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See detailPyridine Derivatives of Nimesulide as New Promising Anti-inflammatory Agents
Renard, Jean-François ULg; Lecomte, Frédéric ULg; de Leval, Xavier et al

Poster (2011, January)

Detailed reference viewed: 36 (2 ULg)
See detailPyridinic sulfonamide derivatives, method of production and use thereof
Delarge, J.; Pirotte, Bernard ULg; Dogné, J. M. et al

Patent (2003)

Detailed reference viewed: 4 (2 ULg)
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See detailPyridinic sulfonamides as potential COX-2 inhibitors
Julemont, F.; De Leval, X.; Damas, J. et al

Poster (2003, May)

Detailed reference viewed: 7 (0 ULg)
See detailPyrido 1,2,4-thiadiazine derivatives, their preparation and use
De Tullio, Pascal ULg; Boverie, S.; Somers, F. et al

Patent (1999)

Detailed reference viewed: 3 (0 ULg)
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See detailPyrido- and benzothiadiazinedioxides structurally related to diazoxide: new activators of the pancreatic and vascular KATP channels
De Tullio, Pascal ULg; Pirotte, Bernard ULg; Antoine, M.-H. et al

in Pflügers Archiv : European Journal of Physiology (1995), 430

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See detailPyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxides: novel class of vasorelaxant drugs
Khelili, S.; Pirotte, Bernard ULg; De Tullio, Pascal ULg et al

Poster (1996, January 12)

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See detailPyridobenzoxazepine and Pyridobenzothiazepine Derivatives as Potential Central Nervous System Agents: Synthesis and Neurochemical Study
Liégeois, Jean-François ULg; Rogister, F. A.; Bruhwyler, J. et al

in Journal of Medicinal Chemistry (1994), 37(4), 519-25

In order to characterize the pharmacological profile of the different chemical classes of pyridobenzazepine derivatives, a series of N-methylpiperazinopyrido[1,4]- and -[1,5]- benzoxa- and benzothiazepine ... [more ▼]

In order to characterize the pharmacological profile of the different chemical classes of pyridobenzazepine derivatives, a series of N-methylpiperazinopyrido[1,4]- and -[1,5]- benzoxa- and benzothiazepine derivatives were prepared. The affinities for D2, D1, 5-HT2, and cholinergic (M) receptors were measured. In comparison to dibenzazepine reference compounds, a strong decrease of the affinities was observed, less pronounced, however, for the substituted analogues. Oxazepine and thiazepine analogues like clozapine (except 8-chloro-6-(4-methylpiperazin-1-yl)-pyrido[2,3-b][1,4]benzoxazepin e (9) and 8-chloro-6-(4-methylpiperazin-1-yl)pyrido[2,3-b][1,4]- benzothiazepine (11)) were found to be inactive against apomorphine stereotypies. In the open-field test in rats, different molecules showed a high disinhibitory activity as observed with anxiolytic drugs. Moreover, 8-chloro-5-(4-methylpiperazin-1-yl)pyrido[2,3-b][1,5]benzoxazepine (14) presented a clozapine-like profile that was confirmed in the behavioral model in dogs and showed most of the behavioral characteristics described for antipsychotic drugs. Its neurochemical profile, in particular the 5-HT2/D2 ratio, was also compatible with atypical antipsychotic activity. [less ▲]

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See detailA pyridothiadiazine (BPDZ 44) as a new and potent activator of ATP-sensitive K+-channels
Pirotte, Bernard ULg; Antoine, M.-H.; De Tullio, Pascal ULg et al

in Biochemical Pharmacology (1994), 47

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See detailPyridothiadiazines as potent activators of KATP channels and inhibitors of insulin secretion
Lebrun, Ph.; De Tullio, Pascal ULg; Antoine, M. H. et al

Poster (1994, October)

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See detailPyridothiadiazines as potent inhibitors of glucose-induced insulin release
Lebrun, P.; Antoine, M.-H.; Ouedraogo, R. et al

in Physiology and Pathophysiology of the Islets of Langerhans (1997)

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See detailPyridothiadiazines inhibit glucose-induced insulin release by activating ATP-sensitive K+ channels
Lebrun, P.; Antoine, M. H.; Ouedraogo, R. et al

Conference (1994, December 10)

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See detailPyrométamorphisme induit par la gézéification souterraine de niveaux charbonneux du Westphalien dans le Bassin de Mons (Belgique)
Nzali, Timothée; Duchesne, Jean-Clair ULg; Jacquemin, Christiane et al

in Geologica Belgica (1999), 2(3-4), 221-234

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See detailPyropheophorbide-a-methyl ester: DMPC liposome vectorization and biophysical properties for PDT
Guelluy, Pierre-Henri ULg; Fontaine-Aupart, Marie-Pierre; Grammenos, Angeliki ULg et al

Poster (2009, July)

Detailed reference viewed: 15 (3 ULg)