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See detailModels for assessing the cost-effectiveness of the treatment and prevention of osteoporosis
Zethraeus, N.; Ben Sedrine, Wafa ULg; Caulin, F. et al

in Osteoporosis International (2002), 13(11), 841-857

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See detailModels for Decision Making: From Applications to Mathematics... and Back
Crama, Yves ULg

Conference (2010, March 15)

In this inaugural lecture, I describe some facets of the interplay between mathematics and management science, economics, or engineering, as they come together in operations research models. I intend to ... [more ▼]

In this inaugural lecture, I describe some facets of the interplay between mathematics and management science, economics, or engineering, as they come together in operations research models. I intend to illustrate, in particular, the complex and fruitful process through which fundamental combinatorial models find applications in management science, which in turn foster the development of new and challenging mathematical questions. [less ▲]

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See detailModels of co-production and social economy in service delivery in Europe
Defourny, Jacques ULg

Scientific conference (2011, June 08)

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See detailModels of irrigation system for Pursat basin planning
Ly, Sarann ULg; Someth, Paradis; Men, Nareth

Poster (2007, May 14)

The Mekong River and the Tonle Sap Great Lake in Cambodia have vast floodplain suitable for rice-based farming system. The Tonle Sap Basin, defined as the catchments of the Tonle Sap River at its ... [more ▼]

The Mekong River and the Tonle Sap Great Lake in Cambodia have vast floodplain suitable for rice-based farming system. The Tonle Sap Basin, defined as the catchments of the Tonle Sap River at its confluence with the Mekong River and other 11 main tributaries draining higher ground on all sides of the basin enclosing 44% of Cambodia’s land area. The Pursat River is one of tributaries of the Tonle Sap Great Lake. It originates at Cardamom Mountains and has very good potential for agricultural development. In this paper, we aim at applying three models of irrigation system for basin planning: Chinit (Dam-Reservoir Irrigation), West Baray (Reservoir Irrigation) and Batheay (Shallow Reservoir Irrigation) to Pursat Basin (one of sub-basin of the Tonle Sap Great Lake). Chinit Dam-Reservoir stores water supplied by one of tributaries of Tonle Sap Great Lake, the Chinit River, located in Kampong Thom Province. Spillway is built to pass up inundation and to release water to downstream part. The rest of water in the Dam-Reservoir is distributed to the paddy field by main canal, secondary canals and tertiary canals. This system can be put at the upstream part of the Pursat River, mountainous area. The West Baray Irrigation system is characterized by a reservoir combined with a dike system in the floodplain of the Tonle Sap Great Lake and an irrigation system situated in Siem Reap province. The reservoir is supplied by a tributary of the Tonle Sap Great Lake, the Siem Reap River, in rainy season. The water is distributed to irrigation area in dry season. A small dike system was constructed in the Tonle Sap floodplain for retarding and storing floodwater. The stored floodwater is used as an additional water source for dry season cultivation. This system can be placed at the central plain of the Pursat Basin. Batheay reservoir directly receives floodwater from the Mekong River. It functions as both a reservoir and a paddy field. In wet season, dike around the Batheay reservoir prevents floodwater from entering the reservoir. Rainy season rice is grown inside the reservoir. After harvesting, gates around the reservoir are opened to receive floodwater. The water is stored for cultivating dry season rice outside the reservoir. This system can be put at the downstream part of the Pursat River, floodplain area of Tonle Sap River. [less ▲]

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See detailModels of red giants in the CoRoT asteroseismology fields combining asteroseismic and spectroscopic constraints
Lagarde, N.; Miglio, A.; Eggenberger, P. et al

in Astronomy and Astrophysics (2015), 580

Context. The availability of asteroseismic constraints for a large sample of red giant stars from the CoRoT and Kepler missions paves the way for various statistical studies of the seismic properties of ... [more ▼]

Context. The availability of asteroseismic constraints for a large sample of red giant stars from the CoRoT and Kepler missions paves the way for various statistical studies of the seismic properties of stellar populations. <BR /> Aims: We use a detailed spectroscopic study of 19 CoRoT red giant stars to compare theoretical stellar evolution models to observations of the open cluster NGC 6633 and field stars. <BR /> Methods: In order to explore the effects of rotation-induced mixing and thermohaline instability, we compare surface abundances of carbon isotopic ratio and lithium with stellar evolution predictions. These chemicals are sensitive to extra-mixing on the red giant branch. <BR /> Results: We estimate mass, radius, and distance for each star using the seismic constraints. We note that the Hipparcos and seismic distances are different. However, the uncertainties are such that this may not be significant. Although the seismic distances for the cluster members are self consistent they are somewhat larger than the Hipparcos distance. This is an issue that should be considered elsewhere. Models including thermohaline instability and rotation-induced mixing, together with the seismically determined masses can explain the chemical properties of red giant targets. However, with this sample of stars we cannot perform stringent tests of the current stellar models. Tighter constraints on the physics of the models would require the measurement of the core and surface rotation rates, and of the period spacing of gravity-dominated mixed modes. A larger number of stars with longer times series, as provided by Kepler or expected with Plato, would help ensemble asteroseismology. [less ▲]

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See detailModels of rotating stars constrained by asteroseismic measurements of red giants
Eggenberger, P.; Lagarde, N.; Miglio, A. et al

in Astronomische Nachrichten (in press)

Solar-like oscillations have now been characterized for a large number of stars, thanks to asteroseismic data obtained recently by space missions. This has led to the determination of the global and ... [more ▼]

Solar-like oscillations have now been characterized for a large number of stars, thanks to asteroseismic data obtained recently by space missions. This has led to the determination of the global and internal properties of these stars. In particular, core rotation rates have been obtained for red-giant stars, which is of prime importance to progress in the modelling of the dynamical processes at work in stellar interiors. In this presentation, we discuss which constraints can be brought by these asteroseismic measurements on stellar models that include rotational effects. Similarly to the solar case, we show that an efficient mechanism is required for the transport of angular momentum in the radiative zones of red giants. The efficiency of this transport process can be determined by asteroseismic observations of red-giant stars. [less ▲]

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See detailModels of the multiperson choice process with application to the adoption of industrial products
Choffray, Jean-Marie ULg; Lilien, Gary L.

E-print/Working paper (1976)

In this paper, a model of industrial adoption of capital equipment is proposed. This model explicitly considers the process of group desicion-making involved in the adoption of such products. The ... [more ▼]

In this paper, a model of industrial adoption of capital equipment is proposed. This model explicitly considers the process of group desicion-making involved in the adoption of such products. The literature dealing with multi-person choice processes is reviewed. [less ▲]

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See detailModels of the η Corvi Debris Disk from the Keck Interferometer, Spitzer, and Herschel
Lebreton, J.; Beichman, C.; Bryden, G. et al

in Astrophysical Journal (2016), 817

Debris disks are signposts of analogs to small-body populations of the solar system, often, however, with much higher masses and dust production rates. The disk associated with the nearby star η Crv is ... [more ▼]

Debris disks are signposts of analogs to small-body populations of the solar system, often, however, with much higher masses and dust production rates. The disk associated with the nearby star η Crv is especially striking, as it shows strong mid- and far-infrared excesses despite an age of ∼1.4 Gyr. We undertake constructing a consistent model of the system that can explain a diverse collection of spatial and spectral data. We analyze Keck Interferometer Nuller measurements and revisit Spitzer and additional spectrophotometric data, as well as resolved Herschel images, to determine the dust spatial distribution in the inner exozodi and in the outer belt. We model in detail the two-component disk and the dust properties from the sub-AU scale to the outermost regions by fitting simultaneously all measurements against a large parameter space. The properties of the cold belt are consistent with a collisional cascade in a reservoir of ice-free planetesimals at 133 AU. It shows marginal evidence for asymmetries along the major axis. KIN enables us to establish that the warm dust consists of a ring that peaks between 0.2 and 0.8 AU. To reconcile this location with the ∼400 K dust temperature, very high albedo dust must be invoked, and a distribution of forsterite grains starting from micron sizes satisfies this criterion, while providing an excellent fit to the spectrum. We discuss additional constraints from the LBTI and near-infrared spectra, and we present predictions of what James Webb Space Telescope can unveil about this unusual object and whether it can detect unseen planets. [less ▲]

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See detailModels to estimate overall analytical measurements uncertainty: assumptions, comparisons and applications
Rozet, Eric ULg; Rudaz, S.; Marini Djang'Eing'A, Roland ULg et al

in Analytica Chimica Acta (2011), 702

Evaluation of analytical results reliability is of core importance as crucial decisions are taken with them. From the various methodologies to evaluate the fitness of purpose of analytical methods ... [more ▼]

Evaluation of analytical results reliability is of core importance as crucial decisions are taken with them. From the various methodologies to evaluate the fitness of purpose of analytical methods, overall measurement uncertainty estimation is more and more applied. Overall measurement uncertainty allows to combine simultaneously the remaining systematic influences to the random sources of uncertainty and allows assessing the reliability of results generated by analytical methods. However there are various interpretations on how to estimate overall measurement uncertainty, and thus various models for estimating it. Each model together with its assumptions has great impacts on the risks to abusively declare that analytical methods are suitable for their intended purpose. This review paper aims at i) summarizing the various models used to estimate overall measurement uncertainty, ii) provide their pros and cons, iii) review the main areas of application and iv) as a conclusion provide some recommendations when evaluating overall measurement uncertainty. [less ▲]

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See detailModels to predict the combined effects of temperature and relative humidity on Pectobacterium Atrosepticum and Pectobacterium carotovorum subsp. Carotovorum population density and soft rot disease development at the surface of wounded potato tubers
Moh, Augustin; Massart, Sébastien ULg; Lepoivre, Philippe ULg et al

in Journal of Plant Pathology [=JPP] (2012), 94(1), 181-191

The main objectives of this study were to evaluate and model the influence of temperature (10, 15 and 20°C), relative humidity (86, 96 and 100%) and initial concentration of bacterial inoculum (105, 107 ... [more ▼]

The main objectives of this study were to evaluate and model the influence of temperature (10, 15 and 20°C), relative humidity (86, 96 and 100%) and initial concentration of bacterial inoculum (105, 107 et 109 CFU ml-1) on the population density of Pectobacterium atrosepticum (Pba) and Pectobacterium carotovorum subsp. carotovorum (Pcc) which are important potato pathogens in temperate climates, and on the development of soft rot symptoms caused by these bacteria at the surface of wounded potatoes tubers under controlled conditions. Experiments were carried out according to a Box-Behnken experimental design, simplifying prediction of the combined effects of three controlled factors. With both bacterial species, statistical analysis showed a significant effect of temperature, relative humidity and initially applied bacterial concentration on population dynamics and soft rot development at the surface of wounded potato tubers. Multiple regression analyses and the contour plots showed that the temperature is the most important factor, followed by the initially applied bacteria concentration and relative humidity. More than 64% of the variability of the soft rot symptoms observed could be explained by the presence of Pba and Pcc at the level of wounded potato tubers under the combined effect of tested factors. The quadratic polynomial models developed in our research should integrate the heterogeneity of tested bacteria belonging to the same species (which was not evaluated in this preliminary investigation) in further research. [less ▲]

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See detailModeltoets 1 : De Europese Talencertificaten : Certificaat Nederlands
Hennen, Karl-Heinz; Peters, Magda; Vromans, Joseph ULg

Book published by Weiterbildungs-Testsysteme (1998)

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See detailThe Modem contribution to Medalpex
Djenidi, Salim ULg; Nihoul, Jacques ULg; Clément, Francis et al

in Annales Geophysicae. Series B, Terrestrial and Planetary Physics (1987), 5B(1), 3-12

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See detailModena e la cittadinanza globale
Martiniello, Marco ULg

Scientific conference (2003, June 05)

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See detailModerate chemical modifications of WAY-100635 improve the selectivity for 5-HT1A versus D4 receptors
Mangin, Floriane; Dilly, Sébastien ULg; Joly, Benoît ULg et al

in Bioorganic & Medicinal Chemistry Letters (2012)

The selectivity for 5-HT1A versus D4 receptors is significantly increased when the basic side chain of WAY-100635 is replaced by a 4-phenylpiperazine (3e) or a 4-phenyl-1,2,3,6-tetrahydropyridine moiety ... [more ▼]

The selectivity for 5-HT1A versus D4 receptors is significantly increased when the basic side chain of WAY-100635 is replaced by a 4-phenylpiperazine (3e) or a 4-phenyl-1,2,3,6-tetrahydropyridine moiety (3i). The 4-phenyl-1,2,3,6-tetrahydropyridine compounds (3i-l) have a higher affinity for 5-HT1A receptors than do the corresponding unsubstituted phenylpiperazine analogues (3e-h). Compounds 3e and 3i appear to be selective for 5-HT1A receptors over other relevant receptors and still behave as neutral antagonists. [less ▲]

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See detailModerate deflection analysis of shelles of revolution, using cylindrical components of the displacement
Debongnie, Jean-François ULg

Report (1984)

This paper is devoted to the analysis of shells of revolution, using cylindrical components of the displacement. This procedure, as coupled with a Fourier expansion by respect of the azimuth, permits the ... [more ▼]

This paper is devoted to the analysis of shells of revolution, using cylindrical components of the displacement. This procedure, as coupled with a Fourier expansion by respect of the azimuth, permits the generation of finite elements in which rigid body are represented exactly, even in the case of doubly curved shells. [less ▲]

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See detailModerate deglection analysis of shells of revolution, using cartesian components of the displacement
Debongnie, Jean-François ULg

Report (1985)

This paper is devoted to the analysis of shells of revolution, using cylindrical components of the displacement. This procedure, coupled with a Fourier expansion by respect of the azimuth, permits the ... [more ▼]

This paper is devoted to the analysis of shells of revolution, using cylindrical components of the displacement. This procedure, coupled with a Fourier expansion by respect of the azimuth, permits the generation of finite elements in which rigid body displacements are represented exactly, even in the case of doubly curved shells. [less ▲]

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See detailModerate hypothermia during cardiopulmonary bypass increases intramyocardial synthesis of heat shock protein 72.
Qing, Ma; Vazquez-Jimenez, Jaime F; Schumacher, Kathrin et al

in Journal of Thoracic and Cardiovascular Surgery (The) (2002), 124(4), 724-31

OBJECTIVES: This study was undertaken to test the hypothesis that the myocardial protective effect of moderate hypothermia during cardiopulmonary bypass involves upward regulation of heat shock protein 72 ... [more ▼]

OBJECTIVES: This study was undertaken to test the hypothesis that the myocardial protective effect of moderate hypothermia during cardiopulmonary bypass involves upward regulation of heat shock protein 72. METHODS: Sixteen young pigs were randomly assigned to a temperature regimen during standardized cardiopulmonary bypass of normothermia or moderate hypothermia (temperatures 37 degrees C and 28 degrees C, respectively, n = 8 per group). Myocardial probes were sequentially sampled from the right ventricle before and during bypass and 6 hours after bypass. Messenger RNA encoding for heat shock protein 72 was assessed by competitive reverse transcriptase-polymerase chain reaction, and heat shock protein 72 synthesis was assessed by Western blot and immunohistochemical methods. Induction of apoptosis was assessed by gene expression of apoptosis-regulating proteins (Bcl-xL, Bak, and Fas) according to competitive reverse transcriptase polymerase chain reaction. Apoptotic cells were identified with an in situ apoptosis-detection kit (terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling) in combination with morphologic criteria. Necrotic cells were detected by standard histologic methods. RESULTS: Moderate hypothermia rather than normothermia was associated with earlier and higher gene expression and synthesis of heat shock protein 72 in the myocardium during and after cardiac surgery. In the hypothermia group both heat shock protein 72 and the messenger RNA encoding it were detected as soon as 30 minutes after initiation of bypass and before aortic clamping, whereas in the normothermia group they were not detected before aortic clamping. Immunohistochemical methods showed localization of heat shock protein 72 in the cardiomyocytes, endothelial cells, and macrophages. Although the percentage of necrotic cells in the myocardium was lower in the hypothermic group, the induction of apoptosis regulatory proteins and the percentage of apoptotic cells did not differ between the groups. CONCLUSIONS: These results suggest that the myocardial protective effect of moderate hypothermia during cardiopulmonary bypass involves upward regulation of heat shock protein 72 and inhibition of necrosis but not of apoptosis. [less ▲]

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See detailModerate hypothermia during cardiopulmonary bypass reduces myocardial cell damage and myocardial cell death related to cardiac surgery.
Vazquez-Jimenez, J. F.; Qing, M.; Hermanns, B. et al

in Journal of the American College of Cardiology (2001), 38(4), 1216-23

OBJECTIVES: The goal of this study was to test the hypothesis that moderate hypothermia during cardiopulmonary bypass (CPB) provides myocardial protection by enhancing intra-myocardial anti-inflammatory ... [more ▼]

OBJECTIVES: The goal of this study was to test the hypothesis that moderate hypothermia during cardiopulmonary bypass (CPB) provides myocardial protection by enhancing intra-myocardial anti-inflammatory cytokine balance. BACKGROUND: Moderate hypothermia during experimental CPB stimulates production of interleukin-10 (IL10) and blunts release of tumor necrosis factor-alpha (TNFalpha). METHODS: Twelve young pigs were assigned to a temperature (T degrees ) regimen during CPB: moderate hypothermia (T degrees : 28 degrees C; n = 6) and normothermia (T degrees : 37 degrees C; n = 6). Intra-myocardial TNFalpha- and IL10-messenger RNA were detected by competitive reverse transcriptase polymerase chain reaction and quantification of cytokine synthesis by Western blot. Levels of cardiac troponin I (cTnI) in cardiac lymph and in arterial and coronary venous blood were examined during and after CPB. Myocardial cell damage was assessed by histologic and ultrastructural anomalies of tissue probes taken 6 h after CPB. RESULTS: Synthesis of IL10 was significantly higher, while that of TNFalpha was significantly lower, in pigs that were in moderate hypothermia during surgery than in the others. In contrast with normothermia, moderate hypothermia was also associated with significantly lower cumulative cardiac lymphatic flow during and after CPB, significantly lower lymphatic cTnI concentrations after CPB, significantly lower percentages of myocardial cell necrosis and a significantly lower score of ultrastructural anomalies of myocardial cells. While the percentage of apoptotic cells was not different between groups, the apoptosis/necrosis ratio tended to be higher in animals that were in moderate hypothermia during surgery. In all animals, TNFalpha synthesis correlated positively while IL10 production correlated negatively with necrosis and total cell death, respectively. CONCLUSIONS: Our results suggest that moderate hypothermia during CPB provides myocardial protection by enhancing intra-myocardial anti-inflammatory cytokine balance. [less ▲]

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See detailModerate patient-prosthesis mismatch can impact on mortality after aortic valve replacement
Dumesnil, J. G.; Magne, Julien ULg; Girerd, N. et al

in Heart (2009), 95(7), 592

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See detailA moderate transfusion regimen may reduce iron loading in beta-thalassemia major without producing excessive expansion of erythropoiesis.
Cazzola, M.; Borgna-Pignatti, C.; Locatelli, F. et al

in Transfusion (1997), 37(2), 135-40

BACKGROUND: Hypertransfusion with a baseline hemoglobin of 10 to 12 g per dL is still considered by many to be the mainstay of conservative therapy for beta-thalassemia major. However, this regimen is ... [more ▼]

BACKGROUND: Hypertransfusion with a baseline hemoglobin of 10 to 12 g per dL is still considered by many to be the mainstay of conservative therapy for beta-thalassemia major. However, this regimen is frequently associated with manifestations of transfusion iron overload, despite regular chelation therapy with subcutaneous desferoxamine. STUDY DESIGN AND METHODS: To verify whether a transfusion regimen with a target pretransfusion hemoglobin level between 9 and 10 g per dL can allow a significant reduction in blood consumption, while still effectively suppressing erythropoiesis, the records were reviewed of 32 beta-thalassemia major patients, who were maintained at a pretransfusion hemoglobin of 11.3 +/- 0.5 g per dL between 1981 and 1986. These patients were switched at the beginning of 1987 to a transfusion regimen with pretransfusion hemoglobin of 9.4 +/- 0.4 g per dL. The degree of erythroid marrow activity was evaluated in these patients and in 32 subjects with beta-thalassemia intermedia through the simple measurement of serum transferrin receptor. RESULTS: After the adoption of the moderate transfusion regimen, transfusion requirements decreased from 137 +/- 26 to 104 +/- 23 mL per kg per year of red cells (p < 0.0001), and mean serum ferritin decreased from 2448 +/- 1515 to 1187 +/- 816 micrograms per L (p < 0.0001), with one-half of patients achieving serum ferritin levels lower than 1000 micrograms per L. The proportion of patients having spontaneous pubertal development increased significantly (p < 0.01), as a result of less iron-related gonadotropin insufficiency. At the lower pretransfusion hemoglobin, erythroid marrow activity did not exceed two to three times normal levels in most subjects. CONCLUSION: As compared with hypertransfusion, moderate transfusion may allow more effective prevention of iron loading, with higher likelihood of spontaneous pubertal development and without producing excessive expansion of erythropoiesis. [less ▲]

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