Stratégies sexuelles des mâles de deux sous-espèces du Triton alpestre en relation au comportement de la femelle

Conference (1997)

Stratégies thérapeutiques dans les adénomes somatotropes avec extension extrasellaire. Place du traitement médical. Etude consensus du Répertoire français de l'Acromégalie.

in Annales d'Endocrinologie (2003), 64(6), 434-441

From the first 198 patient files included into the French Acromegaly Registry, we analyzed 68 patients harboring a somatotroph adenoma with extrasellar extension, after exclusion of those treated by ... [more ▼]

From the first 198 patient files included into the French Acromegaly Registry, we analyzed 68 patients harboring a somatotroph adenoma with extrasellar extension, after exclusion of those treated by stereotactic or conventional radiotherapy. In these patients (including 37 women), aged 21-77 yr. (45.7 +/- 13.3), GH concentrations ranged from 2-260 microg/L (38.6 +/- 44.3), and IGF I from 86-967% of age-matched upper limit of normal (303 +/- 164). Maximal diameter of the adenoma at MRI was 11-36.5 mm (20.4 +/- 6.5), with cavernous sinus involvement in 68% of cases. Three subgroups were defined: 20 patients treated by long-acting somatostatin analogs only (group M), for a mean duration of 3 yr. (extremes 1-7 yr.), 48 patients initially treated by transsphenoidal surgery (group C), of whom 21 were secondarily treated by long-acting somatostatin analogs (group CM) for a mean duration of 1.2 yr. (extremes 0.2-2 yr.). All 3 groups were not statistically different in terms of tumor mass and initial levels of GH and IGF-1. Patients from group M were significantly older than those of the other groups (p<0.05). RESULTS: 46% of patients from group C after surgery vs. 45% of patients from group M had a mean GH below 2.5 microg/L. Biochemical remission (GH<2.5 microg/L and normal IGF1 normal) was obtained in 31% of cases in group C, vs. 25% in group M. In this group, a decrease of the largest tumor diameter was observed in 10 patients (71.5%), ranging from 10-25% in 7 (50%) and exceeded 50% in 3 (21.5%). In group CM, the biochemical remission rate (42%) and final GH or IGF1 values were not significantly different from group M. In conclusion, these data suggest that surgery or long-acting somatostatin analogs have a comparable efficacy in terms of remission rates in somatotroph macroadenomas with extrasellar extensions. [less ▲]

Strategies to estimate ground susceptibility to landslide reactivation. A probabilistic application in W Belgium (Oudenaarde)

(2007)

In the hilly region of the Flemish Ardennes in western Belgium, no new big deep-seated landslides have occurred for decades, whereas several reactivation episodes were recently observed in ancient ... [more ▼]

In the hilly region of the Flemish Ardennes in western Belgium, no new big deep-seated landslides have occurred for decades, whereas several reactivation episodes were recently observed in ancient landslides. We selected a test area comprised of 13 rotational landslides located close to the town of Oudenaarde in order to predict the susceptibility of their main scarp to retreat. We propose here two probabilistic models based on a fuzzy set approach. The models use empirical distribution functions (EDFs) as favourability values to build membership values and combine them by using the fuzzy Gamma operator. Based on Kolmogorov-Smirnov tests applied to these EDFs to select the most relevant data, a first model was obtained bases on a combination of 5 quantitative variables: slope angle, distance from cultivation located upstream of the main scarp, slope aspect, elevation and profile curvature. Another, more empirical approach based on the a posteriori analysis of the prediction-rate curves was applied to select the 4 variables of a second model: slope aspect, plan curvature, vegetation index and focal flow. According to the prediction-rate curves and the resulting susceptibility maps, the empirical model appears more efficient in locating the main scarp areas most prone to reactivation. [less ▲]

Strategies to Regenerate Hair Cells: Identification of Progenitors and Critical Genes

in Hearing Research (2008), 236(1-2), 1-10

Deafness commonly results from a lesion of the sensory cells and/or of the neurons of the auditory part of the inner ear. There are currently no treatments designed to halt or reverse the progression of ... [more ▼]

Deafness commonly results from a lesion of the sensory cells and/or of the neurons of the auditory part of the inner ear. There are currently no treatments designed to halt or reverse the progression of hearing loss. A key goal in developing therapy for sensorineural deafness is the identification of strategies to replace lost hair cells. In amphibians and birds, a spontaneous post-injury regeneration of all inner ear sensory hair cells occurs. In contrast, in the mammalian cochlea, hair cells are only produced during embryogenesis. Many studies have been carried out in order to demonstrate the persistence of endogenous progenitors. The present review is first focused on the occurrence of spontaneous supernumerary hair cells and on nestin positive precursors found in the organ of Corti. A second approach to regenerating hair cells would be to find genes essential for their differentiation. This review will also focus on critical genes for embryonic hair cell formation such as the cell cycle related proteins, the Atoh1 gene and the Notch signaling pathway. Understanding mechanisms that underlie hair cell production is an essential prerequisite to defining therapeutic strategies to regenerate hair cells in the mature inner ear. [less ▲]

Strategies visant a diminuer le delai entre l'admission aux urgences et l'angioplastie coronaire: a propos d'un article recent du New England Journal of Medicine

in Revue Médicale de Liège (2007), 62(3), 147-50

A recent publication in New England Journal of Medicine stresses the fact that the mere presence of a coronarography equipment to dilate acute myocardial infarction is not sufficient to obtain the opening ... [more ▼]

A recent publication in New England Journal of Medicine stresses the fact that the mere presence of a coronarography equipment to dilate acute myocardial infarction is not sufficient to obtain the opening of the related myocardial infarction artery in due time. [less ▲]

A strategy for a sustainable protection and restoration of endangered-vulnerable riverine fish populations. The barbel (Barbus barbus) case study in Belgium.

Conference (1999)

Strategy for bioanalytical method validation : approach of SFSTP commission

Conference (1996)

Strategy for DR-CALUX dioxin screening in feed under EC regulation

in Organohalogen Compounds (2006), 68

Strategy for the development of automated methods involving dialysis and trace enrichment as on-line sample preparation for the determination of basic drugs in plasma by liquid chromatography

in Journal of Chromatography. A (2002), 948(1-2), 151-161

Among the sample preparation techniques, dialysis followed by clean-up and enrichment of the dialysate on a pre-column has proved to be a useful approach for the LC determination of drugs in plasma. By ... [more ▼]

Among the sample preparation techniques, dialysis followed by clean-up and enrichment of the dialysate on a pre-column has proved to be a useful approach for the LC determination of drugs in plasma. By use of sample processors, like the ASTED system, such bioanalytical methods can be fully automated, the dialysis and trace enrichment steps being directly coupled to LC. In order to facilitate the development of such automated methods, a strategy based on a decision tree has been elaborated. After the selection of appropriate conditions for the LC analysis, the decision tree provides information about suggested starting conditions and guidelines for the optimisation of the most important parameters likely to influence analyte recovery and method selectivity. The plasma samples are dialysed on a cellulose acetate membrane in the static-pulsed mode and the dialysate is enriched on a trace enrichment pre-column packed with octadecyl silica or with a strong cation-exchange material. This decision tree is until now restricted to the analysis of basic drugs in plasma. In order to demonstrate the applicability of this method development strategy, an automated procedure based on the coupling of dialysis with trace enrichment has been developed for the LC determination of antifungal agents (clotrimazole, econazole and miconazole) in plasma. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

Strategy for the qualitative and quantitative analysis of crop syrup containing enzymatically produced isomaltooligosaccharides know as emerging prebiotics.

Poster (2006, December)