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See detailLD-based haplotype encoding scheme with iterative pruning principal component analysis (ipPCA) to retrieve population substructures
Chaichoompu, Kridsadakorn ULiege; Fouladi, Ramouna ULiege; Wangkumhang, Pongsakorn et al

Poster (2014, April 29)

Objective To identify and differentiate between subpopulations using a rich set of genetic markers, as using reduced sets of genetic markers for these purposes can become challenging, especially when ... [more ▼]

Objective To identify and differentiate between subpopulations using a rich set of genetic markers, as using reduced sets of genetic markers for these purposes can become challenging, especially when similar geographic regions are involved or when spurious patterns are likely to exist. Method Single Nucleotide Polymorphisms (SNPs) are commonly used to capture variations between populations and often genome-wide SNP data are pruned based on linkage disequilibrium (LD) patterns. Notably, haplotype composition and the pattern of LD between markers may vary between larger populations but may also play a role within more confined geographic regions. Indeed, knowledge about haplotypes in unrelated individuals can reveal useful information about genetic ancestry. Here, we use iterative pruning principal component analysis (ipPCA) [1] to identify and characterize subpopulations in an unsupervised way. As input data, either pruned genome-wide SNP data are used (using PLINK 1.9 with the "indep-pairwise" option, window size = 100k, r2 < 0.25) or multilocus haplotype information derived from the genome-wide SNP panel (using BEAGLE 3.3.2 to infer haplotype). These approaches are applied to real-life data from 992 Thai individuals [2]. Result Preliminary results indicate that ipPCA applied to pruned SNP data or ipPCA that explicitly uses multilocus information (haplotypes) give complementary information about population substructure for geographically confined populations such as the Thai samples in this study. Both methods address different aspects of population structure. Detailed simulation studies are needed to identify the optimal scenarios for haplotype-based ipPCA. Conclusion In this work, we propose to combine an LD-based haplotype encoding scheme with the ipPCA machinery to retrieve fine population substructures. Despite the complexities that are associated with haplotype inference, added value can be obtained when the LD structure between SNPs is exploited in the search for relevant population strata. References 1. Intarapanich, A., et al., Iterative pruning PCA improves resolution of highly structured populations. BMC Bioinformatics, 2009. 10: p. 382. 2. Wangkumhang, P., et al., Insight into the peopling of Mainland Southeast Asia from Thai population genetic structure. PLoS One, 2013. 8(11): p. e79522. [less ▲]

Detailed reference viewed: 170 (23 ULiège)
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See detailLDSO: A program to simulate pedigrees and molecular information under various evolutionary forces
Ytournel, F.; Teyssèdre, S.; Roldan, D. et al

in Journal of Animal Breeding & Genetics (2012), 129(5), 417-421

Simulations are a major tool to evaluate new statistical methods and optimize experimental designs in the genomic era. However, this can only be achieved when the simulations are close enough to reality ... [more ▼]

Simulations are a major tool to evaluate new statistical methods and optimize experimental designs in the genomic era. However, this can only be achieved when the simulations are close enough to reality, as well as diverse enough to be realistic. For mapping studies, it is thus critical to re-create as much as possible the forces generating linkage (mutation, random drift, changes in population sizes, selection and pedigree structure) and the mechanisms producing trait genetic architecture (additivity, dominance, epistasis). We present here a computer program (ldso) simulating these phenomena. Optional outputs provide statistics on the linkage disequilibrium (LD) structure and the identity by descent between chromosomal segments, facilitating further data analyses. Furthermore, ldso enables the simulation of genomic data in known pedigrees, which sticks as precisely as possible to recent population history and structures of the long-range LD, allowing optimization of fine-mapping strategies. © 2012 Blackwell Verlag GmbH. [less ▲]

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See detailLe _Syntactic Reference Corpus of Medieval French_: Structure, outils et exploitation
Mazziotta, Nicolas ULiege

in Dister, Anne; Longrée, Dominique; Purnelle, Gérald (Eds.) 11es Journées internationales d'Analyse statistique des Données Textuelles (JADT) (2012)

Detailed reference viewed: 19 (0 ULiège)
See detailLe bail et la pratique notariale : récents développements
Kohl, Benoît ULiege

Scientific conference (2009, February)

Detailed reference viewed: 118 (2 ULiège)
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See detailLe balbuzard pêcheur: histoire d'une sauvegarde
de Bellefroid, Marie-des-Neiges; Berny, Philippe; Corallo, Christian et al

Book published by Catiche productions (2013)

Ce grand rapace ayant frôlé l'extinction, le balbuzard voit ses effectifs se reconstituer progressivement grâce à des actions de protection de ses habitats mais aussi un programme d'études scientifiques ... [more ▼]

Ce grand rapace ayant frôlé l'extinction, le balbuzard voit ses effectifs se reconstituer progressivement grâce à des actions de protection de ses habitats mais aussi un programme d'études scientifiques: baguage, suivi des couples nicheurs, alimentation... [less ▲]

Detailed reference viewed: 41 (3 ULiège)
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See detailLe bilinguisme gréco-latin au IIe siècle
Rochette, Bruno ULiege

in Verbanck-Pierard, Annie (Ed.) Au temps de Galien. Médecine et société sous l'empire romain (in press)

Detailed reference viewed: 17 (1 ULiège)
See detailLe Bio entre qualité spécifique et qualité différenciée
Stassart, Pierre M ULiege

Conference (2002)

Detailed reference viewed: 5 (0 ULiège)
See detailLe bloc officiel et résidentiel: phase 1
Van der Stede, Véronique ULiege

in Lebeau, Marc; Suleiman, Antoine (Eds.) Tell Beydar, Five Seasons of Excavations (1995-1999), A Preliminary Report (2003)

 Cet article est consacré au palais mis au jour à Tell Beydar, une cité-état du 3e millénaire av. n. è. localisée dans le nord-est de la Syrie. Le lecteur y trouvera une description détaillée du bâtiment ... [more ▼]

 Cet article est consacré au palais mis au jour à Tell Beydar, une cité-état du 3e millénaire av. n. è. localisée dans le nord-est de la Syrie. Le lecteur y trouvera une description détaillée du bâtiment, une analyse du système de circulation ainsi qu’une évaluation des possibilités d’éclairage de l’édifice et de celles de restitution d’un étage. Il se termine par une analyse fonctionnelle des pièces et replace le bâtiment dans le contexte de l’architecture palatiale du Bronze ancien. [less ▲]

Detailed reference viewed: 20 (2 ULiège)
See detailLe Brésil et ses ambitions séculaires au statut de puissance
Santander, Sébastian ULiege

Scientific conference (2010, April 30)

Detailed reference viewed: 6 (0 ULiège)
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See detailLe caillou de Spinoza (à propos de Médias et Censure)
Durand, Pascal ULiege

Article for general public (2004)

Detailed reference viewed: 179 (6 ULiège)
See detailLe calcaire
Gerrienne, Philippe ULiege

in Environnement (1988), 5/88

Detailed reference viewed: 13 (0 ULiège)
Peer Reviewed
See detailLe calcul des adsorbeurs pour le traitement des eaux usées par les méthodes du génie des réacteurs chimiques
Crine, Michel ULiege; Degée, Albert; Pirard, Jean-Paul ULiege

in Tribune de l'Eau (La) (1976), 29

Detailed reference viewed: 45 (2 ULiège)
See detailLe Calendrier et son Histoire
Biémont, Emile ULiege

in Bulletin de la Classe des Sciences. Académie Royale de Belgique (1996), 6e série(VII), 15-71

Detailed reference viewed: 16 (3 ULiège)
See detailLe Cambro-Ordovicien du Massif de Stavelot et sa couverture de Dévonien inférieur
Lamens, J.; Steemans, Philippe ULiege; Vanguestaine, M.

Conference (1988)

Detailed reference viewed: 29 (11 ULiège)
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See detailLe cancer de la prostate
GERARD, Xavier ULiege

Scientific conference (2011, November)

Detailed reference viewed: 59 (4 ULiège)
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Peer Reviewed
See detailLe capital osseux : une épargne qui débute au berceau
Halkin, V; Reginster, Jean-Yves ULiege

in L'agenda Pédiatrie (2000), 22

Detailed reference viewed: 10 (1 ULiège)
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See detailLe caricaturiste offre sinon la réalité, du moins l’illusion d’une liberté
Durand, Pascal ULiege; Vaute, Paul

Article for general public (2002)

Detailed reference viewed: 23 (1 ULiège)
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See detailLe cartoon. Réflexions sur la culture populaire aux États-Unis
Moreau, Timothée ULiege

Conference (2017, June 16)

The aim of this paper is to propose an analysis of the cartoon and its place in popular culture from two different yet connected angles: the idea of "pop culture", linked to mass culture and its critique ... [more ▼]

The aim of this paper is to propose an analysis of the cartoon and its place in popular culture from two different yet connected angles: the idea of "pop culture", linked to mass culture and its critique/analysis by Adorno & Horkheimer and Benjamin ; and the idea of "folk culture", linked to the notion of grotesque as it is developped by Bakhtin. The main idea is that those two paths of analysis are connected through the notion of ambivalence and their link to political conceptions of a particular society and the culture that emerges from it. [less ▲]

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See detailLE CAS CLINIQUE DU MOIS Cas rare d’endométriose urétérale neuf ans après une hystérectomie
Bawin, Isabelle ULiege; Troisfontaines, E; Nisolle, Michelle ULiege

in Revue Médicale de Liège (2013), 68(7-8), 378-381

Ureteral endometriosis is a rare entity, espe- cially when it occurs in the postmenopausal period. In certain circumstances, this severe disease can cause obstruction, leading to ureterohydronephrosis and ... [more ▼]

Ureteral endometriosis is a rare entity, espe- cially when it occurs in the postmenopausal period. In certain circumstances, this severe disease can cause obstruction, leading to ureterohydronephrosis and, finally, to a progressive and often silent loss of renal function. The symptomatology is variable and non specific, making pre- operative diagnosis difficult. The treatment is mainly surgical. Its aim is the relief of obstruction to preserve the renal function. We report the case of a 39 year old patient, hysterect- omised for endometriosis nine years earlier, who developed a recurrence demonstrated by ureteral endometriosis and revealed by ureterohydronephrosis. Robot-assisted lapa- roscopic ureterolysis allowed a complete resection of the lesion and resolved the obstruction. No recurrence of ure- terohydronephrosis was found at the fifth and ninth postop- erative month ultrasonographic controls. [less ▲]

Detailed reference viewed: 146 (12 ULiège)
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See detailLE CAS CLINIQUE DU MOIS Cas rare d’endométriose urétérale neuf ans après une hystérectomie
Bawin, I; Troisfontaines, E; Nisolle, Michelle ULiege

in Revue Médicale de Liège (2012), 67

Ureteral endometriosis is a rare entity, espe- cially when it occurs in the postmenopausal period. In certain circumstances, this severe disease can cause obstruction, leading to ureterohydronephrosis and ... [more ▼]

Ureteral endometriosis is a rare entity, espe- cially when it occurs in the postmenopausal period. In certain circumstances, this severe disease can cause obstruction, leading to ureterohydronephrosis and, finally, to a progressive and often silent loss of renal function. The symptomatology is variable and non specific, making pre- operative diagnosis difficult. The treatment is mainly surgical. Its aim is the relief of obstruction to preserve the renal function. We report the case of a 39 year old patient, hysterect- omised for endometriosis nine years earlier, who developed a recurrence demonstrated by ureteral endometriosis and revealed by ureterohydronephrosis. Robot-assisted lapa- roscopic ureterolysis allowed a complete resection of the lesion and resolved the obstruction. No recurrence of ure- terohydronephrosis was found at the fifth and ninth postop- erative month ultrasonographic controls. [less ▲]

Detailed reference viewed: 166 (12 ULiège)