Somatic MEN1 gene mutation does not contribute significantly to sporadic pituitary tumorigenesis.

in European Journal of Endocrinology (1999), 140(6), 573-6

Pituitary adenomas are a common manifestation of multiple endocrine neoplasia type 1 (MEN1) but most of them occur sporadically. There are only a few well defined genetic abnormalities known to occur in ... [more ▼]

Pituitary adenomas are a common manifestation of multiple endocrine neoplasia type 1 (MEN1) but most of them occur sporadically. There are only a few well defined genetic abnormalities known to occur in these sporadic tumours. The MEN1 gene located on 11q13 has recently been cloned and allelic deletion and mutation analysis studies have implicated the MEN1 gene in a significant fraction of the sporadic counterparts of typical MEN1 neoplasms (parathyroid tumours, insulinomas and gastrinomas). To determine if MEN1 gene inactivation is also involved in the development of sporadic pituitary adenomas, allelic deletions of chromosome 11q13 and MEN1 gene mutations and polymorphisms were assessed in 35 sporadic tumours of the anterior pituitary (9 prolactin-secreting, 8 GH-secreting, 3 TSH-secreting, 2 TSH/GH-secreting, 4 Cushing, 9 silent). Thirty-one tumours were found to be heterozygous for at least one MEN1 intragenic polymorphism (25 cases) or for a flanking gene polymorphism (6 cases). The remaining tumours were not informative. No mutations were found in any tumour except in one prolactinoma which was homozygous or hemizygous for a mutation (1-117 C-->T) in a region close to the promoter. Unfortunately, blood or normal tissue was not available in this case. Our data show that somatic MEN1 mutations do not contribute significantly to tumorigenesis of sporadic pituitary adenomas and suggest that mutation of other genes are likely to contribute to the pathogenesis of these tumours. [less ▲]

Somatic MEN1 gene mutation does not significantly contribute to tumorigenesis in 35 anterior pituitary adenomas not associated with the MEN1 syndrome

in 80th Annual Meeting of the Endocrine society - Abstract book (1998)

Somatosensory evoked high-frequency oscillations reflecting thalamo-cortical activity are decreased in migraine patients between attacks

in Brain (2005), 128(Pt 1), 98-103

A deficit of habituation in cortical information processing, including somatosensory evoked potentials (SSEPs), is the most consistent neurophysiological abnormality in migraine patients between attacks ... [more ▼]

A deficit of habituation in cortical information processing, including somatosensory evoked potentials (SSEPs), is the most consistent neurophysiological abnormality in migraine patients between attacks. To explore further the mechanisms underlying this interictal neural dysfunction, we have studied the high-frequency oscillations (HFOs) embedded in SSEPs because they are thought to reflect spike activity in thalamo-cortical cholinergic fibres (early HFOs) and in cortical inhibitory GABAergic interneurons (late HFOs). Untreated migraine patients with (MA) and without (MO) aura were recorded during (n = 13: nine MO, four MA) and between attacks (n = 29: 14 MO, 15 MA) and compared with healthy volunteers. SSEPs were filtered off-line (digital band-pass between 450 and 750 Hz) to extract the two HFO bursts from the broad-band contralateral N20 somatosensory cortical response obtained by median nerve stimulation. In both migraine groups, amplitudes and latencies of conventional broad-band SSEPs recorded interictally from cervical and parietal active electrodes were not significantly different from those found in healthy volunteers. In contrast, maximum peak-to-peak amplitude and area under the rectified curve of the early HFO burst were significantly smaller in both MA and MO patients than in healthy volunteers. There was no significant difference in the later HFO burst between migraineurs and healthy volunteers. During attacks, all electrophysiological measurements in migraineurs were similar to those found in healthy volunteers. Thalamo-cortical activation, as reflected by the early SSEP HFO burst, may thus be reduced in migraine interictally, but normalizes during an attack, whereas intracortical inhibition, as indexed by the late HFO burst, is normal at any time. This supports the hypothesis that the habituation deficit in migraineurs is due to a reduced pre-activation level of sensory cortices and not to increased cortical excitability or reduced intracortical inhibition. [less ▲]

Somatostatin analogs in the gastroentestinal tract

in The handbook of Biologically Active Peptides (2006)

Peptides play a crucial role in many physiological processes including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience ... [more ▼]

Peptides play a crucial role in many physiological processes including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience, immunology, pharmacology, and cell biology. The Handbook of Biologically Active Peptides presents, for the first time, this tremendous body of knowledge in the field of biologically active peptides in one single reference. The section editors and contributors represent some of the most sophisticated and distinguished scientists working in basic sciences and clinical medicine. The Handbook of Biologically Active Peptides is a definitive, all-encompassing reference that will be indispensable for individuals ranging from peptide researchers, to biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and to endocrinologists. Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas with which they would not ordinarily be familiar. [less ▲]

Somatostatini SSTR2 and dopamine D2 receptors gene expression in Growth hormone-producing pituitary adenomas

in 78th Endocrine Society Annual Meeting - Abstract book (1997)

Somatotropic axis in farm animal, Proceedings

Book published by Base (1998)

Somatotropinomas : The role of ligan activated transcription factor AIP

Scientific conference (2008, April)

Some advice for migrating to IFC

in Proceedings of the 17th International Conference on Computer-Aided Architectural Design Research in Asia (2012)

Nowadays, the BIM (Building Information Modeling) paradigm is a central topic in the CAAD community. Next to the commercial solutions, the IFC (Industry Foundation Classes) have emerged as the best open ... [more ▼]

Nowadays, the BIM (Building Information Modeling) paradigm is a central topic in the CAAD community. Next to the commercial solutions, the IFC (Industry Foundation Classes) have emerged as the best open standard candidate for BIM interoperability. Despite the efforts of the community for promoting IFC over the last 15 years, it seems that its practical adoption in real-life projects has been very limited. The goal of this article is to explore how useful IFC can be today and to provide the reader with some advice for an effective adoption of IFC. Over the last year, we have conducted a project aiming at acquiring a sound understanding of IFC. It was made of two complementary investigations. On one hand, we have focused on the commercial modeling tools and the IFC support they were offering. On the other hand, we have focused on the IFC-based software developments. We have developed a tool converting IFC files into a dedicated thermal assessment based model. We will summarize the experience we have acquired in this project into some advice for users migrating to IFC. Our goal is to confront the practical aspects of the IFC developments, with both the theoretical ambitions and the commercial support currently available. [less ▲]

Some Analytical Aspects of Comprehensive Two-Dimensional GC (GCxGC) MS

Scientific conference (2010, February)

Some Applications of Mathematical Morphology to Range Imagery

Conference (1987, April)