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See detailNeo-pouce par transplantation microchirurgicale du second orteil. A propos de deux observations.
Lejeune, G; Yoshimura, D; Alexandre, G et al

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1978), 133(11), 583-93

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See detailLe néo-régionalisme et l'UE dans le cadre de la globalisation
Santander, Sébastian ULg; Telò, Mario

in Magnette et Remacle, Paul et Eric (Ed.) Le nouveau modèle européen (2000)

L'article porte sur le nouveau régionalisme et l'Union européenne dans les relations internationales. Il vise à répondre aux questions suivantes: l'Union européenne exporte-t-elle son modèle d'intégration ... [more ▼]

L'article porte sur le nouveau régionalisme et l'Union européenne dans les relations internationales. Il vise à répondre aux questions suivantes: l'Union européenne exporte-t-elle son modèle d'intégration dans le monde? Comment? Avec quelles conséquences pour la gouvernance de la globalisation? Il est structuré en trois parties : dans la première partie, nous attirons l'attention sur l'importance du débat ouvert dans la littérature scientifique internationale concernant la nature du néo-régionalisme dans le monde, ses causes et ses implications dans le cadre des négociations multilatérales. Dans la deuxième partie, nous présentons une étude de cas, consacrée aux relations entre l'Union européenne et le MERCOSUR, organisation régionale la plus importante de l'Amérique Latine. Le papier se termine par des réflexions à propos de l'identité internationale de l'Union européenne. [less ▲]

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See detailNéo-rhétoriques made in Belgium : figures de style et argumentation
Leclercq, Bruno ULg

in Argumentum (2011), 9

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See detailNeoadjuvant chemotherapy in breast cancer induces miR-34a and miR-122 expression
FRERES, Pierre ULg; JOSSE, Claire ULg; Bovy, Nicolas ULg et al

in Journal of Cellular Physiology (2014)

Circulating microRNAs (miRNAs) have been extensively studied in cancer as biomarkers but little is known regarding the influence of anti-cancer drugs on their expression levels. In this article, we ... [more ▼]

Circulating microRNAs (miRNAs) have been extensively studied in cancer as biomarkers but little is known regarding the influence of anti-cancer drugs on their expression levels. In this article, we describe the modifications of circulating miRNAs profile after neoadjuvant chemotherapy (NAC) for breast cancer. The expression of 188 circulating miRNAs was assessed in the plasma of 25 patients before and after NAC by RT-qPCR. Two miRNAs, miR- 34a and miR-122, that were significantly increased after NAC, were measured in tumor tissue before and after chemotherapy in 7 patients with pathological partial response (pPR) to NAC. These 2 chemotherapy-induced miRNAs were further studied in the plasma of 22 patients with adjuvant chemotherapy (AC) as well as in 12 patients who did not receive any chemotherapy. Twenty-five plasma miRNAs were modified by NAC. Among these miRNAs, miR-34a and miR-122 were highly upregulated, notably in pPR patients with aggressive breast cancer. Furthermore, miR-34a level was elevated in the remaining tumor tissue after NAC treatment. Studying the kinetics of circulating miR-34a and miR-122 expression during NAC revealed that their levels were especially increased after anthracycline-based chemotherapy. Comparisons of the plasma miRNA profiles after NAC and AC suggested that chemotherapy-induced miRNAs originated from both tumoral and non-tumoral compartments. This study is the first to demonstrate that NAC specifically induces miRNA expression in plasma and tumor tissue, which might be involved in the anti-tumor effects of chemotherapy in breast cancer patients. [less ▲]

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See detailNeoadjuvant chemotherapy in breast cancer patients induces expression of tumor suppressor miR-34a
FRERES, Pierre ULg

Poster (2014, May 19)

Circulating microRNAs (miRNAs) are extensively studied in cancer as biomarkers but little is known about the influence of anti-cancer drugs on their expression. In this presentation, we describe the ... [more ▼]

Circulating microRNAs (miRNAs) are extensively studied in cancer as biomarkers but little is known about the influence of anti-cancer drugs on their expression. In this presentation, we describe the modifications of circulating miRNAs profile under neoadjuvant chemotherapy (NAC) for breast cancer. [less ▲]

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See detailNeoadjuvant Radiochemotherapy of Locally/Regionally Advanced Rectal Cancer is a standard treatment option
Farkas, Róbert; Al-Farhat, Yousuf; GULYBAN, Akos ULg et al

in Radiotherapy & Oncology (2006), 81(suppl1), 237

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See detailNeoadjuvant treatment with docetaxel plus lapatinib, trastuzumab, or both followed by an anthracycline based chemotherapy in HER2-positive breast cancer: results of the randomised phase II EORTC 10054 study.
Bonnefoi, H.; Jacot, W.; Saghatchian, M. et al

in Annals of oncology : official journal of the European Society for Medical Oncology / ESMO (2014)

BACKGROUND: Neoadjuvant trials conducted using a double HER2-blockade with lapatinib and trastuzumab, combined with different paclitaxel-containing chemotherapy regimens, have shown high pathological ... [more ▼]

BACKGROUND: Neoadjuvant trials conducted using a double HER2-blockade with lapatinib and trastuzumab, combined with different paclitaxel-containing chemotherapy regimens, have shown high pathological complete response (pCR) rates, but at the cost of important toxicity. We hypothesised that this toxicity might be due to a specific interaction between paclitaxel and lapatinib. This trial assesses the toxicity and activity of the combination of docetaxel with lapatinib and trastuzumab. PATIENTS AND METHODS: Patients with stage IIA to IIIC HER2-positive breast cancer received six cycles of chemotherapy (three cycles of docetaxel followed by three cycles of fluorouracil, epirubicin, cyclophosphamide). They were randomised 1:1:1 to receive during the first three cycles either lapatinib (1000 mg orally daily), trastuzumab (4 mg/kg loading dose followed by 2 mg/kg weekly), or trastuzumab+lapatinib at the same dose. The primary endpoint was pCR rate defined as ypT0/is. Secondary endpoints included safety and toxicity. pCR rate defined as ypT0/is ypN0 was assessed as an exploratory analysis. In June 2012, arm A was closed for futility based on the results from other studies. RESULTS: From October 2010 to January 2013, 128 patients were included in 14 centres. The percentage of the 122 evaluable patients with pCR in the breast, and pCR in the breast and nodes, was numerically highest in the lapatinib+trastuzumab group (60% and 56%, respectively), intermediate in the trastuzumab group (52% and 52%), and lowest in the lapatinib group (46% and 36%). Frequency (%) of the most common grade 3-4 toxicities in the lapatinib /trastuzumab/lapatinib+trastuzumab arms were: febrile neutropenia 23/15/10, diarrhea 9/2/18, infection (other) 9/4/8, and hepatic toxicity 0/2/8. CONCLUSIONS: This study demonstrates a numerically modest pCR rate increase with double anti-HER2 blockade plus chemotherapy, but suggests that the use of docetaxel rather than paclitaxel may not reduce toxicity. This study is registered with ClinicalTrials.gov, number NCT00450892. [less ▲]

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See detailNeodymium: YAG laser hysteroscopy in large submucous fibroids.
Donnez, Jacques; Gillerot, Stéphane; Bourgonjon, Damien et al

in Fertility and Sterility (1990), 54(6), 999-1003

The preoperative use of a potent, subcutaneously injected gonadotropin-releasing hormone agonist (GnRH-a) was evaluated in a series of 60 women with large submucosal fibroids. Myomectomy by hysteroscopy ... [more ▼]

The preoperative use of a potent, subcutaneously injected gonadotropin-releasing hormone agonist (GnRH-a) was evaluated in a series of 60 women with large submucosal fibroids. Myomectomy by hysteroscopy and Nd:YAG laser was easily performed. In 12 cases, the largest portion of the myoma was not inside the uterine cavity and myomectomy was carried by a two-step hysteroscopy. In women who wished to become pregnant, a pregnancy rate of 66% was achieved. Advantages of preoperative use of a GnRH-a are (1) the significant decrease of the fibroid size, (2) a lower fluid absorption, and (3) the restoration of a normal hemoglobin concentration. [less ▲]

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See detailNEOGENE TO QUATERNARY CLAY MINERAL FLUXES IN THE CENTRAL INDIAN BASIN
DEBRABANT, P.; Fagel, Nathalie ULg; CHAMLEY, H. et al

in Palaeogeography, Palaeoclimatology, Palaeoecology (1993), 103(3-4), 117-131

The late Cenozoic clay sedimentation in the Central Indian Basin was investigated by mineralogical analyses of five very long cores (33-49 m long), which were recovered between 1-degrees and 10-degrees-S ... [more ▼]

The late Cenozoic clay sedimentation in the Central Indian Basin was investigated by mineralogical analyses of five very long cores (33-49 m long), which were recovered between 1-degrees and 10-degrees-S along a transect at about 80-degrees-E and compared with data from adjacent ODP and piston cores. Progressive changes occur from North to South, and are especially marked by a decrease of illite and chlorite amounts balanced by increased contents of smectite and kaolinite. These changes arc attributed to a southwards reduction of Himalaya-derived detrital fluxes, and to a correlative augmentation both of smectite reworked from coastal Indian, Indonesian and volcanic submarine sources, and of kaolinite supplied from Australia and blocked by the equatorial divergence. The stratigraphic changes are more diversified than the geographic changes and develop discontinuously. High fluxes of illitic and chloritic materials during the middle-late Miocene reflect major activity of the Himalayan Main Central Thrust. A tectonic relaxation developed during the latest Miocene-early Pliocene, allowing alternating supply of illite-rich and smectite-rich sediments, which suggests periodical changes from distant to more local supply partly controlled by climate and by Indian intraplate deformations. The more abundant and constant amounts of smectite in late Pliocene-early Pleistocene sediments are chiefly attributed to erosion of Indian coastal zones favored by a worldwide sea-level drop. The middle to late Quaternary increase of the illite group resulted from the resumption of the tectonic activity in the Himalaya-Tibet range associated with a general climatic cooling. [less ▲]

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See detailLe néokantisme comme forme symbolique ? Merleau-Ponty et Panofsky
Cormann, Grégory ULg

Conference (2007, January 17)

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See detailNeoliberaal literatuuronderzoek. Thomas Vaessens over zijn methode, lecturen en stijl
Spinoy, Erik ULg

in Tijdschrift voor Nederlandse Taal- en Letterkunde (2002), 118(3),

This article is a reaction to Thomans Vaessens defence of his book Circus Dubio & Schroom.

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See detailLe Néolithique du Morvan. Etat des connaissances.
Martineau, Rémi; Linton, Jimmy ULg; Affolter, Jehanne et al

in Revue archéologique de l’Est (2011)

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See detailNeología semántica y polisemia: el caso del truncamiento
Steffens, Marie ULg; Baiwir, Esther ULg

in Revista de Investigación Lingüística (2009), 12

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See detailNeomelodici, tamarri e camorristi
Mazzola, Alessandro ULg

in Ferraro, Stefania (Ed.) Discorsi su Napoli. Rappresentazioni della città tra eccessi e difetti (2015)

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See detailThe neon content of nearby B-type stars and its implications for the solar model problem
Morel, Thierry ULg; Butler, K.

in Astronomy and Astrophysics (2008), 487

The recent downward revision of the solar photospheric abundances now leads to severe inconsistencies between the theoretical predictions for the internal structure of the Sun and the results of ... [more ▼]

The recent downward revision of the solar photospheric abundances now leads to severe inconsistencies between the theoretical predictions for the internal structure of the Sun and the results of helioseismology. There have been claims that the solar neon abundance may be underestimated and that an increase in this poorly-known quantity could alleviate (or even completely solve) this problem. Early-type stars in the solar neighbourhood are well-suited to testing this hypothesis because they are the only stellar objects whose absolute neon abundance can be derived from the direct analysis of photospheric lines. Here we present a fully homogeneous NLTE abundance study of the optical Ne I and Ne II lines in a sample of 18 nearby, early B-type stars, which suggests log É (Ne) = 7.97 ± 0.07 dex (on the scale in which log É [H] = 12) for the present-day neon abundance of the local interstellar medium (ISM). Chemical evolution models of the Galaxy only predict a very small enrichment of the nearby interstellar gas in neon over the past 4.6 Gyr, implying that our estimate should be representative of the Sun at birth. Although higher by about 35% than the new recommended solar abundance, such a value appears insufficient by itself to restore the past agreement between the solar models and the helioseismological constraints. Appendices A and B are only available in electronic form at http://www.aanda.org Table [see full text] is also available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsweb.u-strasbg.fr/cgi-bin/qcat?J/A+A/487/307 [less ▲]

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See detailNeonatal ABO incompatibility stays a potentially severe haemolytic disease of the newborn and implies adequate care
Senterre, Thibault ULg; Minon, Jean-Marc

in Archives Françaises de Pédiatrie (2011), 18(3), 279-282

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See detailNeonatal and Preweanling Rats Are Able to Express Short-Term Behavioral Sensitization to Cocaine
Tirelli, Ezio ULg; Ferrara, Marie-Antoinette ULg

in European Journal of Pharmacology (1997), 328(2-3), 103-14

The present study assessed the ability of suckling rats to express short-term behavioral sensitization to cocaine prior to weaning. Rat pups, aged either 3, 5, 10, 12, 17 or 19 days at the beginning of ... [more ▼]

The present study assessed the ability of suckling rats to express short-term behavioral sensitization to cocaine prior to weaning. Rat pups, aged either 3, 5, 10, 12, 17 or 19 days at the beginning of the experiment, were placed in a chamber after daily injection with cocaine (7.5 or 15 mg/kg. i.p.) for either 2 or 4 consecutive days, and were tested for behavioral responsiveness to cocaine in the same chamber 24 h later (at either 7, 14 or 21 days of age). Such a short post-treatment interval was adopted, along with a consistent pairing of the testing context with the drug effect and a sensitive technique of behavioral measurement (video recording), in order to maximize the possibility of detecting any cocaine sensitization. Locomotion was sensitized at all ages, after both regimens in 14-day-old pups, but solely after 2 injections in 21- and 4 injections in 7-day-old pups. Sensitization was also expressed via behaviors specific to each age. Four cocaine injections augmented cocaine-induced uncoordinated movements of head, paws and body (horizontal activity) in 7-day-old pups, and mouth movements in 14-day-old pups. In 21-day-old pups, sensitization was dose- and regimen-dependently expressed via adult-like stereotyped head movements. In neonatal 7-day-old pups, cocaine sensitization was also visible as reductions in immobility (both injection regimens). Contrary to previous studies, these results indicate that, given the use of an appropriate methodology, short-term sensitization to the motoric effects of cocaine can be expressed by suckling rats prior to weaning, even after relatively short regimens of daily injections. [less ▲]

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See detailNeonatal brain injury : pathophysiology and current therapeutic options
VIELLEVOYE, Renaud ULg

Conference (2015, October 23)

Perinatal brain injury is a major contributor to neonatal morbidity and mortality and is a common cause of disability with devastating impact on individuals and families. The mechanisms involved in the ... [more ▼]

Perinatal brain injury is a major contributor to neonatal morbidity and mortality and is a common cause of disability with devastating impact on individuals and families. The mechanisms involved in the genesis of brain lesions depend of the the gestational age at which brain development is altered. In the term infant, the most common pathology implicated in brain damage is hypoxic-ischemic encephalopathy (HIE). HIE is the consequence of an excitotoxic cascade leading to cortical and/or basal ganglia lesions. Therapeutic hypothermia induced in the 6 hours following HIE reduces the risk of death or major neurodevelopmental disability in the neonate with moderate or severe encephalopathy and is the only neuroprotective treatment available in clinical practice. Research is now being focused on other promising strategies such as xenon, allopurinol, N-acetyl cystein, melatonin, anticonvulsant, erythropoietin or stem cell transplantation. In the preterm infant, diffuse white matter injury (dWMI) is the main pathological condition associated with neurological impairment. Based on experimental models, pathophysiological mechanisms of dWMI potentially include infection/inflammation, hypoxia-ischemia and oxidative stress. Experimental studies suggest a sensitizing effect of systemic inflammation that makes the perinatal brain more vulnerable to further insults. Antenatal magnesium sulfate therapy given to women at risk of preterm birth substantially reduced the risk of motor disorders in childhood but is unfortunately unable to reduce long term cognitive impairment or behavioural disorders. Antenatal steroids and caffeine therapy for apnea of prematurity are two other treatments with positive impact on neurodevelopment. Randomized controlled trials studying erythropoietin or melatonin are currently under process. Finally, research performed at the University of Liege suggests that Estetrol (E4), an estrogen synthetized exclusively by the human foetus, has neuroprotective properties in animal models of HIE as well as in inflammatory-induced dWMI. [less ▲]

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See detailNeonatal cirrhosis without iron overload: congenital alloimmune hepatitis
HARVENGT, Julie ULg; de HALLEUX, Virginie ULg; GUIDI, Ornella et al

Conference (2011, March 19)

Background. Fetal liver disease is a rare antenatal disorder for which etiology is frequently unknown. Recently, congenital alloimmune hepatitis emerged as a major cause of antenatal liver disease. Its ... [more ▼]

Background. Fetal liver disease is a rare antenatal disorder for which etiology is frequently unknown. Recently, congenital alloimmune hepatitis emerged as a major cause of antenatal liver disease. Its typical presentation can be as a severe neonatal liver failure with hepatic and extrahepatic iron overload, a clinical state called neonatal hemochromatosis. Methods. A pregnant woman was investigated for heterogeneous fetal hepatomegaly. Pregnancy was also complicated by fetal alloimmune thrombocytopenia. The newborn presented at birth with liver cirrhosis and mild liver dysfunction. Follow-up until 36 months showed progressive normalization of all liver parameters. All metabolic and infectious analyses were negative. Liver biopsy showed severe hepatitis with post-necrotic fibrosis and regenerative nodules. There was no iron overload. To search for immune injury, paraffine sections of the liver biopsy were stained with an antibody against the membrane attack complex (MAC, anti human c5b-9, Peter Whitington’s Lab, Children’s Memorial Hospital, Chicago, IL), the terminal complement cascade neoantigen occurring specifically in complement activation by the IgG-mediated classical pathway, and which is responsible for cell death. Results. Strong immunostaining against MAC-antigen was found in the liver of the patient, with 90% of target hepatocytes whereas in a control group of patients with other neonatal liver diseases, it was 10.8±12.5%. Because IgG in neonates originate only from the mother, it signs the alloimmune nature of the disease. Conclusion. For a long time, pathophysiology of neonatal hemochromatosis remained unsolved. Recently, it was elucidated as congenital alloimmune hepatitis. With this case, we expend the recognized clinical spectrum by showing that congenital alloimmune hepatitis can present as milder cases, without iron overload. It should be considered as a cause of unexplained neonatal liver disease, even in the absence of siderosis. Such diagnosis is of great importance regarding the necessity of immunotherapy in further pregnancies in order to avoid recurrence of alloimmune injury [less ▲]

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