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See detailPre- and post-treatment with pirlindole and dehydropirlindole protects cultured brain cells against nitric oxide-induced death.
Boland, André ULg; Gérardy, Jean; Mossay, Danielle ULg et al

in European Journal of Pharmacology (2003), 466

We have previously shown that pirlindole and dehydropirlindole, two monoamine oxidase type-A inhibitors, protect cultured brain cells against iron-induced toxicity through a mechanism unrelated to ... [more ▼]

We have previously shown that pirlindole and dehydropirlindole, two monoamine oxidase type-A inhibitors, protect cultured brain cells against iron-induced toxicity through a mechanism unrelated to monoamine oxidase type-A inhibition. The current study was performed to test whether the protective effect of pirlindole and dehydropirlindole could be extended to a nitric oxide (NO)-induced insult. A comparison with other monoamine oxidase inhibitors (brofaromine, moclobemide and deprenyl) and with trolox was made. In a first series of experiments, rat hippocampal or cortical cultured cells were exposed to a drug for 3 h, then 5 muM sodium nitroprusside, a NO donor, was added and the incubation was continued for 16 h. Cell survival assessment showed that pirlindole, dehydropirlindole and trolox significantly protected cultures against NO-induced toxicity in a concentration-dependent manner with respective EC50's of 7, 3 and 17 muM. Similarly, pirlindole, dehydropirlindole or trolox, at a concentration of 50 muM, significantly decreased both intracellular peroxide production and lipoperoxidation. Other drugs were ineffective. In a post-hoc treatment protocol (3- or 6-h pre-incubation in the presence of sodium nitroprusside, then addition of one of the above mentioned compounds), only pirlindole and dehydropirlindole significantly improved cell survival in a concentration-dependent manner with respective EC50'S of 9 and 4 muM. The maximal protection in terms of cell survival was 90% and 78% after 3 and 6 h, respectively. They also reduced the production of both lipoperoxides and endoperoxides. Our results show that pirlindole and dehydropirlindole protect neurons against NO-induced toxicity at pharmacologically relevant concentrations. Moreover, their protective effect is still apparent when they are applied after the start of the insult. Therefore, our preclinical study suggests a new strategy that may be efficient to reduce NO-induced damage in the central nervous system. (C) 2003 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailPre- and postoperative laryngoscopic considerations
FINCK, Camille ULg

Scientific conference (2011, March)

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See detailPre- and postperihelion photometry of Comet Halley from several observatories
Sterken, C.; Manfroid, Jean ULg; Arpigny, Claude ULg

in ESLAB Symposium on the Exploration of Halley's Comet (1986, December 01)

Photoelectric observations of P/Halley were carried out during several weeks between 15 Sept. 1985 and 25 June 1986. All measurements were made using the standard IAU/IHW cometary filters. Large amplitude ... [more ▼]

Photoelectric observations of P/Halley were carried out during several weeks between 15 Sept. 1985 and 25 June 1986. All measurements were made using the standard IAU/IHW cometary filters. Large amplitude night-to-night changes over periods of several days superimposed on the general trend of slow brightness variation were seen. Smooth and irregular variations with a range up to 0.2 mag on time scales of several hours were observed. Present photometric scans of comet Halley through the various filters are presented. Successive integrations were made every 5 arc sec, radially from the center out to a distance of 5 arcmin, essentially along the sunward-antisunward direction and in the direction perpendicular to it. [less ▲]

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See detailPre-academic students and vocational choice: Between the past and the present
Broonen, Jean-Paul ULg

in European IRTAC-CRE Conference : Student Counselling in Higher Education: a task of growing importance, (1993, April 13)

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See detailPre-and post-harvest application of antagonistic yeasts for the control of gray and blue mold: efficacy and monitoring
De Clercq, D.; Dickburt, C.; Lepoivre, Philippe ULg et al

in Phytopathology (2001), 91(6), 21

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See detailPre-Cambrian to Palaeozoic Palaeopalynology and Palaeobotany
Steemans, Philippe ULg; Javaux, Emmanuelle ULg

in Carnets de Géologie = Notebooks on Geology (2005), Mémoir 2005/02

Detailed reference viewed: 28 (2 ULg)
See detailLa pré-dialyse
Krzesinski, Jean-Marie ULg

Conference (2008, September 19)

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See detailPré-dimensionnement par simulations dynamiques d’un réacteur de stockage thermochimique assurant l’autonomie d’un système solaire combiné.
Hennaut, Samuel ULg; Thomas, Sébastien ULg; Andre, Philippe ULg et al

in Congrès Français de Thermique 2011 - Energie Solaire et Thermique - Perpignan - 24-27 Mai 2011 (2011, May 24)

Etude du stockage de l’énergie solaire thermique sous forme thermochimique comme moyen d’assurer l’autonomie thermique d’une habitation basse énergie. La surface de capteurs nécessaire et les ... [more ▼]

Etude du stockage de l’énergie solaire thermique sous forme thermochimique comme moyen d’assurer l’autonomie thermique d’une habitation basse énergie. La surface de capteurs nécessaire et les caractéristiques du stockage sont étudiées par simulation dynamique (TRNSYS), de manière générale et pour des couples adsorbant/adsorbat particuliers (CaCl2/H2O et Charbon actif/Méthanol). Un système solaire combiné avec 14,4 m² de capteurs plans et un stockage thermochimique de 12,35 m³ de CaCl2 permet d’assurer l’autonomie thermique d’une habitation « basse énergie » située en Belgique et une grande part de la production d’eau chaude sanitaire (ECS). [less ▲]

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See detailLa pré-éclampsie dans tous ses états. Gestion en anesthésie
Brichant, Jean-François ULg

Conference (2005, September)

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See detailPre-emptive immunotherapy with CD8-depleted donor lymphocytes after CD34-selected allogeneic peripheral blood stem cell transplantation.
Baron, Frédéric ULg; Siquet, Jean; Schaaf-Lafontaine, Nicole ULg et al

in Haematologica (2002), 87(1), 78-88

BACKGROUND AND OBJECTIVES: To maximize graft-versus-leukemia (GVL) effects while minimizing the risk of graft-versus-host disease (GVHD), we undertook a study of allogeneic CD34-selected peripheral blood ... [more ▼]

BACKGROUND AND OBJECTIVES: To maximize graft-versus-leukemia (GVL) effects while minimizing the risk of graft-versus-host disease (GVHD), we undertook a study of allogeneic CD34-selected peripheral blood stem cell (PBSC) transplantation followed by CD8-depleted donor lymphocyte infusion (DLI). DESIGN AND METHODS: Twenty-four patients with advanced hematologic malignancies were included. PBSC were collected in matched (N=16) or one-mismatch (N=8) related donors and CD34-selected. On day 60, donors donated lymphocytes that were CD8-depleted and separated into 3 aliquots containing 2 x 10(6), 1 x 10(7) and 5 x 10(7) CD3+ cells/kg (patients 1-13) or into 2 aliquots containing 1 x 10(7) and 5 x 10(7) CD3+ cells/kg (patients 14-24). The 1st aliquot was infused on day 60 and the other 1 (2) cryopreserved and infused on days 100 (and 140). RESULTS: An average of 100%, 100% and 84% of the scheduled dose could be administered in DLI 1, 2 and 3, respectively. Although the study group was at very high risk of GVHD, the actuarial incidence of grade II-IV acute GVHD was 28% (13% for HLA-identical siblings) with only 1 patient developing grade III-IV GVHD (after DLI). The actuarial 2-year probability of extensive chronic GVHD was similarly low (13% for all patients and 0% for HLA-identical siblings). Individual cases as well as a 30% relapse rate (0% for standard-risk patients versus 55% for high-risk patients) indicated preservation of the GVL effect. INTERPRETATION AND CONCLUSIONS: We conclude that allogeneic transplantation of CD34-selected PBSC followed by pre-emptive CD8-depleted DLI is feasible with rapid engraftment and minimizes the risk of severe GVHD. Large prospective trials are required to prove that it preserves the GVL effect fully. [less ▲]

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See detailPré-étude de reconversion de l'ancienne Linière Saint-Léonard, Liège.
Frankignoulle, Pierre ULg; Jacob, Gauthier; Staessen, Rudolphe

Report (1988)

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See detailPre-feasibility study of Itaipu navigation canal
Marchal, Jean ULg; Rigo, Philippe ULg

Report (1998)

Detailed reference viewed: 13 (1 ULg)
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See detailPre-flight calibration of LYRA, the solar VUV radiometer on board PROBA2
Benmoussa, Ali; Dammasch, Ingolf; Hochedez, Jean-François et al

in Astronomy and Astrophysics (2009), 508(2), 1085-1094

Aims. LYRA, the Large Yield Radiometer, is a vacuum ultraviolet (VUV) solar radiometer, planned to be launched in November 2009 on the European Space Agency PROBA2, the Project for On-Board Autonomy ... [more ▼]

Aims. LYRA, the Large Yield Radiometer, is a vacuum ultraviolet (VUV) solar radiometer, planned to be launched in November 2009 on the European Space Agency PROBA2, the Project for On-Board Autonomy spacecraft. Methods: The instrument was radiometrically calibrated in the radiometry laboratory of the Physikalisch-Technische Bundesanstalt (PTB) at the Berlin Electron Storage ring for SYnchroton radiation (BESSY II). The calibration was done using monochromatized synchrotron radiation at PTB's VUV and soft X-ray radiometry beamlines using reference detectors calibrated with the help of an electrical substitution radiometer as the primary detector standard.<BR /> Results: A total relative uncertainty of the radiometric calibration of the LYRA instrument between 1 and 11 was achieved. LYRA will provide irradiance data of the Sun in four UV passbands and with high temporal resolution down to 10 ms. The present state of the LYRA pre-flight calibration is presented as well as the expected instrument performance. [less ▲]

Detailed reference viewed: 136 (10 ULg)
See detailPre-harvest conditions affect the banana susceptibility to post-hervest disease.
Lassois, Ludivine ULg; Ewane, Cecile; Forret, Marie et al

Conference (2011, May 24)

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See detailLa "pré-histoire" chez Kant et Rousseau : roman ou conjecture
de Villers Grand Champs, Bénédicte ULg

in Klimis, Sophie; Van Eynde, Laurent (Eds.) Littérature et savoir(s) (2002)

Detailed reference viewed: 12 (0 ULg)