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See detailPILOT PROJECT IN CHR-LIEGE: INVITING SIBLINGS OF CHILDREN WITH CANCER TO A CREATIVE AND EXPRESSIVE WEEK-END WITH PSYCHOLOGISTS AND ONCOLOGIST
Forget, Patricia; Badot, Isabelle; Missotten, Pierre ULg et al

Poster (2013, September 27)

The siblings week end with the psycho-medical team was highly successful It opens another way to improve the care of the siblings Questionnary forms should be developped in the future to evaluate the real ... [more ▼]

The siblings week end with the psycho-medical team was highly successful It opens another way to improve the care of the siblings Questionnary forms should be developped in the future to evaluate the real psychological impact [less ▲]

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See detailPilot project « Walphy » : Walloon experimentation of river restoration
Peeters, Alexandre ULg; Verniers, Gisèle; de le Court, Bernard et al

Conference (2012, April 20)

According to the Water Framework Directive (WFD 2000/60), our rivers and water bodies are required to achieve the “good ecological status” by 2015. This requirement is related to the physico-chemical ... [more ▼]

According to the Water Framework Directive (WFD 2000/60), our rivers and water bodies are required to achieve the “good ecological status” by 2015. This requirement is related to the physico-chemical, biological water quality as well as the hydromorphological quality. In this context, a LIFE Environment project, co-founded by the European Union and the Service Publique de Wallonie, was launched in 2009 for a period of five years. It aims to realize the experimental and demonstrative river restoration works on three “at risk” water bodies, based on two axes: longitudinal continuity and transversal continuity. The first two selected water bodies (Bocq, eastern tributary of the Meuse) are suitable for the restoration works which concern the longitudinal continuity due to the presence of dams and other obstacles between 1 and 3 m high. These works consist in dam management (weir removal or fish ladders) taking into account hydromorphological (bedload transport) and biological (invertebrate or fish species free movement) impacts. The third water body (Eau Blanche, western tributary of the Meuse) presents straightened rivers with artificial banks which consequently lead to poor connections between the stream and its floodplain. This water body is therefore appropriated for the works based on the transversal continuity recovery. These works consist in enhancing straightened river channel and restoring meanders or banks. Until now, these works have been realized on more than 5 km. These works are being monitored on the basis of geomorphological and ecological analysis. The geomorphological monitoring is based on surveys conducted before and after the works. It concerns the bedload transport, the clogging of the gravel layer and the morphological changes of the river following the works. The ecological monitoring is based on two indicators: macroinvertebrates and fishes. Standardized and repeatable methods were developed to compare the situation before and after the works, especially through the analysis of microhabitats. In addition, we use another two complementary indexes of physical quality for this monitoring. Developed by the consulting office Teleos, these indexes have a fish orientation and have been implemented in many of our stations. [less ▲]

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See detailPILOT PROJECT « WALPHY »: WALLOON EXPERIMENTATION OF RIVER RESTORATION
Peeters, Alexandre ULg; Verniers, Gisèle; de le Court, Bernard et al

Poster (2013, March 13)

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See detailPilot proof of concept clinical trials of Stochastic Targeted (STAR) glycemic control.
Evans, Alicia; Shaw, Geoffrey M; Le Compte, Aaron et al

in Annals of intensive care (2011), 1

ABSTRACT: INTRODUCTION: Tight glycemic control (TGC) has shown benefits but has been difficult to achieve consistently. STAR (Stochastic TARgeted) is a flexible, model-based TGC approach directly ... [more ▼]

ABSTRACT: INTRODUCTION: Tight glycemic control (TGC) has shown benefits but has been difficult to achieve consistently. STAR (Stochastic TARgeted) is a flexible, model-based TGC approach directly accounting for intra- and inter- patient variability with a stochastically derived maximum 5% risk of blood glucose (BG) < 4.0 mmol/L. This research assesses the safety, efficacy, and clinical burden of a STAR TGC controller modulating both insulin and nutrition inputs in pilot trials. METHODS: Seven patients covering 660 hours. Insulin and nutrition interventions are given 1-3 hourly as chosen by the nurse to allow them to manage workload. Interventions are calculated by using clinically validated computer models of human metabolism and its variability in critical illness to maximize the overlap of the model-predicted (5-95th percentile) range of BG outcomes with the 4.0-6.5 mmol/L band while ensuring a maximum 5% risk of BG < 4.0 mmol/L. Carbohydrate intake (all sources) was selected to maximize intake up to 100% of SCCM/ACCP goal (25 kg/kcal/h). Maximum insulin doses and dose changes were limited for safety. Measurements were made with glucometers. Results are compared to those for the SPRINT study, which reduced mortality 25-40% for length of stay >/=3 days. Written informed consent was obtained for all patients, and approval was granted by the NZ Upper South A Regional Ethics Committee. RESULTS: A total of 402 measurements were taken over 660 hours (~14/day), because nurses showed a preference for 2-hourly measurements. Median [interquartile range, (IQR)] cohort BG was 5.9 mmol/L [5.2-6.8]. Overall, 63.2%, 75.9%, and 89.8% of measurements were in the 4.0-6.5, 4.0-7.0, and 4.0-8.0 mmol/L bands. There were no hypoglycemic events (BG < 2.2 mmol/L), and the minimum BG was 3.5 mmol/L with 4.5% < 4.4 mmol/L. Per patient, the median [IQR] hours of TGC was 92 h [29-113] using 53 [19-62] measurements (median, ~13/day). Median [IQR] results: BG, 5.9 mmol/L [5.8-6.3]; carbohydrate nutrition, 6.8 g/h [5.5-8.7] (~70% goal feed median); insulin, 2.5 U/h [0.1-5.1]. All patients achieved BG < 6.1 mmol/L. These results match or exceed SPRINT and clinical workload is reduced more than 20%. CONCLUSIONS: STAR TGC modulating insulin and nutrition inputs provided very tight control with minimal variability by managing intra- and inter- patient variability. Performance and safety exceed that of SPRINT, which reduced mortality and cost in the Christchurch ICU. The use of glucometers did not appear to impact the quality of TGC. Finally, clinical workload was self-managed and reduced 20% compared with SPRINT. [less ▲]

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See detailPilot scale biotransformation of vegetal oil into natural green note flavor using sugar beet leaves as sources of hydroperoxide lyase
Gigot, Cédric ULg; Ongena, Marc ULg; Fauconnier, Marie-Laure ULg et al

Poster (2009, June 02)

Natural green note aromas (GLVs) are highly attractive flavors commonly used in the food industry. These are produced in extremely low levels upon physiological stress in plant organs of any sort. This ... [more ▼]

Natural green note aromas (GLVs) are highly attractive flavors commonly used in the food industry. These are produced in extremely low levels upon physiological stress in plant organs of any sort. This weak sporadic presence entails a very expensive extraction step to obtain pure GLVs. Therefore catalytic biotransformations of fatty acid sources, the initial substrate for GLVs, have been developed. Enzymatic defense pathways and particularly the LOX pathway produce the major part of GLVs. Unlike GLV molecules that are emitted in the atmosphere, the enzymes are extractible from the plant material. Thus, a combination of plant enzyme extracts and substrate preparations provides all the ingredients for GLV production. Besides, sugar beet leaves present high levels of hydroperoxide lyase among plant sources and are available in large amounts during three months. In this enzymatic pathway, fatty acids are successively transformed by lipase, lipoxygenase and hydroperoxide lyase into aldehydes and alcohols, final compounds of GLVs pathway. Limiting and problematic steps occur with the action of hydroperoxide lyase, when enzymatic catalysis is followed by an enzyme destabilization. Alternative substrates bind irreversibly to the heme group of the enzyme and end the reaction. This poster briefly describes the development of a complete bioprocess for natural GLV production, from hydrolysis to purification. A high level of biotransformation could be achieved using optimum experimental conditions and a cheap source of plant materials. [less ▲]

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See detailThe pilot study on clinical presentation of pituitary adenomas in patients with multiple endocrine neoplasia type I (MEN1) phenotype with and without MEN1 mutation
Rostomyan, Liliya ULg; TICHOMIROWA, M; KIRDYANKINA, N et al

in Endocrine abstracts - May 2012, volume 29 (2012, May)

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See detailA pilot study comparing the antispasmodic effects of inhaled salmeterol, salbutamol and ipratropium bromide using different aerosoldevices on muscarinic bronchoconstriction in healthy cats
Leemans, Jérôme ULg; Kirschvink, Nathalie; Bernaerts, Frederique ULg et al

in Veterinary Journal (2009), 180

This study compared the duration and magnitude of the antispasmodic effects of salmeterol SLM), salbutamol (SAL), ipratropium bromide (IB) and the combination of SAL and IB (SAL/IB) against carbachol ... [more ▼]

This study compared the duration and magnitude of the antispasmodic effects of salmeterol SLM), salbutamol (SAL), ipratropium bromide (IB) and the combination of SAL and IB (SAL/IB) against carbachol-induced bronchoconstriction in healthy cats, and investigated the gain in efficacy using a two or fourfold increase in drug dosages. The drug regimens used were: (1) LM 25 lg, SAL 100 lg, IB 20 lg and SAL/IB 100 lg/20 lg for bronchodilators delivered by a metered-dose inhaler (MDI); (2) SAL 3.75 mg and IB 62.5 lg for nebulised (NEB) medications. To monitor the bronchodilator effect, airway responsiveness was assessed at different time points using barometric whole-body plethysmography and calculation of the concentration of inhaled carbachol inducing a 300% increase of baseline Penh (enhanced pause), an estimator of airflow limitation Maximum C-Penh300 was recorded 15 min after NEB SAL, IB MDI, NEB IB and 1 h after SAL MDI and 4 h after SLM MDI, respectively. C-Penh300 was significantly different from control values (without treatment) up to 24 h for SLM MDI, 8 h for IB MDI and 4 h for other drugs. In terms of efficacy, SAL/IB MDI showed a synergistic antispasmodic effect at 15 min, 4 h and 8 h after administration. A fourfold increase of the initial dose of IB MDI and NEB IB significantly increased C-Penh300. Despite a fourfold dose increase, SLM displayed the weakest degree of bronchoprotection compared to other bronchodilators. The study provides evidence that inhaled bronchodilators are efficient at preventing muscarinic-induced bronchospasm in healthy cats and that SAL and IB appear to be short-acting bronchodilators in contrast to SLM. [less ▲]

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See detailPilot study of flesinoxan in major depression. Effect on REM latency and body temperature
ANSSEAU, Marc ULg; PITCHOT, William ULg; Gonzalez Moreno, Antonio et al

in Human Psychopharmacology (1993)

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See detailA pilot study of silicone tissue expander prosthesis to protect the small bowel during radiation therapy for uterine malignancies
Zouhair, Abderrahim; Delaloye, J-F; Oszahin, Mahmut et al

in Turkish Journal of Cancer (2004), 34(1), 11-18

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See detailA pilot study of the safety and performance of the Otologics fully implantable hearing device: transducing sounds via the round window membrane to the inner ear.
Lefèbvre, Philippe ULg; Martin, Christine ULg; Dubreuil, C. et al

in Audiology & Neuro-otology (2009), 14(3), 172-80

OBJECTIVES: The safety and performance of the Otologics fully implantable hearing device were assessed in adult patients with mixed conductive and sensorineural hearing loss. METHODS: The subcutaneous ... [more ▼]

OBJECTIVES: The safety and performance of the Otologics fully implantable hearing device were assessed in adult patients with mixed conductive and sensorineural hearing loss. METHODS: The subcutaneous microphone of this fully implantable device picks up ambient sounds, converts them into an electrical signal, amplifies the signal according to the user's needs, and sends it to an electromechanical transducer. The transducer tip is customized with a prosthesis in order to be in contact with the round window membrane and is protected by fascia; this translates the electrical signal into a mechanical motion that directly stimulates the round window membrane and enables the user to perceive sound. The implanted battery is recharged daily via an external charger and the user can turn the implant on and off as well as adjust the volume with a hand-held remote control. In this pilot study, 6 patients with mixed conductive and sensorineural hearing loss were implanted with the Otologics fully implantable hearing device. Pre- and postoperative air conduction, bone conduction, as well as aided and unaided thresholds and speech scores were measured. RESULTS: No significant differences between preoperative and postoperative pure-tone averages were noted. Average improvement ranged from 19.16 to 35.8 dB of functional gain across audiometric frequencies with a mean of 26.17 +/- 5.15 dB. Long-term average functional gain at 12 months was 20.83 +/- 6.22 dB. Word recognition scores demonstrated significant differences between unaided and implant-aided conditions. CONCLUSIONS: Preliminary results of this trial of the Otologics fully implantable hearing device provide evidence that this fully implantable device is capable of efficiently transferring the sound to the inner ear via the round window membrane in patients with mixed hearing loss. [less ▲]

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See detailA pilot study on seborrheic dermatitis using pramiconazole as a potent oral anti-Malassezia agent.
Pierard, Gérald ULg; Ausma, Jannie; Henry, Frédérique ULg et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (2007), 214(2), 162-9

BACKGROUND: Seborrheic dermatitis is considered to be a Malassezia-driven disease. Little objective information is available so far from biometrological quantitative assessments of this skin condition ... [more ▼]

BACKGROUND: Seborrheic dermatitis is considered to be a Malassezia-driven disease. Little objective information is available so far from biometrological quantitative assessments of this skin condition. Pramiconazole is a novel triazole with potent in vitro antifungal activity, especially against Malassezia spp. OBJECTIVE: To study the sequential effects of pramiconazole on Malassezia, inflammation and epidermal changes. METHOD:This study was performed in 2 groups of subjects suffering from seborrheic dermatitis. The first group (n = 17) remained untreated and was used as control. Clinical, mycological and biometrological assessments were performed at inclusion and during the following 2 weeks. The second group of subjects (n = 10) received a single 200-mg oral dose of pramiconazole at inclusion. Clinical, mycological and biometrological evaluations were performed before and during 1 month following the single antifungal intake. For both parts of the study, several parameters were assessed including yeast density, desquamation, erythema, itching and sebum excretion. RESULTS: In the control group, no significant changes were observed in any of the parameters during the observation period. The findings were markedly different in the pramiconazole-treated subjects. The yeast density was significantly improved on days 3, 7 and 28. Desquamation, erythema, itching, and the global clinical evaluation as assessed by the patients and investigators became significantly improved on days 7 and 28. A trend in decrease of scaliness was noted. No effect on sebum excretion was evidenced. In conclusion, a single 200-mg dose of pramiconazole exhibitsin vivo efficacy in controlling some important clinical aspects of seborrheic dermatitis. Following a reduction in the number of yeasts on day 3, a decrease in the severity of clinical signs and symptoms occurred from day 7 onwards. Sebum excretion appeared uninvolved in the clearing process of seborrheic dermatitis. CONCLUSION: A single 200-mg dose of pramiconazole appears to abate seborrheic dermatitis. The density in Malassezia present on lesional skin is first decreased, followed by clearing of the clinical signs. [less ▲]

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See detailPilot trial of combined administration of erythropoietin and granulocyte colony-stimulating factor to children undergoing allogeneic bone marrow transplantation.
Locatelli, F.; Zecca, M.; Ponchio, L. et al

in Bone Marrow Transplantation (1994), 14(6), 929-35

We carried out a pilot study to evaluate the combined use of recombinant human erythropoietin (rhEpo) and granulocyte colony-stimulating factor (G-CSF) for accelerating marrow engraftment in children ... [more ▼]

We carried out a pilot study to evaluate the combined use of recombinant human erythropoietin (rhEpo) and granulocyte colony-stimulating factor (G-CSF) for accelerating marrow engraftment in children given allogeneic bone marrow transplantation (BMT). Fifteen consecutive children were enrolled in this study; 13 completed it and were evaluable. Using analysis of variance, laboratory and clinical data referring to these children were compared with those of 15 patients previously treated with rhEpo alone and with those of 16 historical controls. Erythroid repopulation, evaluated sequentially through serum transferrin receptor and reticulocyte count, was similarly accelerated in children receiving rhEpo alone and in those receiving combined treatment. These latter, however, showed a further reduction in the total number of red blood cell units required to reach transfusion independence (1.1 +/- 0.7 in the study population vs 2.7 +/- 1.2 in rhEpo group vs 4.2 +/- 2.3 in historical controls; values are mean +/- 1 SD; p < 0.001). Neutrophil engraftment, i.e. time for neutrophils to reach 0.5 x 10(9)/l, was 11 +/- 3 days in children receiving combined treatment, significantly shorter than that of the control groups (16 +/- 3 and 18 +/- 5, respectively; p < 0.001). Acceleration of neutrophil recovery translated into fewer infections: days of fever were significantly reduced in the study population (4 +/- 2 vs 11 +/- 8 vs 15 +/- 6, respectively).(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailPilot Trial of STAR in Medical ICU
Fisk, Liam M.; Le Compte, Aaron J.; Shaw, Geoffrey M. et al

Poster (2012, March)

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See detailPilot Trial of STAR in Medical ICU
Fisk, LM; Le Compte, A; Shaw, GM et al

in Critical Care (2012), 16 (Suppl 1)

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See detailPilot Trials of STAR Target to Range Glycemic Control
Penning, Sophie ULg; Le Compte, Aaron; Massion, Paul et al

in Intensive Care Medicine (2011), 37 (Suppl 1)

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See detailPilot Trials of STAR Target to Range Glycemic Control
Penning, Sophie ULg; Le Compte, Aaron; Massion, Paul et al

Poster (2011)

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See detailPilot Trials of the STAR TGC Protocol in a Cardiac Surgery ICU
LeCompte, Aaron J.; Penning, Sophie ULg; Moorhead, Katherine ULg et al

in Proceedings of the 10th Annual Diabetes Technology Meeting (2010, November)

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See detailLe pilotage de l'enseignement des sciences : un essai de synthèse...
Rousselet, S.; Monseur, Christian ULg

in Informations pédagogiques (1993), 9

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