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Peer Reviewed
See detailMechanical quantification of porous structures by the combined use of micro-CT and in-situ loading
Kerckhofs, Greet ULg; Schrooten, Jan; Elicegui, Laida et al

in Proceedings book WCNDT 2008 (2008)

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See detailMechanical response and conformational changes of alpha-actinin domains during unfolding: a molecular dynamics study
Soncini, Monica; Vesentini, Simone; Ruffoni, Davide ULg et al

in BIOMECHANICS AND MODELING IN MECHANOBIOLOGY (2007), 6(6), 399-407

Alpha-actinin is a cytoskeleton-binding protein involved in the assembly and regulation of the actin filaments. In this work molecular dynamics method was applied to investigate the mechanical behaviour ... [more ▼]

Alpha-actinin is a cytoskeleton-binding protein involved in the assembly and regulation of the actin filaments. In this work molecular dynamics method was applied to investigate the mechanical behaviour of the human skeletal muscle a-actinin. Five configurations were unfolded at an elongation speed of 0.1 nm/ps in order to investigate the conformational changes occurring during the extension process. Moreover, a sensitivity analysis at different velocities was performed for one of the R2-R3 spectrin-like repeat configuration extracted in order to evaluate the effect of the pulling speed on the mechanical behaviour of the molecule. Two different behaviours were recognized with respect to the pulling speed. In particular, at speed higher than 0.025nm/ps a continuous rearrangement without evident force peaks was obtained, on the contrary at lower speed evident peaks in the range 500-750 pN were detected. R3 repeat resulted more stable than R2 during mechanical unfolding, due to the lower hydrophobic surface available to the solvent. The characterization of the R2-R3 units can be useful for the development of cytoskeleton network models based on stiffness values obtained by analyses performed at the molecular level. [less ▲]

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See detailMECHANICAL STRAIN MODULATES MONOCYTE CHEMOTACTIC PROTEIN-1 AND IL-1BETA EXPRESSION BY CULTURED HUMAN AORTIC SMOOTH MUSCLE CELLS
Defawe, Olivier; Colige, Alain ULg; Deroanne, Christophe ULg et al

in Cardiovascular Pathology (2004), 13(3 suppl), 189

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See detailMechanical stress strongly induces interleukin-6 production by osteoblasts: a new in vitro 3D compression model
Sanchez, Christelle ULg; Gabay, Odile; Salvat, Colette et al

in Osteoarthritis and Cartilage (2007), 15(Suppl C), 84-85

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See detailMechanical stress strongly induces interleukin-6 production by osteoblasts: a new in vitro 3D compression model
Sanchez, Christelle ULg; Gabay, Odile; Salvat, Colette et al

Poster (2007)

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See detailMechanical testing of a modified stabilisation method for tibial tuberosity advancement
Etchepareborde, Sébastien; Barthelemy, Nicolas; Mills, J. et al

in Veterinary and Comparative Orthopaedics and Traumatology (2010)

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See detailMechanical testing of a new osteotomy design for tibial tuberosity advancement using the Modified Maquet Technique (MMT)
Brunel, L.; Etchepareborde, S.; Barthelemy, Nicolas ULg et al

in Veterinary and Comparative Orthopaedics and Traumatology (2013), 26(1), 47-53

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See detailMechanical testing of electrospun PCL fibers
Croisier, Florence ULg; Duwez, Anne-Sophie ULg; Jérôme, Christine ULg et al

in Acta Biomaterialia (2012), 8(1), 218-224

Poly(ε-caprolactone) (PCL) fibers ranging from 250 to 700 nm in diameter were produced by electrospinning a polymer tetrahydrofuran/N,N-dimethylformamide solution. The mechanical properties of the fibrous ... [more ▼]

Poly(ε-caprolactone) (PCL) fibers ranging from 250 to 700 nm in diameter were produced by electrospinning a polymer tetrahydrofuran/N,N-dimethylformamide solution. The mechanical properties of the fibrous scaffolds and individual fibers were measured by different methods. The Young’s moduli of the scaffolds were determined using macro-tensile testing equipment, whereas single fibers were mechanically tested using a nanoscale three-point bending method, based on atomic force microscopy and force spectroscopy analyses. The modulus obtained by tensile-testing eight different fiber scaffolds was 3.8 ± 0.8 MPa. Assuming that PCL fibers can be described by the bending model of isotropic materials, a Young’s modulus of 3.7 ± 0.7 GPa was determined for single fibers. The difference of three orders of magnitude observed in the moduli of fiber scaffolds vs. single fibers can be explained by the lacunar and random structure of the scaffolds. [less ▲]

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See detailMechanical Ventilation During Anaesthesia: Pathophysiology and Clinical Implications
Dresse, Caroline; JORIS, Jean ULg; HANS, Grégory ULg

in Trends in Anaesthesia and Critical Care (2012), 2(2), 71-75

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See detailMechanical work of breathing during treadmill exercise in ponies
Art, Tatiana ULg; Lekeux, Pierre ULg

in Archives Internationales de Physiologie et de Biochimie (1988), 96(5), 42

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See detailMechanically-coupled ring-resonator filter and array (analytical and finite element model).
Pachkawade, Vinayak ULg; Junghare, R; Patrikar, R et al

in IET Computers & Digital Techniques (2016)

In this paper, a design of two microelectromechanical systems based devices is carried out using an analytical and finite-element analysis. The first device is mechanically coupled ring-resonator band ... [more ▼]

In this paper, a design of two microelectromechanical systems based devices is carried out using an analytical and finite-element analysis. The first device is mechanically coupled ring-resonator band-pass filter with centre frequency of 4.4 MHz and a small bandwidth of only 36 kHz. Flexural-mode ring resonators have been mechanically coupled using soft mechanical spring for realising the filtering action. Owing to inherent symmetry in the ring structure, simple approach is used to access a low-velocity coupling locations to set a smallest possible bandwidth. The authors also show a reduction in the amplitude of spurious mode by accentuating the filter structure in its fully differential mode inherently present in the structure. Moreover, the effect of the number of the support beams and structural damping on the frequency response of a filter has been analysed. A second device is mechanically coupled ring-resonator arrays with varying number of rings coupled. The mechanical links using short stubs connect each constituent resonator of an array to its adjacent ones at the high-velocity vibrating locations to accentuate the desired mode and reject all other spurious modes. Both analytical and finite-element based simulation results for parameters of the designed structure are found in good agreement. [less ▲]

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See detailMechanics and characteristics of transition to turbulence in elasto-inertial turbulence
Terrapon, Vincent ULg; Dubief, Yves; Soria, Julio

Conference (2012, November 20)

Numerical experiments of transition in elasto-inertial turbulent channel flows are used to highlight the mechanisms of transition and characterize the MDR regime. Specifically, the pressure kernel from ... [more ▼]

Numerical experiments of transition in elasto-inertial turbulent channel flows are used to highlight the mechanisms of transition and characterize the MDR regime. Specifically, the pressure kernel from the generalized pressure Poisson equation is used to demonstrate the role of elastic instabilities in inducing and sustaining a turbulent-like flow. Additionally, dynamic mode decomposition is applied to statistically steady viscoelastic flows at different Reynolds number to identify the relative contributions of elastic and inertial instabilities. It is shown that elastic instabilities can be triggered through long-range interactions from disturbances in the free-stream, similarly to by-pass transition, and are then sufficient to self-sustain. When the Reynolds number is increased, the relative contribution of inertial instabilities becomes more important, and the flow demonstrates features that are characteristic to Newtonian turbulent flows (e.g., streaks, quasi-streamwise vortices), although at lower intensity. [less ▲]

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See detailMechanics of breathing and gas exchanges in healthy cattle: effect of somatic growth
Lekeux, Pierre ULg

in Archives Internationales de Physiologie et de Biochimie (1987, November), 95(2), 5

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See detailMechanics of breathing and ventilatory drive in double-muscled calves during acute hypoxia
Rollin, Frédéric ULg; Amory, Hélène ULg; Desmecht, Daniel ULg et al

in Proceedings of the 8th Comparative Respiratory Society Meeting (1989)

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See detailMechanics of breathing during strenuous exercise in Thoroughbred horses
Art, Tatiana ULg; Anderson, L.; Woakes, A. J. et al

in Respiration Physiology (1990), 82(3), 279-294

The changes induced by exercise on the mechanics of breathing, as well as the simultaneous changes occurring in arterial blood gas tensions and in respiratory gas exchange were investigated in 6 healthy ... [more ▼]

The changes induced by exercise on the mechanics of breathing, as well as the simultaneous changes occurring in arterial blood gas tensions and in respiratory gas exchange were investigated in 6 healthy thoroughbred horses, performing a treadmill exercise of increasing intensity. Respiratory airflow and tidal volume (VT) were measured with ultrasonic flowmeters. Pleural pressure changes were measured by an oesophageal balloon catheter. Gas concentration of the expired air was analysed with a mass spectrometer; the oxygen consumption (VO2) and the carbon dioxide output (VCO2) were computed breath-by-breath. Arterial blood gas values were obtained by sampling from the carotid artery. Between rest and fast gallop VT, respiratory frequency, expired minute ventilation (VE), VO2, VCO2, total pulmonary resistance (RL), mechanical work of breathing (Wrm) and PaCO2 increased significantly while PaO2 decreased significantly. The Wrm.VO2(-1) ratio in galloping horses increased exponentially with VE. This, together with the relationship between the changes in PaO2 and in PaCO2 and the increase in the ventilatory mechanics parameters, suggests that the mechanics of breathing may be one of the factors constraining further increase in ventilation in exercising healthy horses. [less ▲]

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See detailMechanics of Breathing in Goats
Bakima, M.; Gustin, Pascal ULg; Lekeux, Pierre ULg et al

in Research in Veterinary Science (1988), 45(3), 332-336

Common pulmonary function tests used in man and domestic mammals were adapted to the goat. Requirements for intrathoracic pressure record and pulmonary function investigation were determined. The ... [more ▼]

Common pulmonary function tests used in man and domestic mammals were adapted to the goat. Requirements for intrathoracic pressure record and pulmonary function investigation were determined. The elastance of the mid-thoracic portion of the oesophagus was measured in 17 healthy goats. The calculated percentage error in identifying the endoesophageal intrathoracic pressure decreased with somatic growth, and was found to be smaller than 2 per cent for adult goats. The location of the oesophageal balloon catheter used to measure the intrathoracic pressure was standardised. The following regression equation calculated between the length of catheter (Lcat) and the thoracic circumference (TC) was found: Lcat (cm) = 6.19 +/- 0.7163 X TC (cm) (R2 = 0.96). The influence of the dead space of a face mask on respiration pattern and arterial blood gas were studied. There were no significant changes in arterial partial pressure of oxygen (PaO2) and carbon dioxide (PaCO2), pHa, breathing frequency and intrathoracic pressures. The influence of head and neck position was investigated. Upper airway resistance (Ruaw), measured with the head in a normal position did not significantly differ from values obtained with the head in a horizontal position. Ruaw measured with the head in a vertical position was considerably increased. Arterial blood gas tension and pulmonary mechanics were measured to assess the reproducibility of pulmonary function measurements. Variability in blood gas tension, tidal volume and minute volume is small. The variability of peak to peak intrathoracic pressure change (max delta Plp), dynamic lung compliance (Cdyn), total pulmonary resistance (RL) and Rt were relatively large. [less ▲]

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See detailMechanics of breathing in resting and exercising animals
Lekeux, Pierre ULg; Art, Tatiana ULg

in Lekeux, Pierre (Ed.) Pulmonary Function in Healthy, Exercising and Diseased Animals (1993)

Detailed reference viewed: 21 (3 ULg)
Peer Reviewed
See detailThe mechanics of the gravid uterus. II. Global myometrial activity and its pharmacology
Lambotte, R.; Foidart, Jean-Michel ULg; Lecomte, J.

in Revue Médicale de Liège (1977), 32(12), 369-77

Detailed reference viewed: 6 (0 ULg)