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See detailMapping French terms in a Belgian guideline on heart failure to international classifications and nomenclatures: the devil is in the detail.
Jamoulle, Marc ULg; Cardillo, Elena; Roumier, Joseph et al

in Informatics in Primary Care (2014), 4

Introduction: With growing sophistication of eHealth platforms, the ability increases to share medical information across patients, health care providers, institutions and across borders. This implies ... [more ▼]

Introduction: With growing sophistication of eHealth platforms, the ability increases to share medical information across patients, health care providers, institutions and across borders. This implies more stringent demands on the quality of data-entry at the point-of-care. Non-native English speaking general practitioners experience difficulties in interacting with international classification systems and nomenclatures to facilitate the secondary use of their data and to ensure semantic interoperability. Aim: To identify words and phrases pertaining to the heart failure domain and to explore the difficulties in mapping to corresponding concepts in ICPC-2, ICD-10, SNOMED-CT, and UMLS. Methods: The medical concepts in a Belgian guideline for General Practitioners (GPs) in its French version were extracted manually and coded first in ICPC-2, then ICD-10 by a physician, an expert in classification systems. In addition, mappings were sought with SNOMED-CT and UMLS concepts, using the UMLS SNOMED-CT browser. Results: We retained 143 words and phrases, of which 128 referred to a single concept (1-to-1 mapping), while 15 referred to 2 or more concepts (1-to-n mapping to ICPC rubrics or to the other nomenclatures). In the guideline, words or phrases were often too general for adequate correspondence. Marked discrepancy between semantic tags and types was found. Conclusion: This study illustrates the variability of the various international classifications and nomenclatures, the need for structured guidelines with more attention to precise wording, and the need for classification expertise embedded in sophisticated terminological resources. End-users need support to perform their clinical work in their own language, while still assuring standardized and semantic interoperable medical registration. Collaboration between computational linguists, knowledge engineers, health informaticians and domain experts is needed. [less ▲]

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See detailMapping Gene Regulatory Networks in Drosophila Eye Development by Large-Scale Transcriptome Perturbations and Motif Inference
Potier, Delphine; Davie, Kristofer; Hulselmans, Gert et al

in Cell Reports (2014), 9(6), 2290-2303

Genome control is operated by transcription factors (TFs) controlling their target genes by binding to promoters and enhancers. Conceptually, the interactions between TFs, their binding sites, and their ... [more ▼]

Genome control is operated by transcription factors (TFs) controlling their target genes by binding to promoters and enhancers. Conceptually, the interactions between TFs, their binding sites, and their functional targets are represented by gene regulatory networks (GRNs). Deciphering in vivo GRNs underlying organ development in an unbiased genome-wide setting involves identifying both functional TF-gene interactions and physical TF-DNA interactions. To reverse engineer the GRNs of eye development in Drosophila, we performed RNA-seq across 72 genetic perturbations and sorted cell types and inferred a coexpression network. Next, we derived direct TF-DNA interactions using computational motif inference, ultimately connecting 241 TFs to 5,632 direct target genes through 24,926 enhancers. Using this network, we found network motifs, cis-regulatory codes, and regulators of eye development. We validate the predicted target regions of Grainyhead by ChIP-seq and identify this factor as a general cofactor in the eye network, being bound to thousands of nucleosome-free regions. [less ▲]

Detailed reference viewed: 89 (19 ULg)
See detailMapping genes underlying production traits in livestock
Georges, Michel ULg

in Clark, J. (Ed.) Animal Breeding: Technology for the 21st century (1998)

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See detailMapping human temporal and parietal neuronal population activity and functional coupling during mathematical cognition
Daitch, Amy; Foster, Brett; Schrouff, Jessica ULg et al

in Proceedings of the National Academy of Sciences of the United States of America (2016), 113(46),

Brain areas within the lateral parietal cortex (LPC) and ventral temporal cortex (VTC) have been shown to code for abstract quantity representations and for symbolic numerical representations ... [more ▼]

Brain areas within the lateral parietal cortex (LPC) and ventral temporal cortex (VTC) have been shown to code for abstract quantity representations and for symbolic numerical representations, respectively. To explore the fast dynamics of activity within each region and the interaction between them, we used electrocorticography recordings from 16 neurosurgical subjects implanted with grids of electrodes over these two regions and tracked the activity within and between the regions as subjects performed three different numerical tasks. Although our results reconfirm the presence of math-selective hubs within the VTC and LPC, we report here a remarkable heterogeneity of neural responses within each region at both millimeter and millisecond scales. Moreover, we show that the heterogeneity of response profiles within each hub mirrors the distinct patterns of functional coupling between them. Our results support the existence of multiple bidirectional functional loops operating between discrete populations of neurons within the VTC and LPC during the visual processing of numerals and the performance of arithmetic functions. These findings reveal information about the dynamics of numerical processing in the brain and also provide insight into the fine-grained functional architecture and connectivity within the human brain [less ▲]

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See detailMapping institutionnel du secteur de sécurité
Kabamba, Bob ULg

Report (2009)

Detailed reference viewed: 47 (1 ULg)
See detailMapping Jupiter's auroral features to magnetospheric sources: Comparing results from three different models for Jupiter's ionospheric magnetic field
Vogt, M. F.; Kivelson, M. G.; Khurana, K. K. et al

Conference (2011, July 11)

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See detailMapping key pollutants in the English Channel region: the Channel Catchments Cluster (3C) cross-border project
Richir, Jonathan ULg; Pini, Jennifer; Watson, Gordon

Conference (2014, August 16)

The EU Water Framework Directive was a response to concerns about the previous disparate ways in which water quality was managed under Member State law and early European Directives. Within this context ... [more ▼]

The EU Water Framework Directive was a response to concerns about the previous disparate ways in which water quality was managed under Member State law and early European Directives. Within this context, the Interreg IVA France (Channel) England Region established the ‘sustainable environmental development of this common space’ as one of its priorities to integrate areas that face common problems. The wide variety of cooperative cross-border projects have brought together UK and French scientists and environmental managers to develop practical environmental management tools for the region (3Cs cluster). Using the Solent in the UK as a case study, maps of key pollutants (e.g. metals such as Zn and Cu) will be produced to assess their spatial diversity within the sediment. The incorporation of historical datasets will also provide a temporal component. The inclusion of bioavailable fractions (using sequential extraction methods) will enable the pollutants to be linked to the tissue concentrations of key benthic species such as the polychaete Nereis virens and possible impacts. Not only will this information provide a detailed account of the water quality of key areas of the English Channel, but it will also highlight the gaps in the data and sampling regimes that are necessary to achieve good environmental status for the future, thus ensuring more effective European environmental policy regarding the long-term protection and conservation of aquatic ecosystems. [less ▲]

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See detailMapping landslide susceptibility from small datasets: A case study in the Pays de Herve (E Belgium)
Demoulin, Alain ULg; Chung, C. J.

in Geomorphology (2007), 89

A landslide susceptibility map is proposed for the Pays de Herve (E Belgium), where large landslides affect Cretaceous clay outcrop areas. Based on a Bayesian approach, this GIS-supported probabilistic ... [more ▼]

A landslide susceptibility map is proposed for the Pays de Herve (E Belgium), where large landslides affect Cretaceous clay outcrop areas. Based on a Bayesian approach, this GIS-supported probabilistic map identifies the areas most susceptible to deep landslides. The database is comprised of the source areas of ten pre-existing landslides (i.e. a sample of 154 grid cells) and of six environmental data layers, namely lithology, proximity to active faults, slope angle and aspect, elevation and distance to the nearest valley-floor. A 30-m-resolution DEM from the Belgian National Geographical Institute is used for the analysis. Owing to the small size of the sample, a special cross-validation procedure of the susceptibility map is performed, which uses in an iterative way each of the landslides to test the predictive power of the map derived from the other landslides. Four different sets of variables are used to produce four susceptibility maps, whose prediction curves are compared. While the prediction rates associated with the models not involving the “proximity to active fault” criterion are comparable to those of the models considering this variable, strong weaknesses inherent in the fault data on which the latter rely suggest that the final susceptibility map should be based on a model that excludes any reference to fault. This highlights the difference between a triggering factor and determining factors, and in the same time broadens the scope of the produced map. A single reactivated slide is also used to test the possibility of predicting future reactivation of existing landslides in the area. Finally, the need for geomorphological control over the mathematical treatment is underlined in order to obtain realistic prediction maps. [less ▲]

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See detailMapping Magnetic Near-Field Distributions of Plasmonic Nanoantennas
Denkova, D; Verellen, N; Silhanek, Alejandro ULg et al

in ACS Nano (2013)

We present direct experimental mapping of the lateral magnetic near-field distribution in plasmonic nanoantennas using aperture scanning nearfield optical microscopy (SNOM). By means of full-field ... [more ▼]

We present direct experimental mapping of the lateral magnetic near-field distribution in plasmonic nanoantennas using aperture scanning nearfield optical microscopy (SNOM). By means of full-field simulations it is demonstrated how the coupling of the hollow-pyramid aperture probe to the nanoantenna induces an effective magnetic dipole which efficiently excites surface plasmon resonances only at lateral magnetic field maxima. This excitation in turn affects the detected light intensity enabling the visualization of the lateral magnetic near-field distribution of multiple odd and even order plasmon modes with subwavelength spatial resolution. [less ▲]

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See detailMapping Of B-Neutralizing And T-Helper Cell Epitopes On The Bovine Leukemia-Virus External Glycoprotein Gp51
Callebaut, I.; Voneche, V.; Mager, A. et al

in Journal of Virology (1993), 67(9),

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See detailMapping of kisspeptin fibres in the brain of the pro-oestrous rat.
Desroziers, Elodie ULg; Mikkelsen, J.; Simonneaux, V. et al

in Journal of Neuroendocrinology (2010), 22(10), 1101-12

Kisspeptins are a family of small peptides that play a key role in the neuroendocrine regulation of the reproductive function through neural pathways that have not yet been completely identified. The ... [more ▼]

Kisspeptins are a family of small peptides that play a key role in the neuroendocrine regulation of the reproductive function through neural pathways that have not yet been completely identified. The present study aimed to investigate the distribution of kisspeptin neurone fibres in the female rat brain by comparing precisely the immunoreactive pattern obtained with two antibodies: one specifically directed against kisspeptin-52 (Kp-52), the longest isoform, and the other directed against kisspeptin-10 (Kp-10), whose sequence is common to all putative mature isoforms. With both antibodies, immunoreactive cell bodies were exclusively observed in the arcuate nucleus, and immunoreactive fibres were confined to the septo-preoptico-hypothalamic continuum of the brain. Fibres were observed in the preoptic area, the diagonal band of Broca, the septohypothalamic area, the anteroventral periventricular, suprachiasmatic, supraoptic, paraventricular and periventricular nuclei, the dorsal border of the ventromedian nucleus, the dorsomedial and arcuate nuclei, and the median eminence. In the latter structure, varicose fibres were mainly distributed in the internal layer and were detected to a lesser extent throughout the external layer, including around the deeper part of the infundibular recess. Most regions of immunoreactive cells and fibres matched perfectly for the two antibodies. However, fibres in the dorsolateral septum, anterior fornix, accumbens nucleus and the lateral bed nucleus of the stria terminalis were only recognised by antibody anti-Kp-10, suggesting that anti-Kp-10 may recognise a wider range of kisspeptin isoforms than anti-Kp-52 or cross-react with molecules other than kisspeptin in rat tissue. Overall, these results illustrate the variety of projection sites of kisspeptin neurones in the rat and suggest that these peptides play a role in different functions. [less ▲]

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See detailMapping of kisspeptin projections in the midbrain of the pro-oestrus rat
Desroziers, Elodie ULg; Mikkelsen, Jens; Simmoneaux, Valérie et al

Poster (2010, July)

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See detailMapping of riparian invasive species with supervised classification of Unmanned Aerial System (UAS) imagery
Michez, Adrien ULg; Piégay, Hervé; Lisein, Jonathan ULg et al

in International Journal of Applied Earth Observation and Geoinformation (2016), 44

Riparian zones are key landscape features, representing the interface between terrestrial and aquatic ecosystems. Although they have been influenced by human activities for centuries, their degradation ... [more ▼]

Riparian zones are key landscape features, representing the interface between terrestrial and aquatic ecosystems. Although they have been influenced by human activities for centuries, their degradation has increased during the 20th century. Concomitant with (or as consequences of) these disturbances, the invasion of exotic species has increased throughout the world’s riparian zones. In our study, we propose a easily reproducible methodological framework to map three riparian invasive taxa using Unmanned Aerial Systems (UAS) imagery: Impatiens glandulifera Royle, Heracleum mantegazzianum Sommier and Levier, and Japanese knotweed (Fallopia sachalinensis (F. Schmidt Petrop.), Fallopia japonica (Houtt.) and hybrids). Based on visible and near-infrared UAS orthophoto, we derived simple spectral and texture image metrics computed at various scales of image segmentation (10,30, 45, 60 using eCognition software). Supervised classification based on the random forests algorithm was used to identify the most relevant variable (or combination of variables) derived from UAS imagery for mapping riparian invasive plant species. The models were built using 20% of the dataset, the rest of the dataset being used as a test set (80%). Except for H. mantegazzianum, the best results in terms of global accuracy were achieved with the finest scale of analysis (segmentation scale parameter = 10). The best values of overall accuracies reached 72%, 68%, and 97% for I. glandulifera, Japanese knotweed, and H. mantegazzianum respectively. In terms of selected metrics, simple spectral metrics (layer mean / camera brightness) were the most used. Our results also confirm the added value of texture metrics (GLCM derivatives) for mapping riparian invasive species. The results obtained for I. glandulifera and Japanese knotweed do not reach sufficient accuracies for operational applications. However, the results achieved for H. mantegazzianum are encouraging. The high accuracies values combined to relatively light model-inputs needed (delineation of a few umbels) make our approach a serious contender as a cost-effective tool to improve the field management of H. mantegazzianum. [less ▲]

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See detailMapping of soil-sediment systems contaminations around a metal-ore smelter : The example of Cu in Lubumbashi (R.D.Congo).
Mpundu, Michel; Mukobo, Robert-Prince; Kaya Muyumba, Donato ULg et al

Poster (2009)

The Katanga is famous for its high richness in metal ores, mainly Cu- and Co-minerals. The ore treatments activities lead to metal spreading in the environment which do endanger the viability of ... [more ▼]

The Katanga is famous for its high richness in metal ores, mainly Cu- and Co-minerals. The ore treatments activities lead to metal spreading in the environment which do endanger the viability of ecosystems and human health. The contaminations of soils and sediments around the Gecamines smelter in Lubumbashi have been evaluated through a multi-scale approach. In the first stage, a reference system about the natural contents in soils has been implemented. The main units of the detailed (1:20 000) soil map have been characterized through field observations and laboratory determinations : acido-basic and organic status, particle size distribution, cationic exchange capacity, total contents in Al, Fe, Mn, Cu, Co, Cd, Pb, Zn. An exploratory mapping of soil contaminations (Cu, Co, Cd, Pb, Zn) centered on the Gecamines cheminey was then conducted as a second stage of the approach. Detailed investigations were finally performed in the Gecamines district where signs of soil degradation were the highest. The spatial continuity and the differenciation (C : C0+C ratio) of the studied parameters appeared weak. No clear effect of the dominant wind direction on the spatial distribution of the contaminants could be identified despite a clear degradation of the ecosystem in the area under dominant wind. However the detailed approach showed evidences of (i) significant wind deposits in the Gecamines district, (ii) and local man-made deposits but also (ii) important processes of redistribution in the landscape through erosion/sedimentation or anthropic activities. Our results point out the difficulty to identify the sources of contaminations in an urban environment and stress the need to have approaches with complementary levels of details. [less ▲]

Detailed reference viewed: 79 (14 ULg)