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See detailNo-Carrier-Added Regioselective Preparation of 6-[18f]Fluoro-L-Dopa
Bozet, Claire ULg; Guillaume, Marcel; Cantineau, R. et al

in Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine (1990), 31(7), 1247-51

This paper describes the preparation of 6-[18F]fluoro-L-dopa by a no-carrier-added method based on the nucleophilic displacement of nitro groups of two commercially available substrates, 3,4-dimethoxy-2 ... [more ▼]

This paper describes the preparation of 6-[18F]fluoro-L-dopa by a no-carrier-added method based on the nucleophilic displacement of nitro groups of two commercially available substrates, 3,4-dimethoxy-2-nitrobenzaldehyde (nitroveratraldehyde) and 6-nitropiperonal. Fluorination was conducted in DMSO with fluorine-18 (18F) in the presence of the aminopolyether Kryptofix 222 and potassium carbonate. The condensation of the fluorinated aldehydes with phenyloxazolone and the subsequent hydrolysis with HI/P yield, after purification by HPLC, only the 6-(D, L) isomers. The racemic mixture (50/50) was resolved on an analytical scale chiral column. The method, which requires 100 min (EOB) to complete, produces 6-[18F]fluoro-L-dopa with a decay-corrected radiochemical yield of 10%, an enantiomeric purity greater than 99%, and a specific activity of 1.2 Ci/mumole. [less ▲]

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See detailThe No-Value of Popular Music in the Twenty First Century
Levaux, Christophe ULg

Conference (2014, June 06)

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See detailNO2 and CO interaction with plasma treated Au-decorated MWCNTs: Detection pathways
Leghrib, R.; Llobet, E.; Felten, A. et al

in Procedia Chemistry (2009), 1(1), 931-934

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See detailNO3- Reduction is Fe-Dependent in a Ferruginous Chemocline
Michiels, C.; Darchambeau, François ULg; Roland, Fleur ULg et al

Conference (2014)

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See detailLe Noaillien et le Rayssien sont-ils des "faciès culturels" de la paléoculture gravettienne?
Touzé, Olivier ULg

in Annales d'Histoire de l'Art et d'Archéologie (2011), 33

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See detailNoam Chomsky, De quoi les médias dominants tirent-ils leur domination ?
Durand, Pascal ULg

in Durand, Pascal (Ed.) Médias et Censure. Figures de l'orthodoxie (2004)

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See detailNoble, chevalier, pénitent, martyr : l'idéal de sainteté d'après une Vita mosane du XIIe siècle
George, Philippe ULg

in Moyen Age (Le) (1983), LXXXIX

Un nouvel idéal, l'idéal du chevalier chrétien, est mis en exergue dans une Vie latine mosane du XIIe siècle

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See detailNoblesse éclairée, bourgeoisie tendre dans la principauté de Liège au XVIIIe siècle
Droixhe, Daniel ULg

in Etudes sur le XVIIIe siècle (1982), 9

Detailed reference viewed: 372 (17 ULg)
See detailLa noblesse en milieu urbain dans l’espace mosan (XIIIe-XVe siècles)
Marchandisse, Alain ULg

in Dutour, Thierry (Ed.) Les Nobles et la ville dans l’espace francophone (XIIe-XVIe siècles) (2010)

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See detailNoblesse féodale et pouvoir épiscopal dans la principauté de Liège des XIIIe-XVe siècles
Marchandisse, Alain ULg

in Gentile, Marco; Savy, Pierre (Eds.) Noblesse et États princiers en Italie et en France au XVe siècle (2009)

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See detailA noção de texto em Hjelmslev
Badir, Sémir ULg

in CASA : Cadernos de Semiótica Aplicada (2005), 3(2),

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See detailThe Nociception Coma Scale to assess nociception in disorders of consciousness
Chatelle, Camille ULg; Schnakers, Caroline; VANHAUDENHUYSE, Audrey ULg et al

Poster (2010)

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See detailLa Nociception Coma Scale
Chatelle, Camille ULg

Conference (2012)

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See detailNociception coma scale-revised scores correlate with metabolism in the anterior cingulate cortex.
Chatelle, Camille ULg; Thibaut, Aurore ULg; Bruno, Marie-Aurelie et al

in Neurorehabilitation and neural repair (2014), 28(2), 149-52

BACKGROUND: . The Nociception Coma Scale-Revised (NCS-R) was recently validated to assess possible pain perception in patients with disorders of consciousness. OBJECTIVE: . To identify correlations ... [more ▼]

BACKGROUND: . The Nociception Coma Scale-Revised (NCS-R) was recently validated to assess possible pain perception in patients with disorders of consciousness. OBJECTIVE: . To identify correlations between cerebral glucose metabolism and NCS-R total scores. METHODS: . [18F]-fluorodeoxyglucose positron emission tomography, NCS-R, and Coma Recovery Scale-Revised assessments were performed in 49 patients with disorders of consciousness. RESULTS: . We identified a significant positive correlation between NCS-R total scores and metabolism in the posterior part of the anterior cingulate cortex, known to be involved in pain processing. No other cluster reached significance. No significant effect of clinical diagnosis (vegetative/unresponsive vs minimally conscious states), etiology or interval since insult was observed. CONCLUSIONS: . Our data support the hypothesis that the NCS-R total scores are related to cortical processing of nociception and may constitute an appropriate behavioral tool to assess, monitor, and treat possible pain in brain-damaged noncommunicative patients with disorders of consciousness. Future studies using event-related functional magnetic resonance imaging should investigate the correlation between NCS-R scores and brain activation in response to noxious stimulation at the single-subject level. [less ▲]

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See detailThe nociception coma scale: A new tool to assess nociception in disorders of consciousness.
Schnakers, Caroline ULg; Chatelle, Camille ULg; Vanhaudenhuyse, Audrey ULg et al

in Pain (2010), 148

Assessing behavioral responses to nociception is difficult in severely brain-injured patients recovering from coma. We here propose a new scale developed for assessing nociception in vegetative (VS) and ... [more ▼]

Assessing behavioral responses to nociception is difficult in severely brain-injured patients recovering from coma. We here propose a new scale developed for assessing nociception in vegetative (VS) and minimally conscious (MCS) coma survivors, the Nociception Coma Scale (NCS), and explore its concurrent validity, inter-rater agreement and sensitivity. Concurrent validity was assessed by analyzing behavioral responses of 48 post-comatose patients to a noxious stimulation (pressure applied to the fingernail) (28 VS and 20 MCS; age range 20-82years; 17 of traumatic etiology). Patients' were assessed using the NCS and four other scales employed in non-communicative patients: the 'Neonatal Infant Pain Scale' (NIPS) and the 'Faces, Legs, Activity, Cry, Consolability' (FLACC) used in newborns; and the 'Pain Assessment In Advanced Dementia Scale' (PAINAD) and the 'Checklist of Non-verbal Pain Indicators' (CNPI) used in dementia. For the establishment of inter-rater agreement, fifteen patients were concurrently assessed by two examiners. Concurrent validity, assessed by Spearman rank order correlations between the NCS and the four other validated scales, was good. Cohen's kappa analyses revealed a good to excellent inter-rater agreement for the NCS total and subscore measures, indicating that the scale yields reproducible findings across examiners. Finally, a significant difference between NCS total scores was observed as a function of diagnosis (i.e., VS or MCS). The NCS constitutes a sensitive clinical tool for assessing nociception in severely brain-injured patients. This scale constitutes the first step to a better management of patients recovering from coma. [less ▲]

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