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See detailPossible Role of Human Natural Anti-Gal Antibodies in the Natural Antitumor Defense System
Castronovo, Vincenzo ULg; Colin, Claude ULg; Parent, B. et al

in Journal of the National Cancer Institute (1989), 81(3), 212-6

Expression of Gal alpha 1-3Gal cell surface residues has been correlated with the metastatic potential of murine tumor cells. We report that Gal alpha 1-3Gal residues are expressed at the cell surface of ... [more ▼]

Expression of Gal alpha 1-3Gal cell surface residues has been correlated with the metastatic potential of murine tumor cells. We report that Gal alpha 1-3Gal residues are expressed at the cell surface of malignant human cancer cells, including four cell lines and 50% of the malignant breast specimens obtained by aspiration biopsy. In contrast, all benign breast biopsies and normal cells were Gal alpha 1-3Gal negative. Affinity-purified anti-alpha-galactosyl IgG (anti-Gal) antibody, which specifically recognizes Gal alpha 1-3Gal residues, significantly inhibited cell attachment in two in vitro assays thought to indicate tumor cell extravasation of the circulatory system during the metastatic process: attachment to perfused human umbilical vein endothelium, and attachment to isolated laminin. Since anti-Gal antibody is a natural component of all human sera, we propose that it may be part of the natural antitumor defense system in humans. [less ▲]

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See detailThe Possible Use of VHR Satellite Images in the Public Agencies in Belgium: Brussels, Ghent & Liège from Space.
Binard, Marc ULg; Muller, Fabrice; Donnay, Jean-Paul ULg

in Maktav, Derya; Jürgens, Carsten; Erber Sunar, Filiz (Eds.) et al Proceedings of the 3d International Symposium of Remote Sensing of Urban Areas (2002)

The City promotion project aims at arousing the awareness and possible use of the Very High Resolution (VHR) satellite images in the public agencies and education sector. This project is presently ... [more ▼]

The City promotion project aims at arousing the awareness and possible use of the Very High Resolution (VHR) satellite images in the public agencies and education sector. This project is presently financed by the Belgian federal Office for Scientific, Technical and Cultural affairs (OSTC). Il this purpose, a poster has been prepared showing the three main towns in Belgium _ Brussels, Ghent and Liège - and a website has been devoted to the project. The core of the cities is represented by satellite maps at 1: 5 000 scale. Ikonos panchromatic and multispectral images are merged together in order to obtain coloured images at 1 m resolution able to render the urban fabric of these old cities. Moreover small excerpts at enlarged scale (1: 3 000) show typical places and building in panchromatic mode. The excerpt selected on the famous Brussels “Grand Place” is used to illustrate the fusion process between the panchromatic (1 m) and the multispectral (4 m) images. Two small scale insets present the regional context of these three towns thanks to a natural colour composite made of Landsat 7 ETM+ images on the one hand, and a classical physical map on the other hand. Various exploitations in the classroom of this poster, and others of the same kind, are suggested on the related website (http://www.geo.ulg.ac.be/eduweb). [less ▲]

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See detailPost 9/11 Revisions of the Superhero: Political Subtexts in the Comics’ Series Civil War and Black Summer
Dony, Christophe ULg

Conference (2010, November 06)

Superheroes have been supportive of the state’s ideologies for a long time. From WW II to the Cold War era, they have defended the status quo and fought countless enemies of the establishment while ... [more ▼]

Superheroes have been supportive of the state’s ideologies for a long time. From WW II to the Cold War era, they have defended the status quo and fought countless enemies of the establishment while showing strong nationalist ideology. Yet, in their long existence, these characters and the narratives they feature in, have been subject to many redefinitions, usually during periods of ideological conflicts such as the Vietnam War or the overtly pro-masculine and pro-war politics of the Reagan era. Following this logic, it seems interesting to raise the question whether or not the superhero genre changed after the events of 9/11 and the subsequent ‘War on Terror.’ This question becomes even more important when one draws a parallel between the Bush administration’s political rhetoric of the early aftermath, and the classical superhero Manichean formula whereby good usually prevails over evil. Whereas early superhero comics engaging with 9/11 presented cases of topical suffering, victimization, and sometimes revenge, later superhero texts have confronted readers with moral and political ambiguities. Indirectly or metaphorically referring to the traumatic events of September 11th and its aftermath, many post-9/11 superhero narratives have called into question the binary dialectic, long sustained by the medium itself, and rearticulated by the Bush administration; they have suggested that America was to some extent responsible for, or at least, implicated in the attacks. In doing so, these texts function as powerful political allegories which challenge America’s sense of moral exceptionalism, the state’s implementation of (inter)national security policies, and by extension, the very sociological role of the superheroic figure. In this paper, I aim to demonstrate how two recent superhero comics’ series – Marvel’s multi-authored cross-over Civil War (2006) and Warren Ellis and Juan Jose Ryp’s Black Summer (2008) – have allegorized the events of 9/11 to critique the above issues in different but related ways. More specifically, I argue that these narratives constitute revisions of traditional superhero texts which problematize the morality of superhero figures, comment on the pervasive effects of the mass media, and ultimately challenge the state’s intervention policies in the face of adversity. [less ▲]

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See detailPost earthquake fire and seismic performance of welded steel-concrete composite beam-to-column joints
Pucinotti, Raffaele; Bursi, Oreste; Demonceau, Jean-François ULg

in Journal of Constructional Steel Research (2011), 67

The performance of steel-concrete composite full strength joints endowed with concrete filled tubes, designed with a multi-objective methodology dealing with seismic actions followed by fire is presented ... [more ▼]

The performance of steel-concrete composite full strength joints endowed with concrete filled tubes, designed with a multi-objective methodology dealing with seismic actions followed by fire is presented in this paper. In detail, instead of a traditional single-objective design where fire safety and seismic safety are independently achieved and the sequence of seismic and fire loading are not taken into account, the proposed design approach guarantees: i) both seismic safety and fire safety with regard to accidental actions; ii) fire safety for at least 15 min fire exposure on a joint characterised by stiffness deterioration and strength degradation due to seismic loading. In order to achieve the multi-objective design, full strength beam-to-composite tubular column joints were designed by means of the component method of Eurocode 4 Part 1-1 and Eurocode 3 Part 1-8, while Eurocode 4 Part 1-2 was considered for fire design. Moreover, to face seismic-induced fire, they were enhanced with specific joint components which will be detailed. Both the experimental program and the results provided by seismic tests, pre-damaged tests and fire tests carried out on beam-to-column joints are presented and discussed. The results emonstrate their adequacy in terms of design and performance. Moreover, non-linear numerical simulations clearly show that these joints can be deemed adequate for moment resisting frames of medium ductility class characterized by a behaviour factor of about 4. [less ▲]

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See detailPost hoc analysis of a single IV infusion of zoledronic acid versus daily oral risedronate on lumbar spine bone mineral density in different subgroups with glucocorticoid-induced osteoporosis.
Roux, C.; Reid, D. M.; Devogelaer, J. P. et al

in Osteoporosis International (2012), 23

This study summarizes the treatment effect of zoledronic acid infusion on lumbar spine bone mineral density in different subgroups with glucocorticoid-induced osteoporosis. Zoledronic acid is ... [more ▼]

This study summarizes the treatment effect of zoledronic acid infusion on lumbar spine bone mineral density in different subgroups with glucocorticoid-induced osteoporosis. Zoledronic acid is significantly more effective than risedronate in increasing lumbar spine (LS) bone mineral density (BMD) in both prevention and treatment of glucocorticoid-induced osteoporosis. INTRODUCTION: In patients on glucocorticoids, a single zoledronic acid infusion significantly increased BMD versus daily oral risedronate. We assessed treatment effect on LS BMD in different patient subgroups at month 12 that contributed to the risk of osteoporosis in addition to glucocorticoids. METHODS: Patients randomized to a single IV infusion of zoledronic acid 5 mg or risedronate (5 mg/day) and stratified based on glucocorticoids duration [treatment (>3 months) and prevention (</=3 months) subpopulations] were subgrouped by age; gender; menopausal status in women; dose and duration of prednisone during the trial; and baseline serum 25-OH vitamin D, LS BMD T-score, creatinine clearance, and concomitant medication use. RESULTS: At month 12, zoledronic acid significantly increased LS BMD versus risedronate in patients </=74 years (P < 0.05) in the treatment and 65-74 years (P = 0.0008) in the prevention subpopulation. At month 12, zoledronic acid significantly increased LS BMD versus risedronate in both subpopulations irrespective of gender (all P < 0.05), cumulative prednisone dose (all P < 0.01), and postmenopausal status (all P < 0.05). In premenopausal women, in both subpopulations, zoledronic acid significantly increased total hip BMD (all P < 0.05) versus risedronate at month 12 but not LS BMD. Osteoporotic patients in the prevention (P = 0.0189) and osteopenic patients in the treatment subpopulation (P = 0.0305) showed significant LS BMD increases with zoledronic acid versus risedronate at month 12. CONCLUSIONS: This post hoc analysis suggests that zoledronic acid is significantly more effective than risedronate in increasing LS BMD in prevention and treatment of glucocorticoid-induced osteoporosis across a wide range of patients. [less ▲]

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See detailPost mortem investigations on a fin whale Balaenoptera physalus stranded along the Belgian coast
Jauniaux, Thierry ULg; Charlier, G.; Desmecht, M. et al

in Proceeding of the 13th Annual conference of the European Cetacean Society (1999)

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See detailPost-AGB stars with hot circumstellar dust: binarity of the low-amplitude pulsators
van Winckel, H.; Lloyd Evans, T.; Briquet, Maryline ULg et al

in Astronomy and Astrophysics (2009), 505

Context: The influence of binarity on the late stages of stellar evolution remains an open issue. <BR />Aims: While the first binary post-AGB stars were serendipitously discovered, the distinct ... [more ▼]

Context: The influence of binarity on the late stages of stellar evolution remains an open issue. <BR />Aims: While the first binary post-AGB stars were serendipitously discovered, the distinct characteristics of their spectral energy distribution (SED) allowed us to launch a more systematic search for binaries. We selected post-AGB objects, which exhibit a broad dust excess starting either at H or K, pointing to the presence of a gravitationally bound dusty disc in the system. We initiated an extensive multiwavelength study of those systems and here report on our radial velocity and photometric monitoring results for six stars of early F type, which are pulsators of small amplitude. <BR />Methods: To determine the radial velocity of low signal-to-noise ratio time-series data, we constructed dedicated autocorrelation masks based on high signal-to-noise ratio spectra, used in our published chemical studies. The radial velocity variations were analysed in detail to differentiate between pulsational variability and variability caused by orbital motion. When available, the photometric monitoring data were used to complement the time series of radial velocity data and to establish the nature of the pulsation. Finally, orbital minimalisation was performed to constrain the orbital elements. <BR />Results: All of the six objects are binaries with orbital periods ranging from 120 to 1800 days. Five systems have non-circular orbits. The mass functions range from 0.004 to 0.57 M[SUB]&sun;[/SUB] and the companions are probably unevolved objects of (very) low initial mass. We argue that these binaries must have evolved through a phase of strong binary interaction when the primary was a cool supergiant. Although the origin of the circumstellar disc is not well understood, the disc is generally believed to have formed during this strong interaction phase. The eccentric orbits of these highly evolved objects remain poorly understood. In one object, the line-of-sight grazes the edge of the puffed-up inner rim of the disc. <BR />Conclusions: These results corroborate our earlier statement that evolved objects in binary stars create a Keplerian dusty circumbinary disc. With the measured orbits and mass functions, we conclude that the circumbinary discs seem to have a major impact on the evolution of a significant fraction of binary systems. based on observations collected with the Flemish 1.2 m Mercator telescope at Roque de los Muchachos (Spain), the Swiss 1.2 m Euler telescope at La Silla (Chile) and the 0.5 m and 0.75 m telescopes at SAAO (South-Africa). Tables [see full textsee full text]-[see full textsee full text] are only available in electronic form at http://www.aanda.org Postdoctoral fellow of the Fund for Scientific Research, Flanders. Ph.D. student of the Fund for Scientific Research, Flanders. [less ▲]

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See detailThe post-Born-Oppenheimer regime: dynamics of electronic motion in molecules by attosecond few-cycle spectroscopy
Muskatel, B. H.; Remacle, Françoise ULg; Levine, R. D.

in Physica Scripta (2009), 80(4),

Dynamics of electronic motion when the nuclei are clamped is discussed and shown to be always described as a superposition of adiabatic electronic states. These states are stationary when the nuclei are ... [more ▼]

Dynamics of electronic motion when the nuclei are clamped is discussed and shown to be always described as a superposition of adiabatic electronic states. These states are stationary when the nuclei are clamped but their superposition leads to multiply periodic motion where the natural frequencies are the differences in the energies of the adiabatic electronic states. When one or more of the frequencies are low and the atoms are allowed to move, the electronic rearrangement is commensurate with the motion of the nuclei. This is the usual breakdown of the Born-Oppenheimer approximation. But when the electronic frequencies are higher there is an electronic motion before the nuclei move. The motion can be demonstrated through expectation values such as the multipole moments of the charge distribution. Such superposition states will be excited when the laser pulse width in energy exceeds the spacings of the states. For low-lying valence excited or low Rydberg states this requires a femtosecond or shorter laser pulse. Since the carrier frequency has to be comparable to the excitation energy, the required laser pulses must span only a few cycles. [less ▲]

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See detailPost-buckling behaviour and strength of multi-stiffened aluminium panels under combined axial compression and lateral pressure
Reza Khedmati, Mohammad; Bayatfar, Abbas; Rigo, Philippe ULg

in Marine Structures (2010), 23

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See detailPost-collisional granitoids in the south Carpathians danubian nappes (Romania) : a multi-source origin
Berza, Tudor; Demaiffe, Daniel; Liégeois, Jean-Paul ULg et al

in Terra Abstracts (1997), 9

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See detailPOST-COMBUSTION CO2 CAPTURE: Global Process Simulation and Solvent Degradation
Léonard, Grégoire ULg; Lepaumier, Hélène; Blandina, Fabrice et al

Poster (2012, February)

One of the biggest upcoming challenges concerning both environmental and energy systems engineering is the control and limitation of greenhouse gas emissions due to human activity. Fossil fuels-fired ... [more ▼]

One of the biggest upcoming challenges concerning both environmental and energy systems engineering is the control and limitation of greenhouse gas emissions due to human activity. Fossil fuels-fired power plants are in this context one of the main contributors due to the large amounts of CO2 emitted. Different technologies have been developed for capturing CO2 from such power plants. This work focuses on post-combustion CO2 capture by reactive absorption into amine solvents like monoethanolamine (MEA). The main drawback of this technology is actually the high energy requirement of the process, especially for solvent regeneration. It is then highly interesting to model the capture process so that optimal operating conditions could be approached by simulation thus reducing the number of expensive experimental tests. Thanks to the simulation, it has been possible to identify the most influent process variables and to optimize their value. It was also possible to study the impact of process modifications on the global capture efficiency. The improvements studied allowed for a reduction by up to 14% of the process exergy consumption. Another major drawback of the post-combustion CO2 capture is solvent degradation, which can be due to thermal as well as oxidative mechanisms. Degradation affects the CO2 capture process since it may cause corrosion, foaming and fouling, possibly inducing a decrease of the solvent efficiency and high additional operating costs due to solvent replacement. In order to study degradation of conventional amine solvents as well as degradation of novel solvents, a degradation test rig has been built at the University of Liège in collaboration with the company Laborelec, member of the GDF SUEZ group. First results show that degradation obtained on this lab installation can be compared to degradation results observed on CO2 capture pilot installation. The final objective of this thesis is to make a link between degradation and simulation. Experimental data obtained on the degradation test rig will be implemented into the existing simulation model so that optimal operating conditions considering both process energy efficiency and solvent degradation can be determined. [less ▲]

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See detailPost-encephalitic extra-pyramidal syndrome associating akinesia and stereotyped movements responsive to L-dopa
Picard, F.; Hirsch, E.; Salmon, Eric ULg et al

in Revue Neurologique (1996), 152(4), 267-271

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See detailPost-exposure vaccination improves gammaherpesvirus neutralization.
Gillet, Laurent ULg; May, Janet S; Stevenson, Philip G

in PLoS ONE (2007), 2(9), 899

Herpesvirus carriers transmit infection despite making virus-specific antibodies. Thus, their antibody responses are not necessarily optimal. An important question for infection control is whether ... [more ▼]

Herpesvirus carriers transmit infection despite making virus-specific antibodies. Thus, their antibody responses are not necessarily optimal. An important question for infection control is whether vaccinating carriers might improve virus neutralization. The antibody response to murine gamma-herpesvirus-68 (MHV-68) blocks cell binding, but fails to block and even enhances an IgG Fc receptor-dependent infection of myeloid cells. Viral membrane fusion therefore remains intact. Although gH/gL-specific monoclonal antibodies can block infection at a post-binding step close to membrane fusion, gH/gL is a relatively minor antibody target in virus carriers. We show here that gH/gL-specific antibodies can block both Fc receptor-independent and Fc receptor-dependent infections, and that vaccinating virus carriers with a gH/gL fusion protein improves their capacity for virus neutralization both in vitro and in vivo. This approach has the potential to reduce herpesvirus transmission. [less ▲]

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See detailPost-face : Vers un deuxième âge de la nébuleuse des OSC au Sud?
Poncelet, Marc ULg

in Comhaire, Gaël (Ed.) Société civile et éducation (2010)

The growing number of education (school) hybrid institutions in Africa is supported by transnational trends in education power. A lot of private schools appears but also many "associations" and NGO as ... [more ▼]

The growing number of education (school) hybrid institutions in Africa is supported by transnational trends in education power. A lot of private schools appears but also many "associations" and NGO as parents committees... The paper try to identify some new dimensions in social and political concern. [less ▲]

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See detailPost-fracture management of patients with hip fracture: a perspective.
Bruyère, Olivier ULg; Brandi, M.-L.; Burlet, N. et al

in Current Medical Research & Opinion (2008), 24(10), 2841-51

BACKGROUND: Hip fracture creates a worldwide morbidity, mortality and economic burden. After surgery, many patients experience long-term disability or die as a consequence of the fracture. A fracture is a ... [more ▼]

BACKGROUND: Hip fracture creates a worldwide morbidity, mortality and economic burden. After surgery, many patients experience long-term disability or die as a consequence of the fracture. A fracture is a major risk factor for a subsequent fracture, which may occur within a short interval. METHODS: A literature search on post-fracture management of patients with hip fracture was performed on the Medline database. Key experts convened to develop a consensus document. FINDINGS: Management of hip-fracture patients to optimize outcome after hospital discharge requires several stages of care co-ordinated by a multidisciplinary team from before admission through to discharge. Further studies that specifically assess prevention and post-fracture management of hip fracture are needed, as only one study to date has assessed an osteoporosis medication in patients with a recent hip fracture. Proper nutrition is vital to assist bone repair and prevent further falls, particularly in malnourished patients. Vitamin D, calcium and protein supplementation is associated with an increase in hip BMD and reduction in falls. Rehabilitation is essential to improve functional disabilities and survival rates. Fall prevention and functional recovery strategies should include patient education and training to improve balance and increase muscle strength and mobility. Appropriate management can prevent further fractures and it is critical that high-risk patients are identified and treated. To foster this process, clinical pathways have been established to support orthopaedic surgeons. CONCLUSION: Although hip fracture is generally associated with poor outcomes, appropriate management can ensure optimal recovery and survival, and should be prioritized after a hip fracture to avoid deterioration of health and prevent subsequent fracture. [less ▲]

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See detailThe post-harvest quality of bananas is determined by pre-harvest factors
de Lapeyre de Bellaire, Luc; Chillet, Marc; Lassois, Ludivine ULg et al

Poster (2009)

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See detailPost-invasion evolution of an invasive plant : altitudinal differenciation in germination and growth
Monty, Arnaud ULg; Mahy, Grégory ULg

Conference (2006)

Senecio inaequidens DC. was introduced from South Africa to Europe more than one hundred years ago, in a few precise locations linked to wool industry and extended its distribution throughout Europe. In a ... [more ▼]

Senecio inaequidens DC. was introduced from South Africa to Europe more than one hundred years ago, in a few precise locations linked to wool industry and extended its distribution throughout Europe. In a context of global warming, the potential evolution in germination and growth during the invasion process was studied in relation to altitude and climate. Seeds were collected along two transects (both altitudinal and climatic) in Belgium and France, going from the sea level to high altitudes (respectively 485 m and 1700 m) through the introduction spots. Respectively four and five climatic zones per transect, two populations per zone and ten randomly selected individuals per population were sampled. Seeds were sorted in order to discard maternal effects. Ten seeds per parent individual were thereafter sown in pots in a common garden experiment in Gembloux (Belgium). Germination was checked every two days. Height and diameter of plants, enabling the calculation of plant volume, were measured every 25 days. Despite an important variability, linear regression of first germination time (since sowing) vs altitude was significant (p = 0.001) for the French gradient, but not for the Belgian one. No significant difference was found in germination rate between climatic zones. For each of the three measurement times of plant height and diameter, regression of plant volume vs altitude was also significant for the French transect (p varying from 0.025 to 0.000 according to time), but not for the Belgian one. French plants from elevated locations germinated later and grow slowlier. These preliminary results suggest that contrasted climatic conditions in the French gradient, going from the Mediterranean coast to the Pyrrenean high elevations led to genetic differenciation of Senecio populations during its invasion in southern France. Less contrasted climatic conditions, together with a supposed loss of genetic variability (Lafuma 2003), did not lead to a clear differenciation in Belgium. References : Lafuma, L. (2003). L'invasion de Senecio inaequidens (Asteraceae) en Europe: une approche évolutive. PhD thesis, Montpellier University. [less ▲]

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See detailPost-ischemic hypothermia reduced IL-18 expression and suppressed microglial activation in the immature brain.
Fukui, On; Kinugasa, Yukiko; Fukuda, Aya et al

in Brain Research (2006), 1121(1), 35-45

Inflammation is an important factor for hypoxia-ischemia (HI) brain injury. Interleukin (IL)-18 is a proinflammatory cytokine which may be a contributor to injury in the immature brain after HI. To ... [more ▼]

Inflammation is an important factor for hypoxia-ischemia (HI) brain injury. Interleukin (IL)-18 is a proinflammatory cytokine which may be a contributor to injury in the immature brain after HI. To investigate the effects of post-HI hypothermia on IL-18 in the developing brain, 7-day-old rats were subjected to left carotid artery ligation followed by 8% oxygen for 60 min and divided into a hypothermia group (rectal temperature 32 degrees C for 24 h) and a normothermia group (36 degrees C for 24 h). The IL-18 mRNA was analyzed with real-time RT-PCR, and the protein level was analyzed by Western blot, and the location and source of IL-18 were assessed by immunohistochemistry. The significant increase of the IL-18 mRNA was observed in the ipsilateral hemispheres of the normothermia group at 24 h and 72 h after HI compared with controls, but the level in the ipsilateral hemispheres of the hypothermia group was significantly reduced at both time points, compared with the normothermia group, respectively. The IL-18 protein level in the ipsilateral hemispheres of the normothermia group significantly increased at 72 h after HI compared with controls, however, the protein level of the hypothermia group was significantly decreased, compared with the normothermia group. IL-18-positive cells were observed throughout the entire cortex, corpus callosum (CC) and striatum in the ipsilateral hemispheres of normothermia group at 72 h after HI, however, little positive cells were observed in the hypothermia group. Double labeling immunostaining found that most of the IL-18-positive cells were colocalized with lectin, which is a marker of microglia. The number of ameboid microglia (AM) in the normothermia group was significantly increased in cortex and CC, compared with the number in controls, but there were very few ramified microglia (RM) in these areas. In contrast, the number of AM in the hypothermia group was significantly decreased in cortex and CC, compared with the number in the normothermia group, and there were no significant differences in the number of AM and RM between the hypothermia group and controls. In conclusion, we found that IL-18 mRNA and the protein level were attenuated by post-HI hypothermia and that post-HI hypothermia may decrease microglia activation in the developing brain. [less ▲]

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