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See detailMélanges Fritz Sturm, compte rendu d’ouvrage
Langenaken, Evelyne ULg

in Actualités du droit (2001)

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See detailMélanges mathématiques
Catalan, Eugène ULg

in Mémoires de la Societe Royale des Sciences de Liège (1867), 2

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See detailMélanges mathématiques (Tome deuxième)
Catalan, Eugène ULg

in Mémoires de la Societe Royale des Sciences de Liège (1886), 13

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See detailMélanges mathématiques (Tome premier)
Catalan, Eugène ULg

in Mémoires de la Societe Royale des Sciences de Liège (1885), 12

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See detailMélanges mathématiques (Tome troisième)
Catalan, Eugène ULg

in Mémoires de la Societe Royale des Sciences de Liège (1888), 15

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See detailMélanges offerts à Jean Bobon à l'occasion de la fin de sa carrière professorale
Mormont, Christian ULg; Bobon, Daniel; Croufer, Francis

in Acta Psychiatrica Belgica (1983), 2 et 3

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See detailMélanges Philippe Minguet
Duchesne, Jean-Patrick ULg

in Art&fact (1999), 18

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See detailMélanges Philippe Minguet
Duchesne, Jean-Patrick ULg; Durand, Pascal ULg; Steinmetz, Rudy ULg

Book published by Art&Fact (1999)

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See detailMélanges Pierre Colman
Duchesne, Jean-Patrick ULg

in Art&fact (1996), 15

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See detailMelanin-concentrating hormone and immune function
Lakaye, Bernard ULg; Coumans, Bernard ULg; Harray, Sophie ULg et al

in Peptides (2009), 30

To date,melanin-concentrating hormone (MCH) has been generally considered as peptide acting almost exclusively in the central nervous system. In the present paper, we revise the experimental evidence ... [more ▼]

To date,melanin-concentrating hormone (MCH) has been generally considered as peptide acting almost exclusively in the central nervous system. In the present paper, we revise the experimental evidence, demonstrating that MCH and its receptors are expressed by cells of the immune system and directly influence the response of these cells in some circumstances. This therefore supports the idea that, as with other peptides, MCH could be considered as a modulator of the immune system. Moreover, we suggest that this could have important implications in several immune-mediated disorders and affirm that there is a clear need for further investigation [less ▲]

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See detailMelanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume
Conductier, G; Brau, F; Viola, A et al

in Nature Neuroscience (2013), 16

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See detailMélanodermie infraclinique et cancers photo-induits
QUATRESOOZ, Pascale ULg; PIERARD-FRANCHIMONT, Claudine ULg; HENRY, Frédérique ULg et al

in Actualités en Ingéniérie Cutanée (2006)

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See detailLa melanogenese, expression de la differenciation de cellules cancereuses en culture
Bassleer, Roger; De Pauw-Gillet, Marie-Claire ULg; Giet, Didier ULg et al

in Bulletin de l'Association des Anatomistes (1982), 66(194), 291-295

In B16 mouse melanoma in culture, differentiated cells actively synthesize melanin. They are analyzed by cytological and cytochemical methods. When cultured for long periods (several months ... [more ▼]

In B16 mouse melanoma in culture, differentiated cells actively synthesize melanin. They are analyzed by cytological and cytochemical methods. When cultured for long periods (several months), melanogenesis is expressed according to a cyclic way, even when maintained in a culture medium of constant composition and without adding any chemical agent eventually able to influence this phenomenon. The spontaneous cyclic activity is analyseed and an explanation is given as an hypothesis. [less ▲]

Detailed reference viewed: 29 (7 ULg)
See detailMelanoma AntiGEn D2 (MAGED2) a new partner of the DNA damage response?
Pirlot, Céline ULg; Piette, Jacques ULg; Habraken, Yvette ULg

Poster (2014, January)

MAGED2 belongs to the Melanoma AntiGEn (MAGE) family of proteins. It is ubiquitously expressed and its overexpression in many cancers could make it a potential biomarker of tumor development and ... [more ▼]

MAGED2 belongs to the Melanoma AntiGEn (MAGE) family of proteins. It is ubiquitously expressed and its overexpression in many cancers could make it a potential biomarker of tumor development and metastasis formation. Actually, the only known function of this protein is its involvement in the p53 pathways. Indeed, MAGED2 could be a negative regulator of p53 and it increases apoptosis induced by TRAIL in a p53 dependent manner. Moreover, a phosphoproteomic experiment has shown that this protein is likely phosphorylated by ATM, ATR or DNA-PK after exposition to ionizing irradiation. These three kinases are implicated in the DNA damage response (DDR). Our lab showed by yeast two hybrids an interaction between MAGED2 and ATM. Thus, the aims of the project are to confirm and to find the function of this interaction in a DDR context. Current avenues of investigations include determining the impact of MAGED2 depletion and overexpression in the p53, NF-kappaB and cell cycle regulation following double strand break induced by etoposide treatment. Though this study we plan to confirm a new partner of ATM in the DDR pathway, which could be targeted to limit cancer progression and improve the chemotherapy relying on DNA damaging compounds. [less ▲]

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See detailMelanoma AntiGEn D2 (MAGED2): a new nucleolar protein undergoing re-localization after cellular stress
Pirlot, Céline; Thiry, Marc ULg; Trussart, Charlotte ULg et al

Poster (2015, February 06)

MAGED2 belongs to the Melanoma AntiGEn (MAGE) family of proteins. Actually, the only known function of this protein is its involvement in the p53 pathway. Indeed, MAGED2 could be a negative regulator of ... [more ▼]

MAGED2 belongs to the Melanoma AntiGEn (MAGE) family of proteins. Actually, the only known function of this protein is its involvement in the p53 pathway. Indeed, MAGED2 could be a negative regulator of p53. It contributes to the initiation of melanoma when its overexpression is associated with the mutation of BRAF and it increases apoptosis induced by TRAIL in a p53 dependent manner. Moreover, phosphoproteomic experiments have shown that this protein is likely phosphorylated by kinases implicated in the DNA damage response (DDR). We decided to investigate the intra-cellular localization of MAGED2 in order to find new functions of this protein. In resting cell, MAGE D2 is detected is the nucleus, the nucleolus and the cytoplasm. We observed that MAGED2 localization change during cell cycle and genotoxic stress. Nuclear and nucleolar localization signals were identified. Though present in the nucleolus, the depletion of MAGED2 does not affect the structure of this organel. [less ▲]

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See detailMelanoma AntiGEn D2 : a new nucleolar protein undergoing delocalization during cell cycle and after cellular stress
Pirlot, Céline; Thiry, Marc ULg; Trussart, Charlotte ULg et al

Poster (2015, September 28)

MAGED2 belongs to the Melanoma AntiGEn (MAGE) family of proteins. Actually, little is known on MAGED2 function. It contributes to the initiation of melanoma when its overexpression is associated with the ... [more ▼]

MAGED2 belongs to the Melanoma AntiGEn (MAGE) family of proteins. Actually, little is known on MAGED2 function. It contributes to the initiation of melanoma when its overexpression is associated with the mutation of BRAF and it increases apoptosis induced by TRAIL in a p53-dependent manner. MAGED2 was also shown to be a negative regulator of p53, bur we did not confirm this properties. Moreover, proteomic analyses detected numerous phosphorylated or acetylated residues in response to stess and within cell cycle suggesting its involvement in cellular signal transduction. We investigated the intra-cellular re-localization of MAGED2 during cell cycle and after genotixc stress. Both nucleolar and nuclear signals were identifed. [less ▲]

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See detailMelanoma antigen D2, a substrate of ATM, is a nucleolar protein that shuttles with cell cycle and cellular stress.
Pirlot, Céline; Thiry, Marc ULg; Trussart, Charlotte ULg et al

Poster (2015, November 03)

ATM coordinates numerous facets of the highly regulated DDR network. In order to identify new ATM substrates we have performed a yeast two hybrid experiment with HEAT domains of ATM and an HeLa cDNA ... [more ▼]

ATM coordinates numerous facets of the highly regulated DDR network. In order to identify new ATM substrates we have performed a yeast two hybrid experiment with HEAT domains of ATM and an HeLa cDNA library. Melanoma antigen D2 (MAGED2) was one of the interacting proteins identified in this screen. MAGED2 belongs to the type II Melanoma AntiGEn (MAGE) family. MAGE homology domain, shared by all MAGE proteins, was shown to enhance E3 ligase activity. Actually, little is known about MAGED2 functions. Like every type II MAGE protein, it is expressed in all adult tissues. However, MAGE-D2 has the particularity to be over-expressed in numerous primary cancer and metastasis and it is now recognized as a tumour marker. This over-expression suggests that MAGED2 could be important for the process of cancerisation. MAGED2 was also shown to be a negative regulator of p53, but we did not confirm this property. Proteomic analyses also detected numerous phosphorylated or acetylated residues in response to stress and during cell cycle progression, suggesting a role in cellular signal transduction. We identified the residues targeted by ATM in MAGE-D2 and analysed the localisation of MAGED2 during the interphase and after genotoxic/nucleolar stresses. [less ▲]

Detailed reference viewed: 14 (1 ULg)