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See detailNecessity of phenotypic classification of inflammatory bowel disease.
Louis, Edouard ULg; VAN KEMSEKE, Catherine ULg; Reenaers, Catherine ULg

in Best practice & research. Clinical gastroenterology (2011), 25 Suppl 1

Inflammatory bowel diseases (IBD) are classically divided in Crohn's disease (CD) and ulcerative colitis (UC). However, these two entities are still heterogeneous and a further classification in ... [more ▼]

Inflammatory bowel diseases (IBD) are classically divided in Crohn's disease (CD) and ulcerative colitis (UC). However, these two entities are still heterogeneous and a further classification in subphenotypes is necessary. Clinical subphenotypes are easy to use, do not necessitate complicated tests and can already give very important information for the management of the patients. In CD, clinical subphenotypes are based on age at diagnosis, disease location and disease behaviour. Age at diagnosis allows to differentiating paediatric CD, classical young adult onset and more seldom CD of the elderly. These categories are associated with a different risk of development of complications and disabling disease and may have partly different pathophysiology. The classification on disease behaviour, including stricturin, penetrating or uncomplicated disease may have an impact on reponse to medical treatment and need for surgery. Finally the classification based on location is particularly relevant since it has been associated with different types of complications. Particularly ileal disease has been associated with the risk of surgery and colonic (particularly rectal) disease, with the risk of perianal disease. In UC, the classification in subphenotypes is essentially based on disease location, distinguishing proctitis, left-sided colitis and extensive colitis. This subclassification also has a very significant clinical relevance since extensive colitis has been associated with and increased risk of colon cancer, colectomy and even in some studies, mortality. [less ▲]

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See detailNecessity to compare bacterial transcription factor beyond the HTH motif
Rigali, Sébastien ULg

Scientific conference (2003)

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See detailNecessity to compare the bacterial transcription factors beyond the HTH motif
Rigali, Sébastien ULg

Scientific conference (2002)

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See detailNecitumumab plus pemetrexed and cisplatin as first-line therapy in patients with stage IV non-squamous non-small-cell lung cancer (INSPIRE): an open-label, randomised, controlled phase 3 study.
Paz-Ares, Luis; Mezger, Jorg; Ciuleanu, Tudor E. et al

in The Lancet. Oncology (2015), 16(3), 328-37

BACKGROUND: Necitumumab is a second-generation recombinant human immunoglobulin G1 EGFR monoclonal antibody that competitively inhibits ligand binding. We aimed to compare necitumumab plus pemetrexed and ... [more ▼]

BACKGROUND: Necitumumab is a second-generation recombinant human immunoglobulin G1 EGFR monoclonal antibody that competitively inhibits ligand binding. We aimed to compare necitumumab plus pemetrexed and cisplatin with pemetrexed and cisplatin alone in patients with previously untreated, stage IV, non-squamous non-small-cell lung cancer (NSCLC). METHODS: We did this randomised, open-label, controlled phase 3 study at 103 sites in 20 countries. Patients aged 18 years or older, with an Eastern Cooperative Oncology Group (ECOG) performance status of 0-2 and adequate organ function, were randomly assigned 1:1 to treatment with a block randomisation scheme (block size of four) via a telephone-based interactive voice-response system or interactive web-response system. Patients received either cisplatin 75 mg/m(2) and pemetrexed 500 mg/m(2) on day 1 of a 3-week cycle for a maximum of six cycles alone, or with necitumumab 800 mg on days 1 and 8. Necitumumab was continued after the end of chemotherapy until disease progression or unacceptable toxic effects. Randomisation was stratified by smoking history, ECOG performance status, disease histology, and geographical region. Patients and study investigators were not masked to group assignment. The primary endpoint was overall survival. Efficacy analyses were by intention to treat. This trial is registered with ClinicalTrials.gov, number NCT00982111. FINDINGS: Between Nov 11, 2009, and Feb 2, 2011, we randomly assigned 633 patients to receive either necitumumab plus pemetrexed and cisplatin (n=315) or pemetrexed and cisplatin alone (n=318). Enrolment was stopped on Feb 2, 2011, after a recommendation from the independent data monitoring committee. There was no significant difference in overall survival between treatment groups, with a median overall survival of 11.3 months (95% CI 9.5-13.4) in the necitumumab plus pemetrexed and cisplatin group versus 11.5 months (10.1-13.1) in the pemetrexed and cisplatin group (hazard ratio 1.01 [95% CI 0.84-1.21]; p=0.96). The incidence of grade 3 or worse adverse events, including deaths, was higher in the necitumumab plus pemetrexed and cisplatin group than in the pemetrexed and cisplatin group; in particular, deaths regarded as related to study drug were reported in 15 (5%) of 304 patients in the necitumumab group versus nine (3%) of 312 patients in the pemetrexed and cisplatin group. Serious adverse events were likewise more frequent in the necitumumab plus pemetrexed and cisplatin group than in the pemetrexed and cisplatin group (155 [51%] of 304 vs 127 [41%] of 312 patients). Patients in the necitumumab plus pemetrexed and cisplatin group had more grade 3-4 rash (45 [15%] of 304 vs one [<1%] of 312 patients in the pemetrexed and cisplatin alone group), hypomagnesaemia (23 [8%] vs seven [2%] patients), and grade 3 or higher venous thromboembolic events (23 [8%] vs 11 [4%] patients) than did those in the pemetrexed and cisplatin alone group. INTERPRETATION: Our findings show no evidence to suggest that the addition of necitumumab to pemetrexed and cisplatin increases survival of previously untreated patients with stage IV non-squamous NSCLC. Unless future studies identify potentially useful predictive biomarkers, necitumumab is unlikely to provide benefit in this patient population when combined with pemetrexed and cisplatin. FUNDING: Eli Lilly and Company. [less ▲]

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See detailThe neck domain of myosin V
Terrak, Mohammed ULg; Staford, Walter; Lu, Renne

in Biophysical Journal (2004), 86

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See detailNecopinato doni laetissima oblatio
Gerkens, Jean-François ULg

Speech/Talk (2014)

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See detailNécrologie : Dominique Keiffer
Kurth, Godefroid ULg

in Revue de l'Instruction Publique en Belgique (1902)

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See detailNécrologie d'Emmanuel Closset
George, Philippe ULg

in Bulletin de l'Institut Archéologique Liégeois (in press)

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See detailNécrologie de Rita Lejeune (1906-2009)
Henrard, Nadine ULg

in Estudis Romànics (2011), 33

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See detailNécrologie Jacques Stiennon (1920-2012)
George, Philippe ULg

in Cahiers de Civilisation Médiévale (2012), 55

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See detailNécrologies de grands couturiers dans Paris Match (1957-2010) : vers une haute couture de masse ?
Duchesne, Caroline ULg

Master's dissertation (2010)

La haute couture a généralement été cernée dans les rapports qu'elle entretient avec les opérations de "griffe" propres à la haute culture, dans l'esprit de l'article fondateur réservé à cette question ... [more ▼]

La haute couture a généralement été cernée dans les rapports qu'elle entretient avec les opérations de "griffe" propres à la haute culture, dans l'esprit de l'article fondateur réservé à cette question par Pierre Bourdieu et Yvette Delsaut ("Le couturier et sa griffe : contribution à une théorie de la magie", Actes de la recherche, 1975). L'examen d'un corpus de nécrologies de grands couturiers dans Paris Match montre que la haute couture se trouve aujourd'hui de plus en plus indexée du côté de la culture de masse sous l'impulsion de facteurs internes à son propre secteur de production (allant dans le sens d'une certaine fabrication standardisée) et externes (relevant d'une logique people appliquée aux représentants les plus médiatisés du secteur). [less ▲]

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See detailLa Nécropole de Bavay, « Les Faches les Prés Aulnoys »
Deru, Xavier ULg

Book (2009)

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See detailNecrotising enterocolitis after administration of intravenous immunoglobulin in very low birth weight preterms: a retrospective study
Viellevoye, Renaud ULg; Rigo, Vincent ULg; Rigo, Jacques ULg

in Archives of Disease in Childhood (2008, November), 93(suppl II), 322

Background: Necrotising enterocolitis (NEC) is a major cause of mortality and morbidity in very low birth weight (VLBW) preterms. Pathogenesis remains unclear. Recently, we observed a few NEC occurring ... [more ▼]

Background: Necrotising enterocolitis (NEC) is a major cause of mortality and morbidity in very low birth weight (VLBW) preterms. Pathogenesis remains unclear. Recently, we observed a few NEC occurring within the 48 h following prophylactic administration of intravenous immunoglobulin (IVIgG). The aim of the present study was to evaluate the influence of IVIgG administration on the incidence of NEC in our neonatal intensive care unit (NICU). [less ▲]

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See detailNecrotizing varicella zoster virus folliculitis.
Nikkels, Arjen ULg; Pierard, Gérald ULg

in European Journal of Dermatology (2003), 13(6), 587-9

Although the usual clinical features of the varicella zoster virus (VZV)-induced lesions are readily recognized, the same virus is also responsible for a series of atypical lesions. A patient is presented ... [more ▼]

Although the usual clinical features of the varicella zoster virus (VZV)-induced lesions are readily recognized, the same virus is also responsible for a series of atypical lesions. A patient is presented with a single large infiltrated plaque on the abdomen. Although histology showed a necrotizing folliculitis surrounded by a dense perifollicular inflammatory infiltrate, the clinical presentation was not suggestive of folliculitis. Subtle cyto-histological clues for viral infection were suggested. Immunohistochemistry revealed the presence of VZV in the remnants of the follicular structures. This report underlines one of the protean clinical presentations of VZV skin infections and highlights the discreteness of typical VZV-related cyto-histological alterations. Complementary VZV identification methods such as immunohistochemistry, are helpful in order to increase the diagnostic accuracy of unusual VZV lesions. [less ▲]

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See detailNecrotoxigenic Escherichia coli : study of the roles of CNF2 and CDT-III toxins in an experimental model of infection in calves
Mainil, Jacques ULg

in Annales de Médecine Vétérinaire (2005), 149(Sp. Iss. SI), 46-48

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See detailNecrotoxigenic Escherichia Coli Type-2 Invade and Cause Diarrhoea During Experimental Infection in Colostrum-Restricted Newborn Calves
Van Bost, Sigrid; Roels, S.; Mainil, Jacques ULg

in Veterinary Microbiology (2001), 81(4), 315-29

There exists experimental evidence that necrotoxigenic Escherichia coli (NTEC) strains producing the cytotoxic necrotising factor 1 cause intestinal and extra-intestinal disease in piglets. On the other ... [more ▼]

There exists experimental evidence that necrotoxigenic Escherichia coli (NTEC) strains producing the cytotoxic necrotising factor 1 cause intestinal and extra-intestinal disease in piglets. On the other hand, no experimental model has been developed with NTEC strains producing the cytotoxic necrotising factor 2. In all, 14 colostrum-restricted calves were orally challenged with two strains isolated from the faeces of a diarrheic calf (B20a) or from the heart blood of a septicaemic calf (1404). All calves had diarrhoea which lasted until euthanasia in eight of them. In those calves, diarrhoea was correlated with the faecal excretion of the challenge strains. At necropsy, vascular congestion of the intestinal mucosa, hypertrophy of the mesenteric lymph nodes (MLN) and some congestion of the lungs were observed. Bacteriology confirmed the colonisation of the intestine by the challenge strains which were also recovered from the heart blood, the lungs and/or the liver. Histological sections confirmed enterocolitis, lymphadenitis and limited bronchopneumonia. In the intestinal tissue sections, bacteria testing positive in an in situ DNA hybridisation assay with a CNF2 probe were observed. Those results were confirmed by immunohistochemistry with a polyclonal anti-O78 and a monoclonal anti-F17b antisera. Three of the five control calves receiving either saline or a CNF(-), F17a strain (25KH09) had no clinical signs or lesions. The other two presented a profuse liquid diarrhoea but those calves were positive for the presence of K99(+) E. coli. In this model, both NTEC2 strains were thus, able to colonise the intestine, to cause long-lasting diarrhoea and to invade the blood stream with localisation in various internal organs in colostrum-restricted conventional newborn calves. [less ▲]

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See detailNecrotrophism is a quorum-sensing-regulated lifestyle in Bacillus thuringiensis.
Dubois, Thomas; Faegri, Karoline; Perchat, Stephane et al

in PLoS pathogens (2012), 8(4), 1002629

How pathogenic bacteria infect and kill their host is currently widely investigated. In comparison, the fate of pathogens after the death of their host receives less attention. We studied Bacillus ... [more ▼]

How pathogenic bacteria infect and kill their host is currently widely investigated. In comparison, the fate of pathogens after the death of their host receives less attention. We studied Bacillus thuringiensis (Bt) infection of an insect host, and show that NprR, a quorum sensor, is active after death of the insect and allows Bt to survive in the cadavers as vegetative cells. Transcriptomic analysis revealed that NprR regulates at least 41 genes, including many encoding degradative enzymes or proteins involved in the synthesis of a nonribosomal peptide named kurstakin. These degradative enzymes are essential in vitro to degrade several substrates and are specifically expressed after host death suggesting that Bt has an active necrotrophic lifestyle in the cadaver. We show that kurstakin is essential for Bt survival during necrotrophic development. It is required for swarming mobility and biofilm formation, presumably through a pore forming activity. A nprR deficient mutant does not develop necrotrophically and does not sporulate efficiently in the cadaver. We report that necrotrophism is a highly regulated mechanism essential for the Bt infectious cycle, contributing to spore spreading. [less ▲]

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See detailNederlands en Vlaams in Brussels perspectief
Vromans, Joseph ULg

Conference given outside the academic context (1992)

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See detailNederlands in de wereld - de wereld in het Nederlands
Vromans, Joseph ULg

Conference given outside the academic context (1992)

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See detailNederlands in het perspectief van uitspraakverwerving en contrastieve taalkunde
Rasier, Laurent ULg; Van Heuven, Vincent; Defrancq, Bart et al

Book published by Academia Press (2011)

Detailed reference viewed: 29 (4 ULg)