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See detailPeculiar hydrophobic properties of the 67-78 fragment of α-synuclein are responsible for membrane destabilization and neurotoxicity
Crowet, Jean-Marc ULg; Lins, Laurence ULg; Dupiereux-Fettweis, Ingrid ULg et al

Poster (2007, March 14)

α-synuclein is a 140 residue protein linked to Parkinson’s disease. Intraneural inclusions called Lewy bodies and Lewy neurites are mainly composed of α-synuclein aggregated in amyloid fibrils. Few years ... [more ▼]

α-synuclein is a 140 residue protein linked to Parkinson’s disease. Intraneural inclusions called Lewy bodies and Lewy neurites are mainly composed of α-synuclein aggregated in amyloid fibrils. Few years ago, tilted peptides have been detected in two other amyloidogenic proteins : the amyloid β peptide involved in Alzheimer’s disease, and the PrP protein linked to Creuztfeldt-Jakob’s disease. Tilted peptides are short protein fragments that adopt an oblique orientation when inserted into biological membranes. Tilted peptides are able to destabilize membranes. In this study, we predicted by sequence analysis and molecular modelling that the 67-78 fragment of α-synuclein is a tilted peptide. Like most of them, the α-syn 67-78 peptide is able to induce lipid mixing and leakage of unilamellar liposomes. A mutant designed by molecular modelling to decrease the destabilizing properties of the peptide was shown to be significantly less fusogenic. The neuronal toxicity was studied using human neuroblastoma cells and we demonstrated that the α-syn 67-78 peptide induces neurotoxicity. In conclusion, we have identified a tilted peptide in α-synuclein which could be involved in the toxicity induced during amyloidogenesis of α-synuclein. [less ▲]

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See detailPeculiar hydrophobic properties of the 67-78 fragment of α-synuclein are responsible for membrane destabilization and neurotoxicity
Crowet, Jean-Marc ULg; Lins, Laurence ULg; Dupiereux-Fettweis, Ingrid ULg et al

Poster (2006, December 18)

α-synuclein is a 140 residue protein linked to Parkinson’s disease. Intraneural inclusions called Lewy bodies and Lewy neurites are mainly composed of α-synuclein aggregated in amyloid fibrils. Few years ... [more ▼]

α-synuclein is a 140 residue protein linked to Parkinson’s disease. Intraneural inclusions called Lewy bodies and Lewy neurites are mainly composed of α-synuclein aggregated in amyloid fibrils. Few years ago, tilted peptides have been detected in two other amyloidogenic proteins : the amyloid β peptide involved in Alzheimer’s disease, and the PrP protein linked to Creuztfeldt-Jakob’s disease. Tilted peptides are short protein fragments that adopt an oblique orientation when inserted into biological membranes. Tilted peptides are able to destabilize membranes. In this study, we predicted by sequence analysis and molecular modelling that the 67-78 fragment of α-synuclein is a tilted peptide. Like most of them, the α-syn 67-78 peptide is able to induce lipid mixing and leakage of unilamellar liposomes. A mutant designed by molecular modelling to decrease the destabilizing properties of the peptide was shown to be significantly less fusogenic. The neuronal toxicity was studied using human neuroblastoma cells and we demonstrated that the α-syn 67-78 peptide induces neurotoxicity. In conclusion, we have identified a tilted peptide in α-synuclein which could be involved in the toxicity induced during amyloidogenesis of α-synuclein. [less ▲]

Detailed reference viewed: 10 (1 ULg)
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See detailThe peculiar Of?p stars HD 108 and HD 191612
Nazé, Yaël ULg; Rauw, Grégor ULg; Walborn, N. R. et al

in Massive Stars and High-Energy Emission in OB Associations (2005, November 01)

The Of?p spectral category was introduced by Walborn in 1972 to describe peculiar stars which possess intense emission lines of C III 4647,4650,4651. Recently, two of them, HD 108 and HD 191612, were ... [more ▼]

The Of?p spectral category was introduced by Walborn in 1972 to describe peculiar stars which possess intense emission lines of C III 4647,4650,4651. Recently, two of them, HD 108 and HD 191612, were found to display spectacular line profile variations in the visible domain: these stars apparently alternate between two different spectral states (O6-O8). To discover the origin of this intriguing behaviour, a multiwavelength campaign was undertaken. In this context, the analysis of the X-ray emission is especially important since it provides crucial information for constraining the nature of these peculiar objects and testing conflicting models. We are therefore carrying out high-quality XMM-Newton observations of these stars and we present the results of the data obtained up to now. [less ▲]

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See detailThe Peculiar Of?p Stars HD 108 and HD 191612: The X-ray View
Nazé, Yaël ULg; Rauw, Grégor ULg; Walborn, N. R. et al

in The X-ray Universe 2005 (2006, January 01)

Not Available

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Peer Reviewed
See detailPeculiar polarization and shape properties of Barbarian asteroids: A campaign for their physical characterization
Devogele, Maxime ULg; Hanus, J.; Tanga, P. et al

Conference (2014, July)

A few years ago, asteroid polarimetry allowed to discover a class of asteroids exhibiting peculiar phase polarization curves, collectively called "Barbarians" (a dozen are known) from the prototype of ... [more ▼]

A few years ago, asteroid polarimetry allowed to discover a class of asteroids exhibiting peculiar phase polarization curves, collectively called "Barbarians" (a dozen are known) from the prototype of this class, the asteroid (234) Barbara. All such objects belong to the taxonomic classes L, Ld, and K, all related to the general S-complex. However, the "Barbarian" polarimetric properties are not found among all known L-class asteroids. Therefore, we cannot be sure that composition is the only and one responsible of the wide negative polarization branch. On the other hand, it was also suggested that a peculiar distribution of incidence/diffusion angles, resulting from the presence of large concavities on the object surface, could play a role in the polarimetric behaviour. Based on such motivations, we are running a systematic campaign for shape determination at the C2PU telescope of the Observatoire de la Côte d'Azur (Calern site) and several other sites in the world. By using photometric inversion techniques we hope to obtain indications on the presence of concavities. [less ▲]

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Peer Reviewed
See detail“Peculiar Sites of Amnesia: Recovering the ‘Eclipsed Figures of the Past’ in Francis Quamina Farrier’s The Slave and the Scroll and Michael Gilkes’s Couvade.”
Bada, Valérie ULg

in Bridges Across Chasms. Towards a Transcultural Future in Caribbean Literature. Ed. Bénédicte Ledent. (2004)

Detailed reference viewed: 10 (1 ULg)
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See detailPeculiar Variable in Crux
Della Valle, M.; Hutsemekers, Damien ULg; Saviane, I. et al

in International Astronomical Union Circulars [=IAUCs] (2003), 8185

IAUC 8185 available at Central Bureau for Astronomical Telegrams.

Detailed reference viewed: 4 (1 ULg)
See detailThe Pedagogical and Political Roots of Belgian Design
Prina, Daniela ULg

in Simon Thomas, Mienke; Huygens, Frank (Eds.) Design Derby: Netherlands-Belgium (1815-2015), exh.cat. (2015)

Detailed reference viewed: 6 (0 ULg)
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See detailPedagogical supervision and initial teachers’ education- an international research project
Albuquerque, Alberto; Pinheiro, Claudia; Aranha, Agata et al

Poster (2010, October)

Detailed reference viewed: 33 (4 ULg)
See detailPédagogie de l'écriture : un plan de travail pour apprendre à écrire les textes utilitaires
Dumortier, Jean-Louis ULg

in Revue de la Direction Générale de l’Organisation des Etudes (1987)

Detailed reference viewed: 18 (0 ULg)
See detailPédagogie de la lecture : comment aider à lire un roman complet ?
Dumortier, Jean-Louis ULg

in Revue de la Direction Générale de l’Organisation des Etudes (1979)

Detailed reference viewed: 10 (0 ULg)
See detailLa pédagogie de Niemeyer
de Landsheere, Gilbert ULg

Doctoral thesis (1960)

Detailed reference viewed: 24 (1 ULg)
See detailPédagogie expérimentale
de Landsheere, Gilbert ULg

in Bârsănescu, Stefan (Ed.) Dictionar de pedagogie contemporană (1969)

Detailed reference viewed: 6 (1 ULg)
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Peer Reviewed
See detailLa pédagogie expérimentale en Belgique
de Landsheere, Gilbert ULg

in International Review of Education (1967), 13(3), 298-305

Detailed reference viewed: 14 (0 ULg)
See detailLa pédagogie expérimentale
de Landsheere, Gilbert ULg

in Mialaret, Gaston; Vial, Jean (Eds.) Histoire mondiale de l'éducation. Vol. 4, De 1945 à nos jours (1981)

Detailed reference viewed: 12 (0 ULg)
Peer Reviewed
See detailPédagogie nomade : une école de l’émancipation
Janvier, Antoine ULg; Toussaint, Benoit

in Brausch, Géraldine (Ed.) Petite histoire des pratiques démocratiques (ou comment mettre en œuvre l’égalité) (2012)

Detailed reference viewed: 19 (3 ULg)
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See detailPédagogie Nomade: penser l'école et l'apprentissage depuis l'égalité
Janvier, Antoine ULg

Article for general public (2008)

Detailed reference viewed: 42 (5 ULg)