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See detailPaf-Receptor. iii. Conformational and Electronic Properties of Paf-Like Agonists and Antagonists
Lamotte-Brasseur, Josette; Dive, Georges ULg; Lamouri, Aazdine et al

in Biochimica et Biophysica Acta (1991), 1085(1), 91-105

In order to compare electronic and conformational properties of PAF-agonists and PAF-antagonists, 14 analogues structurally related to PAF were studied. A common conformation of the glycerol backbone was ... [more ▼]

In order to compare electronic and conformational properties of PAF-agonists and PAF-antagonists, 14 analogues structurally related to PAF were studied. A common conformation of the glycerol backbone was present in all agonists and all constrained or flexible antagonists. The distinction between agonists and antagonists appears to be casted on position-2 where the folded conformation of the substituent for agonists should be the most probable. In position-3 the gauche conformation can be adopted by all the analysed compounds. The electrostatic potential well at -30 kcal/mol stretches to the carbonyl group in position-2 in the folded conformation of the agonists. On the contrary, in constrained antagonists, a second negative zone appears around the carbamate group. Given the modelling results, the triethylammonium PAF analogue considered in literature as a weak agonist, was resynthesized and proved to be more potent than previously reported. These experimental results confirm our hypothesis in terms of a common conformation of agonist and antagonist PAF-like molecules. [less ▲]

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See detailPAF67, a novel protein that is associated with the initiation-competent form of RNA polymerase I.
Seither, P.; Iben, S.; Thiry, Marc ULg et al

in Biological Chemistry (2001), 382(8), 1163-70

Mammalian RNA polymerase I (Pol I) is a multisubunit enzyme that is decorated with accessory proteins, termed PAFs (polymerase-associated factors). The presence or absence of distinct PAFs may account for ... [more ▼]

Mammalian RNA polymerase I (Pol I) is a multisubunit enzyme that is decorated with accessory proteins, termed PAFs (polymerase-associated factors). The presence or absence of distinct PAFs may account for the functional differences of distinct fractions of cellular Pol I, and suggests that PAFs could be targets of regulatory pathways. Here we describe and functionally characterize PAF67, a novel 67 kDa protein that is tightly associated with a subpopulation of cellular Pol I. Both PAF67-containing and -deficient Pol I transcribe non-specific templates with similar efficiency, however, only the enzyme that contains PAF67 is capable of specifically transcribing rDNA templates. PAF67 co-localizes with Pol I in the nucleolus at sites of active rDNA transcription, indicating that PAF67 serves a role in rDNA transcription initiation. The results suggest that association of PAF67 with the 'core' enzyme endows Pol I with the capability to assemble into a productive transcription initiation complex at the rDNA promoter. [less ▲]

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See detailPAG és progeszteron profilok alalkulás in vitro embrióbeültetést követõ vemhességnel hormanális stimuláció és petesejt kinyerés után tehenekben
Tomašković, A.; Prvanović, N.; Beckers, Jean-François ULg et al

in Proceedings: The 5th Middle-European Buiatrics Congress (2004)

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See detailPAG profiles in postpartum dairy cows and newborn calves
Ropstad, E; Kalberg, K; Dahl, E et al

in Reproduction in Domestic Animals (2002), 37(4), 249

In ruminants, pregnancy associated glycoproteins (PAG), synthesized in the outer layers of the trophoblast, enter the maternal bloodstream. In this study, blood samples from cows in the postpartum period ... [more ▼]

In ruminants, pregnancy associated glycoproteins (PAG), synthesized in the outer layers of the trophoblast, enter the maternal bloodstream. In this study, blood samples from cows in the postpartum period, pregnant cows and calves were collected to determine 1) the clearance rate of PAG, 2) the accuracy of PAG measurements used for pregnancy diagnosis and 3) PAG concentrations and clearance rate in newborn calves. A curvilinear decline in PAG was found with increasing days from calving. Between day 70–80 pp 3 out of 11 samples (27%) had PAG concentrations > 4 ng/ml plasma. A cut-off value of 4 ng/ml was found to give the best accuracy for pregnancy diagnosis 28–36 days after service (n ¼58: sensitivity¼0.97; specificity ¼1.0). PAG concentrations in newborn calves (n¼10) varied between 78–880 ng/ml, declining with increasing age in a curvilinear pattern to < 1 ng/ml between 20–40 days pp. In two male twin calves PAG concentrations were 880 and 101 ng/ml, respectively, at one day of age. We conclude: 1) 4 ng PAG /ml provides the best cut-off value for pregnancy diagnosis. 2) Cows serviced before 60 days pp can produce false positive pregnancy diagnoses due to PAG originating from the previous pregnancy. 3) High PAG concentrations can be found in newborn calves. [less ▲]

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See detailPage de Beckett et Beckett de Page
Demoulin, Laurent ULg

E-print/Working paper (2013)

Compte rendu du livre de Martin Page L'Apiculture selon Samuel Beckett.

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See detailPaget’s disease of bone : diagnosis and management
Hosking, D; Meunier, PJ; Ringe, JD et al

in British Medical Journal (1996), 312

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See detailPaget's Disease of Bone Treated with a Five Day Course of Oral Tiludronate
Reginster, Jean-Yves ULg; Lecart, Marie-Paule ULg; Deroisy, Rita ULg et al

in Annals of the Rheumatic Diseases (1993), 52(1), 54-7

Chloro-4-phenyl thiomethylene bisphosphonate (tiludronate) is a new drug which can be used as an inhibitor of bone resorption. As it remains in bone for a long time, and as mineralisation defects have ... [more ▼]

Chloro-4-phenyl thiomethylene bisphosphonate (tiludronate) is a new drug which can be used as an inhibitor of bone resorption. As it remains in bone for a long time, and as mineralisation defects have only been seen at doses much higher than those required to decrease osteoclastic activity, it could be given at high doses over a short period of time. Eighteen patients with Paget's disease of bone were randomly allocated to three therapeutic groups receiving respectively 600, 800, and 1200 mg/day tiludronate for five days. Serum alkaline phosphatase activity and the urinary hydroxyproline/creatinine ratio were quickly and drastically reduced in all three groups. A significant reduction of serum alkaline phosphatases and the hydroxyproline/creatinine ratio was still present six months after the five day therapeutic course, reflecting a sustained activity of tiludronate even after stopping treatment. Dose dependent short and long term reductions of bone turnover rate were observed. Biochemical assessment of haematological, renal, or hepatic tolerance did not show any toxicity of tiludronate. Fifty per cent of patients treated by a dose of 1200 mg/day reported gastrointestinal disturbances, however, making this dosage unsuitable for clinical practice. [less ▲]

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See detailPágina impar: el lugar del traductor en el auge de la industria editorial
Willson, Patricia ULg

in Saítta, Sylvia (Ed.) Historia crítica de la literatura argentina. Volumen 9: El oficio se afirma (2004)

This chapter examines the place occupied by the translator during the period in which Buenos Aires was the publishing Mecca of Latin America. Starting in the 1930s and during the forties and fifties ... [more ▼]

This chapter examines the place occupied by the translator during the period in which Buenos Aires was the publishing Mecca of Latin America. Starting in the 1930s and during the forties and fifties, translating activity was particularly intense in Argentina and incorporated a profusion of what was being written in other literatures. Two realities converged in this boom: a favourable context of the book market and a tradition of handling «the new» set forth by the porteño avant-gardes of the 1920s. [less ▲]

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See detailPAI-1 mediates the antiangiogenic and profibrinolytic effects of 16K prolactin.
Bajou, Khalid ULg; Herkenne, Stéphanie ULg; Thijssen, Victor L. et al

in Nature Medicine (2014), sous presse

The N-terminal fragment of prolactin (16K PRL) inhibits tumor growth by impairing angiogenesis, but the underlying mechanisms are unknown. Here, we found that 16K PRL binds the fibrinolytic inhibitor ... [more ▼]

The N-terminal fragment of prolactin (16K PRL) inhibits tumor growth by impairing angiogenesis, but the underlying mechanisms are unknown. Here, we found that 16K PRL binds the fibrinolytic inhibitor plasminogen activator inhibitor-1 (PAI-1), which is known to contextually promote tumor angiogenesis and growth. Loss of PAI-1 abrogated the antitumoral and antiangiogenic effects of 16K PRL. PAI-1 bound the ternary complex PAI-1-urokinase-type plasminogen activator (uPA)-uPA receptor (uPAR), thereby exerting antiangiogenic effects. By inhibiting the antifibrinolytic activity of PAI-1, 16K PRL also protected mice against thromboembolism and promoted arterial clot lysis. Thus, by signaling through the PAI-1-uPA-uPAR complex, 16K PRL impairs tumor vascularization and growth and, by inhibiting the antifibrinolytic activity of PAI-1, promotes thrombolysis. [less ▲]

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See detailPAI-1 Regulates the Invasive Phenotype in Human Cutaneous Squamous Cell Carcinoma
Freytag, J.; Wilkins-Port, C. E.; Higgins, C. E. et al

in Journal of Oncology Management : The Official Journal of the American College of Oncology Administrators (2009)

The emergence of highly aggressive subtypes of human cutaneous squamous cell carcinoma (SCC) often reflects increased autocrine/paracrine TGF-β synthesis and epidermal growth factor receptor (EGFR ... [more ▼]

The emergence of highly aggressive subtypes of human cutaneous squamous cell carcinoma (SCC) often reflects increased autocrine/paracrine TGF-β synthesis and epidermal growth factor receptor (EGFR) amplification. Cooperative TGF-β/EGFR signaling promotes cell migration and induces expression of both proteases and protease inhibitors that regulate stromal remodeling resulting in the acquisition of an invasive phenotype. In one physiologically relevant model of human cutaneous SCC progression, TGF-β1+EGF stimulation increases the production of several matrix metalloproteinases (MMPs), among the most prominent of which is MMP-10—an MMP known to be elevated in SCC in situ. Activation of stromal plasminogen appears to be critical in triggering downstream MMP activity. Paradoxically, PAI-1, the major physiological inhibitor of plasmin generation, is also upregulated under these conditions and is an early event in progression of incipient epidermal SCC. One testable hypothesis proposes that TGF-β1+EGF-dependent MMP-10 elevation directs focalized matrix remodeling events that promote epithelial cell plasticity and tissue invasion. Increased PAI-1 expression serves to temporally and spatially modulate plasmin-initiated pericellular proteolysis, further facilitating epithelial invasive potential. Defining the complex signaling and transcriptional mechanisms that maintain this delicate balance is critical to developing targeted therapeutics for the treatment of human cutaneous malignancies. [less ▲]

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See detailLe paiement dans la loi Breyne
Kohl, Benoît ULg

in Rousseau, Lorette (Ed.) La Loi Breyne (2011)

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See detailPaiement par cartes de crédit et créance en germe susceptible de saisie-arrêt, note sous Liège (7e ch.), 19 févr. 2007
Georges, Frédéric ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2008)

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See detailLes paiements directs dans les politiques agricole et régionale : le cas des régions défavorisées en Belgique
Foguenne, Marielle; Lebailly, Philippe ULg

Conference (1992)

La réforme de la politique agricole commune s'oriente vers une diminution du soutien des revenus agricoles par les politiques des prix et des marchés. Des mesures d'aides directes modulées et plus ciblées ... [more ▼]

La réforme de la politique agricole commune s'oriente vers une diminution du soutien des revenus agricoles par les politiques des prix et des marchés. Des mesures d'aides directes modulées et plus ciblées seront mises en place afin de compenser la baisse du revenu des agriculteurs. En outre, la politique agricole ne peut être dissociée de la politique régionale qui vise la cohésion économique et sociale entre les diverses régions de la Communauté. Le développement des zones rurales représente un de ses objectifs prioritaires. Les dispositions de soutien direct des revenus peuvent donc jouer un rôle en accordant une aide - sous la forme d'un soutien du revenu minimum - à certaines catégories d'agriculteurs opérant dans des régions défavorisées ou confrontés à une situation difficile. L'une des principales difficultés dans l'élaboration d'une politique régionale de soutien direct au revenu des agriculteurs réside dans la détermination des zones pouvant être prises en considération. L'objectif de la recherche menée est précisément de proposer des critères susceptibles d'orienter l'éligibilité des zones rurales dans le cadre d'actions portant sur la politique des structures et d'analyser les effets des choix opérés pour la Belgique. Dans un premier temps, les auteurs examinent les aides directes octroyées aux régions agricoles défavorisées en Belgique ainsi que les critères pris en compte pour déterminer ces zones. Ensuite, ils présentent les principes et les résultats globaux d'une méthode basée sur la classification numérique et visant à déterminer les zones concernées par le soutien direct des revenus. [less ▲]

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See detailPain after laparoscopic cholecystectomy: characteristics and effect of intraperitoneal bupivacaine.
Joris, Jean ULg; Thiry, E.; Paris, P. et al

in Anesthesia and Analgesia (1995), 81(2), 379-84

Although pain after laparoscopic cholecystectomy is less intense than after open cholecystectomy, some patients still experience considerable discomfort. Furthermore, the characteristics of ... [more ▼]

Although pain after laparoscopic cholecystectomy is less intense than after open cholecystectomy, some patients still experience considerable discomfort. Furthermore, the characteristics of postlaparoscopy pain differ considerably from those seen after laparotomy. Therefore, we investigated the time course of different pain components after laparoscopic cholecystectomy and the effects of intraperitoneal bupivacaine on these different components. Forty ASA physical status grade I-II patients were randomly assigned to receive either 80 mL of bupivacaine 0.125% with epinephrine 1/200,000 (n = 20) or the same volume of saline (n = 20) instilled under the right hemidiaphragm at the end of surgery. Intensity of total pain, visceral pain, parietal pain, and shoulder pain was assessed 1, 2, 4, 6, 8, 24, and 48 h after surgery. Analgesic consumption was also recorded. Patient data were similar in the two groups. In the saline group, visceral pain was significantly more intense than parietal pain at each time point; visceral and parietal pain were greater than shoulder pain during the first 8 h postoperatively. Intraperitoneal bupivacaine did not significantly affect any of the different components of postoperative pain. Analgesic consumption was similar in the two groups. This study demonstrates that visceral pain accounts for most of the pain experienced after laparoscopic cholecystectomy. Intraperitoneal bupivacaine is not effective for treating any type of pain after laparoscopic cholecystectomy. [less ▲]

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