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See detailPrevalence and impact of osteoarthritis and osteoporosis on health-related quality of life among active subjects
Rabenda, Véronique ULg; Manette, Christelle; Lemmens, R. et al

in Aging Clinical & Experimental Research (2007), 19(1), 55-60

Background and aims: To assess the prevalence and impact of osteoarthritis (OA) and osteoporosis (OP) on health-related quality of life (HRQOL) among active subjects employed in the public workforce in ... [more ▼]

Background and aims: To assess the prevalence and impact of osteoarthritis (OA) and osteoporosis (OP) on health-related quality of life (HRQOL) among active subjects employed in the public workforce in Belgium. Methods: A cohort of 3440 subjects employed by the Liege City Council was prospectively followed for 6 months. The employees were asked to fill in a monthly log in a health record book, of data regarding their healthcare consumption due to OA and OP. HRQOL was assessed using the Medical Outcomes Study Short Form-36 (SF-36). Results: 1811 subjects (52.6%) filled in at least one questionnaire. The mean duration of follow-up was 3.46 months. The self-reported prevalence of OA and OP at entry to the study were respectively 34.1% and 5.3%. 3.6% of subjects reported suffering from both OA and OP. Subjects with OA and both OA and OP had significantly lower scores on all SF-36 dimensions compared with normal subjects, reflecting a worse HRQOL. The OP group had significantly lower mean scores for physical functioning and pain compared with controls. Subjects with both OA and OP had significantly lower values for physical functioning, physical role and pain when compared with the OA and OP groups. Conclusions: The results of this survey of a large sample of active subjects show that self-reported osteoarthritis and osteoporosis are common in the workplace. Both diseases have a major impact on health-related quality of life compared with that of people without self-reported musculoskeletal diseases. [less ▲]

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See detailPrevalence and impact of osteoarthritis and osteoporosis on health-related quality of life among active subjects
Rabenda, Véronique ULg; Manette, Christelle; Lemmens, Régine et al

in Osteoporosis International (2005, March), 16(Suppl.3), 110

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See detailPrevalence and incidence of epilepsy in 270 GH-treated adult patients with traumatic brain injury (TBI) followed in KIMS database.
Valdes Socin, Hernan Gonzalo ULg; Mattson, A. F.; Koltowska-Haggstrom, M. et al

in European Neuroendocrine Association - Liège, 22-25 septembre 2010 (2010, September)

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See detailPrevalence and management of cancer-related anaemia, iron deficiency and the specific role of intravenous iron
Aapro, M.; Osterborg, A.; Gascon, P. et al

in Annals of Oncology (2012), 23

Background: Chronic diseases reduce the availability of iron for effective erythropoiesis. This review summarises clinical consequences of iron deficiency (ID) and anaemia in cancer patients, mechanisms ... [more ▼]

Background: Chronic diseases reduce the availability of iron for effective erythropoiesis. This review summarises clinical consequences of iron deficiency (ID) and anaemia in cancer patients, mechanisms how impaired iron homeostasis affects diagnosis and treatment of ID, and data from clinical trials evaluating i.v. iron with or without concomitant erythropoiesis-stimulating agents (ESAs). Design: Clinical trial reports were identified in PubMed and abstracts at relevant major congresses. Results: Reported prevalence of ID in cancer patients ranges from 32 to 60% and most iron-deficient patients are also anaemic. Randomised clinical trials have shown superior efficacy of i.v. iron over oral or no iron in reducing blood transfusions, increasing haemoglobin, and improving quality of life in ESA-treated anaemic cancer patients. Furthermore, i.v. iron without additional ESA should be evaluated as potential treatment in patients with chemotherapyinduced anaemia. At recommended doses, i.v. iron is well tolerated, particularly compared with oral iron. No serious drug-related adverse effects were seen during long-term use in renal disease and no effect on tumour growth has been observed in trials with anaemic cancer patients. Conclusions: Reliable diagnosis and treatment of ID are recommended key steps in modern cancer patient management to minimise impact on quality of life and performance status. [less ▲]

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See detailPrevalence and mechanisms of resistance to carbapenems in Enterobacteriaceae
Huang, Te-Din; Berhin, Catherine; Glupczynski, Youri et al

in Journal of Antimicrobial Chemotherapy (2013), 68(8), 1832-7

Objectives: To determine the point prevalence of carbapenem-non-susceptible Enterobacteriaceae (CNSE) and carbapenemase-producing Enterobacteriaceae (CPE) isolates among hospitalized patients in Belgium ... [more ▼]

Objectives: To determine the point prevalence of carbapenem-non-susceptible Enterobacteriaceae (CNSE) and carbapenemase-producing Enterobacteriaceae (CPE) isolates among hospitalized patients in Belgium. Methods: Twenty-four hospital-based laboratories prospectively collected 200 non-duplicated Enterobacteriaceae isolates from clinical specimens of hospitalized patients over a 2 month period. All isolates were screened locally for decreased susceptibility to carbapenem drugs using a disc diffusion method according to CLSI interpretative criteria. CNSE strains were referred centrally for confirmation of carbapenemase by phenotypic and molecular testing. Results: From February to April 2012, 158 of the 4564 screened Enterobacteriaceae isolates were categorized as non-susceptible to carbapenems, resulting in a point prevalence of CNSE of 3.5% (95% CI: 2.9%–4.2%; range per centre: 0.5%–8.5%). Of the 125 referred CNSE isolates, 11 Klebsiella pneumoniae isolates [OXA-48 (n=7), KPC type (n=3) and NDM type (n=1)], 1 OXA-48-positive Escherichia coli isolate and 1 KPC-positive Klebsiella oxytoca isolate were detected in eight hospitals. None of the 72 carbapenem-non-susceptible Enterobacter spp. isolates were confirmed as CPE. The minimal estimated point prevalence of CPE isolates was 0.28% (13/ 4564; 95% CI: 0.13%–0.44%) overall (range per centre: 0%–1.5%). Conclusions: Despite the overall low prevalence of CNSE found in this study, the detection of CPE isolates in one-third of the participating centres raises concerns and highly suggests the spread and establishment of CPE in Belgian hospitals. [less ▲]

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See detailPrevalence and Molecular Typing of Attaching and Effacing Escherichia Coli among Calf Populations in Belgium
China, B.; Pirson, V.; Mainil, Jacques ULg

in Veterinary Microbiology (1998), 63(2-4), 249-259

Attaching and effacing Escherichia coli are involved in diarrhea in 2 to 8-week old calves. The virulence factors of these bacteria include: (i) the secretion of proteins (i.e. EspB) involved in ... [more ▼]

Attaching and effacing Escherichia coli are involved in diarrhea in 2 to 8-week old calves. The virulence factors of these bacteria include: (i) the secretion of proteins (i.e. EspB) involved in microvilli effacement, (ii) the production of the intimin, a 94 kDa outer membrane protein encoded by the eaeA gene and involved in the intimate attachment of bacteria to epithelial cell and (iii) the production of verotoxins: VT1 and/or VT2. We investigated the presence and the pathotype of these strains in several calf populations by colony hybridization or by genetic amplification. Using the colony hybridization method we showed first that only 5% of calves who died from diarrhea presented EaeA+ E. coli strains and secondly that 19% of healthy calves showed an asymptomatic carriage. However, using colony hybridization and genetic amplification, we identified EaeA+ strains in 91% of calves living in farms with recurrent diarrhea problems. In 66% of the calves, there was a correlation between the presence of AEEC and diarrhea. At the pathotype level, most of the EaeA+ isolates were negative for VT probes. In VT+ bacteria, the majority were VT1+. The number of VT positive bacteria was significantly higher in calves who died from diarrhea than in healthy or sick calves. This underlined the aggravating role of verotoxins in the disease. Moreover, only 25% of the bovine AEEC were positive with the EaeB probe. Surprisingly, the proportion of EaeB+ strains was significantly higher in healthy calves than in other populations. [less ▲]

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See detailPrevalence and Richness of Gastrointestinal Parasites of Capuchins (Cebus albifrons) Interacting with humans in the Ecuadorian Amazon
Ramirez, William; Martin, Sarah ULg; Carrillo Bilbao, Gabriel Alberto et al

Poster (2013, September 10)

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See detailPrevalence and Risk Factors for Various Cardiac Diseases in a Hospital-Based Population of 3434 Horses (1994-2011)
Leroux, Aurélia ULg; Detilleux, Johann ULg; Sandersen, Charlotte ULg et al

in Journal of Veterinary Internal Medicine (2013), 27(6), 1563-70

Background: Risk factors for several cardiac diseases have been suspected in horses, but few have been statistically demonstrated in a large equine population. Objectives: To describe risk factors for ... [more ▼]

Background: Risk factors for several cardiac diseases have been suspected in horses, but few have been statistically demonstrated in a large equine population. Objectives: To describe risk factors for various cardiac diseases in a hospital-based equine population. Animals: Files of 3434 horses admitted at the internal medicine department of the Liege Equine Teaching Hospital between 1994 and 2011were reviewed and of those, 284 were categorized as suffering from moderate to severe cardiac disease. Methods: Observational study. After calculating prevalence for each cardiac disease, we tested whether breed (chi-square test) or gender, age, body weight (BW) and other cardiac diseases (logistic regressions) were risk factors (p<0.05 significant). Results: Mitral regurgitation (MR, 4.4%), atrial fibrillation (AF, 2.3%), aortic regurgitation (AR, 2.1%) and tricuspid regurgitation (TR, 1.7%) were the most common cardiac abnormalities. Determinants were male gender and increasing age for AR (OR=2.03, CI=1.07-4.94), racehorses breed and middle-age for TR (OR=4.36; CI=1.10-17.24), and high BW for AF (OR=3.54; CI=1.67-7.49). MR was the major valvular disease associated with AF, pathological ventricular arrhythmia, pulmonary regurgitation (PR) and congestive heart failure (CHF). TR was also linked to AF, PR and CHF; AR was not linked to CHF. Conclusions and clinical importance: Several previously suspected risks factors of a variety of equine cardiac diseases are statistically confirmed in the studied hospital-based population. Similar observation could be suspected in a larger randomized population and should be taken into account in health and sport’s monitoring of horses presenting predisposing factors. [less ▲]

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See detailPrevalence and screening of burnout among Belgian population
DE CIA, Julie ULg; Mairiaux, Philippe ULg; Schippers, Nathalie ULg et al

Poster (2011, May 26)

The aim of the study was to estimate the prevalence of burnout among Belgian workers through the identification of burnout cases within the practices of general practitioners (GP) and the health ... [more ▼]

The aim of the study was to estimate the prevalence of burnout among Belgian workers through the identification of burnout cases within the practices of general practitioners (GP) and the health surveillance carried out by occupational health physicians (OP) .The prevalence may be estimated at about 0,8 % of the Belgian population; this figure is similar among workers consulting GP and OP. [less ▲]

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See detailPrevalence and sources of Campylobacter spp. contamination in free-range broiler production in Belgium
Vandeplas, Sabrina ULg; Dubois Dauphin, Robin ULg; Beckers, Yves ULg et al

in World's Poultry Science Journal (2006), 62(supplément), 557

An one year epidemiological study was carried out between February 2005 and January 2006 in Belgium to assess the Campylobacter prevalence in free-range broiler production. Three successive broiler flocks ... [more ▼]

An one year epidemiological study was carried out between February 2005 and January 2006 in Belgium to assess the Campylobacter prevalence in free-range broiler production. Three successive broiler flocks on 6 belgian farms were investigated for the presence of Campylobacter ssp. during the rearing period. Each flock was visited four times, before and after the outdoor rearing period. During each visit, samples were taken in the broiler houses (litter, cecal droppings, water-lines, feed, entrance premises) as well as from the outer rearing environment (open-air range). Conventional microbiological methods combined with biochemical tests were used for the Campylobacter detection, species identification and isolation. Campylobacter prevalence was very high in free-range broiler production during the experimental period. C. jejuni is the main species isolated from all contaminated samples, while mixed C. jejuni/C. coli infections sometimes occured. Contamination of the broiler flocks was increased in summer/autumn, with a 100% flocks contamination, whereas only 4 (66.7%) and 3 (50%) of the flocks became Campylobacter positive in spring and winter respectively, at the end of the rearing period. Moreover, about 53.8% of contaminated flocks were infected with Campylobacter before chicks have access to the open-air range. In 69.2% of the Campylobacter-positive flocks, the open-air range soil belonged partly of fully to environmental samples found to be Campylobacter-positive before flock infection. The other potential sources of infection were delivery tray, entrance premises floor and water-lines. The access to an open-air range seems to be an important way of contamination of broilers because Campylobacter prevalence in the flocks increased after going out. [less ▲]

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See detailPrevalence and sources of Campylobacter spp. contamination in free-range broiler production in the southern part of Belgium
Vandeplas, Sabrina ULg; Dubois Dauphin, Robin ULg; Palm, Rodolphe ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2010), 14(2), 279-288

A one year epidemiological study was carried out between February 2005 and January 2006 in the southern part of Belgium to assess the Campylobacter prevalence in free-range broiler production. Three ... [more ▼]

A one year epidemiological study was carried out between February 2005 and January 2006 in the southern part of Belgium to assess the Campylobacter prevalence in free-range broiler production. Three successive broiler flocks from six Belgian farms were investigated for the presence of Campylobacter spp. during the rearing period. Each flock was visited four times, before and after the outdoor rearing period. During each visit, samples were taken in the broiler house (litter, cecal droppings, water-lines, feed, anteroom) as well as from the outer rearing environment (open-air range). The Campylobacter detection in all samples was carried out according to the ISO 10272 standard. Identification was based on colonial morphology, microscopic examination, and biochemical tests. PCR multiplex was used for genetic confirmation. Campylobacter jejuni was the main species isolated from all contaminated samples. Overall, mixed infections C. jejuni/C. coli represented 40.6%, while C. jejuni and C. coli represented 46.9% and 12.5% of chicken samples respectively. A 100% flock contamination was observed in the 6 farms during the summer/autumn period, whereas only 66.7% and 33.3% of the flocks became Campylobacter-positive in spring and winter respectively, at the end of the rearing period. Half of contaminated flocks were infected before chickens have access to the open-air range. Environmental samples, especially the open-air range soil, were found to be Campylobacter-positive before flock infection. The other potential sources of contamination were delivery tray, anteroom floor and water-lines. Other animal productions like cattle on the farm, no applied rodent control, no cleaning and disinfection of water-lines between flocks, no detergent used for cleansing and thinning were recorded as risk factors. In conclusion, the contact with the environment, particularly the access to an open-air range, appeared to be the major way of Campylobacter contamination of chickens in free-range broiler production. [less ▲]

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See detailPrevalence and spread of extended-spectrum β-lactamase-producing
Magoue Lonchel, Carine ULg; MELIN, Pierrette ULg; Gangoué-Piéboji, J et al

in Clinical Microbiology & Infection (2013), 19(9), 416-20

During April 2010 and June 2010, 334 Enterobacteriaceae isolates from 590 participants (outpatients, inpatients, inpatient carers, hospital workers and members of their households) were collected from ... [more ▼]

During April 2010 and June 2010, 334 Enterobacteriaceae isolates from 590 participants (outpatients, inpatients, inpatient carers, hospital workers and members of their households) were collected from faecal samples. Based on b-lactamase pattern, origin of strains and the relationship between participants, 44 isolates of extended-spectrum b-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae were selected from 44 participants (in Ngaoundere Protestant Hospital and Ngaoundere Regional Hospital, Cameroon). To determine the relatedness of bacterial strains, these isolates were fingerprinted using the automated, repetitive-sequenced-based PCR-based DiversiLab system. Subsequently, E. coli isolates that had undergone DiversiLab analysis were examined with respect to their phylogenetic group and detection of the ST131 clone to shed light on the epidemiology of these isolates in the Ngaoundere hospitals. The prevalence of faecal carriage of ESBL-producing Enterobacteriaceae among the study participants was 54.06%. According to participant groups, the prevalence of faecal carriage was also high (outpatients 45%; inpatients 67%; inpatient carers 57%; hospital workers 44%; and members of their households 46%). Analysis of the molecular epidemiology of ESBL-producing E. coli and K. pneumoniae showed a close relationship of the isolates between related and nonrelated individuals. In addition, DiversiLab results of E. coli identified four related isolates (4/22) from cluster III belonging to the epidemiologically important clone ST131. Our results highlight the importance of outpatients, inpatients, their carers, hospital workers and their families as reservoirs of ESBLproducing Enterobacteriaceae. [less ▲]

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See detailPrevalence de l'infection par le VIH chez les femmes enceintes. Etude en milieu rural africain.
Mathe, M Kirere; Rigo, Jacques ULg; Sontag, Danièle et al

in Revue d'Epidémiologie et de Santé Publique (2008), 56(6), 407-13

BACKGROUND: The goal of the study is to assess the prevalence and risk factors of HIV in pregnant women in the North-East rural area of the Democratic Republic of Congo. METHODS: We undertook an ... [more ▼]

BACKGROUND: The goal of the study is to assess the prevalence and risk factors of HIV in pregnant women in the North-East rural area of the Democratic Republic of Congo. METHODS: We undertook an exploratory study on women attending the antenatal care during the study period (from December 2002 to December 2004) in the referral General hospital of the health catchments' area of Oicha (DRC). Women with gestational age equal or above 36 weeks were included in the study. After a first test using rapid test Abbott Determine locally, a second crossing check was performed in the referral HIV laboratory in Liege (Belgium). RESULTS: Among 5016 participants tested, 94 were positive (prevalence of 1.9% [CI95% 1.5-2.5]). Following factors predict a risk of being positive among participants: the statute of displacement (OR: 5.77; IC95%: 3.59-9.29); widowhood and divorces (OR: 4.47; IC95%: 1.47-13.60); mobility related to the profession of the husband (OR: 4.00; IC95%: 2.36-6,75); living the countryside (OR: 1.67; IC95%: 1.06-2.62; p: 0.0258). [less ▲]

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See detailPrévalence de l’ostéochondrose chez le cheval de sport en Wallonie
Vander Heyden, Laurent ULg; Serteyn, Didier ULg; Caudron, Isabelle et al

in Annales de Médecine Vétérinaire (2008), 152(3), 131-137

Osteochondrosis (OC), a developmental orthopaedic disease, is consecutive to a defect in the endochondral ossification process, and can result in formation of an osteochondral fragment (osteochondrosis ... [more ▼]

Osteochondrosis (OC), a developmental orthopaedic disease, is consecutive to a defect in the endochondral ossification process, and can result in formation of an osteochondral fragment (osteochondrosis dissecans). Our objective is to establish the prevalence of osteochondrosis in Wallonia, and describe the main observed lesions. One hundred forty-two Warmblood horses, aged from 12 to 36 months, underwent a systematic X-ray examination. Sixty-three of these horses (44.4 %) presented one or more OC lesions, 46 (32.4 %) of them with an articular fragment. This prevalence is similar to those observed in Dutch Warmblood horses (44.3 %). The localisation of the lesions was as follows: 25 (17.6 %) of the experimental group showed one or more lesions in the hindlimbs fetlocks, 23 (16.2 %) in the hocks, 21 (14.8 %) in the stifles and 14 (9.9 %) in the forelimbs fetlocks. The medial ridge of the talus is the most frequently injured anatomical site in our study. This lesion was observed in 12 horses (8.4 %), a prevalence that is by far higher than those observed in Dutch Warmblood horses (2.9 %). Not any significant difference was observed between males and females. The high prevalence and the clinical and economic consequences of this disease in the horse’s industry fully justify further research in order to improve the understanding of its pathogenic process. [less ▲]

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