Successful treatment of equine sarcoids with cisplatin electrochemotherapy: a retrospective study of 48 cases.

in Equine Veterinary Journal (2012), 44(2), 214-220

REASONS FOR PERFORMING STUDY: Sarcoids are the commonest form of equine skin tumour. Several therapeutic measures have been described but none is considered to be universally effective ... [more ▼]

REASONS FOR PERFORMING STUDY: Sarcoids are the commonest form of equine skin tumour. Several therapeutic measures have been described but none is considered to be universally effective. Electrochemotherapy (ECT) is a new anticancer therapy that utilises electrical field pulses to induce increased cell membrane permeability to antitumour hydrophilic drugs, such as cisplatin. The increased intracellular concentration of the drugs has a significant therapeutic benefit. The procedure has not been previously reported in a large number of horses. OBJECTIVE: To validate ECT as a novel alternative treatment for equine sarcoids. METHODS: A retrospective study evaluating the efficacy of cisplatin ECT in the treatment of equine sarcoids was performed. Electrochemotherapy treatments were applied under general anaesthesia at 2 week intervals with or without prior excision or debulking. Electric pulses were directly applied to the lesions following intra-tumoural injections of an aqueous solution of cisplatin. RESULTS: One-hundred-and-ninety-four sarcoids on 34 horses, 2 ponies, 11 donkeys and one mule were treated with ECT. The 4 year nonrecurrence rate was 97.9% for animals (47/48) and 99.5% (193/194) for tumours. When ECT was used as a single treatment, a significant influence of tumour size (ρ= 0.55) on the number of treatments required for cure was shown. When prior surgery was performed, there was a significant influence (P<0.001) of the excision quality (complete or incomplete) and the healing mode (closed or open wound) on the number of treatments. The most common adverse effect was a slight oedematous reaction for lesions located on thin skin regions. CONCLUSION AND CLINICAL RELEVANCE: Results demonstrate that ECT, with or without concurrent tumour debulking, is an effective alternative for treatment of equine sarcoids [less ▲]

Successful treatment of intrauterine supraventricular tachycardia and hydrops fetalis with digoxin

in European Journal of Pediatrics (1986), 145

Successful treatment of progressive mucocutaneous infection due to acyclovir- and foscarnet-resistant herpes simplex virus with (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC).

in Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America (1994), 18(4), 570-8

The acyclic nucleoside phosphonate (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) was used topically for the treatment of persistent mucocutaneous infections in two cases. One patient with ... [more ▼]

The acyclic nucleoside phosphonate (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) was used topically for the treatment of persistent mucocutaneous infections in two cases. One patient with AIDS suffered from a perineal lesion due to infection with herpes simplex virus type 2 (HSV-2) and did not respond to acyclovir and was intolerant of foscarnet. A bone marrow transplant recipient developed orofacial lesions due to infection with herpes simplex virus type 1 (HSV-1) that failed to respond to therapy with both acyclovir and foscarnet. After topical application of HPMPC, the HSV-2 lesions completely resolved. However, the lesions recurred 3 weeks later, and, upon subsequent treatment with HPMPC, regressed. On recurrence, the virus was found to be sensitive to acyclovir, which the patient was given. Again HSV-2, which was resistant to acyclovir, emerged; similar observations were made after another cycle of HPMPC therapy. The HSV-1 isolates were resistant to acyclovir and foscarnet. Following local HPMPC treatment, the lesions regressed, but after 1 week, a second course of topical HPMPC therapy had to be instituted for recurrent infection. The lesions again regressed, and as the recurrent virus was sensitive to acyclovir, the patient was successfully treated with the drug. The results of this study point to the potential usefulness of topical HPMPC in the treatment of immunocompromised patients with HSV-related mucocutaneous infections that are refractory to therapy with acyclovir and/or foscarnet. [less ▲]

Successful Tricuspid Valve Replacement and Pulmonary Valvulotomy for Carcinoid Heart Disease

in Acta Chirurgica Belgica (1996), 96(4), 170-6

A case of successful tricuspid valve replacement with a mechanical prosthesis and pulmonary valvulotomy for carcinoid heart disease is reported. The patient was a 61 years old women. The primary tumor was ... [more ▼]

A case of successful tricuspid valve replacement with a mechanical prosthesis and pulmonary valvulotomy for carcinoid heart disease is reported. The patient was a 61 years old women. The primary tumor was in the terminal ileum. Liver metastasis and carcinoid syndrome were present since 8 years. After cardiac surgery, the patient survived 38 months and late death was related to disseminated metastasis. Even in case of metastasis, carcinoid tumor is slow growing. Without cardiac operation for correction of valvular lesions, terminal symptoms and death may often be related to cardiac operation for correction of valvular lesions, terminal symptoms and death may often be related to cardiac failure rather than to tumoral growth. Thus, even in presence of metastasis, cardiac surgery may be mandatory to improve both quality of life and survival. [less ▲]

Successi artigianali e promesse mancate. La progettazione auto all’Alfa Romeo negli anni Trenta e Quaranta.

in Monografie AISA (2011), 92

L'article examine le rapport entre les projets de rationalisation industrielle mis en oeuvre par l'Ing. Gobbato et l'activité du bureau d'études automobile d'Alfa-Romeo entre 1933 et 1945.

La succession des régions aux obligations aquiliennes de l'Etat relatives à la voirie

in Revue de Jurisprudence de Liège, Mons et Bruxelles (1998)

Les successions d'entreprises en région flamande

in Manuel de planification patrimoniale (2010)

Successions internationales - panorama des difficultés dans les relations belgo-allemandes

Conference (2012, September)

Cette présentation fait le point sur les difficultés que présent le cadre juridique en vigueur actuellement dans les relations belgo-allemandes en matière successorale, pour mieux illustrer l'impact qu ... [more ▼]

Cette présentation fait le point sur les difficultés que présent le cadre juridique en vigueur actuellement dans les relations belgo-allemandes en matière successorale, pour mieux illustrer l'impact qu'aura le Règlement succession dont l'entrée en vigueur est prévue en 2015. [less ▲]

Successions internationales: perspectives d'avenir

in Leleu, Yves-Henri (Ed.) Chroniques notariales, vol. 55 (2012)

Suceptibilité de Prostephanus truncatus à l'égard de deux pyréthrinoïdes

Scientific conference (1987)