Stat5 Is an Ambivalent Regulator of Neutrophil Homeostasis

in PLoS ONE (2007), 2(1), 727

Although STAT5 promotes survival of hematopoietic progenitors, STAT5-/- mice develop mild neutrophilia. METHODOLOGY/PRINCIPAL FINDINGS: Here, we show that in STAT5-/- mice, liver endothelial cells (LECs ... [more ▼]

Although STAT5 promotes survival of hematopoietic progenitors, STAT5-/- mice develop mild neutrophilia. METHODOLOGY/PRINCIPAL FINDINGS: Here, we show that in STAT5-/- mice, liver endothelial cells (LECs) autonomously secrete high amounts of G-CSF, allowing myeloid progenitors to overcompensate for their intrinsic survival defect. However, when injected with pro-inflammatory cytokines, mutant mice cannot further increase neutrophil production, display a severe deficiency in peripheral neutrophil survival, and are therefore unable to maintain neutrophil homeostasis. In wild-type mice, inflammatory stimulation induces rapid STAT5 degradation in LECs, G-CSF production by LECs and other cell types, and then sustained mobilization and expansion of long-lived neutrophils. CONCLUSION: We conclude that STAT5 is an ambivalent factor. In cells of the granulocytic lineage, it exerts an antiapoptotic function that is required for maintenance of neutrophil homeostasis, especially during the inflammatory response. In LECs, STAT5 negatively regulates granulopoiesis by directly or indirectly repressing G-CSF expression. Removal of this STAT5-imposed brake contributes to induction of emergency granulopoiesis. [less ▲]

STAT5 promotes granulocyte survival during inflammation

in Pflügers Archiv : European Journal of Physiology (2004), 447

STAT5 promotes granulocyte survival during inflammation

in Proceedings: The American Thoracic Society (2005)

State complexity of testing divisibility

in McQuillan, Ian, Pighizzini, Giovanni (Ed.) Proceedings Twelfth Annual Workshop on Descriptional Complexity of Formal Systems (2010, August)

Under some mild assumptions, we study the state complexity of the trim minimal automaton accepting the greedy representations of the multiples of m>=2 for a wide class of linear numeration systems. As an ... [more ▼]

Under some mild assumptions, we study the state complexity of the trim minimal automaton accepting the greedy representations of the multiples of m>=2 for a wide class of linear numeration systems. As an example, the number of states of the trim minimal automaton accepting the greedy representations of mN in the Fibonacci system is exactly 2m^2. [less ▲]

The State of Environmental Migration 2010

Report (2011)

The state of Integration in Europe and Stories from the Grass Roots

Scientific conference (2006, April 25)

The State of Open Access in Belgium's French-speaking Universities

Conference (2012, October 22)

An overview of the BICfB report "L'Open Access en Belgique francophone : étude de la BICfB réalisée à la demande des Recteurs des universités et du F.R.S.-FNRS" (May 2012) (http://hdl.handle.net/2268 ... [more ▼]

An overview of the BICfB report "L'Open Access en Belgique francophone : étude de la BICfB réalisée à la demande des Recteurs des universités et du F.R.S.-FNRS" (May 2012) (http://hdl.handle.net/2268/124876). [less ▲]

The state of stress near the Mendocino triple Junction from inversion of earthquake focal mechanism

in Geophysical Research Letters (1997), 23

The State of the Art in Multiple Object Tracking Under Occlusion in Video Sequences

Conference (2003)

State of the Art in Spinal Cord Injury – Research and Clinical Application

Conference (2007, September 06)