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See detailMass spectrometry and ion mobility spectrometry of G-quadruplexes. A study of solvent effects on dimer formation and structural transitions in the telomeric DNA sequence d(TAGGGTTAGGGT).
Ferreira, Ruben; Marchand, Adrien; Gabelica, Valérie ULg

in Methods (2012), 57(1), 56-63

We survey here state of the art mass spectrometry methodologies for investigating G-quadruplexes, and will illustrate them with a new study on a simple model system: the dimeric G-quadruplex of the 12-mer ... [more ▼]

We survey here state of the art mass spectrometry methodologies for investigating G-quadruplexes, and will illustrate them with a new study on a simple model system: the dimeric G-quadruplex of the 12-mer telomeric DNA sequence d(TAGGGTTAGGGT), which can adopt either a parallel or an antiparallel structure. We will discuss the solution conditions compatible with electrospray ionisation, the quantification of complexes using ESI-MS, the interpretation of ammonium ion preservation in the complexes in the gas phase, and the use of ion mobility spectrometry to resolve ambiguities regarding the strand stoichiometry, or separate and characterise different structural isomers. We also describe that adding electrospray-compatible organic co-solvents (methanol, ethanol, isopropanol or acetonitrile) to aqueous ammonium acetate increases the stability and rate of formation of dimeric G-quadruplexes, and causes structural transitions to parallel structures. Structural changes were probed by circular dichroism and ion mobility spectrometry, and the excellent correlation between the two techniques validates the use of ion mobility to investigate G-quadruplex folding. We also demonstrate that parallel G-quadruplex structures are easier to preserve in the gas phase than antiparallel structures. [less ▲]

Detailed reference viewed: 54 (5 ULg)
See detailMass spectrometry applied to biomolecules analysis
Far, Johann ULg; Mazzucchelli, Gabriel ULg; Meuwis, Marie-Alice ULg et al

Conference (2011, March 31)

Detailed reference viewed: 38 (7 ULg)
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See detailMass spectrometry as a tool to search specific ligands for G protein coupled receptors.
Cologna, Camila Takeno; Echterbille, Julien ULg; De Pauw, Edwin ULg et al

Conference (2012)

Detailed reference viewed: 25 (6 ULg)
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See detailMass spectrometry as an evolutive tool for toxinology: from sequencing to toxin shapes
Quinton, Loïc ULg; Gilles, Nicolas; Echterbille, Julien ULg et al

Conference (2011, September 12)

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See detailMass spectrometry imaging is moving toward drug protein co-localization
Ait-Belkacem, Rima; Sellami, Lyna; Villard, Claude et al

in Trends in Biotechnology (2012), 30(9), 466-474

Mass spectrometry (MS)-based technology provides label-free localization of molecules in tissue samples. Drugs, proteins, lipids and metabolites can easily be monitored in their environment. Resolution ... [more ▼]

Mass spectrometry (MS)-based technology provides label-free localization of molecules in tissue samples. Drugs, proteins, lipids and metabolites can easily be monitored in their environment. Resolution can be achieved down to the cellular level (10–20 mm) for conventional matrix-assisted laser desorption/ionization (MALDI) imaging, or even to the subcellular level for more complex technologies such as secondary ionization mass spectrometry (SIMS) imaging. One question remains: are we going to be able to investigate functional relationships between drugs and proteins and compare with localized phenomena? This review describes the various spatial levels of investigation offered by mass spectrometry imaging (MSI), and the advantages and disadvantages compared with other labeling technologies. [less ▲]

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See detailMass spectrometry imaging of rat brain sections: nanomolar sensitivity with MALDI versus nanometer resolution by TOF–SIMS
Benabdellah, Farida; Seyer, Alexandre; Quinton, Loïc ULg et al

in Analytical and Bioanalytical Chemistry (2010), 396(1), 151-162

Mass spectrometry imaging is becoming a more and more widely used method for chemical mapping of organic and inorganic compounds from various surfaces, especially tissue sections. Two main different ... [more ▼]

Mass spectrometry imaging is becoming a more and more widely used method for chemical mapping of organic and inorganic compounds from various surfaces, especially tissue sections. Two main different techniques are now available: matrix-assisted laser desorption/ionizaton, where the sample, preliminary coated by an organic matrix, is analyzed by a UV laser beam; and secondary ion mass spectrometry, for which the target is directly submitted to a focused ion beam. Both techniques revealed excellent performances for lipid mapping of tissue surfaces. This article will discuss similarities, differences, and specificities of ion images generated by these two techniques in terms of sample preparation, sensitivity, ultimate spatial resolution, and structural analysis. [less ▲]

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See detailMass Spectrometry lab activities in Liege - Small molecules
Focant, Jean-François ULg

Scientific conference (2012, March)

Detailed reference viewed: 21 (5 ULg)
See detailMass spectrometry of G-quadruplexes
Gabelica, Valérie ULg

Conference (2010, May 31)

Detailed reference viewed: 74 (3 ULg)
See detailMass Spectrometry Studies of G-quadruplex Nucleic Acid Self-Assembly
Gabelica, Valérie ULg

Conference (2010, November 12)

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Detailed reference viewed: 12 (1 ULg)
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See detailMass Surveillance Technology: Trading Trojan Horses
Caponetti, Lia ULg

in Strategic Trade Review (2016), (Spring 2016), 53-71

This paper challenges the effectiveness and necessity of “mass surveillance technology”(MST) on two dimensions: (a) states’ internal use of MST and the subsequent issue of violation of fundamental ... [more ▼]

This paper challenges the effectiveness and necessity of “mass surveillance technology”(MST) on two dimensions: (a) states’ internal use of MST and the subsequent issue of violation of fundamental freedoms, and (b) surveillance technology export control, especially to third countries likely to use such technology to violate human rights. Following the Snowden Datagate scandal, many States undertook inquiries and adopted measures that, in some cases, were meant to regulate the use of mass surveillance technology. The paper will: a) assess and evaluate current regulations on mass surveillance technology and its place in democratic societies, including what is at stake in terms of technology, threats, reactions to threats, and geographic extension, b) the risks linked to the use of MST on the national level by questioning the validity of counter-terrorism measures as a justification for MST use c) analyze international trade control regimes and legislation to highlighting their inadequacy in the face of the threats posed by MST, and d) map the evolution of the EU dual-use trade control system towards a human security approach with regard to human rights protection, in order to assess the capability of the system to avoid the misuse of MST. [less ▲]

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See detailMass Transfer Across an Interface Induces Formation of Droplets in Lattice Systems
Pfennig, Andreas ULg

in Chemical Engineering Science (2000), 55(22), 5333-5339

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See detailMass transfer and micro drops at interfaces investigated on molecular level
Merzliak, T; Schmäh, M; Schott, R et al

Conference (2002)

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See detailMass transfer by free and forced convection from single spherical liquid drops
Waheed, M Adekojo; Henschke, Martin; Pfennig, Andreas ULg

in International Journal of Heat & Mass Transfer (2002), 45(22), 4507-4514

Detailed reference viewed: 12 (0 ULg)
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See detailMASS TRANSFER DURING THE DRYING OF BUILDING MATERIALS
Kahlerras, Loubna ULg

Poster (2015, October 27)

The study of the durability of cementitious materials like mortar which are the object of massive use in building and engineering works implies a perfect understanding of their mass transfer properties ... [more ▼]

The study of the durability of cementitious materials like mortar which are the object of massive use in building and engineering works implies a perfect understanding of their mass transfer properties. This work reports the results of experimental study concerning the influence of water-to cement ratios used for the preparation of the material on its convective drying kinetics. Three tips of mortar were realized and studied with three different water to cement (W/C) ratios; W/C =0.4, W/C = 0.5 and Mortar with ratio W/C = 0.6. The first experimental campaign was done in a convective dryer, using cubic samples of mortar of size (15 X 15 X 10) mm3. The sample was continuously weighed during the drying test and its mass was recorded every 2 minutes in order to obtain the drying curves. These tests present the advantage of reproducing the natural conditions met in the problems of atmosphere-material interactions. A second experimental campaign aimed to characterize from both a textural and hydric point of views, the materials, by mean of DVS (dynamic vapour sorption). The mass diffusivity coefficient and the pore size distribution of mortar were obtained from adsorption-desorption cycles. On the other hand the influence of the air drying humidity during the convective drying in the conditions of velocity, temperature and debit of air checked by the convective dryer was studied. From these campaigns, it was observed that the increase of the ratio W/C engenders an increase of the drying kinetics due to the increase of the initial porosity [less ▲]

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See detailMass transfer in low-density xerogel catalysts
Heinrichs, Benoît ULg; Pirard, Jean-Paul ULg; Schoebrechts, Jean-Paul

in AIChE Journal (2001), 47(8), 1866-1873

Texture and morphology of a Pd-Ag/SiO2 hydrodechlorination low-density xerogel catalyst prepared by a cogelation sot-gel process were characterized in detail to examine mass transfer in such catalysts ... [more ▼]

Texture and morphology of a Pd-Ag/SiO2 hydrodechlorination low-density xerogel catalyst prepared by a cogelation sot-gel process were characterized in detail to examine mass transfer in such catalysts. The catalyst consists of active Pd-Ag nanocrystallites trapped inside elementary 20 nm microporous silica particles arranged in larger aggregates, which constitute the macroscopic pellet. To reach active sites, reactants must first diffuse through large pores located between aggregates of SiO2 Particles and then through smaller pores located between those elementary particles inside the aggregates. Finally, they, diffuse through micropores located inside silica particles. Diffusion in such a "funnel" structure cannot be described assimilating the pellet to a pseudo-continuum. Diffusion should be examined carefully at three levels of decreasing size: the macroscopic pellet, the aggregate of silica particles, and the elementary silica particle. This approach shows that cogelled xerogel catalysts have remarkable mass-transfer properties. [less ▲]

Detailed reference viewed: 22 (7 ULg)
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See detailMass transfer, mixing and gas hold-up in a circulating jet-loop nitrifying MBR
Kouakou, Edouard; Salmon, Thierry ULg; Toye, Dominique ULg et al

in Proceedings of 7th World Congress of Chemical Enginnering - WCCE7, Glasgow, Scotland, 10-14 July 2005 (2005)

Detailed reference viewed: 31 (2 ULg)
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See detailMass transport in carbon gels with tuned porosity
Job, Nathalie ULg

in Spanish Carbon Group Bulletin (2012)

Detailed reference viewed: 23 (2 ULg)
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See detailMass-murder deletion of 19 Orfs from Saccharomyces cerevisiae chromosome XI
Vandenbol, Micheline ULg; Fairhead, C.

in Gene (2000), 247(1-2),

Detailed reference viewed: 11 (1 ULg)