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See detailLipin-1 regulates cancer cell phenotype and is a potential target to potentiate rapamycin treatment
Brohée, Laura ULiege; Demine, Stéphane; Willems, Jérôme ULiege et al

in Oncotarget (2015), 6(13), 11264-11280

Lipogenesis inhibition was reported to induce apoptosis and repress proliferation of cancer cells while barely affecting normal cells. Lipins exhibit dual function as enzymes catalyzing the ... [more ▼]

Lipogenesis inhibition was reported to induce apoptosis and repress proliferation of cancer cells while barely affecting normal cells. Lipins exhibit dual function as enzymes catalyzing the dephosphorylation of phosphatidic acid to diacylglycerol and as co-transcriptional regulators. Thus, they are able to regulate lipid homeostasis at several nodal points. Here, we show that lipin-1 is up-regulated in several cancer cell lines and overexpressed in 50 % of high grade prostate cancers. The proliferation of prostate and breast cancer cells, but not of non-tumorigenic cells, was repressed upon lipin-1 knock-down. Lipin-1 depletion also decreased cancer cell migration through RhoA activation. Lipin-1 silencing did not significantly affect global lipid synthesis but enhanced the cellular concentration of phosphatidic acid. In parallel, autophagy was induced while AKT and ribosomal protein S6 phosphorylation were repressed. We also observed a compensatory regulation between lipin-1 and lipin-2 and demonstrated that their co-silencing aggravates the phenotype induced by lipin-1 silencing alone. Most interestingly, lipin-1 depletion or lipins inhibition with propranolol sensitized cancer cells to rapamycin. These data indicate that lipin-1 controls main cellular processes involved in cancer progression and that its targeting, alone or in combination with other treatments, could open new avenues in anticancer therapy. [less ▲]

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See detailLipodystrophy reactions to insulin: effects of continuous insulin infusion and new insulin analogs.
Radermecker, Régis ULiege; Pierard, Gérald ULiege; Scheen, André ULiege

in American Journal of Clinical Dermatology (2007), 8(1), 21-8

Management of diabetes mellitus can be responsible for cutaneous adverse events. For example, lipoatrophy or lipohypertrophy can develop at the site of insulin injections. Lipohypertrophy remains a ... [more ▼]

Management of diabetes mellitus can be responsible for cutaneous adverse events. For example, lipoatrophy or lipohypertrophy can develop at the site of insulin injections. Lipohypertrophy remains a frequent complication of insulin therapy irrespective of the insulin source and mode of administration. Lipoatrophy at insulin injection sites is considered to be an immune complex-mediated inflammatory lesion; however, it has become a rare event since the advent of human insulin. Nowadays, continuous subcutaneous insulin infusion (CSII) using a portable pump and/or injections of insulin analogs with an altered amino acid sequence compared with native insulin may cause lipodystrophy in diabetic patients. Some case reports describe the recovery of lipoatrophy following the use of CSII and/or short-acting insulin analogs. Conversely, exceptional cases of lipoatrophy have occurred in patients receiving lispro insulin analog via CSII. Lipodystrophy reactions remain a potential problem when managing diabetic patients with new insulin therapy technologies. [less ▲]

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See detailLipofibromatous hamartoma of the median nerve. Three case reports.
Nardella, D; Sohawon, S; CARLIER, Alain ULiege

in Journal of Plastic, Reconstructive and Aesthetic Surgery (2009), 62(9), 314-7

Nervous lipofibromatous hamartoma is a rare tumour-like condition involving the peripheral nerves, whereby the epineurium and perineurium are enlarged and distorted by excess fatty and fibrous tissues ... [more ▼]

Nervous lipofibromatous hamartoma is a rare tumour-like condition involving the peripheral nerves, whereby the epineurium and perineurium are enlarged and distorted by excess fatty and fibrous tissues that infiltrate between and around nerve boundaries. The median nerve is much more likely than other nerves to develop a hamartoma with a predilection for the carpal tunnel. In this article, we describe three cases of lipofibromatous hamartoma of the median nerve and discuss its management. [less ▲]

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See detailLipolyse electromagnetique et lipoatrophie semi-circulaire des cuisses
Flagothier, Caroline ULiege; Quatresooz, Pascale ULiege; Pierard, Gérald ULiege

in Annales de Dermatologie et de Vénéréologie (2006), 133(6-7, Jun-Jul), 577-80

INTRODUCTION: The semicircular lipoatrophy of the thighs is a disorder whose incidence remained rare for years. Only recently, an "epidemic" situation emerged, affecting hundreds of subjects who shared a ... [more ▼]

INTRODUCTION: The semicircular lipoatrophy of the thighs is a disorder whose incidence remained rare for years. Only recently, an "epidemic" situation emerged, affecting hundreds of subjects who shared a status of administrative employee. OBSERVATION: The older etiopathogenic hypotheses give way to a newer one implying the electromagnetic fields generated by computers and their wirings. The resulting modifications in the intrinsic bioelectrical properties of the skin could influence the biology of macrophages exhibiting lipophagic activity in the hypodermis. The electroactivation of these cells could lead to TNF-alpha release. DISCUSSION: The semicircular lipoatrophy of the thighs is a problem that may affect an employee out of two. Rather than hoping an efficaceous drug therapy, prevention must be advocated by adapting the work conditions related to the use of computerized devices. [less ▲]

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See detailLipolysis inhibition by proteose-peptone : an interfaciale study.
Danthine, Sabine ULiege; Blecker, Christophe ULiege; Deroanne, Claude

Poster (2004, February 11)

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See detailLipomatose pelvienne associee a une cystite glandulaire: rapport de deux cas
Leruth, Julie ULiege; Coppens, Luc ULiege; Andrianne, Robert ULiege et al

in Progrès en Urologie (2005), 15(1), 81-4

The authors report two cases of pelvic lipomatosis associated with glandular cystitis. This is a rare disease with variable and nonspecific clinical features. Complementary investigations useful for the ... [more ▼]

The authors report two cases of pelvic lipomatosis associated with glandular cystitis. This is a rare disease with variable and nonspecific clinical features. Complementary investigations useful for the diagnosis of pelvic lipomatosis are CT and especially MRI, intravenous urography and biopsies. The clinical features, radiological findings and therapeutic approach are discussed in the light of a review of the literature. [less ▲]

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See detailLipomatous hypertrophy of the interatrial septum: the typical echographic aspect is worth being known
ROYER, Ludovic ULiege; HANS, Grégory ULiege; CANIVET, Jean-Luc ULiege et al

in Acta Anaesthesiologica Belgica (2011), 62(3), 157-159

Detailed reference viewed: 46 (15 ULiège)
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See detailLipopeptide production of Pseudomonas cichorii SF154 causing midrib rot on lettuce
Pauwelyn, E.; Ongena, Marc ULiege; Hofte, M.

Conference (2011)

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See detailLipopeptides
Jacques, Philippe ULiege; Savadogo, A.

in Handbook of Indigenous Foods Involving Alkaline Fermentation (2014)

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See detailLipopeptides alter Bacillus subtilis hydrophobicity by adsorbing onto cell surfaces
Ahimou, François; Razafindralambo, Hary ULiege; Paquot, Michel ULiege

Poster (1997, October 29)

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See detailLipopeptides as main ingredients for inhibition of fungal phytopathogens by Bacillus subtilis/amyloliquefaciens
Cawoy, H.; Debois, Delphine ULiege; Franzil, Laurent ULiege et al

in Microbial Biotechnology (2015), 8(2), 281-295

Summary: Some isolates of the Bacillus subtilis/amyloliquefaciens species are known for their plant protective activity against fungal phytopathogens. It is notably due to their genetic potential to form ... [more ▼]

Summary: Some isolates of the Bacillus subtilis/amyloliquefaciens species are known for their plant protective activity against fungal phytopathogens. It is notably due to their genetic potential to form an impressive array of antibiotics including non-ribosomal lipopeptides (LPs). In the work presented here, we wanted to gain further insights into the relative role of these LPs in the global antifungal activity of B.subtilis/amyloliquefaciens. To that end, a comparative study was conducted involving multiple strains that were tested against four different phytopathogens. We combined various approaches to further exemplify that secretion of those LPs is a crucial trait in direct pathogen ward off and this can actually be generalized to all members of these species. Our data illustrate that for each LP family, the fungitoxic activity varies in function of the target species and that the production of iturins and fengycins is modulated by the presence of pathogens. Our data on the relative involvement of these LPs in the biocontrol activity and modulation of their production are discussed in the context of natural conditions in the rhizosphere. © 2014 The Authors. Microbial Biotechnology published by John Wiley & Sons Ltd and Society for Applied Microbiology. [less ▲]

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See detailLes lipopeptides de Bacillus subtilis dans le domaine des émulsions
Deleu, Magali ULiege

in Triennale de la FABI: évolution technologique et emploi (1997)

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See detailThe lipopeptides mycosubtilin and surfactin enhance spreading of Bacillus subtilis strains by their surface-active properties.
Leclere, Valerie; Marti, Romain; Bechet, Max et al

in Archives of microbiology (2006), 186(6), 475-83

The colonizing behaviour and the pellicle formation of Bacillus subtilis strains producing different families of lipopeptides were evaluated under several cultural conditions. The pattern of lipopeptides ... [more ▼]

The colonizing behaviour and the pellicle formation of Bacillus subtilis strains producing different families of lipopeptides were evaluated under several cultural conditions. The pattern of lipopeptides produced determined the architecture of the colony on a swarming medium as well as the flotation and the thickness of the pellicle formed at the air/liquid interface. The overproduction of mycosubtilin, a lipopeptide of the iturin family, led to increased spreading but had no effect on pellicle formation. A physico-chemical approach was developed to gain an insight into the mode of action of the biosurfactants facilitating the colonization. A relationship between surface tension of the culture medium and spreading of a lipopeptide non-producing strain, B. subtilis 168, was established. Goniometry was used to highlight the modification of the in situ wettability in the area where spreading was enhanced. On a solid medium, co-cultures of a surfactin producing with other strains showed a diffusion ring of the surfactin around the colony. This ring characterized by a higher wettability favoured the propagation of other colonies. [less ▲]

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See detailLe lipopolysaccharide d’Escherichia coli : structure, biosynthèse et rôles
Szalo, Ioan Mihai ULiege; Taminiau, Bernard ULiege; Mainil, Jacques ULiege

in Annales de Médecine Vétérinaire (2006), 150(2), 108-124

The lipopolysaccharide (LPS) is a major component of the surface of the Gram negative bacteria. The LPS is composed of three separately synthesized entities: the lipid A, the core oligosaccharide and the ... [more ▼]

The lipopolysaccharide (LPS) is a major component of the surface of the Gram negative bacteria. The LPS is composed of three separately synthesized entities: the lipid A, the core oligosaccharide and the O antigen, that will be linked together after their respective synthesis. The lipid A, embedded inside the outer membrane, is the proximal part of the LPS and the core is the medial part, whereas the O antigen represents the distal part free in the external environment. Amongst the Enterobacteriaceae family, the lipid A is structurally highly conserved and the variation in the structure of the core oligosaccharide is limited whereas the O antigen is the hypervariable region. Diverse biological activities have been associated with LPS, amongst which the endotoxinic activity carried by the lipid A, and the strain immunogenic specificity carried by the O antigen. In this review manuscript we summarize the state of knowledge on the structures and biosynthesis of the different components of the LPS of Escherichia coli and on their respective roles in the virulence of pathogenic bacteria. [less ▲]

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See detailLipopolysaccharide suppresses immune complex retention by follicular dendritic cells without cytological alterations.
Heinen, Ernst ULiege; Cormann, N.; Kinet-Denoel, C. et al

in Immunology Letters (1986), 13(6), 323-7

Follicular dendritic cells (FDC) are peculiar cells only located inside lymph follicles and which may be characterized by complex dendritic evaginations retaining high quantities of immune complexes by Fc ... [more ▼]

Follicular dendritic cells (FDC) are peculiar cells only located inside lymph follicles and which may be characterized by complex dendritic evaginations retaining high quantities of immune complexes by Fc and C3b receptors. After lipopolysaccharide (LPS) injection in mice the retention of gold-labelled immune complexes was abolished in draining lymph nodes. In order to examine the possibility that the transport of immune complexes to lymph follicles was impaired, we isolated FDC from lymph nodes and incubated them in presence of gold-labelled complexes: no or strongly reduced retention was then observed at the ultrastructural level. This LPS-induced impairment of immune complex fixation by FDC is not due to morphological alteration to the cells but to the inhibition of their Fc and C3b receptors. Further, LPS induces changes in the composition of the lymphocyte population in lymph follicles as higher numbers of blast cells and plasmocytes are observed after treatment. [less ▲]

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See detailLipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKK epsilon-dependent lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF
GATOT, Jean-Stéphane ULiege; Gioia, Romain ULiege; Chau, Tieu-Lan ULiege et al

in Journal of Biological Chemistry (2007), 282(43), 31131-31146

Type I interferon gene induction relies on IKK-related kinase TBK1 and IKK epsilon-mediated phosphorylations of IRF3/7 through the Toll-like receptor-dependent signaling pathways. The scaffold proteins ... [more ▼]

Type I interferon gene induction relies on IKK-related kinase TBK1 and IKK epsilon-mediated phosphorylations of IRF3/7 through the Toll-like receptor-dependent signaling pathways. The scaffold proteins that assemble these kinase complexes are poorly characterized. We show here that TANK/ITRAF is required for the TBK1- and IKK epsilon-mediated IRF3/7 phosphorylations through some Toll-like receptor-dependent pathways and is part of a TRAF3-containing complex. Moreover, TANK is dispensable for the early phase of double-stranded RNA-mediated IRF3 phosphorylation. Interestingly, TANK is heavily phosphorylated by TBK1-IKK epsilon upon lipopolysaccharide stimulation and is also subject to lipopolysaccharide- and TBK1-IKK epsilon-mediated Lys(63)-linked polyubiquitination, a mechanism that does not require TBK1-IKK epsilon kinase activity. Thus, we have identified TANK as a scaffold protein that assembles some but not all IRF3/7-phosphorylating TBK1-IKK epsilon complexes and demonstrated that these kinases possess two functions, namely the phosphorylation of both IRF3/7 and TANK as well as the recruitment of an E3 ligase for Lys63-linked polyubiquitination of their scaffold protein, TANK. [less ▲]

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See detailLIPOSOME CONTAINING ESTETROL FOR THE TREATMENT OF ISCHEMIA DISEASES IN PREMATURE BABIES
Palazzo, Claudio ULiege; Karim, Reatul ULiege; Mawet, Marie et al

Poster (2015, April 14)

Detailed reference viewed: 70 (16 ULiège)