference viewed: 38 (7 ULiège)
Peer Reviewed
See detailLigand-independent Identification of orphan GPCR Signaling pathways
Dupuis, Nadine ULiege; Gilissen, Julie; Derj, Anouar ULiege et al

Conference (2014, July 16)

Detailed reference viewed: 29 (3 ULiège)
See detailLigand-independent Identification of orphan GPR27 Signaling pathways
Dupuis, Nadine ULiege; Gilissen, Julie ULiege; Derj, Anouar ULiege et al

Poster (2014, April 04)

Detailed reference viewed: 37 (5 ULiège)
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See detailLigands and tracers for PET studies of the 5-HT system--current status.
Crouzel, C.; Guillaume, Marcel ULiege; Barre, L. et al

in International Journal of Radiation Applications and Instrumentation. Part B : Nuclear Medicine and Biology (1992), 19(8), 857-70

The status of the radiochemical development and biological evaluation of radioligands and tracers for PET studies of the serotonergic system is reviewed, indicating those agents with present value and ... [more ▼]

The status of the radiochemical development and biological evaluation of radioligands and tracers for PET studies of the serotonergic system is reviewed, indicating those agents with present value and those with future potential. Practical recommendations are given for the preparation of two useful radioligands for PET studies of central 5-HT2 receptors, namely [18F]setoperone and [18F]altanserin. Though, it has not proved possible to recommend tracers or radioligands for the study of other aspects of serotonergic system, prospects for future radiochemical development are indicated, especially for developing radioligands for the 5-HT re-uptake site, and for the 5-HT1 and 5-HT3 receptors. [less ▲]

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See detailLigands playing musical chairs with G-quadruplex DNA: A rapid and simple displacement assay for identifying selective G-quadruplex binders
Monchaud, David; Allain, C.; Bertrand, Hélène et al

in Biochimie (2008), 90(8), 1207-1223

We report here the details of G4-FID (G-quadruplex fluorescent intercalator displacement), a simple method aiming at evaluating quadruplex DNA binding affinity and quadruplex- over duplex-DNA selectivity ... [more ▼]

We report here the details of G4-FID (G-quadruplex fluorescent intercalator displacement), a simple method aiming at evaluating quadruplex DNA binding affinity and quadruplex- over duplex-DNA selectivity of putative ligands. This assay is based on the loss of fluorescence upon displacement of thiazole orange from quadruplex and duplex-DNA matrices. The original protocol was tested using various quadruplex and duplex-DNA targets, and with a wide panel of G-quadruplex ligands belonging to different families (i.e. from quinacridines to metalloorganic ligands) likely to display various binding modes. The reliability of the assay is further supported by comparisons with FRET-melting and ESI-MS assays. [less ▲]

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See detailLigated anionic block copolymerization of methyl methacrylate with n-butyl acrylate and n-nonyl acrylate as promoted by lithium 2-(2-methoxyethoxy) ethoxide/diphenylmethyllithium
Nugay, Nihan; Nugay, Turgut; Jérôme, Robert ULiege et al

in Journal of Polymer Science. Part A, Polymer Chemistry (1997), 35(8), 1543-1548

Poly(methyl methacrylate-b-n-butyl acrylate) (PMMA-b-Pn-BuA) and poly(methyl methacrylate-b-n-nonyl acrylate) (PMMA-b-Pn-NonA) diblock copolymers have been successfully synthesized by the sequential ... [more ▼]

Poly(methyl methacrylate-b-n-butyl acrylate) (PMMA-b-Pn-BuA) and poly(methyl methacrylate-b-n-nonyl acrylate) (PMMA-b-Pn-NonA) diblock copolymers have been successfully synthesized by the sequential anionic polymerization of methyl methacrylate (MMA) and the n-alkyl acrylate (n-BuA or n-NonA), in a 90/10 toluene/ tetrahydrofuran (THF) mixture at -78°C. When diphenylmethyllithium (DPMLi) ligated with lithium 2-(2-methoxyethoxy) ethoxide (LiOEEM) is used as the initiator, the polymerization of each block appears to be living. Molecular weight and composition of block copolymers can be predicted from the monomer over initator molar ratio and the molecular weight distribution is narrow. Size exclusion chromatography (SEC) supports that no homo-PMMA contaminates the final copolymer. Although the reverse polymerization sequence Pn-NonA-b-PMMA always results in some contamination by homo-Pn-NonA, it has no really significant effect on the final product characteristics. [less ▲]

Detailed reference viewed: 29 (1 ULiège)
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See detailLight absorption in conical silicon particles
Bogdanowicz, J; Gilbert, M; Innocenti, N et al

in Optics Express (2013), 21(3), 3891

The problem of the absorption of light by a nanoscale dielectric cone is discussed. A simplified solution based on the analytical Mie theory of scattering and absorption by cylindrical objects is proposed ... [more ▼]

The problem of the absorption of light by a nanoscale dielectric cone is discussed. A simplified solution based on the analytical Mie theory of scattering and absorption by cylindrical objects is proposed and supported by the experimental observation of sharply localized holes in conical silicon tips after high-fluence irradiation. This study reveals that light couples with tapered objects dominantly at specific locations, where the local radius corresponds to one of the resonant radii of a cylindrical object, as predicted by Mie theory. [less ▲]

Detailed reference viewed: 34 (4 ULiège)
See detailLight and Electron microscopic immunolocalization of Bovine pregnancy-associated glycoprotein in the Bovine Placentome
Demez, Pierre ULiege; Zolli, A. P.; Beckers, Jean-François ULiege et al

in 1st Joint meeting of the Royal Microscopical society and the Belgian Societies for Cell biology, clinical cytology, Electron Microscopy and pathology-Abstract book (1993)

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See detailLight and electron microscopic immunolocalization of bovine pregnancy-associated glycoprotein in the bovine placentome.
Zoli, A.; Demez, Pierre ULiege; Beckers, Jean-François ULiege et al

in Biology of Reproduction (1992), 46(4), 623-9

A bovine pregnancy-associated glycoprotein (bPAG) of 67 kDa has previously been isolated from bovine fetal cotyledons. The objective of this study was to determine the cytological localization of that ... [more ▼]

A bovine pregnancy-associated glycoprotein (bPAG) of 67 kDa has previously been isolated from bovine fetal cotyledons. The objective of this study was to determine the cytological localization of that protein in the placentomes and possibly the cells responsible for its production. Highly specific antisera raised against pure bPAG were used to demonstrate the cellular localization of the protein in bovine placentomes by light and electron microscopic techniques. Strong immunostaining was observed exclusively in the cytoplasm of large binucleate cells present predominantly in fetal cotyledonary tissue (villi). Some smaller weakly immunostained cells were also present in caruncular epithelium. By ultrastructural immunogold procedures, the protein was detected only within amorphous cytoplasmic granules. Granules of identical size, but weakly labeled, were found on the maternal side. All cells containing labeled granules were binucleate. These results suggest that bPAG is probably synthesized by trophoblast binucleate cells and stored in granules prior to delivery into the maternal circulation after cell migration. [less ▲]

Detailed reference viewed: 31 (2 ULiège)
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See detailLight and electron microscopical localization of structural lipids with Sudan Black B and osmium tetroxide
Compère, Philippe ULiege; Lhoas, Marie-Laure; Goffinet, Gerhard ULiege

in Micron and Microscopica Acta (1989), 20(2), 119-120

Detailed reference viewed: 17 (3 ULiège)
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See detailLight and oxygen induce chain scission of conjugated polymers in solution
Caubergh, Stéphane ULiege; Louis, Boris; Larsson, Per-Olof et al

in Physical Chemistry Chemical Physics [=PCCP] (2017)

Conjugated polymers have been widely studied as flexible, versatile semiconductors in organic electronics. However, the material stability is one of the problems limiting their applications. Thus ... [more ▼]

Conjugated polymers have been widely studied as flexible, versatile semiconductors in organic electronics. However, the material stability is one of the problems limiting their applications. Thus, understanding the degradation process of conjugated polymers is crucial. In this work, we monitored the chain scission of the model polymer MEH-PPV in solutions under different conditions by assessing its molecular weight using Gel permeation chromatography and optical spectral measurements. We showed that changes in the UV-VIS spectrum can be seen only when the degradation has already progressed substantially. Fluorescence spectrum was found to be almost totally insensitive to the degradation stage of the polymers. We demonstrate that chain scission in solutions happens even in the dark leading to a decrease of about 15% of the molecular weight after just one day of storage. If exposed to room-light, the chain length decreases about 10 times over one day of exposure. Using stronger light intensity or enriching the solution with oxygen accelerates the degradation process dramatically. The rate of the reaction follows approximately a square root dependence with light intensity and oxygen concentration. We conclude that some extent of polymer degradation is difficult to avoid in common laboratory practices since to prevent it one needs to work in oxygen free atmosphere in the dark. Preparation of polymer films from partially degraded solutions might lead not only to losing the connection between the molecular weight and the opto-electronic properties but also to unintentional doping of the semiconductor by products of chains scission reactions. [less ▲]

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See detailLight as a modulator of cognitive brain function
Vandewalle, Gilles ULiege; Maquet, Pierre ULiege; Dijk, D. J.

in Trends in Cognitive Sciences (2009), 13(10), 429-38

Humans are a diurnal species usually exposed to light while engaged in cognitive tasks. Light not only guides performance on these tasks through vision but also exerts non-visual effects that are mediated ... [more ▼]

Humans are a diurnal species usually exposed to light while engaged in cognitive tasks. Light not only guides performance on these tasks through vision but also exerts non-visual effects that are mediated in part by recently discovered retinal ganglion cells maximally sensitive to blue light. We review recent neuroimaging studies which demonstrate that the wavelength, duration and intensity of light exposure modulate brain responses to (non-visual) cognitive tasks. These responses to light are initially observed in alertness-related subcortical structures (hypothalamus, brainstem, thalamus) and limbic areas (amygdala and hippocampus), followed by modulations of activity in cortical areas, which can ultimately affect behaviour. Light emerges as an important modulator of brain function and cognition. [less ▲]

Detailed reference viewed: 44 (1 ULiège)
See detailLight as a modulator of cognitive brain functions
Vandewalle, Gilles ULiege

Conference (2013, May 24)

Detailed reference viewed: 7 (1 ULiège)
Peer Reviewed
See detailLight as a modulator of cognitive brain functions
Vandewalle, Gilles ULiege

Conference (2012, April)

Detailed reference viewed: 29 (1 ULiège)
Peer Reviewed
See detailLight as a modulator of cognitive brain functions
Vandewalle, Gilles ULiege

Conference (2012, September)

Detailed reference viewed: 22 (2 ULiège)
Peer Reviewed
See detailLight as a modulator of cognitive brain functions
Vandewalle, Gilles ULiege

Conference (2012, December)

Detailed reference viewed: 21 (2 ULiège)
See detailLight as a modulator of executive and emotional brain functions
Vandewalle, Gilles ULiege

Scientific conference (2014)

Detailed reference viewed: 14 (1 ULiège)
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See detailLight as a modulator of executive and emotional brain functions
Vandewalle, Gilles ULiege

Conference (2012, June)

Detailed reference viewed: 15 (3 ULiège)
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See detailLight charged particle and intermediate mass fragment cross-sections in GeV proton-induced reactions
Bollini, V.; Bubak, A.; Budzanowski, A. et al

in Nuclear Instruments & Methods in Physics Research Section A-Accelerators Spectrometers Detectors and Associated Equipment (2006), 562(2), 733-736

As an international collaboration PISA (Proton Induced SpAllation) has initiated measurements of total and double differential cross-sections for products of spallation reactions at the proton accelerator ... [more ▼]

As an international collaboration PISA (Proton Induced SpAllation) has initiated measurements of total and double differential cross-sections for products of spallation reactions at the proton accelerator COSY in Julich (Germany) in order to study secondary particle production created in structural, window, and target materials by proton beams up to 2.5 GeV incident kinetic energy. In the framework of Spallation Neutron Sources and accelerator-driven systems, residual nuclei (H, He up to intermediate mass fragrments) production cross-sections are of great importance for estimation of damage in target and structural materials. Reliable and comprehensive experimental data, especially for p-energies beyond I GeV will serve as benchmarks for code development and validation. Data taken by Bragg curve spectroscopy and silicon detector telescopes for the reaction 1.9 GeV p + Ni(Au) will be discussed and kinetic energy spectra of light ions and intermediate mass fragments will be presented. (c) 2006 Elsevier B.V. All rights reserved. [less ▲]

Detailed reference viewed: 4 (0 ULiège)