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See detailPositive Action in Belgium: Fragmentation or Reinforcement of Belgian Citizenship ?
Martiniello, Marco ULg

Scientific conference (1998, November 09)

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See detailPositive and negative aspects of « Sport + Studies Programmes » organized at secondary school level, perceived by athletes and their classmates
Cloes, Marc ULg; Schelings, Virginie; Ledent, Maryse et al

in Gomez, Varera; Gonzalez, Valeiro; Sanchez, Molina (Eds.) Preparacion professional y necesidades socials (Educacion fisica, deporte, ocio, tercera edad, salud...). Proceedings of the AIESEP International Congress (2004)

In many sports, top level athletes have experienced years of hard practice. Training must be intensive and abide to high quality criteria. Today, promising teenagers are enrolled in sport programmes ... [more ▼]

In many sports, top level athletes have experienced years of hard practice. Training must be intensive and abide to high quality criteria. Today, promising teenagers are enrolled in sport programmes. However, the success of sport careers is so hazardous that it is necessary to guarantee the best school preparation to youths following their way to top level sport ... [less ▲]

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See detailPositive and negative aspects of « Sport + Studies Programmes » organized at secondary school level, perceived by athletes and their classmates
Cloes, Marc ULg; Schelings, Virginie; Ledent, Maryse et al

Poster (2002, October)

In several sports, athletes reaching the world-class level have experienced hard years of practice. Training must be intensive and respect high quality criteria. Today, promising teenagers are enrolled in ... [more ▼]

In several sports, athletes reaching the world-class level have experienced hard years of practice. Training must be intensive and respect high quality criteria. Today, promising teenagers are enrolled in sport programmes. However sport career achievement being so hazardous, it is necessary to guarantee the best school preparation to youths following the way to high level sport. ... [less ▲]

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See detailPositive and Negative Ion Formation in Ketene by Electron Impact
Collin, Jacques ULg; Locht, Robert ULg

in International Journal of Mass Spectrometry and Ion Physics (1970), 3

Dissociation processes leading to positive and negative ions in ketene are discussed on the basis of appearance potential measurements. All important positive and negative ions are examined. For the ... [more ▼]

Dissociation processes leading to positive and negative ions in ketene are discussed on the basis of appearance potential measurements. All important positive and negative ions are examined. For the negative ions, only resonance dissociative attachment processes are considered. Excited electronic states of negative ions, in particular for O-, may explain the structure observed in the dissociative attachment efficiency curves. [less ▲]

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See detailPositive and negative ion mode ESI-MS and MS/MS for studying drug-DNA complexes
Rosu, Frédéric ULg; Pirotte, Sophie ULg; De Pauw, Edwin ULg et al

in International Journal of Mass Spectrometry (2006), 253(3), 156-171

We report systematic investigation of duplex DNA complexes with minor groove binders (Hoechsts 33258 and 33342, netropsin and DAPI) and intercalators (daunomycin, doxorubicin, actinomycin D, ethidium ... [more ▼]

We report systematic investigation of duplex DNA complexes with minor groove binders (Hoechsts 33258 and 33342, netropsin and DAPI) and intercalators (daunomycin, doxorubicin, actinomycin D, ethidium, cryptolepine, neocryptolepine, m-Amsacrine, proflavine, ellipticine and mitoxantrone) by ESI-MS and ESI-MS/MS in the negative ion mode and in the positive ion mode. The apparent solution phase equilibrium binding constants can be determined by measuring relative intensities in the ESI-MS spectrum. While negative ion mode gives reliable results, positive ion mode gives a systematic underestimation of the binding constants and even a complete suppression of the complexes for intercalators lacking functional groups capable of interacting in the grooves. In the second part of the paper we systematically compare MS/MS fragmentation channels and breakdown curves in the positive and the negative modes, and discuss the possible uses and caveats of MS/MS in drug-DNA complexes. In the negative mode, the drugs can be separated in three groups: (1) those that leave the complex with no net charge; (2) those that leave the complex with a negative charge; and (3) those that remain attached on the strands upon dissociation of the duplex due to their positive charge. In the positive ion mode, all complexes fragment via the loss of protonated drug. Information on the stabilization of the complex by drug-DNA noncovalent interactions can be obtained straightforwardly only in the case of neutral drug loss. In all other cases, proton affinity (in the positive ion mode), gas-phase basicity (in the negative ion mode) and coulombic repulsion are the major factors influencing the fragmentation channel and the dissociation kinetics. [less ▲]

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See detailPositive control of ammonia-sensitive permeases by the positive regulatory factor NPR1
Vandenbol, Micheline ULg; Jauniaux, J. C.; Vissers, S. et al

Poster (1986)

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See detailPositive curvature effects and interparticle capillary condensation during nitrogen adsorption in particulate porous materials
Gommes, Cédric ULg; Ravikovitch, Peter; Neimark, Alexander

in Journal of Colloid and Interface Science (2007), 314

The adsorption of nitrogen in a collection of spheres that touch or merge in a sintering-like manner is modeled using a Derjaguin–Broeckhof–de Boer approach. The proposed model accounts for both positive ... [more ▼]

The adsorption of nitrogen in a collection of spheres that touch or merge in a sintering-like manner is modeled using a Derjaguin–Broeckhof–de Boer approach. The proposed model accounts for both positive curvature effects and for capillary condensation at the contact between two spheres. A methodology is proposed to fit the P/P0 > 0.4 adsorption region with the coordination number of the spheres as the only adjustable parameter. The use of the model is illustrated on a series of silica aerogels. The suitability of various standard isotherms needed for the modeling is also discussed. [less ▲]

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See detailPositive effects of glucocorticoids on T cell function by upregulation of interleukin-7 receptor alpha
Franchimont, Denis; Galon, Jérôme; Vacchio, Melanie S. et al

in Journal of Immunology (2002), 168

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See detailPositive effects of strontium ranelate on spine osteoarthritis progression
Bruyère, Olivier ULg; Delferriere, D.; Roux, C. et al

in Annals of the Rheumatic Diseases (2007, July), 66(Suppl.II), 58

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See detailPositive impact of compliance to strontium ranelate on the risk of non-vertebral osteoporotic fractures
Rabenda, Véronique ULg; Reginster, Jean-Yves ULg

in Osteoporosis International (2009, March), 20(Suppl.1), 89

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See detailPositive impact of compliance to strontium ranelate on the risk of nonvertebral osteoporotic fractures.
Rabenda, Véronique ULg; Reginster, Jean-Yves ULg

in Osteoporosis International (2010), 21(12), 1993-2002

Adherence is now one of the major issues in the management of osteoporosis. This paper relates the relationship existing between adherence to strontium ranelate and the risk of subsequent nonvertebral ... [more ▼]

Adherence is now one of the major issues in the management of osteoporosis. This paper relates the relationship existing between adherence to strontium ranelate and the risk of subsequent nonvertebral fracture among postmenopausal women with osteoporosis. INTRODUCTION: The aim of this study is to investigate compliance to strontium ranelate (SR) therapy and the impact of compliance on the risk of nonvertebral fractures among women with osteoporosis. METHODS: This study was a post-hoc analysis of pooled data from two international, phase III, randomized, placebo-controlled, double-blind studies (the Spinal Osteoporosis Therapeutic Intervention and Treatment Of Peripheral Osteoporosis). A nested case-control study was performed in the strontium ranelate-treated population. Compliance was quantified using the medication possession ratio (MPR). RESULTS: Two hundred eighty-five nonvertebral fracture cases (hip fx n = 70; major nonvertebral fx n = 213) were identified and matched to 1,425 controls. The mean MPR was 86.8% for controls and 82.6% for cases (p < 0.001). Women who were compliant to SR had a 38% reduction in all nonvertebral fractures compared with those who were not (OR = 0.62; 95%CI[0.47-0.81; p < 0.001). Considering hip fractures only, the risk was reduced by 50% for compliant patients compared to noncompliant patients (OR = 0.50; 95%CI[0.28-0.88]; p < 0.05). CONCLUSION: Our analyses emphasize the importance of good compliance to treatment in order to reduce the risk of osteoporotic fractures. In particular, there was a greater reduction in the risk of nonvertebral and hip fractures with increase compliance. [less ▲]

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See detailPositive interactive radiosensitization observed in vitro with the combination of two nucleoside analogs (E)-2'-deoxy-2'-(fluoromethylene) cytidine (FMdC) and iododeoxyuridine (IdUrd).
Coucke, Philippe ULg; Cottin, E; Azria, D et al

in European Journal of Cancer (2004)

(E)-20-Deoxy-20-(fluoromethylene) cytidine (FMdC), an inhibitor of ribonucleotide diphosphate reductase (RR), is a potent radiation-sensitiser acting through alterations in the deoxyribonucleoside ... [more ▼]

(E)-20-Deoxy-20-(fluoromethylene) cytidine (FMdC), an inhibitor of ribonucleotide diphosphate reductase (RR), is a potent radiation-sensitiser acting through alterations in the deoxyribonucleoside triphosphate (dNTP) pool in the de novo pathway to DNA synthesis. The activity of thymidine kinase (TK), a key enzyme in the ‘salvage pathway’, is known to increase in response to a lowering of dATP induced by FMdC. Nucleoside analogues such as iododeoxyuridine (IdUrd) are incorporated into DNA after phosphorylation by TK. Radiation sensitisation by IdUrd depends on IdUrd incorporation. Therefore, we have investigated the radiosensitising effect of the combination of FMdC and IdUrd on WiDr (a human colon cancer cell-line) and compared it to the effect of either drug alone. We analysed the effects of FMdC and IdUrd on the dNTP pools by high-performance liquid chromatography, and measured whether the incorporation of IdUrd was increased by FMdC using a [125I]-IdUrd incorporation assay. The combination in vitro yielded radiation-sensitiser enhancement ratios of >2, significantly higher than those observed with FMdC or IdUrd alone. Isobologram analysis of the combination indicated a supra-additive effect. This significant increase in radiation sensitivity with the combination of FMdC and IdUrd could not be explained by changes in the dNTP pattern since the addition of IdUrd to FMdC did not further reduce the dATP. However, the increase in the radiation sensitivity of WiDr cells might be due to increased incorporation of IdUrd after FMdC treatment. Indeed, a specific and significant incorporation of IdUrd into DNA could be observed with the [125I]-IdUrd incorporation assay in the presence of 1 lM unlabelled IdUrd when combined with FMdC treatment. 2004 Elsevier Ltd. All rights reserved. [less ▲]

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See detailPositive parity pentaquarks in a Goldstone boson exchange model
Stancu, Floarea ULg

in Physical Review. D : Particles and Fields (1998), D58

We study the stability of the pentaquarks $uudd\overline{Q}$, $uuds\overline{Q}$ and $udss\overline{Q}$ ($Q = c$ or $b$) of positive parity in a constituent quark model based on Goldstone boson exchange ... [more ▼]

We study the stability of the pentaquarks $uudd\overline{Q}$, $uuds\overline{Q}$ and $udss\overline{Q}$ ($Q = c$ or $b$) of positive parity in a constituent quark model based on Goldstone boson exchange interaction between quarks. The pentaquark parity is the antiquark parity times that of a quark excited to a p-shell. We show that the Goldstone boson exchange interaction favors these pentaquarks much more than the negative parity ones of the same flavour content but all quarks in the ground state. We find that the nonstrange pentaquarks are stable against strong decays. [less ▲]

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See detailA positive response to infliximab in Crohn disease: Association with a higher systemic inflammation before treatment but not with-308 TNF gene polymorphism
Louis, Edouard ULg; Vermeire, S.; Rutgeerts, P. et al

in Scandinavian Journal of Gastroenterology (2002), 37(7), 818-824

Background: Two-thirds to three-fourths of patients with either refractory luminal or fistulizing Crohn disease respond to infliximab treatment. The ability or inability to respond seems to persist over ... [more ▼]

Background: Two-thirds to three-fourths of patients with either refractory luminal or fistulizing Crohn disease respond to infliximab treatment. The ability or inability to respond seems to persist over time. Biological characteristics and/or genetic background can influence the response to treatment. The aim was to assess the value of C-reactive protein and TNF-alpha serum levels before treatment as well as the TNF -308 gene polymorphism in the prediction of response to infliximab treatment in Crohn disease. Methods: Two-hundred-and-twenty-six Crohn disease patients treated in the setting of an expanded access programme to infliximab in Belgium were studied. There were 136 refractory luminal diseases and 90 refractory fistulizing diseases. Luminal diseases were treated with one single infusion; fistulizing diseases with three infusions at weeks 0, 2 and 6. A clinical response to treatment was defined as either a Crohn disease activity index <150 (complete) or a drop of 70 points (partial) at week 4, for luminal disease, and as either complete fistula healing (complete) or a decrease of at least 50% of the number of draining fistulas on two consecutive visits between weeks 0 and 18, for fistulizing disease. CRP and serum TNF-α levels were measured at week 0 before treatment and were compared between responders and non- responders. Patients were genotyped for the -308 TNF gene polymorphism, and allelic as well as genotype frequencies were compared between responders and non- responders. Results: There were 73.2% responders (46.4% complete and 26.8% partial) and 26.8% non- responders. Response rates were similar in luminal and fistulizing diseases. CRP level before treatment was significantly higher in responders than in non-responders (16.8 mg/l (5-160) versus 9.6 mg/l (5-143); P = 0.02). Furthermore, response rate was significantly higher in patients with elevated CRP (> 5 mg/l) than in patients with a normal CRP value (< 5 mg/l) before treatment (76% versus 46%; P = 0.004; OR: 0.26 (0.11-0.63)). Allelic and genotype frequencies for -308 TNF gene polymorphis m were not significantly different between responders and non- responders - with the exception of a slightly higher TNF2 frequency in nonresponders in luminal disease (22.1% versus 11.6%; P = 0.04). However, this was not associated with a significant difference in genotype frequencies. Conclusion: A positive clinical response to infliximab was associated with a higher CRP level before treatment in our population of Crohn disease patients, but there was no relevant association with -308 TNF gene polymorphism. We therefore suggest that CRP level may help to identify better candidates for infliximab treatment. [less ▲]

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See detailPositively Cooperative Binding of Zinc Ions to Bacillus cereus 569/H/9 beta-Lactamase II Suggests that the Binuclear Enzyme Is the Only Relevant Form for Catalysis
Jacquin, Olivier ULg; Balbeur, Dorothée ULg; Damblon, Christian ULg et al

in Journal of Molecular Biology (2009), 392(5), 1278-1291

Metallo-beta-lactamases catalyze the hydrolysis of most beta-lactam antibiotics and hence represent a major clinical concern. While enzymes belonging to subclass B1 have been shown to display maximum ... [more ▼]

Metallo-beta-lactamases catalyze the hydrolysis of most beta-lactam antibiotics and hence represent a major clinical concern. While enzymes belonging to subclass B1 have been shown to display maximum activity as dizinc species, the actual metal-to-protein stoichiometry and the affinity for zinc are not clear. We have further investigated the process of metal binding to the beta-lactamase H from Bacillus cereus 569/H/9 (known as BcII). Zinc binding was monitored using complementary biophysical techniques, including circular dichroism in the far-UV, enzymatic activity measurements, competition with a chromophoric chelator, mass spectrometry, and nuclear magnetic resonance. Most noticeably, mass spectrometry and nuclear magnetic resonance experiments, together with catalytic activity measurements, demonstrate that two zinc ions bind cooperatively to the enzyme active site (with K-1/K-2 >= 5) and, hence, that catalysis is associated with the dizinc enzyme species only. Furthermore, competitive experiments with the chromophoric chelator Mag-Fura-2 indicates K-2 < 80 nM. This contrasts with cadmium binding, which is clearly a noncooperative process with the mono form being the only species significantly populated in the presence of 1 molar equivalent of Cd(II). Interestingly, optical measurements reveal that although the apo and dizinc species exhibit undistinguishable tertiary structural organizations, the metal-depleted enzyme shows a significant decrease in its alpha-helical content, presumably associated with enhanced flexibility. (C) 2009 Elsevier Ltd. All rights reserved. [less ▲]

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See detailPositron Emission Tomographic Study in Alzheimer's Disease and Pick's Disease
Salmon, Eric ULg; Franck, Georges ULg

in Archives of Gerontology and Geriatrics. Supplement (1989), 1

Positron Emission Tomography has been used to compare patients with Alzheimer's disease and 3 patients with biopsy-proved Pick's disease to age-matched volunteers. In Alzheimer's disease, there was a ... [more ▼]

Positron Emission Tomography has been used to compare patients with Alzheimer's disease and 3 patients with biopsy-proved Pick's disease to age-matched volunteers. In Alzheimer's disease, there was a trend to a decrease of the metabolism parallel to the severity of the affection. The hypometabolism was predominant in the temporo-parieto-occipital and the middle temporal regions. In 2 cases of Pick's disease with a classical "frontal syndrome", there was an important fronto-temporal hypometabolism, very suggestive of the diagnosis owing to both its location and intensity. A third patient presented with a slowly progressive dysphasia. A left perisylvian hypometabolism was observed before any evident anatomical abnormality. The clinical symptoms evolved to a dementia and the hypometabolism extended to both frontal lobes. [less ▲]

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