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See detailA modified surgical model of fulminant hepatic failure in the rat.
DETRY, Olivier ULg; Gaspar, Yves; CHERAMY-BIEN, Jean-Paul ULg et al

in Journal of Surgical Research (2013), 181

BACKGROUND: There is a need for better animal models of fulminant liver failure (FHF). Eguchi et al described an interesting surgical model of FHF in the rat. This model includes 68% partial hepatectomy ... [more ▼]

BACKGROUND: There is a need for better animal models of fulminant liver failure (FHF). Eguchi et al described an interesting surgical model of FHF in the rat. This model includes 68% partial hepatectomy, ischemia of 24% of the liver mass, and 8% of remnant liver left intact. In the original description by Eguchi et al, rats were administered subcutaneous glucose. However, the authors found that normothermic FHF rats with subcutaneous glucose died from deep hypoglycemia. In this report, we describe a modification of that model, and show that administration of intravenous glucose allows better survival and development of intracranial hypertension. METHODS: We operated on FHF rats using the procedure described by Eguchi et al, kept them normothermic, and maintained normoglycemia by continuous intravenous glucose injection (glucose 10%, 1 mL/h). At 24 h, we monitored liver blood tests (n = 5), intracranial pressure (n = 5), clinical encephalopathy, and survival (n = 10), and compared them with sham and 68% hepatectomy rats. RESULTS: The FHF rats developed acute cytolysis, cholestasis, and liver failure, as demonstrated by the liver blood tests. They experienced progressive encephalopathy and intracranial hypertension leading to death. Mean survival was 45.9 h. Of 10 FHF rats from the survival evaluation cohort, one survived 7 d. Laparotomy showed necrosis of lateral liver lobes and enlargement of omental lobes with a normal hepatic aspect, suggesting liver recovery. CONCLUSIONS: This surgical rat model mimics the features of human FHF and seems interesting for further research into the pathophysiology and therapeutic management of the disease. [less ▲]

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See detailA Modified Tetris Model Including The Effect of Friction
Ludewig, François ULg; Dorbolo, Stéphane ULg; Caps, Hervé ULg et al

in Traffic and Granular Flow'03 (2003)

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See detailModified TiO2-based Photocatalytic Films and Powders produced by Aqueous and Non-Aqueous Sol-Gel Processes for Water Purification
Malengreaux, Charline ULg

Doctoral thesis (2013)

Summary Two major research goals have been proposed for this thesis. The first goal concerns the development of photocatalysts in the shape of thin films coated on glass substrates which includes (i) the ... [more ▼]

Summary Two major research goals have been proposed for this thesis. The first goal concerns the development of photocatalysts in the shape of thin films coated on glass substrates which includes (i) the development of a sol-gel chemistry suitable for the production of stable colloidal suspensions of TiO2 particles, (ii) the optimization of the deposition method and (iii) the development of an experimental device to measure the photocatalytic activity of the films. The second objective is the development of innovative non-aqueous and aqueous sol-gel routes, including the development of new methods for the introduction of dopants as well as the photocatalytic testing of the resulting materials. Two original non-aqueous sol-gel processes involving respectively, an in situ production of water and the controlled addition of a small amount of water, have been developed to produce a series of stable colloidal suspensions of TiO2 particles (sols). From those sols, transparent, adherent, homogeneous thin films have been produced using an optimized dip-coating deposition method and have been proven to be photocatalytically active for the degradation of an organic pollutant in aqueous solution. The photocatalytic activity of the films has been improved through an increase of their roughness thanks to the addition of an organic additive into the sol, leading to an increased active surface involved into the photocatalytic reaction. A mathematical model allowing the rigorous evaluation of the kinetic parameters of the photocatalytic reaction taking into account the influence of the variation of the volume inside the batch photoreactor has been developed. The equations have been established in the case of a photocatalytic powder homogeneously dispersed in the pollutant solution, and in the case of a photocatalytic thin film placed at the bottom of the reactor. The particular case of a first order reaction has been treated and the error on the reaction rate constant induced by neglecting the volume variation has been quantified. An environmentally-friendly aqueous sol-gel process for producing undoped and Cu2+, Ni2+, Zn2+, Pb2+, Fe3+, Cr3+, La3+ or Eu3+ single-doped as well as La3+- Fe3+ and Eu3+- Fe3+ co-doped TiO2 bulk photocatalysts composed of nanocrystallites of anatase and exhibiting a remarkably high photocatalytic activity without requiring any calcination step has been developed. Different effects of the metal ion dopant on the photocatalytic activity have been observed and discussed according to the dopant nature and content. A kinetic study of the photocatalytic degradation of a model pollutant (4-nitrophenol) in aqueous solution under UV-Visible light (330 nm < λ < 800 nm) has been performed over a promising TiO2-Zn2+ doped catalyst. Statistical validations have confirmed the suitability of the phenomenological reaction rate model developed to represent the 4-nitrophenol photocatalytic degradation over time. [less ▲]

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See detailA modified TVD scheme for the advection of two or more variables with consideration for their sum
Mercier, Christophe ULg; Delhez, Eric ULg

in Ocean Dynamics (2010), 60

Total variation diminishing (TVD) advection schemes are known to produce results that are free from some of the numerical artifacts (no overshooting, no spurious oscillation, small diffusion) that can ... [more ▼]

Total variation diminishing (TVD) advection schemes are known to produce results that are free from some of the numerical artifacts (no overshooting, no spurious oscillation, small diffusion) that can spoil the physical significance of the results. When two or more tracers are advected separately using a TVD scheme, the sum of these variables can however exhibit some inappropriate behaviors. The total variation of the sum will not necessarily be non- increasing and local artificial oscillations and extrema can appear. We show that these can be avoided with only minor perturbations of the original solution by adjusting the slope limiters used for the different variables. If the sum of these variables has some physical significance, for instance as refinement of a larger model compartment, the correction procedure introduced in this paper should be used to ensure a physically meaningful solution. [less ▲]

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See detailModifier l'utilisation/la destination d'un bâtiment, en Région wallonne
Delnoy, Michel ULg

in Immobilier (1999), 2

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See detailModifier les représentations de l'échec à l'école normale
Beckers, Jacqueline ULg

in Recherche en Education. Théorie & Pratique (1994), 18-19

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See detailModifying eigenvalue interactions near weak resonance
Auvray, Vincent; Dobson, Ian; Wehenkel, Louis ULg

in Proc. of International Symposium on Circuits and Systems (2004)

In electric power system instabilities such as subsynchronous resonance or interarea oscillations, two complex modes can approach each other in frequency and then interact by changing damping so that one ... [more ▼]

In electric power system instabilities such as subsynchronous resonance or interarea oscillations, two complex modes can approach each other in frequency and then interact by changing damping so that one of the modes becomes unstable. Selecting changes in parameters to minimize this interaction is difficult by trial and error. By analyzing the interaction as a perturbation of a weak resonance, we calculate sensitivities that indicate the parameters to be changed to minimize the interaction and stabilize the system. The method is illustrated with a simple example of two coupled linear oscillators. The use of sensitivity methods to change the type of the interaction is also demonstrated. [less ▲]

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See detailMODIFYING PHYSICAL ENVIRONMENT TO BE APPROPRIATE FOR CHILDREN
Jidovtseff, Boris ULg; Delvaux, Anne ULg; Mornard, Manhattan ULg

in Book of abstracts AISEP 2015 (2015, July)

Our experience confirms that adapting physical environments is critical for providing appropriate physical activity for 3 to 8 years old children.. Moreover, the pedagogy has to favour success, discovery ... [more ▼]

Our experience confirms that adapting physical environments is critical for providing appropriate physical activity for 3 to 8 years old children.. Moreover, the pedagogy has to favour success, discovery and a fun environment. This work illustrates what can be achieved and provides clear guidance for developing centres to support the promotion of physical activity in early childhood. [less ▲]

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See detailUn modo attutito d’esistere: Note su Sbarbaro traduttore dal francese
Benzoni, Pietro ULg

in Ferreri, Davide (Ed.) Camillo Sbarbaro in versi e in prosa (2009)

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See detailA modular approach dedicated to dam-break and dam-breaching modelling
Stilmant, Frédéric ULg; Dewals, Benjamin ULg; Erpicum, Sébastien ULg et al

in Advances in Hydroinformatics (2015)

The paper presents an integrated tool for dam-break hazard modelling. It is based on a two-dimensional, depth-averaged hydraulic model that uses a conservative and shock-capturing finite volume scheme on ... [more ▼]

The paper presents an integrated tool for dam-break hazard modelling. It is based on a two-dimensional, depth-averaged hydraulic model that uses a conservative and shock-capturing finite volume scheme on a Cartesian grid. The hydraulic model is designed so that different zones within the computation domain can be modelled with different spatial resolutions and/or different model enhancements (e.g. pressurised flows, sediment transport, etc.). The two-dimensional model can be coupled with lumped models that compute the water stage in reservoirs and the outflow discharge through hydraulic structures, in case of normal operating, failure of a valve or breaching processes. These features make hydraulic modelling versatile and computationally efficient. They enable the definition of different failure scenarios, which is of prominent importance given the uncertainty of such a phenomenon. If several hydraulic structures are involved, the procedure takes the behaviour of each structure into account. The sensitivity of the results with respect to the interactions between the flow and the terrain (roughness coefficient, collapse of buildings, breaching process) can be analysed. The results of the hydraulic model are handled thanks to a graphical user interface that provides one-, two- and three-dimensional views and animations of the unsteady flow-field and enables the understanding and verification of the results. Danger maps are generated based on the results of one or more ‘worst-case’ scenarios. In case of a complete risk analysis, the danger maps are combined with data on the exposure and vulnerability of elements at risk for the computation of the corresponding damage. [less ▲]

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See detailA modular approach to quality of life assessment in paediatric oncology
Fonseca, Marta; Missotten, Pierre ULg; Etienne, Anne-Marie ULg et al

in Psychology & Health (2009), 24(Supp 1), 175

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See detailA Modular Approach To Study Protein Adsorption on Surface Modified Hydroxyapatite
Ozhukil Kollath, Vinayaraj ULg; Van den Broeck, Freya; Fehér, Krisztina et al

in Chemistry : A European Journal (2015), 21(29), 10497-10505

Biocompatible inorganic nano- and microcarriers can be suitable candidates for protein delivery. This study demonstrates facile methods of functionalization by using nanoscale linker molecules to change ... [more ▼]

Biocompatible inorganic nano- and microcarriers can be suitable candidates for protein delivery. This study demonstrates facile methods of functionalization by using nanoscale linker molecules to change the protein adsorption capacity of hydroxyapatite (HA) powder. The adsorption capacity of bovine serum albumin as a model protein has been studied with respect to the surface modifications. The selected linker molecules (lysine, arginine, and phosphoserine) can influence the adsorption capacity by changing the electrostatic nature of the HA surface. Qualitative and quantitative analyses of linker-molecule interactions with the HA surface have been performed by using NMR spectroscopy, zeta-potential measurements, X-ray photoelectron spectroscopy, and thermogravimetric analyses. Additionally, correlations to theoretical isotherm models have been calculated with respect to Langmuir and Freundlich isotherms. Lysine and arginine increased the protein adsorption, whereas phosphoserine reduced the protein adsorption. The results show that the adsorption capacity can be controlled with different functionalization, depending on the protein–carrier selections under consideration. The scientific knowledge acquired from this study can be applied in various biotechnological applications that involve biomolecule–inorganic material interfaces. [less ▲]

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See detailModular assembly of RanBP2-type zinc finger domains to target single- stranded RNA
O'Connell, M.R.; Vandevenne, Marylène ULg; Nguyen, C.D. et al

in Angewandte Chemie International Edition (2012)

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See detailModular bimorph mirrors for adaptive optics
Rodrigues, Goncalo; Bastaits, Renaud; Roose, Stéphane ULg et al

in Optical Engineering : The Journal of the Society of Photo-Optical Instrumentation Engineers (2009), 3(48),

This paper examines the possibility of constructing deformable mirrors for adaptive optics with a large number of degrees of freedom from silicon wafers with bimorph piezoelectric actuation. The mirror ... [more ▼]

This paper examines the possibility of constructing deformable mirrors for adaptive optics with a large number of degrees of freedom from silicon wafers with bimorph piezoelectric actuation. The mirror may be used on its own, or as a segment of a larger mirror. The typical size of one segment is 100to200mm ; the production process relies on silicon wafers and thick film piezoelectric material deposition technology; it is able to lead to an actuation pitch of the order of 5mm , and the manufacturing costs appear to grow only slowly with the number of degrees of freedom in the adaptive optics. [less ▲]

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See detailModular changes of cis-regulatory elements from two functional Pit1 genes in the duplicated genome of Cyprinus carpio.
Kausel, G.; Salazar, M.; Castro, L. et al

in Journal of Cellular Biochemistry (2006), 99(3), 905-21

The pituitary-specific transcription factor Pit1 is involved in its own regulation and in a network of transcriptional regulation of hypothalamo-hypophyseal factors including prolactin (PRL) and growth ... [more ▼]

The pituitary-specific transcription factor Pit1 is involved in its own regulation and in a network of transcriptional regulation of hypothalamo-hypophyseal factors including prolactin (PRL) and growth hormone (GH). In the ectotherm teleost Cyprinus carpio, Pit1 plays an important role in regulation of the adaptive response to seasonal environmental changes. Two Pit1 genes exist in carp, a tetraploid vertebrate and transcripts of both genes were detected by RT-PCR analysis. Powerful comparative analyses of the 5'-flanking regions revealed copy specific changes comprising modular functional units in the naturally evolved promoters. These include the precise replacement of four nucleotides around the transcription start site embedded in completely conserved regions extending upstream of the TATA-box, an additional transcription factor binding site in the 5'-UTR of gene-I and, instead, duplication of a 9 bp element in gene-II. Binding of nuclear factors was assessed by electro mobility shift assays using extracts from rat pituitary cells and carp pituitary. Binding was confirmed at one conserved Pit1, one conserved CREB and one consensus MTF1. Interestingly, two functional Pit1 sites and one putative MTF1 binding site are unique to the Pit1 gene-I. In situ hybridization experiments revealed that the expression of gene-I in winter carp was significantly stronger than that of gene-II. Our data suggest that the specific control elements identified in the proximal regulatory region are physiologically relevant for the function of the duplicated Pit1 genes in carp and highlight modular changes in the architecture of two Pit1 genes that evolved for at least 12 MYA in the same organism. [less ▲]

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See detailModular Design of the Bi(multi?) functional penicillin-binding proteins
Englebert, Serge; El Kharroubi, Aboubaker; Piras, Graziella et al

in De pedro; Höltje, J. V.; Loffelhardt, W. (Eds.) Bacterial Growth & Lysis Metabolism and Structure of the Bacterial Sacculus (1993)

Proceedings of a symposium held in Mallorca, Spain in April 1992. The goal of the meeting was to assess the present state of knowledge on the structure and physiology of the bacterium murien sacculus, and ... [more ▼]

Proceedings of a symposium held in Mallorca, Spain in April 1992. The goal of the meeting was to assess the present state of knowledge on the structure and physiology of the bacterium murien sacculus, and develop new hypotheses and strategies to promote further development of the field. The contributions reflect broadly different approaches. Papers discuss structure and chemistry, biosynthesis and maturation, regulation and control of cell wall hydrolases, penicillin interactive proteins, morphogenesis and septum formation, and cell growth. Annotation c. Book News, Inc., Portland, OR (booknews.com) [less ▲]

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See detailModular Design of the Enterococcus Hirae Muramidase-2 and Streptococcus Faecalis Autolysin
Joris, Bernard ULg; Englebert, Serge; Chu, Chien-Peng et al

in FEMS Microbiology Letters (1992), 91(3), 257-264

The mature forms of the extracellular muramidase-2 of Enterococcus hirae and Streptococcus faecalis autolysin have very similar primary structures. Each consists of an active-site-containing N-terminal ... [more ▼]

The mature forms of the extracellular muramidase-2 of Enterococcus hirae and Streptococcus faecalis autolysin have very similar primary structures. Each consists of an active-site-containing N-terminal domain fused to a multiple-repeat C-terminal domain. Polypeptide segments occurring at equivalent places in these two bacterial wall lytic enzymes have homologues in two phage lysozymes and in three functionally unrelated proteins, illustrating the principle that protein molecules frequently are constructed from modules that are linked in a single polypeptide chain. [less ▲]

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See detailModular Diversification of the Locomotor System in Damselfishes (Pomacentridae)
Aguilar-Medrano, Rosalia; Frederich, Bruno ULg; Barber, Paul H.

in Journal of Morphology (2016)

As fish move and interact with their aquatic environment by swimming, small morphological variations of the locomotor system can have profound implications on fitness. Damselfishes (Pomacentridae) have ... [more ▼]

As fish move and interact with their aquatic environment by swimming, small morphological variations of the locomotor system can have profound implications on fitness. Damselfishes (Pomacentridae) have inhabited coral reef ecosystems for more than 50 million years. As such, habitat preferences and behavior could significantly constrain the morphology and evolvability of the locomotor system. To test this hypothesis, we used phylogenetic comparative methods on morphometric, ecological and behavioral data. While body elongation represented the primary source of variation in the locomotor system of damselfishes, results also showed a diverse suite of morphological combinations between extreme morphologies. Results show clear associations between behavior, habitat preferences, and morphology, suggesting ecological constraints on shape diversification of the locomotor system. In addition, results indicate that the three modules of the locomotor system are weakly correlated, resulting in versatile and independent characters. These results suggest that Pomacentridae is shape may result from the interaction between (1) integrated parts of morphological variation that main- tain overall swimming ability and (2) relatively independent parts of the morphology that facilitate adaptation and diversification. [less ▲]

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