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See detailLarge Sample Size, Wide Variant Spectrum, and Advanced Machine-Learning Technique Boost Risk Prediction for Inflammatory Bowel Disease.
Wei, Zhi; Wang, Wei; Bradfield, Jonathan et al

in American Journal of Human Genetics (2013)

We performed risk assessment for Crohn's disease (CD) and ulcerative colitis (UC), the two common forms of inflammatory bowel disease (IBD), by using data from the International IBD Genetics Consortium's ... [more ▼]

We performed risk assessment for Crohn's disease (CD) and ulcerative colitis (UC), the two common forms of inflammatory bowel disease (IBD), by using data from the International IBD Genetics Consortium's Immunochip project. This data set contains ?17,000 CD cases, ?13,000 UC cases, and ?22,000 controls from 15 European countries typed on the Immunochip. This custom chip provides a more comprehensive catalog of the most promising candidate variants by picking up the remaining common variants and certain rare variants that were missed in the first generation of GWAS. Given this unprecedented large sample size and wide variant spectrum, we employed the most recent machine-learning techniques to build optimal predictive models. Our final predictive models achieved areas under the curve (AUCs) of 0.86 and 0.83 for CD and UC, respectively, in an independent evaluation. To our knowledge, this is the best prediction performance ever reported for CD and UC to date. [less ▲]

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See detailLarge scale 2D numerical modelling of reservoirs sedimentation and flushing operations
Dewals, Benjamin ULiege; Erpicum, Sébastien ULiege; Archambeau, Pierre ULiege et al

in Proceedings of the 9th International Symposium on River Sedimentation (2004)

The quasi-3D flow solver WOLF has been developed at the University of Liege for almost a decade. It has been used to carry out the simulation of silting processes in large reservoirs and to predict the ... [more ▼]

The quasi-3D flow solver WOLF has been developed at the University of Liege for almost a decade. It has been used to carry out the simulation of silting processes in large reservoirs and to predict the efficiency of flushing operations. Besides briefly depicting the mathematical and numerical model, the present paper demonstrates its applicability on the case of a large hydropower project in India. The silting process of the reservoir has been simulated by means of the quasi-3D flow model with a quasi-steady approach. For simulating flushing events, both the topography changes and their interactions with the flow have been carefully handled in a strongly coupled approach. This narrow coupling has required the development of a suitable upwind numerical scheme. Results are presented with 2D- and 3D-views, completed by cross-sections and curves of the variation of key variables. The numerous observations based on those results lead to a global assessment of the silting mechanism and of the flushing efficiency. [less ▲]

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See detailLarge scale acoustic survey as a new tool for the evaluation of coral reef biodiversity (Moorea, French Polynesia)
Bertucci, Frédéric; Lecchini, David; Parmentier, Eric ULiege

Conference (2015)

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See detailLarge Scale and Small Scale Energy Transfer in Relativistic Nuclear Collisions
Cugnon, Joseph ULiege

in Sixième session d'études biennale de Physique Nucléaire, LYCEN 8102, 1981 (1981)

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See detailLarge Scale Assessment of Polyglutamine Repeat Expansions in Parkinson Disease
Wang, Lisa; Aasly, Jan; Anesi, Grazia et al

in Neurology (2015), 85(15), 1283-1292

Objectives: We aim to clarify the pathogenic role of intermediate size repeat expansions of SCA2, SCA3, SCA6, and SCA17 as risk factors for idiopathic Parkinson disease (PD). Methods: We invited ... [more ▼]

Objectives: We aim to clarify the pathogenic role of intermediate size repeat expansions of SCA2, SCA3, SCA6, and SCA17 as risk factors for idiopathic Parkinson disease (PD). Methods: We invited researchers from the Genetic Epidemiology of Parkinson's Disease Consortium to participate in the study. There were 12,346 cases and 8,164 controls genotyped, for a total of 4 repeats within the SCA2, SCA3, SCA6, and SCA17 genes. Fixed- and random-effects models were used to estimate the summary risk estimates for the genes. We investigated between-study heterogeneity and heterogeneity between different ethnic populations. Results: We did not observe any definite pathogenic repeat expansions for SCA2, SCA3, SCA6, and SCA17 genes in patients with idiopathic PD from Caucasian and Asian populations. Furthermore, overall analysis did not reveal any significant association between intermediate repeats and PD. The effect estimates (odds ratio) ranged from 0.93 to 1.01 in the overall cohort for the SCA2, SCA3, SCA6, and SCA17 loci. Conclusions: Our study did not support a major role for definite pathogenic repeat expansions in SCA2, SCA3, SCA6, and SCA17 genes for idiopathic PD. Thus, results of this large study do not support diagnostic screening of SCA2, SCA3, SCA6, and SCA17 gene repeats in the common idiopathic form of PD. Likewise, this largest multicentered study performed to date excludes the role of intermediate repeats of these genes as a risk factor for PD. [less ▲]

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See detailLarge Scale Correlations of Quasar Polarization Vectors: Hints of Extreme Scale Structures?
Cabanac, R. A.; Hutsemekers, Damien ULiege; Sluse, Dominique ULiege et al

in Astronomical Polarimetry: Current Status and Future Directions. ASPC 343 (2005, December 01)

A survey measuring quasar polarization vectors has been started in two regions towards the North and South Galactic Poles. Here, we review the discovery of significant correlations of orientations of ... [more ▼]

A survey measuring quasar polarization vectors has been started in two regions towards the North and South Galactic Poles. Here, we review the discovery of significant correlations of orientations of polarization vectors over huge angular distances. We report new results including a larger sample of the quasars confirming the existence of coherent orientations at redshifts z>1. [less ▲]

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See detailLarge scale enzymatic synthesis of ADP-glucose
Zervosen, Astrid ULiege; Elling, Lothar

Poster (1997, September 22)

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See detailLarge scale experimental study of piano key weirs
Machiels, Olivier ULiege; Erpicum, Sébastien ULiege; Archambeau, Pierre ULiege et al

in Proc. 33rd IAHR Congress: Water Engineering for a Sustainable Environment (2009)

Piano Key Weirs (PKW) are a new type of weir, showing very good flood release capacities as well as strong economic and structural benefits. However, lacks of understanding persist about the flow ... [more ▼]

Piano Key Weirs (PKW) are a new type of weir, showing very good flood release capacities as well as strong economic and structural benefits. However, lacks of understanding persist about the flow conditions on such structures. With the goal to fill some of these lacks, a combined experimental and numerical study has been undertaken at the Laboratory of Structures Hydraulics of the University of Liege. This paper presents the goals and the scientific strategy of this research. The first results of experiments being carried out on a large physical model of PKW are also depicted. These experiments lead to characterization of the flow behavior for low heads and enable to highlight the influence of the crest thickness and the outlet slope on the release capacity. [less ▲]

Detailed reference viewed: 209 (5 ULiège)
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See detailLarge scale network and restoration of peatbogs and wetlands in Southern Belgium
Dufrêne, Marc ULiege; Dierstein, Axelle; Frankard, Philippe et al

Conference (2008)

Detailed reference viewed: 47 (3 ULiège)
See detailLarge scale phenotypic analysis of known and unknown yeast genes
Bianchi, M.; Ngo, S.; Vandenbol, Micheline ULiege et al

Poster (2000)

Detailed reference viewed: 7 (0 ULiège)
See detailLarge scale phenotypic analysis of known and unknown yeast genes.
Bianchi, M.; Ngo, S.; Vandenbol, Micheline ULiege et al

in Last Eurofan Meeting (2000)

Detailed reference viewed: 9 (1 ULiège)
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See detailLarge scale phylogenetic patterns of diversification in Bryophytes
Laenen, Benjamin ULiege

Doctoral thesis (2013)

Detailed reference viewed: 39 (6 ULiège)
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See detailLarge Scale Preparation of [18]Fluoromethoxybenzyl Bromides, Key Precursors for 2-[18F]Fluoro-L-Tyrosine and 6-[18F]Fluoro-L-Dopa
Libert, Lionel ULiege; Lemaire, Christian ULiege; Wouters, Ludovic ULiege et al

in Journal of Labelled Compounds & Radiopharmaceuticals (2009, July), 52(S1), 292

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See detailLarge Scale Preparation of Purified Exocellular DD-carboxypeptidase-Transpeptidase of Streptomyces Strain R61
Fossati, P.; Saint-Ghislain, M.; Sicard, P. J. et al

in Biotechnology and Bioengineering (1978), 20

The exocellular DD-carboxypeptidase–transpeptidase that Streptomyces R61 excretes during growth has been produced in large fermentation units of 15 m3 total capacity. The yield from 15,000 liter culture ... [more ▼]

The exocellular DD-carboxypeptidase–transpeptidase that Streptomyces R61 excretes during growth has been produced in large fermentation units of 15 m3 total capacity. The yield from 15,000 liter culture filtrate was 1.080 g purified enzyme (92% purity) with a total recovery of 29% and at least a 2000-fold increased specific activity. [less ▲]

Detailed reference viewed: 11 (2 ULiège)
See detailLarge scale production of 13-hydroperoxilinolenic acid using soybean lipoxygenase
Fauconnier, Marie-Laure ULiege; Dessart, V.; Marlier, M.

Conference (1996, September 26)

Detailed reference viewed: 23 (0 ULiège)
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See detailLarge scale serological detection in Belgium of enzootic bovine leucosis.
Mammerickx, Marc; Otte, J.; Rase, F. et al

in Zentralblatt für Veterinarmedizin. Reihe B = Journal of Veterinary Medicine. Series B (1978), 25

Detailed reference viewed: 18 (2 ULiège)
See detailLarge Scale Structural Optimization by Finite Elements
Fleury, Claude ULiege

in Atrek, E.; Zienkiewicz, O. C.; Ragsdell, K. M. (Eds.) et al New Directions in Optimum Structural Design (1984)

Detailed reference viewed: 23 (0 ULiège)