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See detailQuantitative analysis of B-adrenergic blocking agents by capillary zone electrophoresis
Bechet, I.; Fillet, Marianne ULg; Hubert, Philippe ULg et al

in Journal de Pharmacie de Belgique (1994), 49

Detailed reference viewed: 6 (1 ULg)
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See detailQuantitative analysis of folic acid in a pharmaceutical formulation by capillary electrophoresis
Fotsing, L.; Fillet, Marianne ULg; Hubert, Philippe ULg et al

in Journal de Pharmacie de Belgique (1998), 53

Detailed reference viewed: 29 (0 ULg)
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See detailQuantitative analysis of l-lysine n-acetylcysteinate and related compounds by LC-MS
Toussaint, B.; Ceccato, Attilio ULg; Hubert, Philippe ULg et al

in Journal de Pharmacie de Belgique (1998), 53

Detailed reference viewed: 15 (0 ULg)
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See detailQuantitative analysis of laser induced carbon plasma by intensity ratio calibration
Yao, Shunchun; Lu, Jidong; Xie, Chengli et al

in High Power Laser and Particle Beams (2008), 20(7), 1089-1092

Samples were excited by pulse laser and plasma was formed at atmospheric pressure.The technique of laser induced breakdown spectroscopy(LIBS)was applied to analyzing the carbon content in the samples.The ... [more ▼]

Samples were excited by pulse laser and plasma was formed at atmospheric pressure.The technique of laser induced breakdown spectroscopy(LIBS)was applied to analyzing the carbon content in the samples.The matrix element Si was selected as internal standard,calibration curves were drawn respectively using the peak intensity of carbon line and the intensity ratio of carbon line and silica line.The fitting degree of two different calibration curves,signal reproducibility and the accuracy of calibrated values were analyzed.The results of the analysis show that the intensity ratio method seems more adequate than the peak intensity method for establishing the calibration cures. [less ▲]

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See detailQuantitative analysis of lead in soil by laser-induced breakdown spectroscopy
Li, Yong; Lu, Jidong; Lin, Zhaoxiang et al

in Journal of Applied Optics (2008), 29(5), 789-792

Fast quantitative analysis of lead in the simulated soil made of chemical reagents (PbC12,SiO2,CaCO3 and KBr)was carried out with the laser—induced breakdown spectroscopy. The result shows that the ... [more ▼]

Fast quantitative analysis of lead in the simulated soil made of chemical reagents (PbC12,SiO2,CaCO3 and KBr)was carried out with the laser—induced breakdown spectroscopy. The result shows that the signal—to—noise ratio increases and then decreases with the time delay. The calibration curves of Pb content were constructed with the spectrogram acquired in experiments.It is found by the investigation that the average relative error of the method for the fast quantitative analysis of lead in soil is 8.33 and the minimum detection limit is 89 ug/g. The experimental result proves LIBS is capable of being used in the detection of lead in soil. [less ▲]

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See detailQuantitative analysis of N-acetylcysteine and its pharmacopeial impurities in a pharmaceutical formulation by LC-UV-MS
Toussaint, B.; Pitti, Ch.; Streel, B. et al

Poster (2000)

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See detailQuantitative Analysis of N-Acetylcysteine and Its Pharmacopeial Impurities in a Pharmaceutical Formulation by Liquid Chromatography-Uv Detection-Mass Spectrometry
Toussaint, B.; Pitti, C.; Streel, B. et al

in Journal of Chromatography. A (2000), 896(1-2), 191-9

A new method for the simultaneous determination of N-acetylcysteine and its pharmacopeial impurities, cysteine, cystine, N,N'-diacetylcystine and N,S-diacetylcysteine in an effervescent tablet has been ... [more ▼]

A new method for the simultaneous determination of N-acetylcysteine and its pharmacopeial impurities, cysteine, cystine, N,N'-diacetylcystine and N,S-diacetylcysteine in an effervescent tablet has been developed. The method is based on on-line LC-UV-MS using a pneumatically-assisted electrospray interface (ionspray). The stability of the thiol moieties of the analytes was ensured by the acidic pH of the LC mobile phase. Quantitation of N-acetylcysteine was performed with UV detection to avoid ion-source overloading effect due to its higher concentration, whereas the impurities could be easily separated and quantified in MS. The method was validated in terms of stability, linearity, precision and accuracy. [less ▲]

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See detailQuantitative Analysis of Non-Steroidal Anti-Inflammatory Drugs by Capillary Zone Electrophoresis
Bechet, Isabelle; Hubert, Philippe ULg; Crommen, Jacques ULg et al

in Journal of Pharmaceutical & Biomedical Analysis (1995), 13(4-5), 497-503

The potential utility of capillary zone electrophoresis (CZE) for the separation and quantitative determination of some non-steroidal anti-inflammatory drugs (NSAIDs) was investigated. The influence of ... [more ▼]

The potential utility of capillary zone electrophoresis (CZE) for the separation and quantitative determination of some non-steroidal anti-inflammatory drugs (NSAIDs) was investigated. The influence of different parameters on migration times, peak symmetry, efficiency and resolution was studied; these parameters included the nature and concentration of the anionic and cationic components of the separation buffer. A buffer consisting of 75 mM glycine adjusted to pH 9.1 with triethanolamine was found to provide a very efficient and stable electrophoretic system for the CZE analysis of NSAIDs, giving RSD values of about 0.1 and 0.5% for the within-day reproducibility of migration times and peak areas, respectively at a concentration of 25 micrograms ml-1 (n = 5). Response was linear from 2-100 micrograms ml-1 for both sulindac and tiaprofenic acid, for which the LOQ values were 2.8 and 1.9 micrograms ml-1, respectively, using UV detection at 280 nm. Accuracy for each drug was 102-103%. [less ▲]

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See detailQuantitative analysis of semi-supine exercise echocardiography - influence of age on myocardial Doppler imaging indices
Petropoulou, E.; LANCELLOTTI, Patrizio ULg; Pierard, L. A.

in Acta Cardiologica (2006), 61(3), 271-277

Objectives - This study was performed to evaluate the feasibility of quantitative analysis of exercise echocardiography using pulsed wave Doppler myocardial imaging (DMI) and to examine the relation ... [more ▼]

Objectives - This study was performed to evaluate the feasibility of quantitative analysis of exercise echocardiography using pulsed wave Doppler myocardial imaging (DMI) and to examine the relation between age and DMI parameters at rest and during graded exercise in normal subjects. Methods and results - Seventy-two healthy volunteers were divided into three age groups (group 1, age :5 40 years, group 11, age 41 - 59 years and group 111, age : 60 years), and underwent a semisupine exercise echocardiogram. Peak systolic velocity (SV), time to peak SV (TPV), systolic velocity time integral (VTI) and peak diastolic velocities (V-E and V-A) were measured off-line. There was a heterogeneity in DMI parameters between different myocardial walls and a gradient was found between basal and mid segments. Both persisted during exercise. Group I had significantly higher TPV than groups II and III. Increase in workload was accompanied by an increase in velocities, while TPV decreased. Differences between groups persisted throughout exercise. Conclusions - Off-line measurements of DMI parameters are feasible during exercise. SV and E decline as age increases while A increases. SV already increases at low charge exercise and may serve as a quantitative marker for the detection of myocardial viability. Change of the absolute DMI velocity values during exercise may provide a better indicator of ischaemia or viability than the absolute values themselves. [less ▲]

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See detailQuantitative analysis of strychnine and brucine in Strychnos nux-vomica using H-1-NMR
Frederich, Michel ULg; Choi, Y. H.; Verpoorte, R.

in Planta Medica (2003), 69(12), 1169-1171

A quantitative analysis using H-1-NMR (Q-NMR) has been developed for the determination of strychnine and brucine in Strychnos nux-vomica seeds and stems. The advantages of the method are that no reference ... [more ▼]

A quantitative analysis using H-1-NMR (Q-NMR) has been developed for the determination of strychnine and brucine in Strychnos nux-vomica seeds and stems. The advantages of the method are that no reference alkaloids are needed for calibration curves, the quantification could be directly realized on a crude extract, strychnine and brucine could easily be distinguished, an overall profile of the preparation (including non alkaloid compounds) could be directly obtained, and a very significant time-gain could be achieved, in comparison to conventional HPLC methods, for instance. [less ▲]

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See detailQuantitative analysis of the porous structure of a petroleum reservoir
Pirard, Eric ULg; Pierroux, Alain; Darimont, Anne ULg

in Microscopy Research and Technique (1993), 25(2), 173-174

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See detailQuantitative Analysis of the Stabilization by Substrate of Staphylococcus Aureus Pc1 Beta-Lactamase
Lejeune, Annabelle ULg; Vanhove, Marc; Lamotte-Brasseur, Josette et al

in Chemistry & Biology (2001), 8(8), 831-42

BACKGROUND: The stabilization of enzymes in the presence of substrates has been recognized for a long time. Quantitative information regarding this phenomenon is, however, rather scarce since the enzyme ... [more ▼]

BACKGROUND: The stabilization of enzymes in the presence of substrates has been recognized for a long time. Quantitative information regarding this phenomenon is, however, rather scarce since the enzyme destroys the potential stabilizing agent during the course of the experiments. In this work, enzyme unfolding was followed by monitoring the progressive decrease of the rate of substrate utilization by the Staphylococcus aureus PC1 beta-lactamase, at temperatures above the melting point of the enzyme. RESULTS: Enzyme inactivation was directly followed by spectrophotometric measurements. In the presence of substrate concentrations above the K(m) values, significant stabilization was observed with all tested compounds. A combination of unfolding kinetic measurements and enzymatic studies, both under steady-state and non-steady-state regimes, allowed most of the parameters characteristic of the two concurrent phenomena (i.e. substrate hydrolysis and enzyme denaturation) to be evaluated. In addition, molecular modelling studies show a good correlation between the extent of stabilization, and the magnitude of the energies of interaction with the enzyme. CONCLUSIONS: Our analysis indicates that the enzyme is substantially stabilized towards heat-induced denaturation, independently of the relative proportions of non-covalent Henri-Michaelis complex (ES) and acyl-enzyme adduct (ES*). Thus, for those substrates with which the two catalytic intermediates are expected to be significantly populated, both species (ES and ES*) appear to be similarly stabilized. This analysis contributes a new quantitative approach to the problem. [less ▲]

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See detailA quantitative analysis of the use of posture verbs by French-speaking learners of Dutch
Lemmens, Maarten; Perrez, Julien ULg

in CogniTextes (2012), 8

This article presents a study of the use of the Dutch cardinal posture verbs staan (‘stand’), liggen (‘lie) and zitten (‘sit’) by French-speaking learners of Dutch; the data is drawn from a corpus of semi ... [more ▼]

This article presents a study of the use of the Dutch cardinal posture verbs staan (‘stand’), liggen (‘lie) and zitten (‘sit’) by French-speaking learners of Dutch; the data is drawn from a corpus of semi-spontaneous oral picture descriptions. Due to the typological differences between French and Dutch in the spatial domain (see Talmy 2000; Lemmens & Slobin 2008), the use of posture verbs is a highly problematic subject for French-speaking learners of Dutch. As a result, their interlanguage is typically characterized by an overall underuse of posture verbs as well as a confusion of the different posture verbs. Our study evaluates how the use of the posture verbs by the learners aligns with their level of proficiency. Strikingly, the statistical tendencies in our data show that a higher proficiency does not correspond to a more accurate use of posture verbs. At first sight, this seems to suggest that advanced learners have become worse at the use of posture verbs. A more refined analysis, however, shows that despite the increase of errors, the learners adopt more native-like strategies as their level of foreign language proficiency increases, suggesting that they gradually become more aware of the strong locative character of Dutch. [less ▲]

Detailed reference viewed: 53 (8 ULg)
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See detailQuantitative analysis of -solanine and -chaconine in potatoes by high performance thin layer chromatography
Bodart, P.; Hubert, Philippe ULg; Kabengera, Ch. et al

Conference (1999)

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See detailQuantitative analysis using near infrared spectroscopy, application to tablet content uniformity test, II
Ginot, Y.-M.; Bernard-Moulin, P.; Boiret, M. et al

in STP Pharma Pratiques (2014), 24(1), 3-36

The first part of this article [1] described the methodology to follow to develop a technique for the quantitative analysis of active substance in a solid tablet type formulation using near infrared ... [more ▼]

The first part of this article [1] described the methodology to follow to develop a technique for the quantitative analysis of active substance in a solid tablet type formulation using near infrared spectroscopy. It seems appropriate to complete this description by detailing the different steps involved through illustrated examples and by proposing useful guidelines for new users. The quantitative analysis example chosen is that of content uniformity (CU) of tablet type solid forms (cf. Ph. Eur. 2.9.6/2.9.40) [2], a test required in the pharmaceutical industry and for which this alternative quantitative analysis could offer substantial gains. It should be noted that the approach described applies to other types of quantitative analysis (mean assay, water content in raw materials, polymorph assay within a tablet, etc.). [less ▲]

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See detailQuantitative analysis using near infrared spectroscopy, Application to tablet content uniformity, I. Methodology
Ginot, Y. M.; Bernard-Moulin, P.; Cinier, R. et al

in STP PHARMA PRATIQUES (2010), 20(2), 117-135

This first document describes guidelines to develop a quantification method for active pharmaceutical ingredient content in solid dose formulation, using near-infrared spectroscopy. This new approach ... [more ▼]

This first document describes guidelines to develop a quantification method for active pharmaceutical ingredient content in solid dose formulation, using near-infrared spectroscopy. This new approach offers several advantages over classical techniques, in particular for tablets content uniformity determination. This document is intended to help users addressing the numerous questions pertaining to number and types of samples, usable spectral range for quantification, importance of the reference method, development of a model and potential pitfalls, use of chemometrics tools and method validation. It also offers a statistical support that used as an aid for decision for routine controls, when a sample falls near acceptance limits. The document gathers basic principles and will be complemented by a second article with practical examples to illustrate the methodology. [less ▲]

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See detailA quantitative and qualitative assessment of verbal short-term memory and phonological processing in 8-year-olds with a history of repetitive otitis media
Majerus, Steve ULg; Amand, Pierre; Boniver, Vincent et al

in Journal of Communication Disorders (2005), 38(6), 473-498

Language outcome in children experiencing fluctuant hearing loss due to otitis media (OME) remains highly equivocal. In the current study, we assessed performance on highly sensitive verbal short-term ... [more ▼]

Language outcome in children experiencing fluctuant hearing loss due to otitis media (OME) remains highly equivocal. In the current study, we assessed performance on highly sensitive verbal short-term memory (STM), new word learning and phonological processing tasks in 8-year-old children who had suffered from recurrent OME before the age of 3. Relative to a control group with no history of OME, we observed strictly normal performance for different STM and new word learning tasks. Performance on these tasks was also normally influenced by phonotactic, lexical and semantic variables. However, at the level of phonological processing, a small but significant decrease of performance was found in a speeded nonword identification task and a rhyme judgment task. The results of this study suggest that outcome of OME is characterized by subtle impairments at the level of perceptual-phonological analysis, but there is no significant impact on verbal STM and new word learning abilities. Learning outcomes: As a result of this activity, the participant will be able to (1) explain the outcome of recurrent OME before age 3 on later language and verbal STM development, (2) be aware of the complex relationships that link language development and verbal STM, (3) explain how fluctuant hearing loss during infancy and early childhood could affect verbal STM development and learning capacity for new phonological information, (4) describe different verbal STM measures that distinguish retention capacities for phonological and lexico-semantic information, and (5) explain the influence of phonotactic frequency on nonword processing in language and verbal STM tasks. (c) 2005 Elsevier Inc. All rights reserved. [less ▲]

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See detailQuantitative and qualitative estimation of bacteria in foodstuffs by genetic amplification
China, Bernard; Ghafir, Yasmine; Daube, Georges ULg

in Annales de Médecine Vétérinaire (2002), 146(2, APR-MAY),

Food quality is a major concern of our modern society. The sudden awareness that food is not sterile underlines the need of a rigorous microbiological analysis of foodstuffs. The techniques developed ... [more ▼]

Food quality is a major concern of our modern society. The sudden awareness that food is not sterile underlines the need of a rigorous microbiological analysis of foodstuffs. The techniques developed until now require the growth of the microorganism on a selective medium allowing to differentiate it from other bacteria. This procedure could be long and difficult for the analysis. To improve these classical methods, molecular biology techniques based on the specific amplification of a DNA sequence are in development. Moreover, the apparition of real time PCR allows new future prospects since it allows to quantify the number of bacteria present in a sample. This quantitative aspect is very important in food microbiology. In this way, the molecular biology tools should allow to develop fast, sensitive, specific and quantitative diagnosis tests to confirm the results obtained by classical methods but also to allow the diagnosis of fastidious bacteria. [less ▲]

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See detailQuantitative and qualitative hydrogeological study of the alluvial aquifer of Somes-Szamos (RO-HU) NATO SfP Project 973684 SQUASH
Dassargues, Alain ULg; Lenart, Laszlo; Drobot, Radu

in Hidrotehnica (2004), 49(9-10), 3-7

Detailed reference viewed: 24 (3 ULg)