Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
Peer Reviewed
See detailL'oxygénothérapie hyperbare. Premières applications
Lamy, Maurice ULg; Hanquet, Marcel

in Acta Anaesthesiologica Belgica (1968), 19

Detailed reference viewed: 34 (2 ULg)
Peer Reviewed
See detailL'oxygénothérapie hyperbare. Principes généraux. Résultats.
Hanquet, Marcel; Lamy, Maurice ULg

in Revue Médicale de Liège (1969), 24(10), 408-12

Detailed reference viewed: 41 (0 ULg)
Full Text
Peer Reviewed
See detailOxylipin Profile And Antioxidant Status Of Potato Tubers During Extended Storage At Room Temperature
Delaplace, Pierre ULg; Rojas-Beltran, J.; Frettinger, P. et al

in Plant Physiology and Biochemistry (2008), 46(12), 1077-1084

Detailed reference viewed: 29 (2 ULg)
See detailOxylipin profiles of Solanum esculentum and Solanum pennellii under salt stress conditions
Ghars, Mohamed Ali ULg; Frettinger, P.; Ghanem, M. E. et al

Poster (2009, June 05)

Detailed reference viewed: 36 (0 ULg)
Full Text
See detailOxylipins in plant defense against aphids
Avila, Carlos; Arevalo-Soliz, Milenka; Fauconnier, Marie-Laure ULg et al

Poster (2011, July 11)

Detailed reference viewed: 32 (8 ULg)
Peer Reviewed
See detailOxytocin and neurophysin in cultures of bovine granulosa cells
Geenen, Vincent ULg; Legros, Jean-Jacques ULg; Hagelstein, Marie-Thérèse ULg et al

in Journal of Steroid Biochemistry (1984), 20

Detailed reference viewed: 7 (0 ULg)
Full Text
Peer Reviewed
See detailOxytocin and vasopressin autocrine/paracrine signaling in small cell lung carcinoma
Pequeux, Christel ULg; Keegan, B. P.; Hagelstein, Marie-Thérèse ULg et al

in International Journal of Molecular Medicine (2003), 12/S1

Detailed reference viewed: 20 (4 ULg)
Peer Reviewed
See detailOxytocin attenuates tolerance not only to the hypothermic but also to the myorelaxant and akinesic effects of ethanol in mice
Jodogne, C.; Tirelli, Ezio ULg; Klingbiel, P. et al

in Pharmacology, Biochemistry & Behavior (1991), 40(2), 261-265

Inhibition of ethanol tolerance by oxytocin has been demonstrated previously using the hypothermic effect only. The purpose of the present experiment was to investigate the effect of oxytocin on the ... [more ▼]

Inhibition of ethanol tolerance by oxytocin has been demonstrated previously using the hypothermic effect only. The purpose of the present experiment was to investigate the effect of oxytocin on the development of tolerance to ethanol-induced hypothermia, myorelaxation and akinesia in mice. Four groups of mice received daily intraperitoneal injections of saline or oxytocin (0.005 mg) plus saline or ethanol (2 g/kg). The peptide was administered 2 hours before ethanol. For five consecutive days, temperature measurements were performed 20 minutes before and after ethanol injection. Myorelaxation and akinesia were evaluated following the second temperature measure. Oxytocin pretreatment, which had no intrinsic effects, resulted in a robust selective attenuation of tolerance to ethanol-induced hypothermia, myorelaxation and akinesia. These results suggest that the mechanisms for peptide modulation are common to these three typical effects of ethanol. [less ▲]

Detailed reference viewed: 17 (0 ULg)
Peer Reviewed
See detailOxytocin blocks the environmentally conditioned compensatory response present after tolerance to ethanol-induced hypothermia in mice
Tirelli, Ezio ULg; Jodogne, C.; Legros, Jean-Jacques ULg

in Pharmacology, Biochemistry & Behavior (1992), 43(4), 1263-1267

The present study tested the hypothesis that the attenuation by oxytocin of tolerance to ethanol-induced hypothermia relies upon an impairment of the putative conditioning processes underlying environment ... [more ▼]

The present study tested the hypothesis that the attenuation by oxytocin of tolerance to ethanol-induced hypothermia relies upon an impairment of the putative conditioning processes underlying environment-specific tolerance. According to the conditioning model of tolerance, such tolerance occurs because an opposite compensatory response conditioned to ethanol-paired cues attenuates ethanol's effects. Tolerance to ethanol-induced hypothermia was established to a particular environment over 4 days by injecting mice (daily) with oxytocin 2 h before ethanol, outside the colony room. As controls, other mice were injected similarly but following testing in the animal room. We found that oxytocin suppressed the conditioned compensatory response, revealed by injecting saline to every group in the tolerance-associated environment. These results suggest that oxytocin acted, at least partly, via an inhibition of the associative learning processes that facilitate tolerance development. [less ▲]

Detailed reference viewed: 20 (2 ULg)
Full Text
Peer Reviewed
See detailOxytocin Facilitates Female Sexual Maturation through a Glia-to-Neuron Signaling Pathway
Parent, Anne-Simone ULg; Rasier, Grégory ULg; Matagne, V. et al

in Endocrinology (2008), 149(3), 1358-65

It has been earlier proposed that oxytocin could play a facilitatory role in the preovulatory LH surge in both rats and humans. We here provide evidence that oxytocin also facilitates sexual maturation in ... [more ▼]

It has been earlier proposed that oxytocin could play a facilitatory role in the preovulatory LH surge in both rats and humans. We here provide evidence that oxytocin also facilitates sexual maturation in female rats. The administration of an oxytocin antagonist for 6 d to immature female rats decreased GnRH pulse frequency ex vivo and delayed the age at vaginal opening and first estrus. The in vitro reduction in GnRH pulse frequency required chronic blockade of oxytocin receptors, because it was not acutely observed after a single injection of the antagonist. Hypothalamic explants exposed to the antagonist in vitro showed a reduced GnRH pulse frequency and failed to respond to oxytocin with GnRH release. Prostaglandin E(2) (PGE(2)) mimicked the stimulatory effect of oxytocin on GnRH pulse frequency, and inhibition of PG synthesis blocked the effect of oxytocin, suggesting that oxytocin accelerates pulsatile GnRH release via PGE(2). The source of PGE(2) appears to be astrocytes, because oxytocin stimulates PGE(2) release from cultured hypothalamic astrocytes. Moreover, astrocytes express oxytocin receptors, whereas GnRH neurons do not. These results suggest that oxytocin facilitates female sexual development and that this effect is mediated by a mechanism involving glial production of PGE(2). [less ▲]

Detailed reference viewed: 33 (9 ULg)
Full Text
Peer Reviewed
See detailOxytocin receptor of small cell carcinoma of human lung cell lines
Pequeux, Christel ULg; Breton, Christophe; Hagelstein, Marie-Thérèse ULg et al

in Pflügers Archiv : European Journal of Physiology (2000), 440/6

Detailed reference viewed: 12 (2 ULg)
Full Text
Peer Reviewed
See detailOxytocin receptor pattern of expression in primary lung cancer and in normal human lung
Pequeux, Christel ULg; Breton, C.; Hagelstein, M. T. et al

in Lung Cancer (2005), 50(2), 177-188

In order to assess if oxytocin- and vasopressin-induced mitogenic effects detected on small-cell lung carcinoma (SCLC) cell lines could be transposed on primary SCLC, the aim of the present work was to ... [more ▼]

In order to assess if oxytocin- and vasopressin-induced mitogenic effects detected on small-cell lung carcinoma (SCLC) cell lines could be transposed on primary SCLC, the aim of the present work was to identify mediators of these mitogenic actions on primary tumours samples. This was addressed on normal human lung tissue, on SCLC and on non-SCLC (NSCLC). Herein, we observe, in normal human lung, that OTR is colocalized with vascular endothelial cells of the lung and is not expressed by lung cells of epithelial nature. We detected mRNA amplification of V1aR, V2R and of a V2R variant. We observed that 86% of SCLC biopsies analyzed expressed at least the OTR and that 71% expressed the OTR, the V1aR and the V2R altogether. Comparatively, 50% of NSCLC biopsies tested expressed at least the OTR and 32% expressed the OTR, the V1aR and the V2R altogether. The occurrence of the V1bR/V3R is of 28 and 18% for SCLC and NSCLC, respectively. Nevertheless, for the SCLC biopsies analyzed in this study, V1bR/V3R expression correlates, in all cases, with the expression of all the other neurohypophysial peptide receptors. Our results suggest that neurohypophysial peptide antagonists may offer promise as a potential new therapeutic modality for the treatment of lung cancer expressing at least one of the neurhypophysial peptide receptor subtypes. (c) 2005 Elsevier Ireland Ltd. All rights reserved. [less ▲]

Detailed reference viewed: 23 (1 ULg)
Peer Reviewed
See detailOxytocin secretion by bovine granulosa cells: regulation and interactions with steroidogenesis
Geenen, Vincent ULg; Legros, Jean-Jacques ULg; Hustin, Jean et al

in Journal of Endocrinological Investigation (1985), 8

Detailed reference viewed: 3 (0 ULg)
Peer Reviewed
See detailOxytocin secretion by bovine granulosa cells: regulation and interactions with steroidogenesis
Geenen, Vincent ULg; Legros, Jean-Jacques ULg; Hustin, Jean et al

in Journal of Endocrinological Investigation (1985), 8 (Suppl. 3)

Detailed reference viewed: 5 (0 ULg)
Full Text
Peer Reviewed
See detailOxytocin synthesis and oxytocin receptor expression by cell lines of human small cell carcinoma of the lung stimulate tumor growth through autocrine/paracrine signaling
Pequeux, Christel ULg; Breton, Christophe; Hendrick, Jean-Claude et al

in Cancer Research (2002), 62(16), 4623-4629

The objective of the present work was to investigate the existence of an oxytocin (OT)-mediated autocrine/paracrine signaling upon small cell carcinoma of the lung (SCCL) cell growth. In that view, OT ... [more ▼]

The objective of the present work was to investigate the existence of an oxytocin (OT)-mediated autocrine/paracrine signaling upon small cell carcinoma of the lung (SCCL) cell growth. In that view, OT receptor (OTR) expression, concomitant with OT synthesis and secretion, was evidenced on three different SCCL cell lines (DMS79, H146, and H345) and related to the vasopressin (VP) system. Specific OT, VP, OTR, Via VP receptor (V1aR), and V1b/V3 VP receptor (V1bR/V3R) transcripts were identified by reverse transcription-.PCR in all cell lines studied. Binding of I-125-(d(CH2)(5)(1),Tyr(Me)(2), Thr(4), Orn(3),Tyr(9)-NH2)-vasotocin (OVTA) was observed on all SCCL cell lines, with a K-d (dissociation constant) ranging from 0.025-0.089 nm, depending; on the cell line and the analytical method. Selectivity of I-125-OVTA binding was confirmed by displacement curves obtained with various OTR and VP receptor agonists and antagonists (OT, OVTA, L-371,257, VP, F180). Immunocytochemistry identified cellular OT and VP, and peptide secretion was measured in supernatants of SCCL cultures. [H-3]Thymidine incorporations, applied on H345 cells, demonstrated a dose-dependent mitogenic effect of exogenous OT (1 and 100 nM) that was abolished by the OTR antagonist OVTA. A decrease of proliferation was also observed with OVTA alone, showing a functional mitogenic effect of tumor-derived OT. Taken together, these observations demonstrate the existence of a functional OT-mediated autocrine/paracrine signaling actively implicated in growth and development of SCCL tumors. Furthermore, these findings point to the potential of OT antagonists for development as therapeutic agents for the treatment of SCCL. [less ▲]

Detailed reference viewed: 46 (5 ULg)
Full Text
Peer Reviewed
See detailOXYTOCIN, VASOPRESSIN AND ANXIETY IN MAJOR DEPRESSION: AGO-ANTAGONIST NEUROHROMONES
Scantamburlo, Gabrielle ULg; Hansenne, Michel ULg; Fuchs, Sonia et al

in European Neuropsychopharmacology (2006), 16

Detailed reference viewed: 37 (1 ULg)
Full Text
Peer Reviewed
See detailOxytocin- and vasopressin-induced growth of human small-cell lung cancer is mediated by the mitogen-activated protein kinase pathway
Pequeux, Christel ULg; Keegan, B. P.; Hagelstein, M. T. et al

in Endocrine-Related Cancer (2004), 11(4), 871-885

Malignant growth of small-cell lung carcinoma is promoted by various neuroendocrine autocrine/paracrine loops. Therefore, to interfere with this mitogenic process, it is crucial to elucidate the ... [more ▼]

Malignant growth of small-cell lung carcinoma is promoted by various neuroendocrine autocrine/paracrine loops. Therefore, to interfere with this mitogenic process, it is crucial to elucidate the mechanisms involved. It is known that the oxytocin (OT) and vasopressin (VP) genes, normally transcriptionally restricted in their expression, are activated in small-cell lung cancer (SCLC), concomitantly with expression of their receptors (OTR, V1aR, V1bR/V3R and V2R). The aim of the present study was to characterize, in concentrations close to physiological and pharmacological conditions, intracellular signalling events triggered by OT and VP binding to their specific receptors in SCLC cells and to identify factors mediating OT- and VP-induced mitogenic effects on SCLC. Known agonists for OTR ([Thr(4),GlY(7)]OT) and V1aR (F180), in addition to OT and VP, were able to elicit increases in cytosolic Ca2+ levels and this effect could be blocked using an OTR antagonist (OVTA) or a V1aR antagonist (SR49059) respectively. There was no activation of the cAMP pathway detected after VP, dDAVP (a V2R agonist), or OT treatment. Stimulation of SCLC cells with OT and VP led to an increase of extracellular signal-regulated kinase (ERK) 1/2 phosphorylation, maximal at 5 min, and the subsequent phosphorylation of its downstream target p90 ribosomal S6 kinase (p90(RSK)). Pre-incubation with OVTA and SR49059, and with inhibitors of phospholipase C (PLC), protein kinase C (PKC), mitogen-activated protein kinase/ERK kinase (MEK) 1/2 and a Ca2+ chelator significantly reduced OT- and VP-induced ERK1/2 phosphorylations. OVTA, SR49059 as well as MEK1/2 and PKC inhibitors also downregulated OT- and VP-induced p90RSK phosphorylation. In [H-3]thymidine-uptake 2, experiments, we subsequently observed that PLC, Ca2+, PKC and ERK1/2 are absolutely required for the OT- and VP-stimulated SCLC cellular growth process. In conclusion, the results presented here indicate that OT- and VP-induced mitogenic effects on SCLC are respectively mediated by OTR and V1aR signalling and that this mitogenic signalling passes through the phosphorylation of ERK1/2 and p90(RSK) in a PLC-, Ca2+-, PKC- and MEK1/2-dependent pathway. [less ▲]

Detailed reference viewed: 28 (2 ULg)