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See detailA new discontinuous Galerkin method for non-linear Mechanics
Noels, Ludovic ULg; Radovitzky, Raúl

(2006)

A discontinuous Galerkin framework for large deformations of solids is established. The method is based on a general Hu-Washizu-de Veubeke functional allowing for displacement and stress discontinuities ... [more ▼]

A discontinuous Galerkin framework for large deformations of solids is established. The method is based on a general Hu-Washizu-de Veubeke functional allowing for displacement and stress discontinuities in the domain interior. The focus of this paper is on the treatment of large elasto-plastic deformations. The method is shown to possess the required numerical properties: consistency in the non-linear range and linearized stability. In order to demonstrate the versatility, accuracy and robustness of the method examples of application and convergence studies in three dimensions are provided. Further developments of the method will lead to applications where physical discontinuities must be modeled like fragmentation or failure. [less ▲]

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See detailNew disruption cassettes for rapid gene disruption and marker rescue in the yeast Yarrowia lipolytica
Fickers, Patrick ULg; Le Dall, M. T.; Gaillardin, C. et al

in Journal of Microbiological Methods (2003), 55(3), 727-737

Yarrowia lipolytica is one of the most extensively studied nonconventional yeasts. Unfortunately, few methods for gene disruption have been reported for this yeast, and all of them are time-consuming and ... [more ▼]

Yarrowia lipolytica is one of the most extensively studied nonconventional yeasts. Unfortunately, few methods for gene disruption have been reported for this yeast, and all of them are time-consuming and laborious. The functional analysis of unknown genes requires powerful disruption methods. Here, we describe such a new method for rapid gene disruption in Y lipolytica. This knockout system combines SEP method and the Cre-lox recombination system, facilitating efficient marker rescue. Versatility was increased by using both auxotrophic markers like ylURA3 and ylLEU2, as well as the antibiotic resistance marker hph. The hph marker, which confers resistance to hygromycin-B, allows gene disruption in a strain lacking any conventional auxothrophic marker. The disruption cassette was shown to integrate at the correct locus at an average frequency of 45%. Upon expression of Cre recombinase, the marker was excised at a frequency of 98%, by recombination between the two lox sites. This new method for gene disruption is an ideal tool for the functional analysis of gene families, or for creating large-scale mutant collections in general. (C) 2003 Elsevier B.V. All rights reserved. [less ▲]

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See detailA new distribution of vegetation types and its inclusion in a global biosphere model
Warnand; François, Louis ULg; Nemry, B. et al

Poster (1995, August)

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See detailA new diterpene enone from the soldier beetle Cantharis livida (Coleoptera : Cantharidae)
Durvaux, Christophe; Laurent, Pascal ULg; Daloze, Désiré et al

in ARKIVOC (2007), 10

Cantharenone, a new diterpene structurally related to the prenylbisabolane skeleton, has been isolated from the beetle Cantharis livida (Cantharidae). Its structure has been determined on the basis of its ... [more ▼]

Cantharenone, a new diterpene structurally related to the prenylbisabolane skeleton, has been isolated from the beetle Cantharis livida (Cantharidae). Its structure has been determined on the basis of its spectral properties. This is the first report of such a type of diterpenoid from an insect. [less ▲]

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See detailNew diversity patterns of Triassic conodonts
Plasencia, Pablo; Martínez-Perez, Carlos; Cascales - Miñana, Borja ULg et al

Conference (2013, July)

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See detailNew drugs and nutraceuticals in the treatment of osteoarthritis
Henrotin, Yves ULg; Reginster, Jean-Yves ULg

in Cox Gad, Shayne (Ed.) Development of Therapeutic Agents Handbook (2012)

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See detailNew Dynamics in Female Migration and Integration
Martiniello, Marco ULg; Timmerman, C.; Rea, A. et al

Book published by Routledge - Routledge Research and Gender and Society (2015)

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See detailA new easy method for specific measurement of active myeloperoxidase in human biological fluids and tissue extracts
Franck, Thierry ULg; Kohnen, Stephan; Zouaoui Boudjeltia, Karim et al

in Talanta (2009), 80

The SIEFED (“Specific Immunological Extraction Followed by Enzymatic Detection”) method already developed for the specific detection of the activity of equine myeloperoxidase (MPO) was adapted for the ... [more ▼]

The SIEFED (“Specific Immunological Extraction Followed by Enzymatic Detection”) method already developed for the specific detection of the activity of equine myeloperoxidase (MPO) was adapted for the specific measurement of active human MPO in biological fluids or tissue extracts. [less ▲]

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See detailNew Economy, New Myths ? The American Media Industry in Perspective
Geuens, Geoffrey ULg

Scientific conference (2008, October 16)

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See detailNew efficient bicomponent organocatalysts for the chemical fixation of CO2 onto epoxides: a theoretical study
Alves, Margot ULg; Méreau, Raphaël; Grignard, Bruno ULg et al

Poster (2015, May 18)

Regarding the economic and environmental issues, valorising CO2 as a C1 feedstock for producing useful building blocks is seducing as it is a free and abundant waste resulting from the human activity ... [more ▼]

Regarding the economic and environmental issues, valorising CO2 as a C1 feedstock for producing useful building blocks is seducing as it is a free and abundant waste resulting from the human activity. Cyclic carbonates are useful compounds that found application as green solvents, electrolytes for lithium battery or monomers for polycarbonates or polyurethanes synthesis. These cyclocarbonates can be synthesized with a total atom economy by chemical fixation of CO2 onto epoxides using organometallic complexes or organocatalysts. To date, although this area of research has been the subject of many studies, the identification and development of (organo)catalysts highly efficient under mild experimental conditions still remains challenging. In this context, we developed a new organocatalytic platform based on the use of ammonium salts in combination with single or double hydrogen bond donor activators derived from fluorinated alcohols that showed unexpected booster effect. In this contribution, the ammonium/fluoroalcohol promoted CO2/propylene oxide coupling was investigated through detailed kinetic studies by IR spectroscopy under pressure and results were compared to the most efficient organocatalysts based on ammonium salts and (multi)phenolic derivatives that were reported in the literature. In order to finely understand the reaction mechanism, this study was completed by molecular modeling. DFT calculations showed that the addition of H-bond donors (HBD) with hexafluoroisopropanol functionalities modified the mechanism of the ammonium promoted coupling of CO2 with epoxides. HBDs dramatically decreased the epoxide ring-opening step barrier which highlights the key role of the fluorinated activators in stabilizing the intermediates and transitions states by inter- and intra-molecular hydrogen bonds. [less ▲]

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See detailNew efficient organocatalytic system for solvent-free chemical fixation of CO2 into epoxides
Panchireddy, Satyannarayana ULg; Gennen, Sandro ULg; Alves, Margot ULg et al

Poster (2015, September 11)

Due to concerns about global warming combined with the decrease of fossil resources, the chemical transformation of carbon dioxide (CO2) into added-value products has gained interest in both academic and ... [more ▼]

Due to concerns about global warming combined with the decrease of fossil resources, the chemical transformation of carbon dioxide (CO2) into added-value products has gained interest in both academic and industrial fields. To date, the chemical fixation of CO2 onto epoxides with the formation of cyclic carbonates (CC) is one of the most promising ways to valorise CO2 at an industrial scale. Indeed, CC are useful monomers for polycarbonate synthesis and they can react with primary amines to produce 2-hydroxyethylurethane. This reaction can be extrapolated to the synthesis of non-isocyanate polyurethanes (NIPUs) by a step growth polymerization between bifunctional CC and diamines. [less ▲]

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See detailA new elastic-visco-plastic damage model for annealed aluminium: theory, calibration and validation
Habraken, Anne ULg; Zhang, Lihong ULg; Wang, X. C. et al

in Benallal, A. (Ed.) Proceedings of the Continuous Damage and Fracture Symposium (2000)

This article describes an energy based, two variables, isotropic damage model merged with Bodner's elasto-visco-plastic model and implemented in a non-linear finite element code. The procedure to identify ... [more ▼]

This article describes an energy based, two variables, isotropic damage model merged with Bodner's elasto-visco-plastic model and implemented in a non-linear finite element code. The procedure to identify the parameters of the model and its experimental validation are presented and applied to an annealed aluminium. [less ▲]

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See detailNew emission lines in Mira Ceti
Swings, Polydore ULg

in Publications of the Astronomical Society of the Pacific [=PASP] (1940), 52

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See detailNew Energy Levels in Ne II deduced from FTS spectra in the Infrared Region (1800-9000 cm-1)
Quinet, Pascal ULg; Palmeri, P.; Biémont, Emile ULg

in Physica Scripta (1994), 49

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See detailA New Energy-Dissipative Momentum-Conserving Time Integration Scheme Using the Variational Updates Framework.
Noels, Ludovic ULg; Stainier, Laurent ULg; Ponthot, Jean-Philippe ULg

(2007)

Although they are the most widely used time integration algorithms for finite-element discretizations, algorithms based on the Newmark family are numerically stable only for linear models. To overcome ... [more ▼]

Although they are the most widely used time integration algorithms for finite-element discretizations, algorithms based on the Newmark family are numerically stable only for linear models. To overcome that drawback, researches have recently focused on time integration algorithms stable in the non-linear range, leading to the development of Energy Momentum Conserving Algorithms or EMCA. A new Energy Momentum Conserving Algorithm was recently presented by the authors for elasto-plastic material models. This algorithm is based on a variational formulation of elasto-plastic updates for which the stress tensor always derives from an incremental potential, even when plastic behavior is considered. In this work this formalism is used to develop Energy-Dissipative Momentum-Conserving time integration algorithms, which have property of being stable in non-linear range, but also dissipate high-frequency numerical modes to improve the convergence properties. Using the potential existence of the variational updates framework, the verification of the numerical dissipation of energy in the non-linear range can easily be demonstrated. [less ▲]

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See detailA new ent-clerodane diterpenoid from Crassocephalum bauchiense Huch. (Asteraceae).
Tchinda, Alembert T.; Mouokeu, Simplice R.; Ngono, Rosalie A. N. et al

in Natural product research (2015)

A phytochemical investigation of the whole plant of Crassocephalum bauchiense Huch. resulted in the isolation of a new clerodane diterpenoid, ent-2beta,18,19-trihydroxycleroda-3,13-dien-16,15-olide (1 ... [more ▼]

A phytochemical investigation of the whole plant of Crassocephalum bauchiense Huch. resulted in the isolation of a new clerodane diterpenoid, ent-2beta,18,19-trihydroxycleroda-3,13-dien-16,15-olide (1), together with two known flavonoids 3',5-dihydroxy-4',5',6,7,8-pentamethoxyflavone (2) and 4',5-dihydroxy-3',5',6,7,8-pentamethoxyflavone (3). The compounds were tested against the chloroquine-sensitive 3D7 strain of Plasmodium falciparum. Compound 2 showed weak activity (IC50 = 10.1 g/mL) whilst compounds 1 and 3 were inactive. The structures of the compounds were elucidated by using detailed spectral analyses, especially 1H and 13C NMR, 1H-1H COSY, NOESY, HMBC and HR-ESI-MS. [less ▲]

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See detailA New Equilibrium Cell with Variable Cell Volume for Static Vapour-Pressure Measurements
Gaube, J; Hammer, S; Pfennig, Andreas ULg

in Fluid Phase Equilibria (1996), 123((1-2)), 245-257

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See detailA new era of coma and consciousness science.
Owen, Adrian M.; Schiff, Nicholas D.; Laureys, Steven ULg

in Progress in Brain Research (2009), 177

In the past ten years, rapid technological developments in the field of neuroimaging have produced a cornucopia of new techniques for examining both the structure and function of the human brain in vivo ... [more ▼]

In the past ten years, rapid technological developments in the field of neuroimaging have produced a cornucopia of new techniques for examining both the structure and function of the human brain in vivo. In specialized centers, many of these methods are now being employed routinely in the assessment of patients diagnosed with disorders of consciousness, mapping patterns of residual function and dysfunction and helping to reduce diagnostic errors between related conditions such as the vegetative and minimally conscious states. Moreover, such efforts are beginning to provide important new prognostic indicators, helping to disentangle differences in outcome on the basis of a greater understanding of the underlying mechanisms responsible and providing information that will undoubtedly contribute to improved therapeutic choices in these challenging populations. Of course, these emerging technologies and the new information that they provide will bring new ethical challenges to this area and will have profound implications for clinical care and medical-legal decision-making in this population of patients. We review the most recent work in this area and suggest that the future integration of emerging neuroimaging techniques with existing clinical and behavioral methods of assessment will pave the way for new and innovative applications, both in basic neuroscience and in clinical practice. [less ▲]

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See detailA new era of improving progression-free survival with dual blockade in postmenopausal HR, HER2 advanced breast cancer.
Jerusalem, Guy ULg; Bachelot, Thomas; Barrios, Carlos et al

in Cancer treatment reviews (2014)

Disease progression despite existing endocrine therapies remains a major challenge to the effective management of hormone-receptor-positive (HR+), human epidermal growth factor receptor-2-negative (HER2 ... [more ▼]

Disease progression despite existing endocrine therapies remains a major challenge to the effective management of hormone-receptor-positive (HR+), human epidermal growth factor receptor-2-negative (HER2-), advanced breast cancer. Recent advances in elucidating the molecular mechanisms of disease progression have identified the existence of adaptive "cross-talk" between the estrogen receptor (ER) and various growth factor receptor and intracellular signaling pathways, allowing breast cancer cells to escape the inhibitory effects of endocrine therapy. These findings provide the clinical rationale for enhancing or extending endocrine sensitivity by combining endocrine therapy with a targeted agent against a compensatory pathway. In BOLERO-2, adding the mTOR inhibitor everolimus to endocrine therapy significantly improved progression-free survival (PFS) in patients with HR+ advanced breast cancer previously treated with nonsteroidal aromatase inhibitor therapy. Notably, PFS benefits were comparable in subgroup analyses of first- and later-line settings. These results contrast with those of the large first-line HORIZON study, wherein adding the mTOR inhibitor temsirolimus to endocrine therapy did not improve PFS. Therefore, it is unclear whether a targeted agent should only be combined with endocrine therapy to restore endocrine sensitivity or whether it may also prevent or delay resistance in hormone-sensitive advanced breast cancer. Numerous additional targeted agents are currently being evaluated in combination with endocrine therapies, including PI3K, cyclin-dependent kinase 4/6, SRC, and histone deacetylase inhibitors. Appropriate patient selection based on prior treatment history will become increasingly important in maximizing the incremental benefit derived from these new agents combined with existing endocrine therapies in HR+ advanced breast cancer. [less ▲]

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