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See detailPlatelet-rich plasma (PRP) to treat upper patellar tendinopathies
Kaux, Jean-François ULg; Croisier, Jean-Louis ULg; SIMONI, Paolo ULg et al

in Meeusen, R; Duchateau, J; Roelands, B (Eds.) et al Book of Abstracts of the 17th annual Congress of the ECSS (2012, July)

Introduction: Tendinopathies, especially upper patellar tendinopathy also known as jumper’s knee, often remain rebel to conservative treatments. Several experimental studies have shown the healing ... [more ▼]

Introduction: Tendinopathies, especially upper patellar tendinopathy also known as jumper’s knee, often remain rebel to conservative treatments. Several experimental studies have shown the healing properties of platelet and their growth factors. These factors have the potentiality to improve healing of different tissues: bones, muscles, tendons... Researches have specifically demonstrated the platelets action as mediator and/or enhancer of tissue healing. On the other hand, such treatment has been totally removed of list of doping treatments. The aim of our study was to investigate the effect of 1 injection of PRP in patients suffering from chronic jumper’s knee. Methods: Patients performed imaging (US and MRI) and functional assessments, and a clinical examination using an algometer, before treatment and 6 weeks after PRP treatment. They were also invited to answer to questionnaire relative to pain and functional status. PRP was obtained from autologous blood using an apheresis system (COM.TEC, Fresenius). The injection of 6mL of PRP was realised without local anaesthesia into the proximal insertion of the patellar tendon. A 48h rest-time was recommended after infiltration. Afterwards, a submaximal eccentric reeducation was initiated 1 week after infiltration 3 times a week during 5 weeks. In case of pain, anti-inflammatory drugs were prohibited and patient were encouraged to take class I or II painbrakers. Our protocol was approved by Ethic Committee of University and University Hospital of Liège. Results: Eighteen patients with jumper’s knee were included in our study. Pre-injection tests revealed pain of the upper part of the patellar tendon just below the patella, associated with loss of function. Imaging exams confirmed diagnosis. Six weeks post-injection, the clinical status was improved for the majority of the patients, with a significant decrease of algo-functional scores. The pain reported during functional assessments was decreased (in particular for the eccentric actions), yet no significant improvement of physical performances was observed. We found no significant differences between imaging exams before and 6 weeks after PRP injection. Conclusion: One in situ injection of PRP clinically improved patients with jumper’s knee 6 weeks after treatment. Most patients reported a decrease of pain during day-life and through physical activities. However nor functional performances neither imaging were improved. A followup at 3 months is actually in process to evaluate more long term efficacy of PRP treatment. [less ▲]

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See detailPlatelet-rich plasma (PRP) to treat upper patellar tendinopathies
Kaux, Jean-François ULg; Croisier, Jean-Louis ULg; SIMONI, Paolo ULg et al

in Book of abstracts of 18th Annual Congress of the ECSS (2013, June)

Introduction: Tendinopathies, especially upper patellar tendinopathy also known as jumper’s knee, often remain rebel to conservative treatments. Several experimental studies have shown the healing ... [more ▼]

Introduction: Tendinopathies, especially upper patellar tendinopathy also known as jumper’s knee, often remain rebel to conservative treatments. Several experimental studies have shown the healing properties of platelet and their growth factors. These factors have the potentiality to improve healing of different tissues: bones, muscles, tendons... Researches have specifically demonstrated the platelets action as mediator and/or enhancer of tissue healing. On the other hand, such treatment has been totally removed of list of doping treatments. The aim of our study was to investigate the effect of 1 injection of PRP in patients suffering from chronic jumper’s knee. Methods: Patients performed imaging (US and MRI) and functional assessments, and a clinical examination using an algometer, before treatment and 6 weeks after PRP treatment. They were also invited to answer to questionnaire relative to pain and functional status. PRP was obtained from autologous blood using an apheresis system (COM.TEC, Fresenius). The injection of 6mL of PRP was realised without local anaesthesia into the proximal insertion of the patellar tendon. A 48h rest-time was recommended after infiltration. Afterwards, a submaximal eccentric reeducation was initiated 1 week after infiltration 3 times a week during 5 weeks. In case of pain, anti-inflammatory drugs were prohibited and patient were encouraged to take class I or II painbrakers. Our protocol was approved by Ethic Committee of University and University Hospital of Liège. Results: Eighteen patients with jumper’s knee were included in our study. Pre-injection tests revealed pain of the upper part of the patellar tendon just below the patella, associated with loss of function. Imaging exams confirmed diagnosis. Six weeks post-injection, the clinical status was improved for the majority of the patients, with a significant decrease of algo-functional scores. The pain reported during functional assessments was decreased (in particular for the eccentric actions), yet no significant improvement of physical performances was observed. We found no significant differences between imaging exams before and 6 weeks after PRP injection. Conclusion: One in situ injection of PRP clinically improved patients with jumper’s knee 6 weeks after treatment. Most patients reported a decrease of pain during day-life and through physical activities. However nor functional performances neither imaging were improved. A followup at 3 months is actually in process to evaluate more long term efficacy of PRP treatment. [less ▲]

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See detailPlatelet-rich plasma and tendons healing: rat model
Kaux, Jean-François ULg; Drion, Pierre ULg; Colige, Alain ULg et al

in Annales de Réadaptation et de Médecine Physique (2011, October), 54(Sup 1), 125

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See detailPlatelet-rich plasma and tendons healing: rat model
Kaux, Jean-François ULg; Drion, Pierre ULg; Colige, Alain ULg et al

in Biomedica Life Science Summit (2011, April 07)

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See detailPlatelet-rich plasma application in the management of chronic tendinopathies
Kaux, Jean-François ULg; Crielaard, Jean-Michel ULg

in Acta Orthopaedica Belgica (2013), 79(1), 10-15

Platelet-rich plasma (PRP) may represent a new therapeutic option for chronic tendinopathies. Platelets release various cytokines and growth factors which promote angiogenesis, tissue remodeling, and ... [more ▼]

Platelet-rich plasma (PRP) may represent a new therapeutic option for chronic tendinopathies. Platelets release various cytokines and growth factors which promote angiogenesis, tissue remodeling, and wound healing. We made an exhaustive review of the use of PRP in chronic tendinopathies: epicondylitis, rotator cuff, patellar and calcaneal tendinopathies, and plantar fasciitis. Medline, Embase and Google Scholar were used (until July 31, 2012). Clinical studies about PRP and tendinopathies (in English and French language peer-reviewed journals) were included. Articles with a high level of evidence were considered preferentially. Despite the proven efficacy of PRP on tissue regeneration in experimental studies, there is currently scanty tangible clinical evidence with respect to chronic tendon disorders. The few studies that have been performed appear unlikely to be comparable. Randomized controlled studies with appropriate placebo groups are needed to determine the real effectiveness of PRP for treating chronic musculoskeletal injuries. [less ▲]

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See detailPlatelet-Rich Plasma injection to improve tendon healing process
Kaux, Jean-François ULg; Drion, Pierre ULg; Renouf, Julien et al

in Osteoarthritis and Cartilage (2010, September), 18(Supplement 2), 221

Introduction It is well known that injured tendons do not heal easily. For example, tendinopathy is a condition which often becomes chronic in the case of bad or late management. Recently, several studies ... [more ▼]

Introduction It is well known that injured tendons do not heal easily. For example, tendinopathy is a condition which often becomes chronic in the case of bad or late management. Recently, several studies, essentially in vitro and, more recently, a few in clinical practice, have demonstrated the positive effects of platelets on the healing process of different tissues. In fact, platelets contain lots of growth factors which can be released after a local injection. These growth factors have the potentiality to enhance the tendon healing process, for example after rupture or tendinopathy. The aim of our experiment was to ascertain whether the use of Platelet-Rich Plasma (PRP) was of interest for accelerating the healing process of Achilles tendon after surgical induced lesion. Methods All experimental procedures and protocols used in this investigation / were reviewed and approved by the Institutional Animal Care and Use Committee of the University of Liège. 60 rats were divided into 2 groups: A: control (no injection) and B: PRP injection. A 5mm defect was surgically induced in the rats’ Achilles tendon after resection of plantaris tendon. Rats of group B received a PRP injection in situ after the surgery. Afterwards, rats of both groups were placed in their cages without immobilization. After 5, 15 and 30 days, the traumatized Achilles tendons of 10 rats of both groups were removed and dissected during their healing process. Immediately after sampling, tendons were submitted to a biomechanical tensile test up to rupture, using a “Cryo-jaw”. Rats were then euthanized. Statistical analyses were made with an ANOVA. Values are significant when p-value is below 0.05. Results We observed that the force necessary to induce tendon rupture during biomechanical tensile testing increased with time in both groups; that this force was greater for tendons which had been submitted to an injection of PRP. The ratio between force and weight increased with time in both groups; that this ratio was greater for tendons which had been submitted to an injection of PRP too. There is also a significant interaction between time and the group. The surface area of the section of the tendons increased between 5 and 15 days followed by a stabilization. After 30 days, sections in both groups were similar. Thus, the constraint was similar after 5 and 15 days but is significantly better for PRP group after one month. Discussion – Conclusion We demonstrated that the force necessary to induce tendon rupture during biomechanical tensile testing was greater for tendons which had been submitted to an injection of PRP. These results were observed and significant (p<0.05) from day 5 onwards. We observed too that the section of the tendon was the same in both groups after 30 days. Thus the quality of the healing tendon is better with an injection of PRP, as shown with the increase of the constraint until rupture. Acknowledgement This experimentation was partially financed by “Standard de Liège 2007” and “Lejeune-Lechien 2008” grants. [less ▲]

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See detailPlatelet-rich plasma to treat jumper’s knee: preliminary results
Kaux, Jean-François ULg; CROISIER, Jean-Louis ULg; SIMONI, Paolo ULg et al

in Biomedica 2012 (2012, April)

Introduction: Tendinopathies, especially jumper’s knee, often remain rebel to conservative treatments. Several experimental studies have shown the healing properties of platelet and their growth factors ... [more ▼]

Introduction: Tendinopathies, especially jumper’s knee, often remain rebel to conservative treatments. Several experimental studies have shown the healing properties of platelet and their growth factors. Researches have specifically demonstrated the platelets action as mediator and/or enhancer of tissue healing. The aim of our study was to investigate the effect of 1 injection of PRP in patients suffering from chronic jumper’s knee. Our protocol was approved by Ethic Committee of University and University Hospital of Liège. Methods: Patients performed imaging (US and MRI) and functional assessments, and a clinical examination using an algometer, before treatment and 6 weeks after PRP treatment. They were also invited to answer to questionnaire relative to pain and functional status. PRP was obtained from autologous blood using an apheresis system (COM.TEC, Fresenius). The injection of 6mL of PRP was realised without local anaesthesia into the proximal insertion of the patellar tendon. A 48h rest-time was recommended after infiltration. Afterwards, a submaximal eccentric reeducation was initiated 1 week after infiltration 3 times a week during 5 weeks. In case of pain, anti-inflammatory drugs were prohibited and patient were encouraged to take class I or II painbrakers. Results: At this time, 10 patients with jumper’s knee were included in our study. Pre-injection tests revealed pain of the upper part of the patellar tendon just below the patella, associated with loss of function. Imaging exams confirmed diagnosis. Six weeks post-injection, the clinical status was improved in all patients, with a significant decrease of algo-functional scores. The pain reported during functional assessments was decreased (in particular for the eccentric actions), yet no significant improvement of physical performances was observed. We found no significant differences between imaging exams before and 6 weeks after PRP injection. Conclusion: One in situ injection of PRP clinically improved patients with jumper’s knee 6 weeks after treatment. All the 10 patients reported a decrease of pain during day-life and through physical activities. However nor functional performances neither imaging were improved. [less ▲]

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See detailPlatelet-rich plasma to treat patellar tendinopathies: a 1 year follow-up.
Kaux, Jean-François ULg; Croisier, Jean-Louis ULg; Bruyère, Olivier ULg et al

in Clinical Chemistry & Laboratory Medicine (2014, June), 52(Special Suppl), 1285

Background: Jumper’s knee is a frequent chronic overuse syndrome of the upper part of the patellar tendon. Platelets contain lots of growth factors which could enhance the healing process of tendons ... [more ▼]

Background: Jumper’s knee is a frequent chronic overuse syndrome of the upper part of the patellar tendon. Platelets contain lots of growth factors which could enhance the healing process of tendons. Infiltration of Platelet Rich Plasma (PRP) may be considered as a recent therapeutic option for chronic tendinopathies. The aim of the current study is to evaluate the clinical status and the return to sports activities in patients with chronic upper patellar tendinopathies up to 1 year after 1 infiltration of PRP. Methods: Twenty patients with chronic upper patellar tendinopathy were enrolled. Assessments were made before infiltration of PRP, and 6 weeks and 3 months and 1 year after the infiltration, using a 10-point Visual Analogic Scale and algofunctional scores (IKDC and VISA-P). Moreover, they had to answer an information questionnaire concerning their life and sports activities. The PRP was obtained with an apheresis system (COM.TEC, Fresenius). Six millilitres of PRP were injected without local anaesthetic. One week after infiltration, patients started a standardised sub-maximal eccentric reeducation. Results: Pain during daily activities significantly decreased with time. VAS has significantly dropped, IKDC and VISA-P significantly improved over the follow-up of 1 year. Seventy percents of patients reported a favourable evolution with decrease of pain, 15% did never report any improvement and 15% were treated surgically. Seventy percents returned to sports activities, 64,3% without any pain, and 50% of them recovered the same sport level. Younger patients seemed to be more susceptible to have an improvement of pain by the PRP infiltration. Conclusions: This study demonstrates that a local infiltration of PRP associated with a submaximal eccentric protocol can improve, at 1 year, symptoms of chronic jumper’s knee in patients non-responsive to classical conservative treatments. [less ▲]

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See detailA Platform for High Performance and Flexible Virtual Routers on Commodity Hardware
Egi, Norbert; Greenhalgh, Adam; Handley, Mark et al

in ACM SIGCOMM Computer Communication Review (2010, January)

Multi-core CPUs, along with recent advances in memory and buses, render commodity hardware a strong candidate for software router virtualization. In this context, we present the design of a new platform ... [more ▼]

Multi-core CPUs, along with recent advances in memory and buses, render commodity hardware a strong candidate for software router virtualization. In this context, we present the design of a new platform for virtual routers on modern PC hardware. We further discuss our design choices in order to achieve both high performance and flexibility for packet processing. [less ▲]

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See detailA platform for the fast interpretation of movements and localization of users in 3D applications driven by a range camera
Pierard, Sébastien ULg; Pierlot, Vincent ULg; Barnich, Olivier ULg et al

in Proceedings of the 3DTV Conference (2010, June)

Interactivity is one of the key challenges for immersive applications like gaming. Manufacturers have been working towards interfaces that are driven by a device (e.g. a Wiimote) or interfaces that are ... [more ▼]

Interactivity is one of the key challenges for immersive applications like gaming. Manufacturers have been working towards interfaces that are driven by a device (e.g. a Wiimote) or interfaces that are controlled by a camera with a subsequent computer vision module. Both approaches have unique advantages, but they do not permit to localize users in the scene with an appropriate accuracy. Therefore, we propose to use both a range camera and accurate range sensors to enable the interpretation of movements. This paper describes a platform that uses a range camera to acquire the silhouettes of users, regardless of illumination, and to improve the pose recovery with range information after some image processing steps. In addition, to circumvent the difficult process of calibration required to map range values to physical distances, we complete the system with several range laser sensors. These sensors are located in a horizontal plane, and measure distances up to a few centimeters. We combine all these measurements to obtain a localization map, used to locate users in the scene at a negligible computational cost. Our method fills a gap in 3D applications that requires absolute positions. [less ▲]

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See detailThe PLATO 2.0 Mission
Rauer, H.; Catala, C.; Aerts, C. et al

in Experimental Astronomy (2014)

PLATO 2.0 has recently been selected for ESA’s M3 launch opportunity (2022/24). Providing accurate key planet parameters (radius, mass, density and age) in statistical numbers, it addresses fundamental ... [more ▼]

PLATO 2.0 has recently been selected for ESA’s M3 launch opportunity (2022/24). Providing accurate key planet parameters (radius, mass, density and age) in statistical numbers, it addresses fundamental questions such as: How do planetary systems form and evolve? Are there other systems with planets like ours, including potentially habitable planets? The PLATO 2.0 instrument consists of 34 small aperture telescopes (32 with 25 s readout cadence and 2 with 2.5 s candence) providing a wide field-of-view (2232 deg 2) and a large photometric magnitude range (4–16 mag). It focusses on bright (4–11 mag) stars in wide fields to detect and characterize planets down to Earth-size by photometric transits, whose masses can then be determined by ground-based radial-velocity follow-up measurements. Asteroseismology will be performed for these bright stars to obtain highly accurate stellar parameters, including masses and ages. The combination of bright targets and asteroseismology results in high accuracy for the bulk planet parameters: 2 %, 4–10 % and 10 % for planet radii, masses and ages, respectively. The planned baseline observing strategy includes two long pointings (2–3 years) to detect and bulk characterize planets reaching into the habitable zone (HZ) of solar-like stars and an additional step-and-stare phase to cover in total about 50 % of the sky. PLATO 2.0 will observe up to 1,000,000 stars and detect and characterize hundreds of small planets, and thousands of planets in the Neptune to gas giant regime out to the HZ. It will therefore provide the first large-scale catalogue of bulk characterized planets with accurate radii, masses, mean densities and ages. This catalogue will include terrestrial planets at intermediate orbital distances, where surface temperatures are moderate. Coverage of this parameter range with statistical numbers of bulk characterized planets is unique to PLATO 2.0. The PLATO 2.0 catalogue allows us to e.g.: - complete our knowledge of planet diversity for low-mass objects, - correlate the planet mean density-orbital distance distribution with predictions from planet formation theories,- constrain the influence of planet migration and scattering on the architecture of multiple systems, and - specify how planet and system parameters change with host star characteristics, such as type, metallicity and age. The catalogue will allow us to study planets and planetary systems at different evolutionary phases. It will further provide a census for small, low-mass planets. This will serve to identify objects which retained their primordial hydrogen atmosphere and in general the typical characteristics of planets in such low-mass, low-density range. Planets detected by PLATO 2.0 will orbit bright stars and many of them will be targets for future atmosphere spectroscopy exploring their atmosphere. Furthermore, the mission has the potential to detect exomoons, planetary rings, binary and Trojan planets. The planetary science possible with PLATO 2.0 is complemented by its impact on stellar and galactic science via asteroseismology as well as light curves of all kinds of variable stars, together with observations of stellar clusters of different ages. This will allow us to improve stellar models and study stellar activity. A large number of well-known ages from red giant stars will probe the structure and evolution of our Galaxy. Asteroseismic ages of bright stars for different phases of stellar evolution allow calibrating stellar age-rotation relationships. Together with the results of ESA’s Gaia mission, the results of PLATO 2.0 will provide a huge legacy to planetary, stellar and galactic science. [less ▲]

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See detailThe PLATO End-to-End CCD Simulator -- Modelling space-based ultra-high precision CCD photometry for the assessment study of the PLATO Mission
Zima, W.; Arentoft, T.; De Ridder, J. et al

in Astronomische Nachrichten (2010, October 09), 331(9-10),

The PLATO satellite mission project is a next generation ESA Cosmic Vision satellite project dedicated to the detection of exo-planets and to asteroseismology of their host-stars using ultra-high ... [more ▼]

The PLATO satellite mission project is a next generation ESA Cosmic Vision satellite project dedicated to the detection of exo-planets and to asteroseismology of their host-stars using ultra-high precision photometry. The main goal of the PLATO mission is to provide a full statistical analysis of exo-planetary systems around stars that are bright and close enough for detailed follow-up studies. Many aspects concerning the design trade-off of a space-based instrument and its performance can best be tackled through realistic simulations of the expected observations. The complex interplay of various noise sources in the course of the observations made such simulations an indispensable part of the assessment study of the PLATO Payload Consortium. We created an end-to-end CCD simulation software-tool, dubbed PLATOSim, which simulates photometric time-series of CCD images by including realistic models of the CCD and its electronics, the telescope optics, the stellar field, the pointing uncertainty of the satellite (or Attitude Control System [ACS] jitter), and all important natural noise sources. The main questions that were addressed with this simulator were the noise properties of different photometric algorithms, the selection of the optical design, the allowable jitter amplitude, and the expected noise budget of light-curves as a function of the stellar magnitude for different parameter conditions. The results of our simulations showed that the proposed multi-telescope concept of PLATO can fulfil the defined scientific goal of measuring more than 20000 cool dwarfs brighter than mV =11 with a precision better than 27 ppm/h which is essential for the study of earth-like exo-planetary systems using the transit method. [less ▲]

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See detailThe PLATO Simulator: modelling of high-precision high-cadence space-based imaging
Marcos-Arenal, P.; Zima, W.; De Ridder, J. et al

in Astronomy and Astrophysics (2014)

Many aspects of the design trade-off of a space-based instrument and its performance can best be tackled through simulations of the expected observations. The complex interplay of various noise sources in ... [more ▼]

Many aspects of the design trade-off of a space-based instrument and its performance can best be tackled through simulations of the expected observations. The complex interplay of various noise sources in the course of the observations make such simulations an indispensable part of the assessment and design study of any space-based mission. We present a formalism to model and simulate photometric time series of CCD images by including models of the CCD and its electronics, the telescope optics, the stellar field, the jitter movements of the spacecraft, and all important natural noise sources. This formalism has been implemented in a versatile end-to-end simulation software tool, called PLATO Simulator, specifically designed for the PLATO space mission to be operated from L2, but easily adaptable to similar types of missions. We provide a detailed description of several noise sources and discuss their properties, in connection with the optical design, the allowable level of jitter, the quantum efficiency of the detectors, etc. The expected overall noise budget of generated light curves is computed as a function of the stellar magnitude, for different sets of input parameters describing the instrument properties. The simulator is offered to the scientific community for future use. [less ▲]

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See detailPlaton néokantien
Dewalque, Arnaud ULg

Book published by Vrin (in press)

Recueil de textes des principaux philosophes néokantiens sur la théorie platonicienne des Idées (R. H. Lotze, H. Cohen, P. Natorp, W. Windelband, E. Lask, B. Bauch, R. Hönigswald).

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See detailPlaton: le Politique, introduction, traduction et commentaire
Dixsaut, Monique; El Murr, Dimitri; Gavray, Marc-Antoine ULg et al

Book published by Vrin (in press)

Nouvelle traduction commentée et annotée du Politique de Platon

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See detailPlatonisme et néoplatonisme antique
Gavray, Marc-Antoine ULg

in Touati, Houari (Ed.) Encyclopédie de l'humanisme méditerranéen (2014)

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See detailPlatyhypnidium mutatum, a mysterious new moss from Germany
Ochyra, R.; Vanderpoorten, Alain ULg

in Journal of Bryology (1999), 21

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See detailPlatypsyllus castoris Ritsema, 1869 (Coleoptera, Leptinidae), espèce nouvelle pour la faune de Belgique
Libois, Roland ULg

in Bulletin de la Société Royale Belge d'Entomologie = Bulletin van de Koninklijke Belgische Vereniging voor Entomologie (2000), 136(1), 30-31

This paper reports for the first time, the presence of Platypsyllus castoris Rits. in Belgium. The insects were collected on a road killed European beaver found in Anseremme (Dinant) in December 1999 ... [more ▼]

This paper reports for the first time, the presence of Platypsyllus castoris Rits. in Belgium. The insects were collected on a road killed European beaver found in Anseremme (Dinant) in December 1999. This beaver is one of those that were recently illegaly reintroduced in various parts of southern Belgium. [less ▲]

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