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See detailPyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxides: novel class of vasorelaxant drugs
Khelili, S.; Pirotte, Bernard ULg; De Tullio, Pascal ULg et al

Poster (1996, January 12)

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See detailPyridobenzoxazepine and Pyridobenzothiazepine Derivatives as Potential Central Nervous System Agents: Synthesis and Neurochemical Study
Liégeois, Jean-François ULg; Rogister, F. A.; Bruhwyler, J. et al

in Journal of Medicinal Chemistry (1994), 37(4), 519-25

In order to characterize the pharmacological profile of the different chemical classes of pyridobenzazepine derivatives, a series of N-methylpiperazinopyrido[1,4]- and -[1,5]- benzoxa- and benzothiazepine ... [more ▼]

In order to characterize the pharmacological profile of the different chemical classes of pyridobenzazepine derivatives, a series of N-methylpiperazinopyrido[1,4]- and -[1,5]- benzoxa- and benzothiazepine derivatives were prepared. The affinities for D2, D1, 5-HT2, and cholinergic (M) receptors were measured. In comparison to dibenzazepine reference compounds, a strong decrease of the affinities was observed, less pronounced, however, for the substituted analogues. Oxazepine and thiazepine analogues like clozapine (except 8-chloro-6-(4-methylpiperazin-1-yl)-pyrido[2,3-b][1,4]benzoxazepin e (9) and 8-chloro-6-(4-methylpiperazin-1-yl)pyrido[2,3-b][1,4]- benzothiazepine (11)) were found to be inactive against apomorphine stereotypies. In the open-field test in rats, different molecules showed a high disinhibitory activity as observed with anxiolytic drugs. Moreover, 8-chloro-5-(4-methylpiperazin-1-yl)pyrido[2,3-b][1,5]benzoxazepine (14) presented a clozapine-like profile that was confirmed in the behavioral model in dogs and showed most of the behavioral characteristics described for antipsychotic drugs. Its neurochemical profile, in particular the 5-HT2/D2 ratio, was also compatible with atypical antipsychotic activity. [less ▲]

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See detailA pyridothiadiazine (BPDZ 44) as a new and potent activator of ATP-sensitive K+-channels
Pirotte, Bernard ULg; Antoine, M.-H.; De Tullio, Pascal ULg et al

in Biochemical Pharmacology (1994), 47

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See detailPyridothiadiazines as potent activators of KATP channels and inhibitors of insulin secretion
Lebrun, Ph.; De Tullio, Pascal ULg; Antoine, M. H. et al

Poster (1994, October)

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See detailPyridothiadiazines as potent inhibitors of glucose-induced insulin release
Lebrun, P.; Antoine, M.-H.; Ouedraogo, R. et al

in Physiology and Pathophysiology of the Islets of Langerhans (1997)

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See detailPyridothiadiazines inhibit glucose-induced insulin release by activating ATP-sensitive K+ channels
Lebrun, P.; Antoine, M. H.; Ouedraogo, R. et al

Conference (1994, December 10)

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See detailPyrométamorphisme induit par la gézéification souterraine de niveaux charbonneux du Westphalien dans le Bassin de Mons (Belgique)
Nzali, Timothée; Duchesne, Jean-Clair ULg; Jacquemin, Christiane et al

in Geologica Belgica (1999), 2(3-4), 221-234

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See detailPyropheophorbide-a-methyl ester: DMPC liposome vectorization and biophysical properties for PDT
Guelluy, Pierre-Henri ULg; Fontaine-Aupart, Marie-Pierre; Grammenos, Angeliki ULg et al

Poster (2009, July)

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See detailPyrosequencing of epizootic rabbit enteropathy inocula and rabbit caecal samples.
Huybens, N.; Houeix, J.; Licois, D. et al

in Veterinary Journal (2013), 196

The aetiological agent of epizootic rabbit enteropathy (ERE) is still unknown although a bacterial infection seems the most likely hypothesis. In this study, amplification of the V5 and V6 regions of ... [more ▼]

The aetiological agent of epizootic rabbit enteropathy (ERE) is still unknown although a bacterial infection seems the most likely hypothesis. In this study, amplification of the V5 and V6 regions of 16SrDNA from four virulent and two non-virulent caecal samples was performed using a pyrosequencing platform. The virulent samples did not group in the same cluster. The bacterial flora identified was both different and richer than the cultivable bacterial flora. These findings highlight the need for biomolecular techniques to identify the aetiological agent of ERE. [less ▲]

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See detailPyruvate dehydrogenase deficiency presenting as intermittent isolated acute ataxia
Debray, François-Guillaume ULg; Lambert, M.; Gagne, R. et al

in Neuropediatrics (2008), 39(1), 20-23

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See detailPythium root rot of common bean : biology and control methods. A review
Nzungize, J.R.; Lyumugabe, F.; Busogoro, J.-P. et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2012), 16(3), 405-413

Pythium root rot constitutes a highly damaging constraint on the common bean, Phaseolus vulgaris L., grown in several areas of Eastern and Central Africa. Here, this food legume is cultivated intensively ... [more ▼]

Pythium root rot constitutes a highly damaging constraint on the common bean, Phaseolus vulgaris L., grown in several areas of Eastern and Central Africa. Here, this food legume is cultivated intensively under poor conditions of crop rotation due to the exiguity of the land in the region. Yield losses of up to 70 % in traditional local bean cultivars have been reported in Kenya and Rwanda. In this study, a detailed analysis of the biology and diversity of the Pythium genus was carried out in order to understand the mechanisms leading to the development of the disease. Various control methods for reducing the damage provoked by this disease were analyzed. [less ▲]

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See detailQ 1208 + 1011 - The most distant imaged quasar, or a binary?
Magain, Pierre ULg; Surdej, Jean ULg; Vanderriest, C. et al

in Astronomy and Astrophysics (1992), 253(Letters), 13-16

The paper reports the discovery of a new gravitational lens candidate: the high redshift (z = 3.803) and highly luminous (V = 17.5, M[SUB]V[/SUB] = -30.3) quasar Q 1208 + 1011. As derived from the ... [more ▼]

The paper reports the discovery of a new gravitational lens candidate: the high redshift (z = 3.803) and highly luminous (V = 17.5, M[SUB]V[/SUB] = -30.3) quasar Q 1208 + 1011. As derived from the analysis of direct CCD frames taken with the ESO/MPI 2.2 m telescope, this multiple quasar consists of two pointlike images, separated by 0.45 arcsec and characterized by a brightness ratio of 3.5, in red light. Existing spectroscopic data support the gravitational lens interpretation for this system but cannot exclude the hypothesis of a binary quasar. In the former case, the spectrum suggests that, if the metallic absorption line system reported by Steidel (1990) at a redshift z = 2.9157 is associated with the deflector, the mass of the lens should be of the order of M = 7.8 x 10 exp 11 solar masses. Evaluation of a recent HST PC frame obtained for Q 1208 + 1011 within the snapshot survey for gravitational lenses confirms the above results. [less ▲]

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See detailQ fever IN JApaN: an update REVIEW
Porter, Sarah ULg; Czaplicki, G.; Mainil, Jacques ULg et al

in Veterinary Microbiology (2011), 149

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See detailQ FEVER: CURRENT STATE OF KNOWLEDGE AND PERSPECTIVES OF RESEARCH OF A NEGLECTED ZOONOSIS
Porter, Sarah ULg; Czaplicki, G.; Mainil, Jacques ULg et al

in International Journal of Microbiology (2011)

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See detailQ0059-2735: A Hybrid Starburst/Broad Absorption Line QSO ? Clues from Spectropolarimetry
Hutsemekers, Damien ULg; Lamy, H.

in Mass Outflow in Active Galactic Nuclei: New Perspectives. ASPC 255 (2002)

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See detailQCD description of charmonium plus light meson production in p̄-N annihilation
Pire, Bernard; Semenov-Tyan-Shanskiy, Kirill ULg; Szymanowski, Lech

in Physics Letters B (2013), 724

Detailed reference viewed: 10 (1 ULg)