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See detailProgrammes verticaux: stratégies d'approvisionnement en médicaments
Kiba, Alice; Franckh, Marc ULg

Report (2008)

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See detailProgramming action analysis in LOGO for achievement evaluation
Hardy, J. L.; Denis, Brigitte ULg

Learning material (1986)

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See detailProgramming of neuroendocrine self in the thymus and its defect in neuroendocrine autoimmunity
Geenen, Vincent ULg; Bodart, Gwennaëlle ULg; Henry, Séverine et al

in Frontiers in Neuroscience (2013), 7

During centuries after its first description by Galen, the thymus has been considered only as a vestigial endocrine organ until the discovery in 1961 by Jacques FAP Miller of its essential role in the ... [more ▼]

During centuries after its first description by Galen, the thymus has been considered only as a vestigial endocrine organ until the discovery in 1961 by Jacques FAP Miller of its essential role in the development of T (thymo-dependent) lymphocytes. A unique thymus appeared for the first time in cartilaginous fishes some 500 millions years ago, in the same time or shortly after the emergence of the adaptive (acquired) immune system. The thymus may be compared to a small brain or a computer highly specialized in the orchestration of central immunological self-tolerance. This latter was a necessity for the survival of species given the potent evolutionary pressure impacted by the high risk of autotoxicity inherent to the stochastic generation of the diversity of immune cell receptors that characterize the adaptive immune response. The new paradigm of neuroendocrine self-peptides has been proposed together with the definition of neuroendocrine self. Neuroendocrine self-peptides are not secreted by thymic epithelial cells (TECs) according to the classic model of neuroendocrine signaling, but processed for a presentation by, or in association with, the thymic major histocompatibility complex (MHC) proteins. The autoimmune regulator (AIRE) gene/protein controls the transcription of neuroendocrine genes in TECs. The presentation of self-peptides in the thymus is responsible for the clonal deletion of self-reactive T cells emerging during the random recombination of gene segments that encode variable parts of the T cell receptor for the antigen (TCR). In the same time, self-antigen presentation in the thymus also generates regulatory T (Treg) cells that are able to inhibit in the periphery self-reactive T cells having escaped negative selection in the thymus. Several arguments show that the origin of autoimmunity directed against neuroendocrine glands primarily results from a defect in the intrathymic programming of self-tolerance to neuroendocrine functions. This defect may be genetic or acquired during an enteroviral infection, for example. This novel knowledge of normal and pathologic functions of the thymus already constitutes a solid basis for the development of a novel type of tolerogenic/negative self-vaccination against type 1 diabetes (T1D). [less ▲]

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See detailProgramming of neuroendocrine self-tolerance in the thymus and its defect in the development of neuroendocrine autoimmunity
Geenen, Vincent ULg

Conference (2014, March 27)

The thymus may be compared to a computer highly specialized in the programming of central immunological self-tolerance. A unique thymus first appeared some 500 million years ago in cartilaginous fishes ... [more ▼]

The thymus may be compared to a computer highly specialized in the programming of central immunological self-tolerance. A unique thymus first appeared some 500 million years ago in cartilaginous fishes, at the same time or shortly after the emergence of the adaptive immune system. A new paradigm of neuroendocrine self-peptides has been proposed, together with the definition of neuroendocrine self. Neuroendocrine self-peptides are secreted by thymic epithelial cells (TECs) not according to the classic model of neurosecretion, but are processed for presentation by the thymic major histocompatibility complex (MHC) machinery. The autoimmune regulator (AIRE) gene/protein controls the transcription of neuroendocrine genes in TECs. Presentation of neuroendocrine self-peptides in the thymus is responsible for the clonal deletion of self-reactive T cells directed toward neuroendocrine antigens, which emerge during the random recombination of gene segments encoding variable parts of the T cell receptor for the antigen (TCR). Quite paradoxically, neuroendocrine self-peptide presentation in the thymus also generates regulatory T (tTreg) cells that inhibit, in the periphery, those self-reactive T cells having escaped thymic negative selection. Several arguments indicate that the origin of autoimmunity directed against neuroendocrine glands results from a primary defect in the intrathymic programming of self-tolerance to neuroendocrine principles. This defect may be genetic or acquired, for example during a viral infection. This novel knowledge of normal and pathologic functions of the thymus constitutes a solid scientific basis for the development of a novel type negative self-vaccination against type 1 diabetes. (Supported by NFSR of Belgium, Wallonia and FP6 Eurothymaide.) [less ▲]

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See detailLes progrès de la cytologie
Gravis, Auguste ULg

Speech (1910)

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See detailLes progrès de la poésie en 1867. Portrait de Gautier en grand rapporteur
Durand, Pascal ULg

in Saminadayar-Perrin, Corinne (Ed.) Théophile Gautier et l'invention médiatique de l'histoire littéraire (in press)

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See detailProgrès ou barbarisme ?
Legros, Willy ULg

Speech (2000)

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See detailProgres recents dans la pharmacologie des hypnotiques et anxiolytiques
Scuvée-Moreau, Jacqueline ULg; Seutin, Vincent ULg

in Revue Médicale de Liège (2001), 56(3), 159-64

Recent studies on the respective contribution of GABAA receptor subunits in the various pharmacological effects of benzodiazepines suggest that the sedative and amnesic properties of diazepam are mediated ... [more ▼]

Recent studies on the respective contribution of GABAA receptor subunits in the various pharmacological effects of benzodiazepines suggest that the sedative and amnesic properties of diazepam are mediated by enhancement of gabaergic transmission in neurons expressing the alpha 1 subunit while the anxiolytic effect is selectively mediated by alpha 2 subunit. These findings suggest that a separation of the pharmacological properties of benzodiazepines is possible and that drugs with increased clinical specificity could be developed. [less ▲]

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See detailProgrès technique et croissance économique
Artige, Lionel ULg

Learning material (2013)

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See detailProgress from 1989 to 1992 in understanding the circulation of the Western Mediterranean Sea
Lehucher, P. M.; Beautier, L.; Chartier, M. et al

in Oceanologica Acta (1995), 18(2), 255-271

The present paper describes the major results obtained from 1989 to 1992 by the EUROMODEL group in studying the circulation in the Western Mediterranean Sea. Particular emphasis has been given to the ... [more ▼]

The present paper describes the major results obtained from 1989 to 1992 by the EUROMODEL group in studying the circulation in the Western Mediterranean Sea. Particular emphasis has been given to the physical processes responsible for seasonal and mesoscale variabilities. Observations (in situ and satellite), together with theoretical, physical and numerical models, have been widely used in the course of these studies. Attention has been focused on the dynamics of the northern basin (deep water formation, dynamics of the Northern Mediterranean Current, circulation and shelf/slope interaction in the Balearic Sea) and of the southern basin (Alboran Sea circulation, instabilities of the Algerian Current). The straits dynamics have been studied with particular reference to the Corsica channel. Preliminary runs of a basin-scale circulation model of the Western Mediterranean Sea forced by the straits are also presented. They are shown to be capable of generating a cyclonic circulation in the western basin. [less ▲]

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See detailProgress in Arabidopsis genome sequencing and functionnal genomics.
Wambutt, R.; Portetelle, Daniel ULg; Vandenbol, Micheline ULg et al

in Journal of Biotechnology (2000), 78

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See detailProgress in cobalt-mediated radical polymerization
Debuigne, Antoine ULg; Hurtgen, Marie ULg; Piette, Yasmine ULg et al

Poster (2011, May 12)

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See detailProgress in microscopic modeling of damage in steel at high temperature
Remy, M.; Castagne, Sylvie; Habraken, Anne ULg

in International Journal of Forming Processes (2002), 5(N°2-3-4/2002), 445-455

With the goal to study crack propagation in continuous casting, this paper presents an on going project to develop and identify a mathematical finite element model of damage in steel at high temperature ... [more ▼]

With the goal to study crack propagation in continuous casting, this paper presents an on going project to develop and identify a mathematical finite element model of damage in steel at high temperature. A representative microscopic cell of the material is presented and adapted to available chemical information, precipitation state and micro-structures observed using metallographic as weel as imaging methods (optical microscopy, SEM, orientation imaging microscopy). Compression tests of cylindrical samples after a thermal treatment have been performed to identify the parameters of an elasto-visco-plastique law of Norton-Hoff type. Hot damage tests in tensile and compression states help to provide information on crack appearance. [less ▲]

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See detailProgress in milk fat globule membrane research: a review.
Danthine, Sabine ULg; Blecker, Christophe ULg; Paquot, Michel ULg et al

in Lait (Le) (2000), 80(2), 209-222

The milk fat globule is essentially an oil droplet enclosed in a protective 'membrane', partially derived from the plasma membrane of the lactating cell, and which assures the dispersion of the milk fat ... [more ▼]

The milk fat globule is essentially an oil droplet enclosed in a protective 'membrane', partially derived from the plasma membrane of the lactating cell, and which assures the dispersion of the milk fat in the milk plasma. This protective coat is generally called 'the milk fat globule membrane' (MFGM). This review examines the present state of knowledge on the MFGM. The topics dealt with are: origin and formation, isolation From milk, composition (lipids and proteins), structure (a new model is proposed), functional properties and the role that the MFGM plays in protection against lipolysis. [less ▲]

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See detailProgress in Sounding the Interior of Pulsating Hot Subdwarf Stars
Charpinet, Stéphane; Brassard, Pierre; Fontaine, Gilles et al

in AIP Conference Proceedings (2009, September), 1170

Hot subdwarf stars, including helium core burning subdwarf B (sdB) stars and more evolved subdwarf O (sdO) stars, host three classes of nonradial pulsators. Two of them show rapid acoustic mode ... [more ▼]

Hot subdwarf stars, including helium core burning subdwarf B (sdB) stars and more evolved subdwarf O (sdO) stars, host three classes of nonradial pulsators. Two of them show rapid acoustic mode oscillations (with periods in the 60-600 s range), while the third class features slow gravity mode vibrations of period typically 1h. All three classes provide a strong potential for sounding the internal properties of stars in these evolved phases of stellar evolution through asteroseismology. This has so far been exploited mainly for the rapid p-mode sdB pulsators, but the long period g-mode sdB pulsators, with the advent of space observations, carry good promises for sounding even deeper regions inside these stars. In this review paper, we summarize the properties of pulsating hot subdwarf stars and we outline progress that have recently occured in the asteroseismic exploitation of the pulsations observed in sdB stars. [less ▲]

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See detailProgress in the asteroseismic analysis of the pulsating sdB star PG 1605+072
Van Grootel, Valérie ULg; Charpinet, Stéphane; Fontaine, Gilles et al

Conference (2009, July)

The hot pulsating sdB star PG 1605+072 exhibits uncommon spectroscopic and pulsation prop- erties, and is one of the biggest challenge in the field of sdB star modeling. Two hypotheses have been proposed ... [more ▼]

The hot pulsating sdB star PG 1605+072 exhibits uncommon spectroscopic and pulsation prop- erties, and is one of the biggest challenge in the field of sdB star modeling. Two hypotheses have been proposed to explain its unusually rich pulsation spectrum. The first is the natural explanation of a fast-rotating pulsator, which lifts the (2l+1)-fold degeneracy of the frequency components. Another approach, where PG 1605+072 can be seen as a slow rotator, considers that the numerous low amplitude frequency components are second- and third-order harmonics and nonlinear com- binations of the highest amplitude frequencies. We investigated the two hypotheses in the light of asteroseismology, using our latest tools - including pulsation codes that incorporate star rotation and new generation complete sdB models. The results of both approaches are presented, showing interesting results and raising new questions for our understanding of this mysterious sdB star. [less ▲]

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See detailProgress in the asteroseismic analysis of the pulsating sdB star PG 1605+072
Van Grootel, Valérie ULg; Charpinet, Stéphane; Fontaine, Gilles et al

in Astrophysics & Space Science (2010, October), 329

The hot pulsating sdB star PG 1605+072 exhibits uncommon spectroscopic and pulsation properties, and is one of the biggest challenge in the field of sdB star modeling. Two hypotheses have been proposed to ... [more ▼]

The hot pulsating sdB star PG 1605+072 exhibits uncommon spectroscopic and pulsation properties, and is one of the biggest challenge in the field of sdB star modeling. Two hypotheses have been proposed to explain its unusually rich pulsation spectrum. The first is the natural explanation of a fast-rotating pulsator, which lifts the (2 l+1)-fold degeneracy of the frequency components. Another approach, where PG 1605+072 can be seen as a slow rotator, considers that the numerous low amplitude frequency components are second- and third-order harmonics and nonlinear combinations of the highest amplitude frequencies. We investigated the two hypotheses in the light of asteroseismology, using our latest tools—including pulsation codes that incorporate star rotation and new generation complete sdB models. The results of both approaches are presented, showing interesting results and raising new questions for our understanding of this mysterious sdB star. [less ▲]

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See detailProgress in the field of GPIIb/IIIa antagonists
Hanson, Julien ULg; De Leval, X.; David, Jean-Louis ULg et al

in Current Medicinal Chemistry - Cardiovascular and Hematological Agents (2004), 2

Detailed reference viewed: 17 (1 ULg)