Structure cordale et pathologies vocales

in Revue de Laryngologie - Otologie - Rhinologie (2005), (126,5), 295-300

Communication présentée lors du LXIième congrès de la Société Française de Phoniatrie et des Pathologies de la Communication; Paris, le 9 octobre 2005.Our knowledge of vocal fold structure has profoundly ... [more ▼]

Communication présentée lors du LXIième congrès de la Société Française de Phoniatrie et des Pathologies de la Communication; Paris, le 9 octobre 2005.Our knowledge of vocal fold structure has profoundly evolved since the description by M.Hirano in 1974 of the laminar organization of the connective tissue of the human vocal fold , the lamina propria. The molecular composition of the extracellular matrix (ECM) of the lamina propria is essential in determining the viscoelastic properties of the tissue. This is particularly true in the superficial layer of the lamina propria ( also called Reinke’s space). With the epithelium, Reinke’s space constitutes the vocal fold main vibrator. In normal subjects, the jelly like structure of the Reinke’s space is due to a very loose fibrous scaffolding and to a balance between the interstitial proteins of the ECM : proteoglycans like decorin and hyaluronic acid and glycoproteins like fibronectin. Vibratory trauma leads , in disease states , to molecular modification of the extracellular matrix of Reinke’s space resulting in benign cordal lesions like nodules, submucosal fibrosis and vocal folds scars. Improving the knowledge of the homeostasis of Reinke’s space ECM can lead to improvement of the therapeutic and prevention strategies of vocal fold benign lesions. The main histologic and viscoelastic characteristics, as well as surgical treatment of cordal nodular lesions and scars are described. The recent researches in the field of regeneration of Reinke’s space are evoked. Rappel des connaissances de la microstructure cordale normale( et en particulier de la structure laminaire de la corde vocale ainsi que la répartition particulière des protéo- et glycosaminoglycans) , de l'altération de celle ci en cas de nodule cordal et de cicatrice cordale.Implications thérapeutiques en terme de technique microchirurgicale, en particulier implantation d'acide hyaluronique estérifié dans la plaie microchirurgicale afin de moduler le processus de cicatrisation [less ▲]

Structure cordale, phonotraumatisme et lésions cordales

Conference (2009, June)

Structure cristalline et moléculaire d'un nouvel alclaoïde bisindolique: complexe moléculaire 1:2 Strychnofoline-Ethanol

in Acta Crystallographica. Section B-Structural Crystallography and Crystal Chemistry (1977), B33

Strychnofoline is a phenolic alkaloid isolated from leaves of Strychnos usambarensis. The crystals of the complex Strychnofoline-Ethanol are monoclinic. the crystal structure has been solvad by direct ... [more ▼]

Strychnofoline is a phenolic alkaloid isolated from leaves of Strychnos usambarensis. The crystals of the complex Strychnofoline-Ethanol are monoclinic. the crystal structure has been solvad by direct methods. The configuration determined by biogenetic arguments is 3S?4R?7S?15S?17S?20R. This is the first oxindole alkaloid found in a Strychnos species. [less ▲]

Structure d'un nouvel alcaloïde bisindolinique: complexe moléculaire 1:1 Sungucine-Acétone

in Acta Crystallographica. Section B-Structural Crystallography and Crystal Chemistry (1980), B 36

Sungucine ( found only in Strychnos icaja ) represents a new type of bisindolinic alkaloid with an unusual C(23)-C(5') bond between the two parts of the molecule, which have the same stereochemistry. Ring ... [more ▼]

Sungucine ( found only in Strychnos icaja ) represents a new type of bisindolinic alkaloid with an unusual C(23)-C(5') bond between the two parts of the molecule, which have the same stereochemistry. Ring D (and D') is almost in a boat conformation and C(2)-C(16) is cis. There are only van der Waals interactions in the orthorombic crystals of the molecular complex 1:1 sungucine-acetone. [less ▲]

Structure de l'acide diphénylamino-2 carboxylique

in Acta Crystallographica Section C-Crystal Structure Communications (1987), C43

Structure de l'espace et représentation du divin. L'exemple de l'île de Cos

Scientific conference (2012, April 20)

Structure de l'hydrogénonitrate de l'isopropyl-1 {[(pipéridyl-1 amino)-4 pyridyl-3]sulfonyl}-3 urée

in Acta Crystallographica. Section B-Structural Crystallography and Crystal Chemistry (1982), 38(5), 1495-1500

Structure de la bétaïne du carboxyméthyl-1 phénylacétylamino-4 triazolium-1,2,4

in Acta Crystallographica (1989), C45

Structure de la clothiapine

in Acta Crystallographica Section C-Crystal Structure Communications (1987), C43

Structure de la Panarine Dihydratée, un Nouvel Alcaloïde Extrait d'un Curare Vénézuélien

in Acta Crystallographica Section C-Crystal Structure Communications (1988), C44

The crystal structure of Panarine dihydrate isolated from a kind of Venezuelian Curare, C20H22N2O2.2H2O, Mr=358,44 has been solved by direct methods. Panarine has a conformation very similar to that of ... [more ▼]

The crystal structure of Panarine dihydrate isolated from a kind of Venezuelian Curare, C20H22N2O2.2H2O, Mr=358,44 has been solved by direct methods. Panarine has a conformation very similar to that of macusine A with a 3-alpha cis configuration. The positive charge on the quaternary nitrogen coexists with a negative charge on a carboxylate group. Molecules are linked together through van der Waals interactions and five hydrogen bonds involving water molecules. [less ▲]