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See detailLa limite Paléocène-Eocène dans le Bassin de Douala Biostratigraphie et essai de reconstitution des paléoenvironnements
Mbesse, Cecile Olive ULg

Doctoral thesis (2013)

ABSTRACT This work consists of the analysis of the palynoflora (dinoflagellates and sporomorphs) identified from four petroleum exploration wells drilled through the Nkapa Formation (Douala Basin ... [more ▼]

ABSTRACT This work consists of the analysis of the palynoflora (dinoflagellates and sporomorphs) identified from four petroleum exploration wells drilled through the Nkapa Formation (Douala Basin, Cameroon). The vertical distribution of index taxa in the Moulongo, Ngata, Mamiwater and North Matanda wells allowed establishing a biostratigraphic frame of the first half of the Paleogene of the Douala Basin and identifying the Paleocene/Eocene boundary in each well through a comparison with surrounding sedimentary basins. Seventy dinoflagellate species have been identified, among which 30 are stratigraphically informative. Four biozones have been established, three for the Paleocene and one for the Early Eocene. The biozone 1 is characterized by Cretaceous species such as Cerodinium diebelii, Lejeunecysta hyalina, Andalusiella gabonensis, Palaeocystodinium australinum and Palaeocystodinium golzowense. The biozone 2 is defined by the acme of Areoligera coronata, Adnatosphaeridium multispinosum and Glaphyrocysta ordinata. The biozone 3 is defined by the acme of several Apectodinium species (A. hyperacanthum, A. homomorphum, A. paniculatum, A. parvum, A. quinquelatum). The biozone 4 is defined by the occurrence of Eocene taxa such as Deflandrea cf. oebisfeldensis, Hystrichosphaeridium tubiferum and Wetzeliella sp. Based on the position of the Paleocene/Eocene boundary in the Moulongo well, correlations have been established with the others sedimentary sequences analysed. Our study shows that, as previously demonstrated for Nigeria in an other study, the acme of Apectodinium in the Douala Basin can be attributed a Late Paleocene age and hence occurred before the carbon isotope excursion (CIE) of the Paleocene-Eocene boundary and the coeval Paleocene-Eocene thermal maximum (PETM). The acme of Apectodinium in the Douala Basin is thus markedly diachronous with the Apectodinium acme identified in various Nordic Basins, where it is contemporaneous with the PETM (earliest Eocene). Ninety-four sporomorph species have been recognized, among which fifty are stratigraphically informative. Three biozones have been established. The biozone 1 is predominantly characterized by Palmae- and Proteaceae-type pollens, the latter with Cretaceous characteristics. The biozone 2, Late Paleocene in age, is characterized by a transition from original floras towards more « modern » floras. The biozone 3 is earliest Eocene in age and shows the early steps of the extant « Leguminosae flora » of West Africa. Together with the biostratigraphic analysis, a palaeoenvironmental reconstruction is proposed, based on dinoflagellate ecology, on the evolution of the dinoflagellate /sporomorph ratio, as well as on the reconstruction of the plant environments in the studied sedimentary sequences. The evolution of the Douala Basin during the timespan studied occurred according to two geographical axes: a WE (Moulongo-Ngata) axis and a SSW-NNE (Moulongo-Mamiwater-North Matanda) axis. During the Early and Middle Paleocene, the Douala Basin was open towards the sea and showed a coastal-estuarine environment, with marginal mangroves and lowland swamp forests. During the Late Paleocene, the marine character of the sedimentation was less prominent as brackish fluvio-lagoonal intertidal environments developped. They were accompanied by gallery forests and surrounded by dense, periodically flooded, forests northwards and by forests on wet soils eastwards. During the earliest Eocene, a marine regression occurred. The palaeoenvironments included confined coastal lagoon systems with a peripheral impoverished local flora northwards, and moist, dense, evergreen forests eastwards. [less ▲]

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See detailLa limite Paléocène-Eocène dans le Bassin de Douala Biostratigraphie et essai de reconstitution des paléoenvironnements
Mbesse, Cécile ULg

Doctoral thesis (2013)

RESUME Ce travail présente une analyse du phytoplancton et des sporomorphes recensés dans divers puits de prospection pétrolière ayant traversé la Formation de Nkapa dans le Bassin de Douala au Cameroun ... [more ▼]

RESUME Ce travail présente une analyse du phytoplancton et des sporomorphes recensés dans divers puits de prospection pétrolière ayant traversé la Formation de Nkapa dans le Bassin de Douala au Cameroun. La distribution verticale de taxons marqueurs dans les sondages de Moulongo, Ngata, Mamiwater et Nord Matanda a permis d’établir une biostratigraphie du Tertiaire inférieur du Bassin et d’y préciser la position de la limite Paléocène-Eocène sur base d’une comparaison avec les bassins sédimentaires avoisinants. En considérant trente espèces de dinoflagellés à caractère stratigraphique sur les quelque septante inventoriées, quatre biozones ont pu être établies, trois pour le Paléocène, une pour l’Eocène basal. La biozone 1 se caractérise par des espèces héritées du Crétacé, Cerodinium diebelii, Lejeunecysta hyalina, Andalusiella gabonensis, Palaeocystodinium australinum et Palaeocystodinium golzowense; les biozones 2 et 3 par les acmés de certaines espèces, pour la 2, de Areoligera coronata, Adnatosphaeridium multispinosum et Glaphyrocysta ordinata, pour la 3, de diverses espèces du genre Apectodinium (A. hyperacanthum, A. homomorphum, A. paniculatum, A. parvum, A. quinquelatum). La biozone 4 voit apparaître des espèces caractéristiques de l’Eocène: Deflandrea cf. oebisfeldensis, Hystrichosphaeridium tubiferum et Wetzeliella sp. En tenant compte de la limite Paléocène/Eocène établie par les stratigraphes pétroliers à Moulongo, les corrélations ont été précisées avec les autres séquences analysées. L’étude a mis en évidence l’existence d’un diachronisme entre deux acmés d’Apectodinium, celui pré-CIE (Carbon Isotope Excursion) observé au Paléocène supérieur dans le Bassin de Douala comme dans celui du Nigeria voisin et celui contemporain du PETM (Paleocene-Eocene Thermal Maximum) dans l’Eocène basal de divers bassins nordiques passés en revue dans le travail. Sur les nonante-quatre espèces de sporomorphes identifiées, une cinquantaine de taxons a été retenue dans un objectif biostratigraphique. Trois biozones à caractère évolutif se sont dégagées: une biozone inférieure à caractère paléocène soulignée par une dominance de formes de types « Palmae » et « Proteaceae », ces dernières d’aspect archaïque crétacé; une biozone intermédiaire du Paléocène supérieur avec évolution de la flore originelle vers un ensemble qui peut être qualifié de plus « moderne » et enfin, à l’Eocène basal, de l’installation d’associations annonçant les prémices de la mise en place de la flore actuelle à « Légumineuses » d’Afrique de l’Ouest. En parallèle de l’analyse biostratigraphique est proposée une reconstitution paléoenvironnementale basée sur l’écologie des dinoflagellés, sur l’évolution du ratio dinoflagellés/pollen et spores et sur la reconstitution des milieux végétaux dans les différentes séquences étudiées. L’évolution du Bassin selon deux axes géographiques a été mise en évidence: un axe WE (Moulongo-Ngata) et un axe SSW-NNE (Moulongo-Mamiwater-Nord Matanda). Au Paléocène inférieur et moyen, le Bassin, largement ouvert sur la mer, présente un milieu côtier-estuarien frangé de mangroves et de forêts de basse plaine marécageuse. Au Paléocène supérieur, l’influence marine se faisant moins importante, des milieux saumâtres fluvio-lagunaires soumis aux marées se développent, ils sont bordés de galeries forestières et entourés de forêts denses périodiquement inondées vers le Nord et de forêts sur sols humides vers l’Est. Avec la régression marine amorcée à la base de l’Eocène, les paléoenvironnements s’individualisent: vers le Nord s’installent des milieux lagunaires confinés entourés d’une flore locale appauvrie et vers l’Est, autour de milieux d’eau douce d’arrière-delta, une forêt dense sempervirente humide de terre ferme occupe le terrain. [less ▲]

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See detailLimited clinical utility of a self-evaluating risk assessment scale for postmenopausal osteoporosis: lack of predictive value of lifestyle-related factors
Goemaere, S; Zegels, Brigitte ULg; Toye, K et al

in Calcified Tissue International (1999), 65(5), 354-358

The aim of this study was to assess the efficiency of a self-administered questionnaire to identify subjects with postmenopausal osteoporosis in the setting of first line medical care. A sample of 300 ... [more ▼]

The aim of this study was to assess the efficiency of a self-administered questionnaire to identify subjects with postmenopausal osteoporosis in the setting of first line medical care. A sample of 300 postmenopausal women completed the questionnaire based on 18 items. Bone mineral density at the lumbar spine (BMD-L), total hip (BMD-H), and femoral neck (BMD-N) was used as objective criterion for evaluation. The mean risk score was 8.2 +/- 3.21. BMD was correlated with total risk score: r = -0.32 for BMD-L, -0.36 for BMD-N, and -0.43 for BMD-H. Cutoff points for the risk score (equal likelihood points) according to a T-score threshold of -2.5 were 8.6 for BMD-L and BMD-N and 9.3 for BMD-H; specificity and sensitivity was 62% and 62%, respectively, for BMD-L, 65% and 62% for BMD-N, and 75% and 63% for BMD-H. Stepwise multiple regression analysis of the questionnaire items in relation to BMD showed higher correlation coefficients for models including individual items rather than the overall risk score. Items concerning low weight, older age, and wrist fracture after 50 years of age were always selected as significant determinants of BMD (R = 0.43-0.55). Hormonal replacement therapy was also an important determinant. Lifestyle-related items did not contribute significantly. In conclusion, the diagnostic performance of the 18-item self-administered questionnaire was poorer than a shortened questionnaire omitting lifestyle factors. The clinical utility of a questionnaire should ultimately be evaluated in the specific optic of a chosen global strategy for prevention of osteoporotic fractures. [less ▲]

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See detailLimited effects of placental and pituitary growth hormone on cytokine expression in vitro
Thellin, Olivier ULg; Coumans, Bernard ULg; Devos, Sébastien ULg et al

in European Cytokine Network (2000), 11(3), 452-455

The hypothesis that growth hormone (GH) can affect immune responses in man has been evaluated by monitoring cytokine expression in cultures from peripheral blood mononuclear cells, by enzyme-linked ... [more ▼]

The hypothesis that growth hormone (GH) can affect immune responses in man has been evaluated by monitoring cytokine expression in cultures from peripheral blood mononuclear cells, by enzyme-linked immunosorbent assay (ELISA) and ribonuclease protection assay, and in tonsillar cells by ELISA. In addition to pituitary GH (GH-N), the placental form (GH-V), differing from pituitary GH by 13 amino acids has also been tested. Only few effects reached statistical significance and were in no case greater than 15%. Pituitary GH slightly reduced IL-5 production and stimulated IFN-gamma production. The latter effect was also observed with prolactin and could thus be induced through the prolactin receptor. It is proposed that GH has no strong effects on the parameters investigated, possibly as a result of redundancy in the cytokine network. Alternatively, effects on leukocytes are mediated by other tissues such as the liver or are clear only in response to stronger challenges. [less ▲]

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See detailLimited evidence for trans-generational effects of maternal dietary supplementation with ?-3 fatty acids on immunity in broiler chickens
Koppenol, A.; Delezie, E.; Parmentier, H. K. et al

in Veterinary Journal (2015), 203(2), 244-249

The aim of the present study was to investigate whether the immune response of broiler chickens is modulated by including different omega-3 (?-3) polyunsaturated fatty acids (PUFAs) in the maternal diet ... [more ▼]

The aim of the present study was to investigate whether the immune response of broiler chickens is modulated by including different omega-3 (?-3) polyunsaturated fatty acids (PUFAs) in the maternal diet. Broiler breeder hens (n = 120 birds per group) were fed one of four diets, differing in the ratios of n-6:n-3 PUFAs and eicosapentaenoic acid (EPA):docosahexaenoic acid (DHA). At 28 weeks of age, the eggs produced were incubated to obtain 720 chicks (n = 180 per group). All broiler chicks were fed a control diet and were vaccinated against Newcastle disease virus (NDV). Blood samples were taken at different time points after immunisation with human serum albumin (HuSA) in Freund's adjuvant to determine the acute phase response, antibody response and cytokine production. Addition of EPA to the maternal diet was associated with greater ovotransferrin concentrations post-immunisation, compared to other groups. Altering the ratios of n-6:n-3 PUFA or EPA:DHA in the maternal diet did not affect the offspring in terms of production of caeruloplasmin, ?1-acid glycoprotein, interleukin (IL)-1?, IL-6, IL-12 or tumour necrosis factor (TNF)-?. Dietary manipulation of the maternal diet did not influence the specific antibody response to HuSA or NDV, nor did it alter the levels of natural antibody binding to keyhole limpet haemocyanin in the offspring. Thus, maternal supplementation with n-3 PUFAs played a minor role in perinatal programming of the immune response of broiler chickens. � 2014 Elsevier Ltd. [less ▲]

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See detailLimited HIV-1 Reactivation in Resting CD4+ T cells from Aviremic Patients under Protease Inhibitors.
Kumar, Amit; Abbas, Wasim; Bouchat, Sophie et al

in Scientific Reports (2016), 6

A latent viral reservoir that resides in resting CD4+ T cells represents a major barrier for eradication of HIV infection. We test here the impact of HIV protease inhibitor (PI) based combination anti ... [more ▼]

A latent viral reservoir that resides in resting CD4+ T cells represents a major barrier for eradication of HIV infection. We test here the impact of HIV protease inhibitor (PI) based combination anti-retroviral therapy (cART) over nonnucleoside reverse transcriptase inhibitor (NNRTI)-based cART on HIV-1 reactivation and integration in resting CD4+ T cells. This is a prospective cohort study of patients with chronic HIV-1 infection treated with conventional cART with an undetectable viremia. We performed a seven-year study of 47 patients with chronic HIV-infection treated with cART regimens and with undetectable plasma HIV-1 RNA levels for at least 1 year. Of these 47 patients treated with cART, 24 were treated with a PI-based regimen and 23 with a NNRTI-based regimen as their most recent treatment for more than one year. We evaluated the HIV-1 reservoir using reactivation assay and integrated HIV-1 DNA, respectively, in resting CD4+ T cells. Resting CD4+ T cells isolated from PI-treated patients compared to NNRTI-treated patients showed a limited HIV-1 reactivation upon T-cell stimulation (p = 0.024) and a lower level of HIV-1 integration (p = 0.024). Our study indicates that PI-based cART could be more efficient than NNRTI-based cART for limiting HIV-1 reactivation in aviremic chronically infected patients. [less ▲]

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See detailLimited impact of abiotic stress on surfactin production in planta and on disease resistance induced by Bacillus amyloliquefaciens S499 in tomato and bean
Pertot, I.; Puopolo, G.; Hosni, T. et al

in FEMS Microbiology Ecology (2013), 86(3), 505-519

Understanding how temperature and water stress affect protocooperation between plants and beneficial rhizobacteria may enhance the efficacy of biocontrol agents in reducing plant diseases. However, little ... [more ▼]

Understanding how temperature and water stress affect protocooperation between plants and beneficial rhizobacteria may enhance the efficacy of biocontrol agents in reducing plant diseases. However, little is known about the impact of these factors on biocontrol mechanisms and effectiveness, especially when provided by beneficial Bacillus spp. This work aimed to evaluate the influence of low/high temperature combined with a normal and reduced water regime on the interaction between Bacillus amyloliquefaciens strain S499 and plants, resulting in the induction of systemic resistance (ISR). A reduction in ISR level was observed when plants were subjected to stress before bacterization; however, root treatment with S499 prior to stress exposure attenuated this negative effect. Colonization of S499 during exposure to temperature/water stress allowed the three crops to conserve their overall ability to mount defense lines to a similar degree at all the temperatures tested. Further investigation revealed that relative production of surfactin by S499 was clearly enhanced at low temperature, making it possible to counter-balance the negative effect on traits associated with rhizosphere fitness (colonization, motility, and biofilm formation) observed in vitro in cold conditions. This work thus represents a first step in deciphering the effect of high/low temperatures and/or drought on key plant-microorganism interactions culminating in ISR. © 2013 Federation of European Microbiological Societies. [less ▲]

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See detailLimited Impact of Imatinib in a Murine Model of Sclerodermatous Chronic Graft-versus-Host Disease
Belle, Ludovic ULg; Fransolet, Gilles ULg; Somja, Joan ULg et al

in PLoS ONE (2016), 11

Background Sclerodermatous chronic Graft-versus-Host Disease (scl-cGVHD) is one of the most severe form of cGVHD. The Platelet-derived Grotwth Factor (PDGF) and the Transforming Growth Factor-β (TGF-β ... [more ▼]

Background Sclerodermatous chronic Graft-versus-Host Disease (scl-cGVHD) is one of the most severe form of cGVHD. The Platelet-derived Grotwth Factor (PDGF) and the Transforming Growth Factor-β (TGF-β) play a significant role in the fibrosing process occurring in scl-cGVHD. This prompted us to assess the impact of the PDGF-r and c-Abl tyrosine kinase inhibitor imatinib on scl-cGVHD. Methods To assess the impact of imatinib on T cell subset proliferation in vivo, Balb/cJ recipient mice were lethally (7 Gy) irradiated and then injected with 10x106 bone marrow cells from B10.D2 mice on day 0. Fourteen days later, 70x106 carboxyfluorescein succinimidyl ester (CFSE)-labeled splenocytes from B10.D2 mice were infused and imatinib or sterile water was administered for 5 days. To induce severe scl-cGVHD, Balb/cJ mice were injected i.v. with 10.106 bone marrow cells and 70.106 splenocytes from B10.D2 donor mice after 7 Gy irradiation. Mice were then given sterile water or imatinib from day +7 after transplantation to the end of the experiment (day +52). Results Imatinib decreased the proliferation of total T cells (P = 0.02), CD8+ T cells (P = 0.01), and of regulatory T cells (Tregs) (P = 0.02) in the spleen. In the severe scl-cGVHD model, imatinib-treated mice had significantly lower levels of PDGF-r phosphorylation than control mice on day 29 after transplantation (P = 0.008). However, scl-cGVHD scores were similar between vehicle- and imatinib-treated mice during the whole experiment, while there was a suggestion for less weight loss in imatinib-treated mice that reached statistical significance at day +52 following transplantation (P = 0.02). [less ▲]

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See detailLimited impact of imatinib in a murine model of sclerodermatous chronic graft-versus-host disease (scl-cGVHD)
Fransolet, Gilles ULg; Belle, Ludovic; SOMJA, Joan ULg et al

Conference (2016, December 08)

- Introduction: Graft-versus-host disease (GVHD) remains one of the major complications following haematopoietic stem cell transplantation (HSCT). Approximately 15% of the patients with chronic GVHD ... [more ▼]

- Introduction: Graft-versus-host disease (GVHD) remains one of the major complications following haematopoietic stem cell transplantation (HSCT). Approximately 15% of the patients with chronic GVHD develop the sclerodermatous form of the disease characterized by multiple organ fibrosis and loss of skin elasticity. Several studies have shown the potential benefits of imatinib, a tyrosine kinase inhibitor (TKI), as a treatment of fibrosis in cGVHD due to its ability to inhibit simultaneously PDGF-R and c-Abl pathways which are both involved in fibrosis mechanisms. - Aims: Some early-phase clinical studies have assessed the impact of TKIs in patients with steroid-refractory cGVHD. Unfortunately, these studies yielded to conflicting results underlying the importance of re-assessing the impact of imatinib in scl-cGVHD pre-clinical models. This work investigates the possible benefits of imatinib on fibrosis in a murine model of sclerodermatous chronic GVHD (scl-cGVHD). - Methods and results: Lethally irradiated Balb/cJ mice (7 Gy TBI) were injected i.v. with 1.106 or 10.106 bone marrow cells and 2.106 or 70.106 splenocytes from B10.D2 donnor mice (Moderate and Classical scl-cGVHD models respectively). Mice were then treated with sterile water or imatinib (150 mg/kg/day) by oral gavage from day +7 to day +52 following transplantation. cGVHD severity was assessed three times/week with a scoring system encompassing 5 criteria (mice posture, weight loss, activity, hair loss, skin integrity ; 0-1-2 point(s)/criteria). Skin biopsies were performed on day +29 following transplantation to assess phosphorylation of c-Abl (TGF-β pathway) and PDGF receptor. Our results show that imatinib failed to prevent/improve GVHD with a similar evolution of the GVHD severity with no differences between groups (neither in moderate cGVHD model, nor in the classical cGVHD model). Mice weight loss during the experiments was also comparable between groups in both models of cGVHD. In the classical model, histological analyses indicate a significant reduction of the phosphorylation level of the PDGR receptor (p = 0.0079). In vivo cell proliferation assay with CFSE were also performed and showed a reduced proliferation of T cells and subsets (CD4, CD8 and Tregs) in spleen, lymph nodes, bone marrow and blood after imatinib treatment. Finally, FACS analyses performed on days +21 and +35 after transplantation did not show any differences in the absolute T-cell counts. - Conclusions: Although we have observed a decreased phosphorylation level of PDGR receptor and less proliferation of T cells and subsets in vivo, imatinib failed to alleviate scl-cGVHD both in moderate and classical murine models of scl-cGVHD. [less ▲]

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See detailLimited impact of imatinib in a murine model of sclerodermic chronic graft-versus-host disease
Belle, Ludovic; Fransolet, Gilles ULg; SOMJA, Joan ULg et al

Poster (2016, November 17)

Background: Graft-versus-host disease (GVHD) remains one of the major complications following haematopoietic stem cell transplantation (HSCT). Approximately 15% of the patients with chronic GVHD develop ... [more ▼]

Background: Graft-versus-host disease (GVHD) remains one of the major complications following haematopoietic stem cell transplantation (HSCT). Approximately 15% of the patients with chronic GVHD develop the sclerodermatous form of the disease characterized by multiple organ fibrosis and loss of skin elasticity. Several studies have shown the potential benefits of imatinib, a tyrosine kinase inhibitor, as a treatment of fibrosis in cGVHD due to its ability to inhibit simultaneously PDGF-R and c-Abl pathways which are both involved in fibrosis mechanisms. This work investigates the possible benefits of imatinib on fibrosis in a murine model of sclerodermatous chronic GVHD (sclcGVHD). Methods: Lethally irradiated Balb/cJ mice (7 Gy TBI) were injected i.v. with 10.106 bone marrow cells and 70.106 splenocytes from B10.D2 donnor mice. Mice were then treated with sterile water or imatinib (150 mg/kg/day) by oral gavage from day +7 to day +52 following transplantation. GVHD severity was assessed three times/week with a scoring system encompassing 5 criteria (mice posture, weight loss, activity, hair loss, skin integrity ; 0-1-2 point(s)/criteria). Results: Our results show that imatinib failed to prevent/improve GVHD with a similar evolution of the GVHD severity with no differences between groups. Histological analyses indicate a significant reduction of the phosphorylation level of the PDGR receptor (p = 0,033) and a trend to a decreased level of phosphorylated c-Abl (p = 0,1854). In vivo cell proliferation assay with CFSE were also performed and showed a reduced proliferation of T cells and subsets (CD4, CD8 and Tregs) in spleen, lymph nodes, bone marrow and blood after imatinib treatment. Finally, FACS analyses performed on days +21 and +35 after transplantation did not show any differences in the absolute T-cell counts. Conclusion: Although we have observed a decreased phosphorylation level of PDGR receptor and less proliferation of T cells and subsets in vivo, imatinib failed to alleviate scl-cGVHD in a murine model of severe scl-cGVHD. [less ▲]

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See detailLimited usefulness of CA125 measurement in the management of Hodgkin's and non-Hodgkin's lymphoma.
Bonnet, Christophe ULg; Beguin, Yves ULg; Fassotte, Marie-France ULg et al

in European Journal of Haematology (2007), 78(5), 399-404

BACKGROUND: Several papers have reported an association of high CA125 serum levels with advanced non-Hodgkin's lymphoma (NHL) as well as a relationship between high CA125 values and poor outcome. PATIENTS ... [more ▼]

BACKGROUND: Several papers have reported an association of high CA125 serum levels with advanced non-Hodgkin's lymphoma (NHL) as well as a relationship between high CA125 values and poor outcome. PATIENTS AND METHODS: Ninety-nine patients with NHL or Hodgkin's disease (HD) underwent serum CA125 assessment at diagnosis. Gender, age, presence of B symptoms, performance status (PS), histology, sites of tumor involvement, presence of effusion, clinical stage, age-adjusted International Prognostic Index, C-reactive protein (CRP), Hb, lactate deshydrogenase (LDH) and beta2-microglobulin were evaluated for their association with serum CA125 levels. The impact of CA125 levels and other features on overall (OS) and progression-free (PFS) survival was also assessed. RESULTS: CA125 serum levels were elevated in 34% of the patients, including 19% of patients with aggressive NHL, 45% of patients with indolent NHL, and 29% of patients with HD. Univariate analyses showed that CA125 levels correlated with poor PS, the presence of B symptoms, advanced clinical stage, abdominal, bone marrow or mediastinal involvement, presence of effusions, high aaIPI, low Hb levels and high CRP, LDH or beta2-microglobulin levels. In multivariate analysis, bone marrow involvement, the presence of effusions, and high aaIPI were all associated with high CA125 serum levels. In univariate analyses, OS and PFS were affected by age (PFS only), poor PS, B symptoms, advanced clinical stage, bone marrow or abdominal involvement (PFS only), high aaIPI, low Hb, high CRP or beta2-microglobulin levels. OS and PFS were not different in patients with normal or elevated CA125 levels. Multivariate analyses showed significantly inferior OS and PFS in patients with high beta2-microglobulin but no influence of CA125. CONCLUSION: While CA125 serum level correlates significantly with a number of features associated with more aggressive disease, it does not enhance the performance of standard prognostic markers in the management of patients with NHL or HD. [less ▲]

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See detailLes limites d'une politique de consultation des migrants et des minorités ethniques d'origine immigrée
Martiniello, Marco ULg

in La participation politique et sociale des immigrés à travers des mécanismes de consultation (1999)

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See detailLimites de courbes:théorie et applications en analyse
Bair, Jacques ULg; Henry, Valérie ULg; Antibi, André

in Mathématique et Pédagogie (2004), 147

Nous présentons la notion de limite de courbes planes et l'appliquons à l'emploi de microscopes ou de télescopes virtuels. Nous étudions des liens entre cette notion de limite de courbes et celle de ... [more ▼]

Nous présentons la notion de limite de courbes planes et l'appliquons à l'emploi de microscopes ou de télescopes virtuels. Nous étudions des liens entre cette notion de limite de courbes et celle de convergence uniforme de fonctions. [less ▲]

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See detailLes limites de l’administration de la PCL - R à une population de sujets schizophrènes dans le contexte médico-légal
Englebert, Jérôme ULg; Matteucci, Marie; De Page, Louis et al

Poster (2017, May 31)

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See detailLimites de l'approche de la dominance dans un modèle input-output
Lejeune, Bernard ULg

in Economie Appliquée (1992), XLV(2), 105-128

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See detailLes limites de la lecture externaliste du meinen wittgensteinien. Une “intentionnalité” grammaticale”
Gauvry, Charlotte ULg

in Bulletin d'Analyse Phénoménologique (2010), VI(8),

En partant des analyses grammaticales de Ludwig Wittgenstein, essentiellement des Recherches philosophiques, l’article interroge la pertinence du modèle intentionaliste mobilisé en philosophie de l’esprit ... [more ▼]

En partant des analyses grammaticales de Ludwig Wittgenstein, essentiellement des Recherches philosophiques, l’article interroge la pertinence du modèle intentionaliste mobilisé en philosophie de l’esprit, tant dans sa version « internaliste » qu’« externaliste ». Il récuse aussi bien l’acception internaliste qui conçoit l’intentionnalité comme la structure d’un vécu psychique que l’acception externaliste qui considère que l’intention est l’action elle-même et qu’elle se détermine, non pas par un vécu psychique, mais par le récit élargi du contexte dans lequel elle s’inscrit. En amont de cette distinction, l’article adopte une conception grammaticale du meinen (vouloir-dire) et souligne son statut exclusivement conceptuel. [less ▲]

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See detailLes limites de la liberté
Jamin, Jérôme ULg

Article for general public (2005)

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