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See detailModulation of B lymphocyte proliferation inside the germinal center.
Bosseloir, A. L.; Defrance, T.; Bouzahzah, F. et al

in Advances in Experimental Medicine and Biology (1995), 378

Detailed reference viewed: 15 (3 ULg)
See detailModulation of beta oscillations by dopamine: novel insights from a STN-GPe network model
Dethier, Julie ULg

Scientific conference (2013, September 06)

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See detailModulation of brain activity during a Stroop inhibitory task by the kind of cognitive control required
Grandjean, Julien ULg; D'Ostilio, Kevin ULg; Phillips, Christophe ULg et al

in PLoS ONE (2012), 7(7), 41513

This study used a proportion congruency manipulation in the Stroop task in order to investigate, at the behavioral and brain substrate levels, the predictions derived from the Dual Mechanisms of Control ... [more ▼]

This study used a proportion congruency manipulation in the Stroop task in order to investigate, at the behavioral and brain substrate levels, the predictions derived from the Dual Mechanisms of Control (DMC) account of two distinct modes of cognitive control depending on the task context. Three experimental conditions were created that varied the proportion congruency: mostly incongruent (MI), mostly congruent (MC), and mostly neutral (MN) contexts. A reactive control strategy, which corresponds to transient interference resolution processes after conflict detection, was expected for the rare conflicting stimuli in the MC context, and a proactive strategy, characterized by a sustained task-relevant focus prior to the occurrence of conflict, was expected in the MI context. Results at the behavioral level supported the proactive/reactive distinction, with the replication of the classic proportion congruent effect (i.e., less interference and facilitation effects in the MI context). fMRI data only partially supported our predictions. Whereas reactive control for incongruent trials in the MC context engaged the expected fronto-parietal network including dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex, proactive control in the MI context was not associated with any sustained lateral prefrontal cortex activations, contrary to our hypothesis. Surprisingly, incongruent trials in the MI context elicited transient activation in common with incongruent trials in the MC context, especially in DLPFC, superior parietal lobe, and insula. This lack of sustained activity in MI is discussed in reference to the possible involvement of item-specific rather than list-wide mechanisms of control in the implementation of a high task-relevant focus. [less ▲]

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See detailModulation of brain activity during phonological familiarization
Majerus, Steve ULg; Van der Linden, Martial ULg; Collette, Fabienne ULg et al

in Brain & Language (2005), 92(3), 320-331

We measured brain activity in 12 adults for the repetition of auditorily presented words and nonwords, before and after repeated exposure to their phonological form. The nonword phoneme combinations were ... [more ▼]

We measured brain activity in 12 adults for the repetition of auditorily presented words and nonwords, before and after repeated exposure to their phonological form. The nonword phoneme combinations were either of high (HF) or low (LF) phonotactic frequency. After familiarization, we observed, for both word and nonword conditions, decreased activation in the left posterior superior temporal gyrus, in the bilateral temporal pole and middle temporal gyri. At the same time, interaction analysis showed that the magnitude of decrease of activity in bilateral posterior temporal lobe was significantly smaller for LF nonwords, relative to words and HF nonwords. Decrease of activity in this area also correlated with the size of behavioral familiarization effects for LF nonwords. The results show that the posterior superior temporal gyrus plays a fundamental role during phonological learning. Its relationship to sublexical and lexical phonological processing as well as to phonological short-term memory is discussed. (c) 2004 Elsevier Inc. All rights reserved. [less ▲]

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See detailModulation of brain response to emotional conflict as a function of current mood in bipolar disorder: preliminary findings from a follow-up state-based fMRI study.
Rey, Gwladys; Desseilles, Martin ULg; Favre, Sophie et al

in Psychiatry research (2014), 223(2), 84-93

We used functional magnetic resonance imaging (fMRI) to examine affective control longitudinally in a group of patients with bipolar disorder (BD). Participants comprised 12 BD patients who underwent ... [more ▼]

We used functional magnetic resonance imaging (fMRI) to examine affective control longitudinally in a group of patients with bipolar disorder (BD). Participants comprised 12 BD patients who underwent repeated fMRI scans in euthymic (n=11), depressed (n=9), or hypomanic (n=9) states, and were compared with 12 age-matched healthy controls. During fMRI, participants performed an emotional face-word interference task with either low or high attentional demands. Relative to healthy controls, patients showed decreased activation of the cognitive control network normally associated with conflict processing, more severely during hypomania than during depression, but regardless of level of task demand in both cases. During euthymia, a decreased response to conflict was observed only during the high load condition. Additionally, unlike healthy participants, patients exhibited deactivation in several key areas in response to emotion-conflict trials - including the rostral anterior cingulate cortex during euthymia, the hippocampus during depression, and the posterior cingulate cortex during hypomania. Our results indicate that the ability of BD patients to recruit control networks when processing affective conflict, and the abnormal suppression of activity in distinct components of the default mode network, may depend on their current clinical state and attentional demand. [less ▲]

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See detailModulation of cardiac contraction, relaxation and rate by the endothelial nitric oxide synthase (eNOS): lessons from genetically modified mice.
MASSION, Paul ULg; Balligand, J.-L.

in Journal of Physiology (2003), 546(Pt 1), 63-75

The modulatory role of endothelial nitric oxide synthase (eNOS) on heart contraction, relaxation and rate is examined in light of recent studies using genetic deletion or overexpression in mice under ... [more ▼]

The modulatory role of endothelial nitric oxide synthase (eNOS) on heart contraction, relaxation and rate is examined in light of recent studies using genetic deletion or overexpression in mice under specific conditions. Unstressed eNOS-/- hearts in basal conditions exhibit a normal inotropic and lusitropic function, with either decreased or unchanged heart rate. Under stimulation with catecholamines, eNOS-/- mice predominantly show a potentiation in their beta-adrenergic inotropic and lusitropic responsiveness. A similar phenotype is observed in beta 3-adrenoceptor deficient mice, pointing to a key role of this receptor subtype for eNOS coupling. The effect of eNOS on the muscarinic cholinergic modulation of cardiac function probably operates in conjunction with other NO-independent mechanisms, the persistence of which may explain the apparent dispensability of this isoform for the effect of acetylcholine in some eNOS-/- mouse strains. eNOS-/- hearts submitted to short term ischaemia-reperfusion exhibit variable alterations in systolic and diastolic function and infarct size, while those submitted to myocardial infarction present a worsened ventricular remodelling, increased 1 month mortality and loss of benefit from ACE inhibitor or angiotensin II type I receptor antagonist therapy. Although non-conditional eNOS gene deletion may engender phenotypic adaptations (e.g. ventricular hypertrophy resulting from chronic hypertension, or upregulation of the other NOS isoforms) potentially confounding the interpretation of comparative studies, the use of eNOS-/- mice has undoubtedly advanced (and will probably continue to improve) our understanding of the complex role of eNOS (in conjunction with the other NOSs) in the regulation of cardiac function. The challenge is now to confirm the emerging paradigms in human cardiac physiology and hopefully translate them into therapy. [less ▲]

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See detailModulation Of Cd3-Gamma Gene Expression After Hiv Type 1 Infection Of The We17/10 T Cell Line Is Progressive And Occurs In Concert With Decreased Production Of Viral P24 Antigen
Willardgallo, Ke.; Delmellewibaut, C.; Segurazapata, I. et al

in Aids Research and Human Retroviruses (1996), 12(8),

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See detailModulation of cerebral functional interactions by cortical dopamine in health and Parkinson's disease
Garraux, Gaëtan ULg; Talagala, S.; Carson, R. et al

in Movement Disorders : Official Journal of the Movement Disorder Society (2007), 22(Suppl. 16), 478

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See detailModulation of chondrocyte cytokines synthesis by endogeneously produced nitric oxide
Henrotin, Yves ULg; Zheng, X; Deby, G et al

in Revue du Rhumatisme (English ed.) (1997), 11

Detailed reference viewed: 14 (4 ULg)
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See detailModulation of chondrocyte cytokines synthesis by endogeneously produced nitric oxide
Henrotin, Yves ULg; Zheng, X; Deby, G et al

in Rheumatology in Europe (1997), 26(S2), 83

Detailed reference viewed: 14 (6 ULg)
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See detailModulation of ciliary phosphoinositide content regulates trafficking and Sonic hedgehog signaling output
Chavez, M; Van Sande, J; de Kerchove d'Exaerde, A et al

in Developmental Cell (2015), 34

Ciliary transport is required for ciliogenesis, signal transduction, and trafficking of receptors to the primary cilium. Mutations in inositol polyphosphate 5-phosphatase E (INPP5E) have been associated ... [more ▼]

Ciliary transport is required for ciliogenesis, signal transduction, and trafficking of receptors to the primary cilium. Mutations in inositol polyphosphate 5-phosphatase E (INPP5E) have been associated with ciliary dysfunction; however, its role in regulating ciliary phosphoinositides is unknown. Here we report that in neural stem cells, phosphatidylinositol 4-phosphate (PI4P) is found in high levels in cilia whereas phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2) is not detectable. Upon INPP5E inactivation, PI(4,5)P2 accumulates at the ciliary tip whereas PI4P is depleted. This is accompanied by recruitment of the PI(4,5)P2-interacting protein TULP3 to the ciliary membrane, along with Gpr161. This results in an increased production of cAMP and a repression of the Shh transcription gene Gli1. Our results reveal the link between ciliary regulation of phosphoinositides by INPP5E and Shh regulation via ciliary trafficking of TULP3/Gpr161 and also provide mechanistic insight into ciliary alterations found in Joubert and MORM syndromes resulting from INPP5E mutations. [less ▲]

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See detailModulation of Collagen and Fibronectin Synthesis in Fibroblasts by Normal and Malignant Cells
Noël, Agnès ULg; Munaut, Carine ULg; Boulvain, A. et al

in Journal of Cellular Biochemistry (1992), 48(2), 150-61

The influence of various normal and malignant human cells on the level of collagen synthesis by human fibroblasts was tested in coculture. As revealed by immunoperoxidase staining, in cocultures with ... [more ▼]

The influence of various normal and malignant human cells on the level of collagen synthesis by human fibroblasts was tested in coculture. As revealed by immunoperoxidase staining, in cocultures with breast adenocarcinoma cells (MCF7, SA52, T47D) fibroblasts synthesized collagen while tumor cells did not. Fibroblasts displayed increased collagen production without change in the overall protein synthesis. Several other types of cells derived from normal human tissues (keratinocytes, normal mammary cells) or from fibrosarcoma, melanoma, cervical carcinoma, choriocarcinoma, or other breast adenocarcinoma (SW613, MDA, BT20) did not affect collagen synthesis of fibroblasts. Although to a lesser extent, this stimulating effect was reproduced by using the conditioned medium (CM) of the active cells but not with CM of the other cell types. A slight stimulation was also obtained when tumoral MCF7 cells and fibroblasts shared the same medium but were physically separated, suggesting that close contact was required for optimal stimulation of collagen synthesis. The collagen synthesis stimulating activity was not related to a modification of fibroblast proliferation rate. The production of collagen types I, III, and VI and fibronectin were increased in cocultures of fibroblasts with MCF7 cells. The increased synthesis of collagen types I and III and fibronectin was paralleled by similar changes in the steady-state level of their mRNAs. On the contrary, the increased production of collagen type VI appeared regulated at a post-transcriptional level. [less ▲]

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See detailModulation of CYP1A1 activity by a Ginkgo biloba extract in the human intestinal Caco-2 cells
Ribonnet, Laurence; Callebaut, Alfons; Nobels, Ingrid et al

in Toxicology Letters (2011), 202(3), 193-202

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See detailModulation of cytochrome P450 1A1 expression and activity in intestinal Caco-2 cells by components of Ginkgo biloba-based dietary supplements
Ribonnet, Laurence; Callebaut, Alfons; Scippo, Marie-Louise ULg et al

in Toxicology Letters (2009), 189

Detailed reference viewed: 41 (12 ULg)
See detailModulation of Dayside Reconnection During Northward IMF
Provan, G.; Lester, M.; Cowley, S. W. et al

Poster (2005, December 01)

On 17 September 2000 the IMF was directed continuously northward for more than three hours. Density fluctuations in the solar wind resulted in quasi-periodic variations in the solar wind dynamic pressure ... [more ▼]

On 17 September 2000 the IMF was directed continuously northward for more than three hours. Density fluctuations in the solar wind resulted in quasi-periodic variations in the solar wind dynamic pressure, and correlated fluctuations also occurred in the IMF Bz component. The Northern hemisphere SuperDARN radars observed bursts of high-latitude high-velocity plasma flow during this northward IMF interval, both when ionospheric signatures consistent with low-latitude merging were observed, and when lobe merging was occurring. On average the recurrence period of these flow bursts was ~22 min. During this time the SI-12 spectrographic imager channel on the IMAGE spacecraft observed the dayside proton auroral spot continuously (Frey et al., 2003). The brightness of the auroral spot varied over time. Here we find a direct correlation between the occurrence of bursts of plasma flow and periodic fluctuations in the brightness of the proton auroral spot. Our results suggest that correlated fluctuations in the solar wind dynamic pressure and IMF Bz component modulated ionospheric precipitation and dayside reconnection, resulting in fluctuations in the brightness of the proton auroral spot and periodic variations in the dayside high-latitude plasma flow. [less ▲]

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See detailModulation of dayside reconnection during northward interplanetary magnetic field
Provan, G.; Lester, M.; Cowley, S. W. H. et al

in Journal of Geophysical Research. Space Physics (2005), 110(A10),

On 17 September 2000 the IMF was directed continuously northward for more than 3 hours. Density fluctuations in the solar wind resulted in quasiperiodic variations in the solar wind dynamic pressure, and ... [more ▼]

On 17 September 2000 the IMF was directed continuously northward for more than 3 hours. Density fluctuations in the solar wind resulted in quasiperiodic variations in the solar wind dynamic pressure, and correlated fluctuations also occurred in the IMF B-z component. The Northern Hemisphere SuperDARN radars observed bursts of high-latitude high-velocity plasma flow during this northward IMF interval, both when ionospheric signatures consistent with low-latitude merging were observed and when lobe merging was occurring. On average the recurrence period of these flow bursts was similar to 22 min. During this time the SI-12 spectrographic imager channel on the IMAGE spacecraft observed the dayside proton auroral spot continuously (Frey et al., 2003a). The brightness of the auroral spot varied over time. Here we find a direct correlation between the occurrence of bursts of plasma flow and periodic fluctuations in the brightness of the proton auroral spot. Our results suggest that correlated fluctuations in the solar wind dynamic pressure and IMF Bz component modulated ionospheric precipitation and dayside reconnection, resulting in fluctuations in the brightness of the proton auroral spot and periodic variations in the dayside high-latitude plasma flow. [less ▲]

Detailed reference viewed: 8 (1 ULg)
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See detailModulation of dendritic cell phenotype by PGD2 and PGJ2 : consequence on the orientation of T helper response
Gosset, P.; Bureau, Fabrice ULg; Angeli, V. et al

in Proceedings : International Conference of the American Thoracic Society (2002)

Detailed reference viewed: 13 (0 ULg)