Obesite, insulinoresistance et diabete de type 2: facteurs de risque du cancer du sein.
SCHEEN, André ; Beck, Emmanuel ; DE FLINES, Jenny et al
in Revue Médicale de Liège (2011), 66(5-6), 238-44
Obesity and type 2 diabetes are two risk factors of breast cancer, especially after menopause. Underlying mechanisms are multiple and include hyperinsulinism due to insulin resistance (insulin, as insulin ... [more ▼]
Obesity and type 2 diabetes are two risk factors of breast cancer, especially after menopause. Underlying mechanisms are multiple and include hyperinsulinism due to insulin resistance (insulin, as insulin-like-growth factor -IGF-, is a growth factor), hyperleptinaemia associated with hypoadiponectinaemia, and high levels of estrogens resulting from aromatization of androgens in adipose tissue. In presence of type 2 diabetes associated with obesity, hyperglycaemia might provide energy substrate promoting tumour growth. These data have therapeutic implications with expected favourable effects of weight loss, resulting in a reduction of fat mass and insulin resistance, and the promising results recently reported with metformin contrasting with the negative effects of exogenous administration of high doses of insulin. [less ▲]Detailed reference viewed: 130 (8 ULg)
Obesite: aspects therapeutiques.
in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (2001), 156(10-12), 471-9480-2
Obesity is now recognized as a chronic disease. Its treatment implies a prolonged negative energy balance, by reducing caloric intake and/or increasing energy expenditure. In practice, three therapeutic ... [more ▼]
Obesity is now recognized as a chronic disease. Its treatment implies a prolonged negative energy balance, by reducing caloric intake and/or increasing energy expenditure. In practice, three therapeutic approaches can be considered: 1) life-style modifications, combining well-balanced hypocaloric diet and regular physical exercise, the key-issue in obesity management; 2) in case of failure and as adjunct treatment, anti-obesity drugs, especially orlistat, an intestinal lipase inhibitor, and sibutramine, a central appetite regulator; and 3) in patients with extreme refractory obesity, surgical procedures consisting of gastric restriction (gastroplasty) or intestinal bypass. Anti-obesity treatments must be evaluated in the long run, in terms of efficacy/safety ratio, upon criteria of weight loss, reduction in associated risk factors, improvement of quality of life and, if possible, reduction of morbidity and mortality. [less ▲]Detailed reference viewed: 37 (3 ULg)
Obésité: aube hésitée, et quoi pour moi demain
Conference (2006, June)
cette journée aborde le cocnept familial, l'aspect communautaire, l'épidémiologie, l'aspect nutritionnel, l'aspect somatique et l'aspect psychologique de l'obésité de l'enfant dans le cadre familial.Detailed reference viewed: 41 (2 ULg)
L'obésité: un modèle d'interactions complexes entre génétique et environnement
PAQUOT, Nicolas ; DE FLINES, Jenny ; RORIVE, Marcelle
in Revue Médicale de Liège (2012), 67(5-6), 332-336Detailed reference viewed: 53 (7 ULg)
Obesity : epidemiology, pathophysiology and management of the obese dog
Diez, Marianne ;
in Pibot, Pascale; Biourge, Vincent; Elliott, Denise (Eds.) Encyclopedia of Canine Clinical Nutrition (2006)Detailed reference viewed: 325 (1 ULg)
Obesity and liver disease.
Scheen, André ; Luyckx, Françoise
in Best practice & research. Clinical endocrinology & metabolism (2002), 16(4), 703-16
Non-alcoholic steatohepatitis (NASH) is a disease of emerging identity and importance. It is frequently associated with obesity, especially visceral fat, and is intimately related to fatty liver and ... [more ▼]
Non-alcoholic steatohepatitis (NASH) is a disease of emerging identity and importance. It is frequently associated with obesity, especially visceral fat, and is intimately related to fatty liver and markers of the insulin resistance syndrome. Both the prevalence and the severity of liver steatosis are related to body mass index, waist circumference, hyperinsulinaemia, hypertriglyceridaemia and impaired glucose tolerance or type 2 diabetes. The identification of obese patients who may progress from steatosis to NASH and from NASH to fibrosis/cirrhosis is an important clinical challenge. Substantial weight loss is accompanied by a marked attenuation of insulin resistance and related metabolic syndrome and, concomitantly, by a remarkable regression of liver steatosis in most patients, although increased inflammation may be detected in some subjects. Thus, NASH may be considered as another disease of affluence, as is the insulin resistance syndrome, and perhaps being part of it, especially in obese patients. [less ▲]Detailed reference viewed: 65 (1 ULg)
Obesity and nutrition in children. The Belgian Luxembourg Child Study IV.
Guillaume, Michèle ; ;
in European Journal of Clinical Nutrition (1998), 52(5), 323-8
OBJECTIVE: To analyse the association between nutritional and familial factors and obesity in boys and girls. DESIGN: Randomized, cross-sectional population study. SETTING: Province de Luxembourg, Belgium ... [more ▼]
OBJECTIVE: To analyse the association between nutritional and familial factors and obesity in boys and girls. DESIGN: Randomized, cross-sectional population study. SETTING: Province de Luxembourg, Belgium. Subjects: One thousand and twenty-eight boys and girls in age strata 6-8, 8-10 and 10-12 y, comprising 70.3% of primary cohort. METHODS: Examinations included anthropometric measurements and questionnaires covering familial, socioeconomic and psychosocial factors. A three day dietary record was obtained in 955 children. This was analysed in relation to the anthropometric data. RESULTS: In comparison with similar studies from other regions and recommended allowances, the intakes of total energy, fat, particularly saturated fat and cholesterol, were high, while consumption of carbohydrate and fiber was low, as well as the polyunsaturated/saturated ratio of fat. Total energy intake showed no or weakly significant correlations with anthropometric factors. However, total fat (P=0.045) and saturated fat (P=0.0005) intake showed consistent positive correlations with body mass index (BMI, kg/m2) and skinfold thickness, with corresponding negative relationships to carbohydrate intake (P=0.034) in boys. Such relationships were also found when calculated as energy density. These associations were not statistically significant in girls. The high fat, low carbohydrate pattern of the nutritional status seemed to be more pronounced in families where the father had a low level of education (lipids, boys, P=0.0007), and where both parents were obese (saturated fat, boys, P=0.023), suggesting involvement of socioeconomic and familial factors. CONCLUSION: The lack of correlation between factors indicating obesity and total energy intake suggests that the positive energy balance causing obesity is due mainly to a low energy output. However, since energy intake measurements are imprecise, overeating can not be excluded, particularly since elevated consumption of food with high contents of fat, found in these children seems to be poorly regulated. [less ▲]Detailed reference viewed: 19 (2 ULg)
Obesity and nutrition. The Belgian Luxembourg Child Study
in International Journal of Obesity (1997, June)Detailed reference viewed: 11 (0 ULg)
Obesity and nutrition. The Belgian Luxembourg Child Study.
Guillaume, Michèle ; ; et al
in Obesity Research (1997)Detailed reference viewed: 9 (0 ULg)
Obesity and other cardiovascular risk factors in children. Results from a population study. "The Belgian Luxembourg Child Study".
Guillaume, Michèle ; ; et al
in Prog European meeting of EASO (1993)Detailed reference viewed: 7 (2 ULg)
Obesity and the metabolic syndrome in children in Province de Luxembourg, Belgium
Guillaume, Michèle ; ; et al
in Prog. 7th ICO meeting (1994)Detailed reference viewed: 10 (2 ULg)
Obesity in children. Environmental and genetic Aspects
Guillaume, Michèle ;
in Hormone and Metabolic Research. Supplement Series (1996), 28Detailed reference viewed: 11 (2 ULg)
Obesity phenotype is related to NLRP3 inflammasome activity and immunological profile of visceral adipose tissue
ESSER, Nathalie ; L'Homme, Laurent ; DE ROOVER, Arnaud et al
in Diabetologia (2013), 56
Aims/hypothesis Obesity is a heterogeneous condition comprising both individuals who remain metabolically healthy (MHO) and those who develop metabolic disorders (metabolically unhealthy, MUO). Adipose ... [more ▼]
Aims/hypothesis Obesity is a heterogeneous condition comprising both individuals who remain metabolically healthy (MHO) and those who develop metabolic disorders (metabolically unhealthy, MUO). Adipose tissue is also heterogeneous in that its visceral component is more frequently associated with metabolic dysfunction than its subcutaneous component. The development of metabolic disorders is partly mediated by the NLR family pyrin domain containing-3 (NLRP3) inflammasome, which increases the secretion of inflammatory cytokines via activation of caspase-1. We compared the immunological profile and NLRP3 activity in adipose tissue between MUO and MHO individuals. Methods MHO and MUO phenotypes were defined, respectively, as the absence and the presence of the metabolic syndrome. Cellular composition and intrinsic inflammasome activity were investigated by flow cytometry, quantitative RTPCR and tissue culture studies in subcutaneous and visceral adipose tissue from 23 MUO, 21 MHO and nine lean individuals. Results We found significant differences between the three study groups, including an increased secretion of IL-1β, increased expression of IL1B and NLRP3, increased number of adipose tissue macrophages and decreased number of regulatory T cells in the visceral adipose tissue of MUO patients compared with MHO and lean participants. In macrophages derived from visceral adipose tissue, both caspase-1 activity and IL-1β levels were higher in MUO patients than in MHO patients. Furthermore, caspase-1 activity was higher in CD11c+CD206+ adipose tissue macrophages than in CD11c−CD206+ cells. Conclusions/interpretation The MUO phenotype seems to be associated with an increased activation of the NLPR3 inflammasome in macrophages infiltrating visceral adipose tissue, and a less favourable inflammatory profile compared with the MHO phenotype. [less ▲]Detailed reference viewed: 55 (13 ULg)
Obesity: A new paradigm for treating obesity and diabetes mellitus.
Scheen, André ; Paquot, Nicolas
in Nature reviews. Endocrinology (2015), 11(4), 196-198Detailed reference viewed: 18 (2 ULg)
Obesity: causes and new treatments.
Lefebvre, Pierre ; Scheen, André
in Experimental & Clinical Endocrinology & Diabetes (2001), 109 Suppl 2
The prevalence of obesity increases rapidly in developed and developing countries. Obesity results from a cumulative positive energy balance and is favoured by both genetic and environmental factors ... [more ▼]
The prevalence of obesity increases rapidly in developed and developing countries. Obesity results from a cumulative positive energy balance and is favoured by both genetic and environmental factors. Preventing obesity requires a major investment in nutritional and lifestyle education, particularly in children and adolescents.--The pharmacological approach to obesity includes drugs that reduce food intake (noradrenergic and serotoninergic agents), drugs that increase energy expenditure and compounds that affect nutrient partitioning. In all instances, the benefit-to-risk ratio needs to be carefully assessed. In some patients (severe obesity or obesity accompanied by serious high-risk comorbid conditions), gastric surgery (gastric restriction or gastric bypass) should be considered. In our own experience, it is safe and effective. [less ▲]Detailed reference viewed: 47 (0 ULg)
L’obituaire de la cathédrale Saint-Lambert de Liège (XIe-XVe siècles)
Book published by Académie royale de Belgique - Commission royale d'Histoire (1991)Detailed reference viewed: 36 (3 ULg)
L’obituaire de la cathédrale Saint-Lambert de Liège. Notes pour une édition
in Moyen Age (Le) (1990), 96Detailed reference viewed: 15 (4 ULg)