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See detailPreparation and evaluation of liposomes encapsulating synthetic MMP inhibitor (Ro 28-2653) - cyclodextrin complexes
Piette, Marie ULg; Castagne, Delphine ULg; Delattre, Luc ULg et al

in Journal of Inclusion Phenomena and Macrocyclic Chemistry (2007, April), 57(1-4), 101-103

In this study, preparation and evaluation of liposomes, intended for intravenous administration, encapsulating synthetic MMP inhibitor (Ro 28-2653) - cyclodextrin complexes were realized. An increase in ... [more ▼]

In this study, preparation and evaluation of liposomes, intended for intravenous administration, encapsulating synthetic MMP inhibitor (Ro 28-2653) - cyclodextrin complexes were realized. An increase in Ro solubility, via formation of binary (Ro/HP beta CD) or ternary (Ro/HP beta CD/L-lysine) complexes, permitted a similar increase in encapsulation efficiency of liposomes (Table 1). Moreover, Ro release kinetics depend on the encapsulation efficiency. [less ▲]

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See detailPreparation and in vivo toxicity study of solid lipid microparticles as carrier for pulmonary administration
Sanna, V.; Kirschvink, Nathalie; Gustin, Pascal ULg et al

in AAPS PharmScitech (2004), 5(2), 27

The purpose of this research was to investigate the effects of processing conditions on the characteristics of solid lipid microparticles (SLM) with a potential application as carriers for pulmonary ... [more ▼]

The purpose of this research was to investigate the effects of processing conditions on the characteristics of solid lipid microparticles (SLM) with a potential application as carriers for pulmonary administration. Compritol ( 5.0% wt/ wt) SLM dispersions were prepared by rotor-stator homogenization, at different surfactant concentrations and emulsification times. The SLM were characterized, in terms of morphology and size, after lyophilization and sterilization by autoclaving process. In vivo assessment was carried out in rats by intratracheal instillation of either placebo or SLM dispersion, and by bronchoalveolar lavage for cytological analysis. Mean particle size of 4 to 5 mum was achieved using 0.3% and 0.4% ( wt/ wt) of emulsifier ( Poloxamer 188) and emulsification times of 2 and 5 minutes. The particles showed spherical shape and smooth surface. The morphology of microparticles, the size, and the size distribution were not substantially modified after lyophilization and sterilization. Total cell counts showed no significant differences between placebo and SLM 0.5% or 2.5% groups. Regarding cytology, percentage of polymorphonuclear neutrophils and macrophages did not significantly differ between groups. These results suggest that a single intratracheal administration of the SLMs does not induce a significant inflammatory airway response in rats and that the SLMs might be a potential carrier for encapsulated drug via the pulmonary route. [less ▲]

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See detailPreparation and labelling of biodegradable drug nanocarriers
Rieger, Jutta ULg; Qiu, Hongjin; Mazza, Michaël et al

Poster (2003, May 16)

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See detailPreparation and partial chemical analysis of milk-fat-globule membrane and mammary tumour virus obtained from swiss albino mice
Calberg-Bacq, C. M.; François, C.; Gosselin, L. et al

in Hoppe Seyler's Zeitschrift für Physiologische Chemie (1974)

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See detailPreparation and pharmacological evaluation of the R- and S-enantiomers of 3-(2’-butylamino)-4H- and 3-(3’-methyl-2’-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide, two tissue selective ATP-sensitive potassium channel openers
Khelili, S.; De Tullio, Pascal ULg; Lebrun, P. et al

in Bioorganic & Medicinal Chemistry (1999), 7(8), 1513-1520

The preparation and the pharmacological evaluation of the R- and S-isomers of 3-(2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide (BPDZ 42) and 3-(3-methyl-2-butylamino)-4H-pyrido[4,3-e]-1,2,4 ... [more ▼]

The preparation and the pharmacological evaluation of the R- and S-isomers of 3-(2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide (BPDZ 42) and 3-(3-methyl-2-butylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxide (BPDZ 44), two potassium channel openers, is described. Their optical purity was estimated by means of capillary electrophoresis (R- and S-BPDZ 42) and chiral HPLC (R- and S-BPDZ 44). The absolute configuration of each isomer of BPDZ 44 was deduced from crystallographic data. Pharmacological assays performed with the R- and S-isomers of BPDZ 44 revealed only slight differences in their activity on pancreatic B-cells but significant differences in their activity on vascular smooth muscle cells: the R-isomer being sixfold more potent than its corresponding S-isomer. The R-isomer of BPDZ 42 was shown to be more potent than its corresponding S-isomer on the endocrine pancreas. S-BPDZ 44 as well as R- and S-BPDZ 42 were found to exhibit tissue selectivity for the pancreatic versus the vascular smooth muscle tissue. [less ▲]

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See detailPreparation and properties of layered silicate nanocomposites based on ethylene vinyl acetate copolymers
Alexandre, Michaël ULg; Beyer, Günter; Henrist, Catherine ULg et al

in Macromolecular Rapid Communications (2001), 22(8), 643-646

(Nano)composites based on ethylene vinyl acetate copolymers (EVA) and montmorillonite modified by various alkylammonium cations were processed by mechanical kneading. Polymer intercalation and filler ... [more ▼]

(Nano)composites based on ethylene vinyl acetate copolymers (EVA) and montmorillonite modified by various alkylammonium cations were processed by mechanical kneading. Polymer intercalation and filler exfoliation were evidenced by X-ray diffraction and transmission electron microscopy, respectively. Nano-composites tensile properties showed that Young's modulus increases significantly even at very low content of the organo-modified filler while preserving high ultimate elongation and tensile stress. The matrix thermal stability in air was increased by 40°C and, interestingly, the obtained nanocomposites present flame retardant properties. TEM micrograph of the nanocomposite based on EVA3 filled with 5 wt.-% of Mont-2CN2C18. [less ▲]

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See detailPréparation aux cliniques de chirurgie pédiatrique
Battisti, Oreste ULg

Learning material (2008)

cours préparatoire aux cliniques et stages en chirurgie viscérale du nouveau-né et de l'enfant.

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See detailPréparation aux cliniques: douleur, inconfort et angoisse chez le nouveau-né et l'enfant
Battisti, Oreste ULg

Learning material (2009)

texte synthtétique concernant la douleur, l'angoisse et l'inconfort chez le nouveau-né et l'enfant, y compris les réflexions éthiques et philosophiques

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See detailPréparation aux cliniques: examen neurologique de l'enfant
Battisti, Oreste ULg

Learning material (2006)

présentation pratique des symptomes et signes de l'examen neurologique chez l'enfant

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See detailPréparation aux cliniques: orthopédie et traumatologie de l'enfant
Battisti, Oreste ULg

Learning material (2007)

notes de traumatologie et d'orthopédie sous forme de précis, clinique et imagerie.

Detailed reference viewed: 60 (21 ULg)
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See detailPréparation de complexes mebendazole-HPβCD à l'aide de polymères solubles dans l'eau et d'acides organiques
Alvarez, C; Van Hees, Thierry ULg; Piel, Géraldine ULg et al

in Annales Pharmaceutiques Françaises (2001), 59

Detailed reference viewed: 18 (1 ULg)
See detailPréparation de couches catalytiques pour PEMFC à partir de xérogels de carbone.
Deschamps, Fabien ULg; Traina, Karl; Pirard, Jean-Paul et al

Conference (2012, October 01)

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See detailPréparation de lames minces par FIB et étude MET de la patine de bronze noir
Mirguet, Claude; Malavelle, F.; BenAssayag, G. et al

Conference (2006)

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See detailPréparation de nouveaux copolymères amphiphiles mannosylés d'architecture greffée et caractérisation par QCM-D
Freichels, Hélène ULg; Broze, Guy; Alaimo, David ULg et al

Conference (2009, October 14)

Durant les dernières décennies, le domaine pharmaceutique s’est intéressé aux micelles et nanoparticules polymères celles-ci pouvant être utilisées comme vecteurs à libération contrôlée. Dans ce domaine ... [more ▼]

Durant les dernières décennies, le domaine pharmaceutique s’est intéressé aux micelles et nanoparticules polymères celles-ci pouvant être utilisées comme vecteurs à libération contrôlée. Dans ce domaine, des copolymères amphiphiles combinant le poly(oxyde d’éthylène) (POE), polymère possédant des propriétés répulsives vis-à-vis des protéines plasmiques, et la poly-epsilon-caprolactone (PCL), un polyester aliphatique, polymère hydrophobe biocompatible et biodégradable permettant l’incorporation d’un principe actif hydrophobe, sont d’excellents candidats pour cette d’application. Jusqu’à présent, ce type de copolymère amphiphile principalement étudié est d’architecture linéaire. Récemment, notre laboratoire a développé une stratégie permettant la préparation de nouveaux copolymères greffés, composés d’un squelette principal de PCL et de greffons de POE. De plus, des agents de ciblage peuvent être introduits à l’extrémité du POE de ces copolymères amphiphiles, faisant de ceux-ci des candidats idéaux comme vecteur de troisième génération, permettant un ciblage spécifique au sein même de l’organisme. Le mannose est un agent intéressant, car il est reconnu à la surface des cellules dendritiques. Dans ce travail, la préparation de copolymères greffés fonctionnalisés par du mannose est décrite. La présence de mannose à la surface des micelles a d’abord été mise en évidence par test ELLA (Enzyme Linked Lectin Assay). Ensuite une étude plus approfondie a été réalisée par QCM-D (Microbalance à Cristal de Quartz avec Dissipation). Cette technique originale permet de mettre en évidence l’interaction entre la lectine immobilisée sur la surface du cristal de la microbalance et le mannose exposés à la périphérie des micelles du copolymère. [less ▲]

Detailed reference viewed: 138 (12 ULg)