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See detailPlasticity of Developing and Adult Dorsal Root Ganglion Neurons as Revealed in Vitro
Delree, P.; Ribbens, Clio ULg; Martin, Didier ULg et al

in Brain Research Bulletin (1993), 30(3-4), 231-7

We review recent data on the plasticity of dorsal root ganglion (DRG) neurons as revealed during cultivation in vitro. Some experiments on cultured developing DRG neurons and on adult DRG neurons in vivo ... [more ▼]

We review recent data on the plasticity of dorsal root ganglion (DRG) neurons as revealed during cultivation in vitro. Some experiments on cultured developing DRG neurons and on adult DRG neurons in vivo are also mentioned. Cultured developing and adult DRG neurons can be switched from an apolar to a multipolar phenotype by fetal calf serum or fibronectin. The effect is concentration dependent and occurs through an early modification of cell-substratum interaction. Adult DRG neurons synthesize and release within hours after injury TGF beta-1, which is a mitogen and a differentiation factor for Schwann cells. Finally, adult DRG neurons express in vitro neurotransmitters that are not expressed in vivo. This neurotransmitter plasticity can be modulated in vitro by some growth factors and in vivo by distal or proximal axotomy. [less ▲]

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See detailPlasticity of rat central inhibitory synapses through GABA metabolism
Engel, Dominique ULg; Pahner, I; Schulze, K et al

in Journal of Physiology (2001), 535(2), 473-82

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See detailPlasticity of the mitoproteome to nitrogen sources (nitrate and ammonium) in Chlamydomonas reinhardtii: the logic of Aox1 gene localization
Gérin, Stéphanie ULg; Mathy, Grégory ULg; Blomme, Arnaud ULg et al

in Biochimica et Biophysica Acta-Bioenergetics (2010), 1797

Nitrate and ammonium constitute primary inorganic nitrogen sources that can be incorporated into carbon skeletons in photosynthetic eukaryotes. In Chlamydomonas, previous studies and the present one ... [more ▼]

Nitrate and ammonium constitute primary inorganic nitrogen sources that can be incorporated into carbon skeletons in photosynthetic eukaryotes. In Chlamydomonas, previous studies and the present one showed that the mitochondrial AOX is up-regulated in nitrate-grown cells in comparison with ammonium-grown cells. In this work, we have performed a comparative proteomic analysis of the soluble mitochondrial proteome of Chlamydomonas cells growth either on nitrate or ammonium. Our results highlight important proteomics modifications mostly related to primary metabolism in cells grown on nitrate. We could note an up-regulation of some TCA cycle enzymes and a down-regulation of cytochrome c1 together with an up-regulation of l-arginine and purine catabolism enzymes and of ROS scavenging systems. Hence, in nitrate-grown cells, AOX may play a dual role: (1) lowering the ubiquinone pool reduction level and (2) permitting the export of mitochondrial reducing power under the form of malate for nitrate and nitrite reduction. This role of AOX in the mitochondrial plasticity makes logical the localization of Aox1 in a nitrate assimilation gene cluster. [less ▲]

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See detailPlasticization of biphasic ionomers by chemically identical, short, monofunctional oligomers
Plante, Michel; Bazuin, C Géraldine; Jérôme, Robert ULg

in Macromolecules (1995), 28(5), 1567-1574

Blends of carboxylated polystyrene ionomers containing 7 mol% of ionic units and carboxylate-terminated, monofunctional, monodisperse styrene oligomers of MW 800 were investigated by dynamic mechanical ... [more ▼]

Blends of carboxylated polystyrene ionomers containing 7 mol% of ionic units and carboxylate-terminated, monofunctional, monodisperse styrene oligomers of MW 800 were investigated by dynamic mechanical analysis and small angle X-ray scattering(SAXS). Both Cs and Ba carboxylate salts were studied,as well as blends of the Cs oligomer with homopolystyrene. The cluster phase is preferentially plasticized by the oligomers for both salts.; However, whereas the nonclustered phase of the Cs system is only a Little more plasticized than that of the Ba system, the cluster phase in the Cs system undergoes dramatic plasticization, the cluster transition disappearing at 5 wt % oligomer content. Simultaneously, the SAXS ''ionomer peak'' disappears. A peak reappears at 20 wt % oligomer content, suggesting the development of a new morphology, proposed to be micelles or ''inverted multiplets''. The difference between the two systems is attributed to the much stronger electrostatic interactions in the Ba system; this is analyzed in terms of elementary ion units. It is concluded that, whereas the nature of the nonpolar tail is relatively unimportant, the nature and strength of the electrostatic interactions involved can be of critical importance to the plasticization effects in blends of ionomers with short, monofunctional oligomers. [less ▲]

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See detail(Plasticized) polylactide/(organo-)clay nanocomposites by in situ intercalative polymerization
Paul, Marie-Amélie; Delcourt, Cécile; Alexandre, Michaël ULg et al

in Macromolecular Chemistry and Physics (2005), 206(4), 484-498

Both intercalated and exfoliated poly(L,L-lactide) (P(L,L-LA)/organomodified montmorillonite nanocomposites were synthesized by in situ ring-opening polymerization Of L,L-lactide, in bulk, directly in the ... [more ▼]

Both intercalated and exfoliated poly(L,L-lactide) (P(L,L-LA)/organomodified montmorillonite nanocomposites were synthesized by in situ ring-opening polymerization Of L,L-lactide, in bulk, directly in the presence of the nanofiller. Intercalation of polyester chains was found to appear even for natural unmodified montmorillonite-Na+, while exfoliation occurred when the aluminosilicate layers were modified by ammonium cations bearing primary hydroxyl groups. Clay delamination was effectively triggered by the grafting reaction of the growing PLA chains onto the hydroxyl groups. Aluminium triisopropoxide, triethylaluminium, and stannous octoate, as initiating or co-initiating species, were compared in terms of polymerization control. The influence of nanoclay content (from 1 to 10 wt.-% in inorganics) on morphology and thermal behavior was also studied. In parallel, a highly filled nanocomposite (called masterbatch), prepared by in situ polymerization, was dispersed into a (plasticized) preformed polylactide matrix in the molten state, to reach a better clay delamination than that obtained by direct melt blending. Finally, L-,L-lactide and alpha,w-dihydroxylated poly(ethylene glycol) (PEG 1000) were copolymerized in presence of clay in order to study the behavior of the resulting triblocks towards nanocomposite formation. [less ▲]

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See detailPlate Forme Multi Acteurs (PMA) : quel degré d’appropriation de l’approche par les acteurs dans les bas-fonds de « Sissiotan (Houéyogbé ) et de Kossou-Togba (Dogbo) »
Dossouhoui, François Vihôdé ULg; Kinha, Christophe

Conference (2010, December 07)

Le projet RAP est mis en œuvre selon un processus multi-acteurs (PMA). La PMA constitue un cadre de concertation de plusieurs acteurs : producteurs, transformateurs, commerçants, pisciculteurs, éleveurs ... [more ▼]

Le projet RAP est mis en œuvre selon un processus multi-acteurs (PMA). La PMA constitue un cadre de concertation de plusieurs acteurs : producteurs, transformateurs, commerçants, pisciculteurs, éleveurs, structures d’appui, Partenaires Techniques et financiers, etc. Les intérêts de ces acteurs sont très souvent divergents. Mais, ces acteurs sont appelés à apprendre, agir, et innover ensemble dans une approche systémique pour une utilisation optimale et une gestion durable des ressources naturelles de ces bas-fonds. Après deux années de mise en œuvre de cette approche, nous évaluions le niveau d’appropriation par les acteurs. Les conditions de mobilisation des ressources humaines et financières pour la concrétisation de cette innovation ont été évaluées de même que les actions qui ont été mises en œuvre dans le processus d’ancrage de ce partenariat. Les acquis, les faiblesses et les contraintes à l’appropriation ont fait l’objet d’une analyse critique. En somme, les PMA sont en construction et il existe de réelles motivations autour de cette approche. [less ▲]

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See detailPlate Forme Multi Acteurs (PMA) : quel degré d’appropriation de l’approche par les acteurs dans les bas-fonds de « Sissiotan (Houéyogbé ) et de Kossou-Togba (Dogbo) »
Dossouhoui, François Vihôdé ULg; Kinha, Christophe

Conference (2010, December 07)

Le projet RAP est mis en œuvre selon un processus multi-acteurs (PMA). La PMA constitue un cadre de concertation de plusieurs acteurs : producteurs, transformateurs, commerçants, pisciculteurs, éleveurs ... [more ▼]

Le projet RAP est mis en œuvre selon un processus multi-acteurs (PMA). La PMA constitue un cadre de concertation de plusieurs acteurs : producteurs, transformateurs, commerçants, pisciculteurs, éleveurs, structures d’appui, Partenaires Techniques et financiers, etc. Les intérêts de ces acteurs sont très souvent divergents. Mais, ces acteurs sont appelés à apprendre, agir, et innover ensemble dans une approche systémique pour une utilisation optimale et une gestion durable des ressources naturelles de ces bas-fonds. Après deux années de mise en œuvre de cette approche, nous évaluions le niveau d’appropriation par les acteurs. Les conditions de mobilisation des ressources humaines et financières pour la concrétisation de cette innovation ont été évaluées de même que les actions qui ont été mises en œuvre dans le processus d’ancrage de ce partenariat. Les acquis, les faiblesses et les contraintes à l’appropriation ont fait l’objet d’une analyse critique. En somme, les PMA sont en construction et il existe de réelles motivations autour de cette approche. [less ▲]

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See detailDas Plateau des Kammer- und Aortenpules
Fredericq, Léon ULg

in Zentralblatt für Physiologie (1893)

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See detailLa plateforme ExAMS, un "assessment management system" pour instrumenter la construction et la gestion qualité des évaluations des apprentissages
Gilles, Jean-Luc ULg; Detroz, Pascal ULg; Crahay, Vinciane ULg et al

in Blais, Jean-Guy (Ed.) Evaluation des apprentissages et technologie de l'information et de la communication - Tome 2 (2011)

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See detailPlateforme interactive utilisée comme outil diagnostique et de remédiation adapté aux grandes populations étudiantes suivant un cours de physique
Marique, Pierre-Xavier ULg; Hoebeke, Maryse ULg

Conference (2014, May 01)

La réforme des études de médecine introduite en 2012 en Communauté Française (Belgique) a fortement modifié les programmes de cours, entre autres celui de physique, pour lequel certaines notions sont ... [more ▼]

La réforme des études de médecine introduite en 2012 en Communauté Française (Belgique) a fortement modifié les programmes de cours, entre autres celui de physique, pour lequel certaines notions sont désormais considérées comme prérequises. Conscientes que celles-ci ne sont pas toujours acquises par les étudiants, les équipes pédagogiques de l'ULg ont élaboré des systèmes de remédiation. Un espace en ligne a notamment été développé, parallèlement au cours présentiel (cours ex-cathedra, répétitions et laboratoires), afin de permettre aux enseignants et aux étudiants d'évaluer les difficultés et lacunes de ces derniers et d’y remédier. Cet outil est conçu pour offrir une aide spécifique adaptée à chacun malgré le nombre important d’étudiants inscrits (800 en 2013). Ils peuvent y travailler, de manière progressive et autonome, les aspects théoriques (notes et tests formatifs) et pratiques (exercices, problèmes décomposés ou non). Des tests diagnostiques en début et fin de parcours permettent aux apprenants d’apprécier leur évolution. De plus, la plate-forme centralise différents outils interactifs (forums, calendrier, annonces, …) accompagnant l’étudiant dans l’organisation de son apprentissage. Les premières analyses de traces indiquent une corrélation entre travail en ligne et réussite. Une adaptation progressive de l’outil sera basée sur l’analyse des résultats et du ressenti de étudiants. [less ▲]

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See detailLa plateforme Open-source ExAMS : une approche qualité pour le testing standardisé
Gilles, Jean-Luc ULg; Detroz, Pascal ULg; Crahay, Vinciane ULg et al

in Chafiqi, Fouad (Ed.) Mondialisation et éducation - Vers une société de la connaissance. Recueil des résumés des conférences et des communications (tome I) (2008)

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See detailPlatelet adhesion receptors do not modulate infarct volume after a photochemically induced stroke in mice.
Frederix, Kim ULg; Chauhan, Anil K; Kisucka, Janka et al

in Brain Research (2007), 1185

Photochemically induced cerebral infarction has been considered a clinically relevant model for ischemic stroke. We evaluated various transgenic mice to study the role of platelet adhesion molecules in ... [more ▼]

Photochemically induced cerebral infarction has been considered a clinically relevant model for ischemic stroke. We evaluated various transgenic mice to study the role of platelet adhesion molecules in this model. Infarction to the sensorimotoric cortex was induced by erythrosin B and laser light. Infarct volumes were calculated from triphenyltetrazolium chloride stained brain slices. Thrombus formation and vessel leakage were observed in vivo by multiphoton microscopy. Mice mutant in VWF, GPIbalpha, beta3 integrin, and P-selectin did not show any significant differences in infarct volume compared to wild type (WT). This is in contrast to the intraluminal middle cerebral artery occlusion model in which alphaIIbbeta3 integrin, GPIbalpha, and P-selectin are known to modulate infarct size. Multiphoton microscopy showed that small, non-occlusive embolizing platelet thrombi formed in the photochemically injured brains. Massive vessel leakage was observed within 25 min of laser injury. Interestingly, we observed a significant increase in infarct size with aging, accordant with heightened fragility of the blood brain barrier (BBB) in older mice. This model of photochemically induced stroke is closer to a BBB injury model than a thrombotic stroke model in which platelets and their adhesion molecules are crucial. This model will be useful to study mechanisms regulating BBB permeability. [less ▲]

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See detailThe platelet ATP and ADP receptors.
Oury, Cécile ULg; Toth-Zsamboki, Emese; Vermylen, Jos et al

in Current Pharmaceutical Design (2006)

This review focuses on recent findings on the physiology of these platelet ADP and ATP receptors, their distinct downstream intracellular signaling pathways as well as on the available agonists ... [more ▼]

This review focuses on recent findings on the physiology of these platelet ADP and ATP receptors, their distinct downstream intracellular signaling pathways as well as on the available agonists, antagonists and inhibitors that allow their pharmacological discrimination. [less ▲]

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See detailPlatelet expression of non-functional P2X1delL ion channels in mice reduces arterial thrombosis
Oury, Cécile ULg; Daenens, Kim; Feijge, Marion et al

in Haematologica (2004)

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See detailThe platelet purinergic receptors
Oury, Cécile ULg; Hoylaerts, Marc

Book published by Leuven University Press (2003)

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See detailPlatelet reactivity and cardiovascular events after percutaneous coronary intervention in patients with stable coronary artery disease: the Stent Thrombosis In Belgium (STIB) trial
LEGRAND, Victor ULg; CUISSET, T; CHENU, P et al

in EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology (2014), 10

PR measured before PCI in stable patients undergoing elective PCI who are preloaded with 500 mg of aspirin and 600 mg of clopidogrel is not predictive of periprocedural myocardial injury or adverse ... [more ▼]

PR measured before PCI in stable patients undergoing elective PCI who are preloaded with 500 mg of aspirin and 600 mg of clopidogrel is not predictive of periprocedural myocardial injury or adverse ischaemic complications up to 30 days. [less ▲]

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