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See detailPrécision du positionnement par satellites: influence de la géométrie de la constellation
Lonchay, Matthieu ULg

Master's dissertation (2009)

Precision of GNSS (Global Navigation Satellite System) is affected by a lot of different factors, such as satellite geometry. The quality of satellite geometry is evaluated by an indicator: DOP (Dilution ... [more ▼]

Precision of GNSS (Global Navigation Satellite System) is affected by a lot of different factors, such as satellite geometry. The quality of satellite geometry is evaluated by an indicator: DOP (Dilution Of Precision). Specific satellite geometry, such as conical satellite geometry, are able to strongly harm to the precision of positioning. These particular situations lead the normal matrix to a singular state and the DOP to high values. [less ▲]

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See detailPrécision du positionnement par satellites: influence de la géométrie de la constellation
Lonchay, Matthieu ULg

Conference (2010, February 24)

De nombreux facteurs sont susceptibles d’influencer la précision des systèmes globaux de positionnement et de navigation par satellites (GNSS, Global Navigation Satellite System), dont la géométrie de la ... [more ▼]

De nombreux facteurs sont susceptibles d’influencer la précision des systèmes globaux de positionnement et de navigation par satellites (GNSS, Global Navigation Satellite System), dont la géométrie de la constellation. La qualité de la géométrie de la constellation s’évalue au moyen d’un indicateur : le DOP (Dilution Of Precision). Certaines formes très particulières de la géométrie de la constellation nuisent de manière importante à la précision du positionnement par satellites. C’est le cas de la constellation de forme conique. Ces situations particulières se caractérisent par un état singulier de la matrice normale et de hautes valeurs du DOP. [less ▲]

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See detailPrécision fonctionnelle du schéma de structure communal
Collette, Jean-Pierre ULg; Goossens, Marc ULg; Hanocq, Philippe ULg

in Environnement et Société (1992), 9/10

Examen comparé des notions de "fonctions" et de "densités" dans les divers documents planologiques élaborés à différentes échelles territoriales.

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See detailPrecision of continuous neonatal ventilator respiratory mechanics is improved with selected optimal respiratory cycles.
RIGO, Vincent ULg; Graas, Estelle; RIGO, Jacques ULg

in European journal of pediatrics (2012), 171(4), 689-96

Given their high apparent variability, bedside continuous respiratory mechanics (RM) parameters (excepting tidal volume (VT)) remain infrequently used for adjustment of neonatal ventilatory settings. RM ... [more ▼]

Given their high apparent variability, bedside continuous respiratory mechanics (RM) parameters (excepting tidal volume (VT)) remain infrequently used for adjustment of neonatal ventilatory settings. RM parameters provided by ventilator (VRC) from 10 recordings of newborns (10 minutes in synchronized intermittent mandatory ventilation and Assist/control (A/C)) were compared to those computed from visually selected assisted leak-free optimal respiratory cycles (SRC). Mean values, variability and ability to distinguish patients were compared between VRC and SRC. Dynamic resistances were more correlated (r²=0.95) than compliances (r²=0.42). VT’s were correlated only in A/C (r²=0.78). C20/C was significantly higher in VRC (1.81±0.67) than in SRC (1.23±0.36) and frequently out of neonatal reference range. In A/C ventilation, VT was higher in VRC (5.6 ±1.8 ml/kg) than in SRC (4.8 ±1.0 ml/kg) (p<0.05). Displayed VT’s don’t reflect those found in optimal assisted breaths and therefore have incomplete value in assessing adequacy of ventilator settings. The variability of RM parameters provided by the ventilator is large, and coefficients of variation were significantly lower with optimal respiratory cycles (for Resistance, Compliance, VT and C20/C: 27, 26, 18, 24% in SRC, 36, 35, 40, 33% in VRC). Selecting optimal cycles yields RM with a 2-3 times higher discriminating power between patients. Conclusion: Current ventilator’s RM parameters have limited clinical use. Using optimal breaths to calculate RM parameters improves precision and discriminating power. For integration to ventilatory care, automation of this selection must be implemented first. [less ▲]

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See detailPrecision polymer design by organometallic-mediated radical polymerization
Debuigne, Antoine ULg

Scientific conference (2014, March 13)

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See detailPrecision study on capillary electrophoresis methods for metacycline
Do Thi, Thao; Pomponi, Romeo; Gotti, Roberto et al

in Electrophoresis (2006), 27(12), 2317-2329

A CE method for metacycline (MTC) determination was investigated in an inter-laboratory experiment. Many problems were encountered in this study, most of which were related to the transfer of the method ... [more ▼]

A CE method for metacycline (MTC) determination was investigated in an inter-laboratory experiment. Many problems were encountered in this study, most of which were related to the transfer of the method to different CE equipment. The reported problems could be classified into different categories: problems related to the precision, to the parameters in the protocol, and to the MTC peak shape. As the peak shape problem was partially responsible for the poor precision, a new CE method was developed in order to obtain a good MTC peak shape on all equipment. The precision of this new method for MTC determination was examined in an intermediate precision study, where the influence of the factors "time" and "equipment" was investigated. Although the new method could be transferred to different instruments, the precision remained poor mainly due to the contributions of the between-replicate and the between-injection variances. [less ▲]

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See detailPrecision synthesis of poly(ionic liquid)-based block copolymers by cobalt-mediated radical polymerization and preliminary study of their self-assembling properties
Coupillaud, Paul; Fèvre, Maréva; Wirotius, Anne-Laure et al

in Macromolecular Rapid Communications (2014), 35(4), 422-430

A poly(ionic liquid)-based block copolymer (PIL BCP), namely, poly(vinyl acetate)-b-poly(N-vinyl-3-butylimidazolium bromide), PVAc-b-PVBuImBr, is synthesized by sequential cobalt-mediated radical ... [more ▼]

A poly(ionic liquid)-based block copolymer (PIL BCP), namely, poly(vinyl acetate)-b-poly(N-vinyl-3-butylimidazolium bromide), PVAc-b-PVBuImBr, is synthesized by sequential cobalt-mediated radical polymerization (CMRP). A PVAc precursor is first prepared at 30 °C in bulk by CMRP of VAc, using bis(acetylacetonato)cobalt(II), Co(acac)2, and a radical source (V-70). Growth of PVBuImBr from PVAc-Co(acac)2 is accomplished by CMRP in DMF/MeOH (2:1, v/v). This PIL BCP self-assembles in the sub-micron size range into aggregated core–shell micelles in THF, whereas polymeric vesicles are observed in water, as evidenced by dynamic light scattering (DLS) and transmission electron microscopy (TEM). Thin-solid sample cut from raw materials analyzed by TEM shows an ordered lamellar organization by temperature-dependent synchrotron small-angle X-ray scattering (SAXS). Anion exchange can be accomplished to achieve the corresponding PIL BCP with bis(trifluorosulfonyl)imide (Tf2N−) anions, which also gives rise to an ordered lamellar phase in bulk samples. A complete suppression of SAXS second-order reflection suggests that this compound has a symmetric volume fraction (f ≈ 0.5). SAXS characterization of both di- and triblock PIL BCP analogues previously reported also shows a lamellar phase of very similar behavior, with only an increase of the period by about 8% at 60 °C. [less ▲]

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See detailPrécisions biostratigraphiques relatives au Dévonien Supérieur de Ferques (Boulonnais).
Brice, D; Coen, M; Loboziak, S et al

in Annales de la Société Géologique du Nord (1981), C

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See detailPrécisions conceptuelles et méthodologiques en matière d’éducation au changement climatique.
Semal, Nathalie ULg

Speech (2003)

Cette allocutiona été présentée lors d'une réunion de travail organisée dans le cadre de la Convention des Nations Unies sur le Changement Climatique, dédiée à l'implémentation de son article 6, relatif à ... [more ▼]

Cette allocutiona été présentée lors d'une réunion de travail organisée dans le cadre de la Convention des Nations Unies sur le Changement Climatique, dédiée à l'implémentation de son article 6, relatif à l'éducation et à la sensibilisation du public au réchauffement climatique. Elle tente de développer quelques principes de base, tirés des enseignements des expériences menées en éducation relative à l'environnement. [less ▲]

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See detailLes précisions de la Cour constitutionnelle quant à la nature juridique de la condamnation d'office visée par l'article 35 § 1er aliéna 3 de la loi du 27 juin 1969 concernant la sécurité sociale des travailleurs salariés
Michiels, Olivier ULg

in Revue de la Faculté de Droit de l'Université de Liège (2008), 2008/3

L'article s'attache à définir la nature juridique des condamnations d'office portées par la loi du 27 juin 1969 concernant la sécurité sociale des travailleurs salariés en cas de non-assujetissement ou d ... [more ▼]

L'article s'attache à définir la nature juridique des condamnations d'office portées par la loi du 27 juin 1969 concernant la sécurité sociale des travailleurs salariés en cas de non-assujetissement ou d'assujettissement frauduleux à la sécurité sociale [less ▲]

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See detailPrecisions on the Palynostratigraphy of the Siluro-Devonian boundary in Lybia
Steemans, Philippe ULg; Rubinstein, C. V.; Le Hérissé, A.

Conference (1996)

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See detailPrécisions sur l'Ouverture de cuisine de Lancelot de Casteau, imprimée à Liège en 1604
Adam, Renaud ULg

in De Gulden Passer = Le compas d'or (2012), 90(1), 89-96

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See detailPrécisions sur la distribution et l'écologie de quelques Coléoptères de Belgique
Baguette, Michel; Dufrêne, Marc ULg; Lesuisse, Emmanuel et al

in Bulletin et Annales de la Société Royale Belge d’Entomologie = Bulletin en Annalen van de Koninklijke Belgische Vereniging voor Entomologie (1985), 121

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See detailPrécisions sur la structure des complexes disaccharide-peptide libérés des parois de Micrococcus lysodeikticus sous l'action des β (I → 4) N-acetylhexosaminidases
Ghuysen, Jean-Marie ULg

in Biochimica et Biophysica Acta (1961), 47(3), 561-568

Two types of disaccaride-peptide complexes have been studied. In a first type of complex, the fragment 6-O-[beta]-N-acetylglucosaminyl-N-acetyl-muraminyl is joined to a peptide moiety consisting of 2 ... [more ▼]

Two types of disaccaride-peptide complexes have been studied. In a first type of complex, the fragment 6-O-[beta]-N-acetylglucosaminyl-N-acetyl-muraminyl is joined to a peptide moiety consisting of 2 alanines, 1 glycine, 1 glutamic acid and 1 lysine, by an amide bond between the COOH of N-acetylmuramic acid and the NH2 of one of the alanine residues of the peptide. The reaction with 1-fluoro-2,4 dinitrobenzene shows that the [epsilon]-NH2 group of lysine is free. The electroheophoretic properties suggest that the [gamma]-COOH group of glutamic acid and an unspecified [alpha]-COOH group are free too. The second type of complex is a dimer of the former, joined by a peptide linkage between an [epsilon]-NH2 group of lysine and, very probably, an [alpha]-COOH group. THe F2B amidase splits the amidic acetylmuraminyl-alanine linkage. Consequently, the disaccharide is liberated and a new free [alpha]-NH2 group of alanine appears in the peptide moiety. [less ▲]

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See detailPrecisions sur le statut des Nymphalidae en Belgique.
Goffart, Philippe; Baguette, Michel; Dufrêne, Marc ULg

in Bulletin et Annales de la Société Royale Belge d’Entomologie = Bulletin en Annalen van de Koninklijke Belgische Vereniging voor Entomologie (1988), 124

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See detailPreclinical and clinical pharmacology of alcohol dependence
Tambour, Sophie ULg; Quertemont, Etienne ULg

in Fundamental & Clinical Pharmacology (2007), 21(1), 9-28

In recent years, advances in neuroscience led to the development of new medications to treat alcohol dependence and especially to prevent alcohol relapse after detoxification. Whereas the earliest ... [more ▼]

In recent years, advances in neuroscience led to the development of new medications to treat alcohol dependence and especially to prevent alcohol relapse after detoxification. Whereas the earliest medications against alcohol dependence were fortuitously discovered, recently developed drugs are increasingly based on alcohol's neurobiological mechanisms of action. This review discusses the most recent developments in alcohol pharmacotherapy and emphasizes the neurobiological basis of anti-alcohol medications. There are currently three approved drugs for the treatment of alcohol dependence with quite different mechanisms of action. Disulfiram is an inhibitor of the enzyme aldehyde dehydrogenase and acts as an alcohol-deterrent drug. Naltrexone, an opiate antagonist, reduces alcohol craving and relapse in heavy drinking, probably via a modulation of the mesolimbic dopamine activity. Finally, acamprosate helps maintaining alcohol abstinence, probably through a normalization of the chronic alcohol-induced hyperglutamatergic state. In addition to these approved medications, many other drugs have been suggested for preventing alcohol consumption on the basis of preclinical studies. Some of these drugs remain promising, whereas others have produced disappointing results in preliminary clinical studies. These new drugs in the field of alcohol pharmacotherapy are also discussed, together with their mechanisms of action. [less ▲]

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See detailPreclinical evidence for a beneficial impact of valproate on the response of small cell lung cancer to first-line chemotherapy
Hubaux, Roland; Vandermeers, Fabian ULg; Crisanti, Cecilia et al

in European Journal of Cancer (2010), 46

Prognosis of small cell lung carcinoma (SCLC) is particularly poor, less than 5% of patients with extensive stage being alive after two years.We hypothesized that SCLC chemotherapy could be improved by ... [more ▼]

Prognosis of small cell lung carcinoma (SCLC) is particularly poor, less than 5% of patients with extensive stage being alive after two years.We hypothesized that SCLC chemotherapy could be improved by using histone deacetylase (HDAC) inhibitors based on their ability to interfere with lysine acetylation and to alter gene expression. The goal of this study was to evaluate the anticancer efficacy of a HDAC inhibitor (valproate: VPA) on SCLC cells in combination with the standard chemotherapeutic first-line regimen (cisplatin + etoposide). We show that VPA induces apoptosis of small cell lung cancer cell lines and improves efficacy of cisplatin combined with etoposide. Both mitochondrial and death receptor pathways are involved in VPA-induced apoptosis. As expected for an HDAC inhibitor, VPA hyperacetylates histone H3. The mechanism of VPA pro-apoptotic activity involves induction of p21, inhibition of Bcl-xL, cleavage of Bid and phosphorylation of Erk and H2AX. In the presence of VPA, Bax is translocated from the cytoplasm to the mitochondria and cleaved in an 18 kDa isoform. Cytochrome c is released from the mitochondria into the cytosol. Transcriptomic analyses by microarray show that VPA modulates transcription of genes (Na+/ K+ ATPase, Bcl-xL) involved in chemoresistance to cisplatin and etoposide. Finally, the efficacy of VPA combined with cisplatin and etoposide is supported by preclinical models of SCLC cells engrafted into SCID mice. Together, these data demonstrate that VPA augments anticancer activity of cisplatin and etoposide, two components of the standard first-line chemotherapy of small cell lung cancer. [less ▲]

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See detailPreclinical radiation dosimetry for the novel SV2A radiotracer [18F]UCB-H
Bretin, Florian ULg; Warnock, Geoffrey; Bahri, Mohamed Ali ULg et al

in European Journal of Nuclear Medicine and Molecular Imaging Research (2013), 3(1), 35

Background: [18F]UCB-H was developed as a novel radiotracer with a high affinity for synaptic vesicle protein 2A, the binding site for the antiepileptic levetiracetam. The objectives of this study were to ... [more ▼]

Background: [18F]UCB-H was developed as a novel radiotracer with a high affinity for synaptic vesicle protein 2A, the binding site for the antiepileptic levetiracetam. The objectives of this study were to evaluate the radiation dosimetry of [18F]UCB-H in a preclinical trial and to determine the maximum injectable dose according to guidelines for human biomedical research. The radiation dosimetry was derived by organ harvesting and dynamic micro positron emission tomography (PET) imaging in mice, and the results of both methods were compared. Methods: Twenty-four male C57BL-6 mice were injected with 6.96 ± 0.81 MBq of [18F]UCB-H, and the biodistribution was determined by organ harvesting at 2, 5, 10, 30, 60, and 120 min (n = 4 for each time point). Dynamic microPET imaging was performed on five male C57BL-6 mice after the injection of 9.19 ± 3.40 MBq of [18F]UCB-H. A theoretical dynamic bladder model was applied to simulate urinary excretion. Human radiation dose estimates were derived from animal data using the International Commission on Radiological Protection 103 tissue weighting factors. Results: Based on organ harvesting, the urinary bladder wall, liver and brain received the highest radiation dose with a resulting effective dose of 1.88E-02 mSv/MBq. Based on dynamic imaging an effective dose of 1.86E-02 mSv/MBq was calculated, with the urinary bladder wall and liver (brain was not in the imaging field of view) receiving the highest radiation. Conclusions: This first preclinical dosimetry study of [18F]UCB-H showed that the tracer meets the standard criteria for radiation exposure in clinical studies. The dose-limiting organ based on US Food and Drug Administration (FDA) and European guidelines was the urinary bladder wall for FDA and the effective dose for Europe with a maximum injectable single dose of approximately 325 MBq was calculated. Although microPET imaging showed significant deviations from organ harvesting, the Pearson’s correlation coefficient between radiation dosimetry derived by either method was 0.9666. [less ▲]

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