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See detailPrediction of response and other improvements on the limitations of recombinant human erythropoietin therapy in anemic cancer patients.
Beguin, Yves ULg

in Haematologica (2002), 87(11), 1209-21

BACKGROUND AND OBJECTIVES: The majority of cancer patients suffer from chronic anemia. While recombinant human erythropoietin (rHuEPO) offers many of the advantages of blood transfusions, response rates ... [more ▼]

BACKGROUND AND OBJECTIVES: The majority of cancer patients suffer from chronic anemia. While recombinant human erythropoietin (rHuEPO) offers many of the advantages of blood transfusions, response rates to this treatment are variable and in some trials a large proportion of patients (30 50%) did not respond. This failure may be due to factors related to the underlying disease, the chemotherapy given or functional iron deficiency. An accurate means of predicting response to rHuEPO would be beneficial to both healthcare providers and patients. EVIDENCE AND INFORMATION SOURCES: Data were identified by searches of the published literature, including PubMed, references from relevant reviews, and abstracts presented at recent international oncology and hematology meetings. Only papers in English published between 1990 and 2002 were included. References were selected according to direct relevance to the topic discussed and availability. STATE OF THE ART: The best algorithms for predicting response appear to be those combining an assessment of the adequacy of endogenous erythropoietin production together with some early indicators of erythropoietic marrow response. Further characterization of the dose-response relationship of erythropoietic agents may allow better understanding of ways in which response may be enhanced. Adequate iron availability could also contribute to better response rates. PERSPECTIVES: Further characterization of the predictors of response for current and upcoming erythropoietic agents may enhance the management of anemia associated with cancer, and provide more convenient, effective, and flexible therapy. [less ▲]

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See detailPrediction of response to optimize outcome of treatment with erythropoietin.
Beguin, Yves ULg

in Seminars in Oncology (1998), 25(3 Suppl 7), 27-34

Recombinant human erythropoietin (EPO; epoetin) has been shown to be effective in improving anemia in a proportion of cancer patients. The response rate is approximately 60%, but varies considerably ... [more ▼]

Recombinant human erythropoietin (EPO; epoetin) has been shown to be effective in improving anemia in a proportion of cancer patients. The response rate is approximately 60%, but varies considerably according to baseline hematocrit and transfusion needs, as well as the response criteria used. Response is not greatly influenced by the type of tumor, except in situations of major marrow involvement and limited residual hematopoiesis, or in the presence of specific mechanisms of anemia, such as hemolysis, splenomegaly, bleeding, hemodilution, or ineffective erythropoiesis. Stem cell damage by previous therapy as well as marrow suppression by current intensive chemotherapy can impair response. Besides its intensity, the type of chemotherapy may not be critical, although patients undergoing platinum-based chemotherapy may respond faster than those receiving non-platinum regimens. Complications, such as infections, bleeding, or nutritional deficiencies, may have a major negative impact on outcome. An important response-limiting factor is functional iron deficiency (ie, an imbalance between iron needs in the erythropoietic marrow and iron supply), which depends on the level of iron stores and its rate of mobilization. Functional iron deficiency is best monitored by the percentage of hypochromic red blood cells, and oral or intravenous iron supplements should be given when this percentage increases above 10%. All these factors explain why the response rate to epoetin is only approximately 60%. Therefore, it would be interesting to develop models that could help predict response to epoetin to help select the most appropriate cancer patients for this therapy. Few baseline parameters have been shown to be highly predictive of response in patients with solid tumors, although most studies in patients with myeloma or lymphoma have indicated that patients with a low baseline serum EPO level will respond better. Early changes after 2 to 4 weeks of treatment are also of great interest. Among these early changes, increments of soluble transferrin receptor, reticulocytes, and hemoglobin, as well as the persistence of elevated ferritin or EPO levels, have all shown some predictive value. Combination of baseline serum EPO and the 2-week increment of soluble transferrin receptor or hemoglobin may provide the best prediction of response. [less ▲]

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See detailPrediction of response to recombinant human erythropoietin (rHuEpo) in anemia of malignancy.
Cazzola, M.; Ponchio, L.; Pedrotti, C. et al

in Haematologica (1996), 81(5), 434-41

BACKGROUND: Since only a portion of anemic patients outside the uremia setting benefit from erythropoietin treatment, a reliable means of predicting potential responders and nonresponders would be very ... [more ▼]

BACKGROUND: Since only a portion of anemic patients outside the uremia setting benefit from erythropoietin treatment, a reliable means of predicting potential responders and nonresponders would be very useful. MATERIALS AND METHODS: We retrospectively reviewed the clinical records of 58 patients with refractory anemia associated with various malignant disorders who had been treated with subcutaneous rHuEpo. The starting rHuEpo dose was 375 U/kg/week for 4 weeks, and was increased to 750 U/kg/week for another 4 weeks if no response was observed. Response was defined as a Hb increase > or = 2 g/dL with no need for blood transfusion. We examined the value of various laboratory parameters (baseline levels, 2-week and 4-week changes) as predictors of response. Endogenous erythropoietin production was evaluated by its serum level and erythroid activity was assessed through reticulocyte count and circulating transferrin receptor. RESULTS: Forty-eight individuals were evaluable, 58% of whom responded to rHuEpo within 8 weeks. Multiple regression analysis showed that 53% of the variation in the 8-week Hb concentration was explained by variations in baseline serum erythropoietin and the 2-week change in serum transferrin receptor (p < 0.001). Based on these two parameters, response prediction in individual patients would have resulted in a sensitivity of 96%, a specificity of 79% and an overall accuracy of 88%. In addition, 58% of the variation in the 8-week Hb was explained by variations in the 4-week changes in Hb and reticulocyte count (p < 0.001). Utilizing these latter parameters and baseline serum erythropoietin, response prediction in individual patients would have resulted in a sensitivity of 92%, a specificity of 82% and an overall accuracy of 88%. CONCLUSIONS: This retrospective analysis suggests that response to rHuEpo can be reasonably predicted by pretreatment serum erythropoietin together with early changes in simple laboratory parameters. [less ▲]

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See detailPrediction of response to recombinant human erythropoietin in the anemia of cancer
Beguin, Yves ULg; Vanstraelen, Gaetan

in Nowrousian, M. R. (Ed.) Recombinant human erythropoietin (rhEPO) in clinical oncology (2nd Ed.) (2008)

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See detailPrediction of response to rHuEpo
Beguin, Yves ULg

in Bokemeyer, C.; Ludwig, H. (Eds.) ESO Scientific Upadtes, Vol. 6 Anaemia in cancer (2001)

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See detailPrediction of response to treatment with recombinant human erythropoietin in anaemia associated with cancer.
Beguin, Yves ULg

in Medical Oncology (Northwood, London, England) (1998), 15 Suppl 1

The anaemia associated with cancer can be effectively treated with recombinant human erythropoietin (rHuEpo) in about 60% of the patients. However, the response rate varies according to treatment ... [more ▼]

The anaemia associated with cancer can be effectively treated with recombinant human erythropoietin (rHuEpo) in about 60% of the patients. However, the response rate varies according to treatment modalities as well as the response criteria used. A number of disease- or chemotherapy-related factors determines the probability of response. Several specific mechanisms of anaemia, such as haemolysis, splenomegaly, bleeding, haemodilution, or ineffective erythropoiesis can seriously interfere with response. However, the type of tumor, in particular haematologic versus non-haematologic, is not critical, except in situations of major marrow involvement and limited residual haematopoiesis. Stem cell damage by previous therapy, reflected by low platelet counts or high transfusion needs, will impair response. In addition, marrow suppression by current intensive chemotherapy will also have a negative impact. Besides its intensity, the type of chemotherapy may not be critical, although patients undergoing platinum-based chemotherapy may respond faster than those receiving non-platinum regimens. Complications such as infections, bleeding or nutritional deficiencies may have a major negative impact on outcome. An important response-limiting factor is functional iron deficiency, i.e. an imbalance between iron needs in the erythropoietic marrow and iron supply, which depends on the level of iron stores and its rate of mobilisation. Therefore, oral or preferably intravenous iron supplements should be given when serum ferritin is below 40-100 micrograms/l, reflecting the absence of iron stores, or when the percentage of hypochromic red cells rises above 10%, indicating functional iron deficiency even in the presence of adequate storage iron. Because up to 40% of the patients will not respond to rHuEpo, it is of utmost importance to develop models that could help predict response to rHuEpo and thus select the most appropriate cancer patients for this therapy. Most studies of patients with myeloma or lymphoma have indicated that patients with a low baseline serum Epo level will respond better, but this is not true of patients with solid tumors. Also of considerable interest are early changes of erythropoietic parameters after 2 to 4 weeks of treatment, including increments of serum transferrin receptor (sTfR), reticulocytes and haemoglobin, as well as the persistence of elevated ferritin or Epo levels. Combination of baseline serum Epo and the 2-week increment of sTfR or haemoglobin may provide the best prediction of response. [less ▲]

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See detailPrediction of selectivity for enantiomeric separations of uncharged compounds by capillary electrophoresis involving dual cyclodextrin systems
Abushoffa, Adel M.; Fillet, Marianne ULg; Hubert, Philippe ULg et al

in Journal of Chromatography. A (2002), 948(1-2), 321-9

The single-isomer polyanionic cyclodextrin (CD) derivative heptakis-6-sulfato-beta-cyclodextrin (HSbetaCD) has been tested as chiral additive for the enantioseparation of non-steroidal anti-inflammatory ... [more ▼]

The single-isomer polyanionic cyclodextrin (CD) derivative heptakis-6-sulfato-beta-cyclodextrin (HSbetaCD) has been tested as chiral additive for the enantioseparation of non-steroidal anti-inflammatory drugs, such as fenoprofen, flurbiprofen, ibuprofen and ketoprofen, in capillary electrophoresis, using a pH 2.5 phosphoric acid-triethanolamine buffer in the reversed polarity mode. In most cases, the enantiomers of these acidic compounds, present in uncharged form at that pH, were only poorly resolved with HSbetaCD alone. However, the use of HSbetaCD in combination with the neutral CD derivative, heptakis-(2,3,6-tri-O-methyl)-beta-cyclodextrin (TMbetaCD), which has a particularly high enantioselectivity towards these compounds, has led to complete enantioresolution in reasonably low migration times in most cases. Affinity constants for the enantiomers with the two cyclodextrins were determined, using linear regression in a two-step approach. Affinity constants with the charged HSbetaCD were first calculated in single systems while those with the neutral TMbetaCD were determined in dual systems. Selectivity for the enantiomeric separation of these compounds in dual CD systems could be predicted using recently developed mathematical models. [less ▲]

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See detailPrediction of signal peptide functional properties: a study of the orientation and angle of insertion of yeast invertase mutants and human apolipoprotein B signal peptide variants.
Talmud, P.; Lins, Laurence ULg; Brasseur, Robert ULg

in Protein Engineering (1996), 9(4), 317-21

A number of studies have introduced mutations into the yeast invertase signal peptide, using it as a model system to elucidate features for targeting, translocation and intracellular transport. Using ... [more ▼]

A number of studies have introduced mutations into the yeast invertase signal peptide, using it as a model system to elucidate features for targeting, translocation and intracellular transport. Using molecular modelling of the invertase signal peptide we have analysed the hydrophobicity potential and the change in dielectric constant of the energy transfer, when the molecule moves from a hydrophobic to a hydrophilic phase at the simulated hydrophobic-hydrophilic interface. This modelling has been carried out on wild type and mutant invertase signal peptides of altered function, previously reported in the literature. While the predicted angle of insertion correlates with the measured extent of invertase secretion, with an optimum angle of 45 degrees, mutations that change the angle of orientation reduce the extent of invertase secretion. We have applied these same molecular modelling principles to the naturally occurring variants of the human apolipo-protein B (apoB) signal peptide, that confer a secretion defective phenotype when fused to yeast invertase and expressed in yeast. Our modelling thus identifies a strong correlation between the predicted angle of insertion of the signal peptide into the membrane and its ability to direct secretion. [less ▲]

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See detailPrediction of SOx and NOx Emissions from a Medium Size Biomass Boiler Biomass and Bioenergy
Sartor, Kevin ULg; Restivo, Yannick ULg; Ngendakumana, Philippe ULg et al

in Biomass and Bioenergy (2014), 65

While small and medium size biomass combined heat and power (CHP) plants (i.e., up to 5 MW of electrical rated power) represent an attractive option to exploit locally available biomass resources at low ... [more ▼]

While small and medium size biomass combined heat and power (CHP) plants (i.e., up to 5 MW of electrical rated power) represent an attractive option to exploit locally available biomass resources at low cost, the corresponding investment per unit of rated power significantly rises when the installed power decreases. In these cases, secondary pollutant emissions control measures are most of the time not economically viable and primary emissions control must be used alone to avoid the formation of undesired compounds such as $NO_x$ and $SO_x$. Primary control measures require the careful optimization of fuel quality and combustion process. For plant operators, being able to accommodate biomass quality changes in order to minimize the fuel cost can be of great importance in order to guarantee the profitability of the plant. This contribution is dedicated to the development of a zero-dimensional (input-output) combustion simulation model able to predict the pollutants emissions resulting from complete and incomplete combustion with respect to varying combustion operation (ambient temperature, humidity, fumes recirculation,..). This tool is intended to be integrated in a global simulation model of the CHP plant and the attached district heating network installed on the University campus in Liège. Doing so, the plant operation can be optimized with respect to economic as well as environmental and energetic aspects (3E approach) thus ensuring the sustainability of the approach. [less ▲]

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See detailPrediction of Stiction in Microswitch Systems
Wu, Ling ULg; Rochus, Véronique ULg; Noels, Ludovic ULg et al

in EUROSIME 2010 (2010)

Stiction is a major failure mode of MEMS as microscopic structures tend to adhere to each other when their surfaces enter into contact. Although increasing the restoring forces of switch devices could ... [more ▼]

Stiction is a major failure mode of MEMS as microscopic structures tend to adhere to each other when their surfaces enter into contact. Although increasing the restoring forces of switch devices could overcome the stiction effect, this is not practical, as in turn, it also increases the actuation voltage. Therefore stiction prediction is important to be considered when designing micro- and nano- devices. In this paper, the numerical prediction of stiction for capacitive MEMS switches is considered. Toward this end, a micro-adhesive-contact law is derived from previous work and combined with a finite-element model. [less ▲]

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See detailPrediction of stillbirth by monotoring endocrine and metabolic parameters in dairy cattle
Szenci, 0; Bajcsy, A. C.; Brydl, E. et al

in Reproduction in Domestic Animals (2010), 45(Suppl 3), 109

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See detailPrediction of stillbirth in Holstein-Friesian dairy cows by monotoring endocrine profiles in the periparturient period.
Szenci, O.; Bajcsy, A.Cs; Nagy, K. et al

in Proceedings of the 6th European Congress of Bovine Health and Management (ECBHM) (2011, September 07)

During the last decades, there is a declining trend in conception and calving rates in high yielding Holstein dairy cattle. At the same time, the gradual increase in stillbirth rates, especially in ... [more ▼]

During the last decades, there is a declining trend in conception and calving rates in high yielding Holstein dairy cattle. At the same time, the gradual increase in stillbirth rates, especially in Holstein heifers, has until recently received relatively little attention. Birth weight and gender of the calf, parity, age and breed of the dam, and season of calving are all factors associated with calving difficulties and stillbirths. Other causes of stillbirths not related to calving difficulties are, for example, herd size, infections (e.g. BVD), insufficient placenta development and/or function, metabolic disorders of the cow, and congenital malformations of the calf. The objective of the present study was to investigate the possible effect of hormonal disturbances on the incidence of stillbirth in dairy cows on a Holstein-Friesian dairy farm in Hungary. Dairy cows (n=173) were sampled three times during the periparturient period (at drying-off, 3 weeks prior to expected calving, and within 1 h after calving) in 2006 and two times (3 weeks prior to expected calving, and within 1 h after calving) in 2007. Dairy cows were grouped according to the incidence of stillbirth: Group 1 (control): n=165 and Group 2 (stillbirth): n=8. Hormone and pregnancy protein parameters measured by RIA were as follows: progesterone (P4), estradiol (E2), cortisol, triiodine-thyronin (T3), thyroxin (T4), insulin, insulin-like growth factor (IGF-1) and pregnancy associated glycoprotein (PAG). To determine, which of the hormones and PAG were the best predictors of the presence or absence of stillbirth at a given time (2 months and 3 weeks before calving and within 1 h after calving), a generalised linear model was used with binomial error distribution and logit link function (multivariate logistic regression). All analyses were carried out by R 2.7.2. Statistical Software. The significant level was set at P< 0.05 and an effect was considered a trend when P was between 0.05 and 0.10. The overall prevalence of stillbirth was 4.6 % (4.0% in 2006 and 5.4% in 2007). Interestingly, most calves (7 out of 8) with stillbirth were bulls, but this difference was not significant. Weight of the calves, body score condition of the cows and number of people needed to assist at calving also did not affect the presence or absence of stillbirth significantly, and there was no significant difference among the groups regarding the gestation length or parity either (P>0.100 in all cases). Regarding hormone and pregnancy protein parameters, no significant differences were found during the periparturient period (at 2 months and 3 weeks before expecting calving), however, there was a trend for lower IGF-1 values (P=0.079, OR=0.96) in stillbirth group compared to controls at dry off (2 months before expecting calving). Within one hour after calving significant differences were observed in case of P4 (P<0.001, OR= 3.06), and IGF-1 (P=0.021, OR= 0.94), resulting significantly higher values in P4 and lower values in IGF-1 in stillbirth cows compared to controls. The higher P4 values observed in stillbirth cows also resulted a higher P4/E2 ratio compared to controls (P=0.003, OR= 1.60). Changes in the IGF-1, P4 and P4/E2 ratio may be one of the reasons for stillbirth in Holstein-Friesian dairy cows however more examinations are needed to be confirmed. Other hormones (P4, cortisol, T3, T4, insulin, PAG) did not mirror dependency due to the incidence of stillbirth in dairy cows. [less ▲]

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See detailPrediction of strain for intermittent heat exposures
Mairiaux, Philippe ULg; Libert, J. P.; Candas, V. et al

in Ergonomics (1986), 29(7), 913-23

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See detailPrediction of technological and organoleptic properties of beef Longissimus thoracis from near-infrared reflectance and transmission spectra
Leroy, Bernadette ULg; Lambotte, S.; Dotreppe, Olivier ULg et al

in Meat Science (2003), 66(1), 45-54

Technological and organoleptic properties of beef cuts were predicted by near-infrared (NIR) spectroscopy. Spectra were collected on 189 beef Longissimus thoracis muscle samples using, transmission (NIRT ... [more ▼]

Technological and organoleptic properties of beef cuts were predicted by near-infrared (NIR) spectroscopy. Spectra were collected on 189 beef Longissimus thoracis muscle samples using, transmission (NIRT) and reflectance with a probe. Quality assessment and NIR recordings were performed on sliced loin after 2 and 8 days ageing. Partial least squares regression yielded determination coefficients of cross-validation (R-cv(2)) of 0.12-0.25 for the prediction of Warner-Bratzler Peak Shear Force in reflectance and 0.15-0.41 in transmission. Higher R-cv(2) were obtained for L* parameter (0.83-0.85), a* (0.39-0.49) and b* (0.73-0.75) with reflectance. Predictions of drip loss and cooking loss were less accurate with a R-cv(2) range of 0.38 to 0.54 and 0.25 to 0.47, respectively. The NIR spectra collected on fresh meat show good potential to predict CIE L* and b* parameters in reflectance mode. (C) 2003 Elsevier Ltd. All rights reserved. [less ▲]

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See detailPrediction of technological and organoleptic properties of porcine meat by near infrared spectroscopy
Meulemans, Alexandra; Dotreppe, Olivier ULg; Leroy, Bernadette ULg et al

in Proceedings of the 48th International Congress of Meat Science and Technology (2002)

The aim of the present study was to evaluate the Fourier Transform NIR spectroscopy as a potential technique for prediction of technological (pH and WHC) and organoleptic (color and tenderness) properties ... [more ▼]

The aim of the present study was to evaluate the Fourier Transform NIR spectroscopy as a potential technique for prediction of technological (pH and WHC) and organoleptic (color and tenderness) properties of porcine meat. From this study, it can be concluded that NIR spectroscopy shows good potentiality for prediction of several color and water holding capacity parameters. The quality of the models could be improved by using a larger number of samples or, alternatively, by choosing samples with larger variability, or possibly by performing reference analysis and NIR analysis on the same day. Since the spectra were obtained on minced meat, these results have to be confirmed when applying the technique on intact meat in the laboratory or on the slaughterline. [less ▲]

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See detailPrediction of the acoustics of coupled rooms with the acoustic-diffusion model
Valeau, Vincent; Billon, Alexis ULg; Hodgson, Murray et al

Conference (2006, June)

A general model is proposed to simulate the acoustics of coupled rooms. It is based on a diffusion equation, solved numerically to perform acoustic predictions. The presence of scattering objects –or the ... [more ▼]

A general model is proposed to simulate the acoustics of coupled rooms. It is based on a diffusion equation, solved numerically to perform acoustic predictions. The presence of scattering objects –or the “fittings”– is also taken into account. Distinct sub-volumes can be defined, representing either coupled volumes or zones with different fitting characteristics. Some sample results are presented, and compared with ray-tracing results and experimental data. Two situations are assessed: two coupled classrooms, and a room divided into two zones, one empty, one fitted. The diffusion-model predictions match the other data satisfactorily, both in terms of sound attenuation and sound decay. Diffusion-based results are obtained with the advantage of low computational time compared to ray-tracing results. [less ▲]

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See detailPrediction Of The Antigenic Sites Of The Cystic-Fibrosis Transmembrane Conductance Regulator Protein By Molecular Modeling
Gallet, X.; Benhabiles, N.; Lewin, M. et al

in Protein Engineering (1995), 8(8), 829-34

Antibodies are powerful tools for studying the in situ localization and physiology of proteins. The prediction of epitopes by molecular modelling has been used successfully for the papilloma virus, and ... [more ▼]

Antibodies are powerful tools for studying the in situ localization and physiology of proteins. The prediction of epitopes by molecular modelling has been used successfully for the papilloma virus, and valuable antibodies have been raised [Muller et al. (1990) J. Gen. Virol., 71, 2709-2717]. We have improved the modelling approach to allow us to predict epitopes from the primary sequences of the cystic fibrosis transmembrane conductance regulator. The procedure involves searching for fragments of primary sequences likely to make amphipathic secondary structures, which are hydrophilic enough to be at the surface of the folded protein and thus accessible to antibodies. Amphipathic helices were predicted using the methods of Berzofsky, Eisenberg and Jahnig. Their hydrophobic-hydrophilic interface was calculated and drawn, and used to predict the orientation of the helices at the surface of the native protein. Amino acids involved in turns were selected using the algorithm of Eisenberg. Tertiary structures were calculated using 'FOLDING', a software developed by R. Brasseur for the prediction of small protein structures [Brasseur (1995) J. Mol. Graphics, in press]. We selected sequences that folded as turns with at least five protruding polar residues. One important property of antibodies is selectivity. To optimize the selectivity of the raised antibodies, each sequence was screened for similarity (FASTA) to the protein sequence from several databanks. Ubiquitous sequences were discarded. This approach led to the identification of 13 potential epitopes in the cystic fibrosis transmembrane conductance regulator: seven helices and six loops. [less ▲]

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See detailPrediction of the cross-section capacity of hot-rolled profiles using the direct strength method and the continuous strength method
Li, Yongzhen ULg; Rossi, Barbara ULg

in Chan, S.L.; Shu, G.P. (Eds.) Proceedings of seventh International Conference on Advances in Steel Structures (2012, April)

Material yielding on one hand and local buckling on the other hand limit the cross-section capacity of steel structural members. Current structural design codes use the concept of cross-section ... [more ▼]

Material yielding on one hand and local buckling on the other hand limit the cross-section capacity of steel structural members. Current structural design codes use the concept of cross-section classification to determine the cross-section resistance of hot-rolled profiles. In this system, the Effective Width Method (EWM) is employed to account for local buckling effects for slender, class 4, cross-sections. Alternative design methods for treatment of local buckling in metallic cross-sections have been proposed, including the Direct Strength Method (DSM), developed for cold-formed steel structural profiles, and, recently, the Continuous Strength Method (CSM). The DSM is based on the assumption that the strength can be predicted from the ratio of the yield strength to the elastic critical load in conjunction with a strength curve for the entire cross-section. Thus it is essentially an extension of the use of column curves for global buckling, but with application to local buckling instability. The CSM is a deformation-based design approach which is based on a continuous relationship between cross-sectional slenderness and cross-section deformation capacity and a rational exploitation of strain hardening. This paper is focused on the evaluation of the cross-sectional resistance of hot-rolled structural profiles. Test data from literature experimental programmes have been gathered and analysed to compare the predictions from the DSM and CSM design approaches. [less ▲]

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