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See detailPolymorphisme du syndrome d'activite continue des fibres musculaires Relation possible avec la choree fibrillaire de Morvan.
Delwaide, P.; Figiel, C.; Schoenen, Jean ULg et al

in Revue Neurologique (1979), 135(8-9), 615-24

Two cases presenting the main features of the continuous muscle activity syndrome (neuromyotonia) are reported. The clinical particularities between the two patients are under lined. The second case is ... [more ▼]

Two cases presenting the main features of the continuous muscle activity syndrome (neuromyotonia) are reported. The clinical particularities between the two patients are under lined. The second case is special because of its acute and reversible evolution and the possible role of gold salts in its etiology. This latter point suggests Morvan's fibrillary chorea. The possible relationships between the two syndrome are discussed. [less ▲]

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See detailPolymorphisms at the Five Exons of the Growth Hormone Gene in the Algarvia Goat. Possible Association with Milk Traits
Malveiro, E.; Pereirab, M.; Marques, P. X. et al

in Small animal research (2001), 41

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See detailPolymorphisms in innate immunity genes predispose to bacteremia and death in the medical intensive care unit
Henckaerts, L.; Nielsen, K. R.; Steffensen, R. et al

in Critical Care Medicine (2009), 37(1), 192-2011-3

OBJECTIVE: Critically ill patients are at risk of sepsis, organ failure, and death. Studying the impact of genetic determinants may improve our understanding of the pathophysiology and allow ... [more ▼]

OBJECTIVE: Critically ill patients are at risk of sepsis, organ failure, and death. Studying the impact of genetic determinants may improve our understanding of the pathophysiology and allow identification of patients who would benefit from specific treatments. Our aim was to study the influence of single nucleotide polymorphisms in selected genes involved in innate immunity on the development of bacteremia or risk of death in patients admitted to a medical intensive care unit. DESIGN, SETTING, AND PATIENTS: DNA was available from 774 medical intensive care unit patients. We selected 31 single nucleotide polymorphisms in 14 genes involved in host innate immune defense. Serum levels of MASP2 and chemotactic capacity, phagocytosis, and killing capacity of monocytes at admission were quantified. Univariate Kaplan-Meier estimates with log-rank analysis and multivariate logistic regression were performed. Bootstrap resampling technique and ten-fold cross-validation were used to assess replication stability, prognostic importance of the variables, and repeatability of the final regression model. MAIN RESULTS: Patients with at least one NOD2 variant were shown to have a reduced phagocytosis by monocytes (p = 0.03) and a higher risk of bacteremia than wild-type patients (p = 0.02). The NOD2/TLR4 combination was associated with bacteremia using survival analyses (time to bacteremia development, log-rank p < 0.0001), univariate regression (p = 0.0003), and multivariate regression analysis (odds ratio [OR] 4.26, 95% confidence interval [CI] 1.85-9.81; p = 0.0006). Similarly, the same combination was associated with hospital mortality using survival analysis (log-rank p = 0.03), univariate regression (p = 0.02), and multivariate regression analysis (OR 2.27, 95% CI 1.09-4.74; p = 0.03). Also variants in the MASP2 gene were significantly associated with hospital mortality (survival analysis log-rank-p = 0.003; univariate regression p = 0.02; multivariate regression analysis OR 2.35, 95% CI 1.38-3.99; p = 0.002). CONCLUSIONS: Functional polymorphisms in genes involved in innate immunity predispose to severe infections and death, and may become part of a risk model, allowing identification of patients at risk, who could benefit from early introduction of specific preventive or therapeutic interventions. [less ▲]

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See detailPolymorphisms in the CYP 2D6 gene: Association with plasma concentrations of fluoxetine and paroxetine
Charlier, Corinne ULg; Broly, Franck; Pinto, Emmanuel ULg et al

in Therapeutic Drug Monitoring (2003), 25(6), 738-742

Most antidepressants are metabolized by cytochrome P450 (CYP) 2D6, and it is well known that there may be significant interindividual variation in the capacity to metabolize xenobiotics. About 7 to 10% of ... [more ▼]

Most antidepressants are metabolized by cytochrome P450 (CYP) 2D6, and it is well known that there may be significant interindividual variation in the capacity to metabolize xenobiotics. About 7 to 10% of whites are poor metabolisers (PM), and, on the contrary, about 5% are ultrarapid metabolizers (UM), inducing very different rates in the transformation of antidepressants extensively metabolized by CYP 2D6. CYP 2D6 polymorphism can be a potential risk factor for the development of side effects or a reason for the poor efficacy of the treatment. Various probe drugs may be used for phenotyping CYP 2D6, but genotyping is now available using leukocyte DNA and is independent of concomitant drug use. in this study, we used PCR-based methods for the identification of CYP 2D6 genotypes in 49 patients receiving standard doses of fluoxetine or paroxetine and found that plasma concentration of the antidepressant drugs was significantly correlated with genetic status. In one patient who displayed CYP 2D6 gene duplication (UM), paroxetine plasma concentration was extremely low. in PM fluoxetine-treated patients, drug plasma concentration was significantly higher than that seen in extensive metabolizers. [less ▲]

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See detailPolymorphisms in Type-II SH2 domain-containing Inositol 5-Phosphatase (INPPL1, SHIP2) are Associated with Physiological Abnormalities of the Metabolic Syndrome
Kaisaki, P. J.; Delépine, M.; Woon, P. Y. et al

in Diabetes (2004), 53

Type II SH2 domain-containing inositol 5-phosphatase (INPPL1, or SHIP2) plays an important role in the control of insulin sensitivity. INPPL1 mutations affecting gene function have been found in rat ... [more ▼]

Type II SH2 domain-containing inositol 5-phosphatase (INPPL1, or SHIP2) plays an important role in the control of insulin sensitivity. INPPL1 mutations affecting gene function have been found in rat models of type 2 diabetes and hypertension and in type 2 diabetic patients. We investigated the influence of nucleotide variation in INPPL1 on components of the metabolic syndrome. Following comprehensive resequencing of the gene, we genotyped 12 informative polymorphisms in 1,304 individuals from 424 British type 2 diabetes families that were characterized for several metabolic phenotypes. We have found highly significant associations of single nucleotide polymorphisms (SNPs) and haplotypes of INPPL1 with hypertension as well as with other components of the metabolic syndrome. In a cohort of 905 French type 2 diabetic patients, we found evidence of association of INPPL1 SNPs with the presence of hypertension. We conclude that INPPL1 variants may impact susceptibility to disease and/or to subphenotypes involved in the metabolic syndrome in some diabetic patients [less ▲]

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See detailPolymorphisms of the SHBG gene contribute to the interindividual variation of sex steroid hormone blood levels in young, middle-aged and elderly men
Vanbillemont, G.; Bogaert, V.; De Bacquer, D. et al

in Clinical Endocrinology (2009), 70(2), 303-310

In men there is a large interindividual variation of SHBG levels and consequently of testosterone (T) and E-2 levels. Family and twin studies suggested a strong genetic contribution, besides metabolic and ... [more ▼]

In men there is a large interindividual variation of SHBG levels and consequently of testosterone (T) and E-2 levels. Family and twin studies suggested a strong genetic contribution, besides metabolic and hormonal influences. The aim of this study was to examine the influence of a missense mutation in exon 8 (Asp327Asn) and a (TAAAA)(n)-repeat in the promoter region of the SHBG gene, on SHBG and sex steroid serum concentrations in a population of healthy men. SHBG and hormone levels were measured in 1485 men, contributed by three independent cohort studies and representing three different age groups (young, middle-aged and elderly men). The number of TAAAA-repeats was determined by fragment-analysis; carriers of the Asn(327)-allele were identified using restriction fragment length polymorphism analysis. In the different age groups, carriers of six TAAAA-repeats presented with higher SHBG (young 19%, middle-aged 20% and elderly 26%; P < 0.001) and T (young 9%, middle-aged 22% and elderly 21%; P < 0.05) levels compared to non-carriers. For free T, a modest increase was found for carriers in the middle-aged group, but not for the young and elderly group. E-2 and free E-2 did not differ between carriers and non-carriers in the different age-groups. The Asn(327)-allele was associated with higher mean SHBG (14.20%, P < 0.001) and T levels (7.33%; P = 0.01) in the middle-aged group only. Our findings show that and the (TAAAA)(n)-repeat and the Asp327Asn polymorphism contribute to the genetically determined interindividual variation in total serum T levels in healthy men through variation in SHBG concentrations. [less ▲]

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See detailPolymorphous light eruption-like lesions on sun-protected injection sites of recombinant IFN-alpha-2b
Nikkels, Arjen ULg; Delwaide, Jean ULg; Letawe, C. et al

in Journal of Dermatological Treatment (1997), 8(4), 285

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See detailPolymorphus Minutus Affects Antitoxic Responses of Gammarus Roeseli Exposed to Cadmium
Gismondi, Eric ULg; Beisel, Jean-Nicolas; Cossu-Leguille, Carole

in PLoS ONE (2012), 7

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See detailPolyneuritis equi. Literatuurstudie & retrospectieve studie
Van Galen, Gaby ULg

Master's dissertation (2003)

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See detailPolynomial approximation of aerodynamic coefficients based on the statistical description of the wind incidence
Denoël, Vincent ULg

in Probabilistic Engineering Mechanics (2009), 24(2), 179-189

In civil engineering applications, the aerodynamic coefficients are usually measured in wind tunnels for several wind incidences. The measurement results need to be linearized in order to perform the ... [more ▼]

In civil engineering applications, the aerodynamic coefficients are usually measured in wind tunnels for several wind incidences. The measurement results need to be linearized in order to perform the design of the structure. This paper justifies the use of different linearization techniques for different assessments as divergence or buffeting analysis. In this latter context, it is proposed to linearize the aerodynamic coefficient by the least-square method, using the probability density function of the wind incidence as a weighting function. First this probability density function is computed for a 2-D wind flow, as a function of the wind intensities and their correlation. Then, the comparison of results from different linearization techniques provides surprising results indicating that what is usually performed should be considered with care. [less ▲]

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See detailPolynomial regression with censored data based on preliminary nonparametric estimation
Heuchenne, Cédric ULg; Van Keilegom, Ingrid

in Annals of the Institute of Statistical Mathematics (2007), 59(2), 273-297

Consider the polynomial regression model Y = (beta)0 + beta(1) X + center dot center dot center dot beta X-p(p) + sigma (X)epsilon, where sigma(2)(X) = Var(Y vertical bar X) is unknown, and epsilon is ... [more ▼]

Consider the polynomial regression model Y = (beta)0 + beta(1) X + center dot center dot center dot beta X-p(p) + sigma (X)epsilon, where sigma(2)(X) = Var(Y vertical bar X) is unknown, and epsilon is independent of X and has zero mean. Suppose that Y is subject to random right censoring. A new estimation procedure for the parameters beta(0), center dot center dot center dot, beta (p) is proposed, which extends the classical least squares procedure to censored data. The proposed method is inspired by the method of Buckley and James (1979, Biometrika, 66, 429-436), but is, unlike the latter method, a noniterative procedure due to nonparametric preliminary estimation of the conditional regression function. The asymptotic normality of the estimators is established. Simulations are carried out for both methods and they show that the proposed estimators have usually smaller variance and smaller mean squared error than Buckley-James estimators. The two estimation procedures are also applied to a medical and a astronomical data set. [less ▲]

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See detailPolynomial regression with censored data based on preliminary nonparametric estimation.
Heuchenne, Cédric ULg; Van Keilegom, Ingrid

in Annals of the Institute of Statistical Mathematics (2007), 59

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See detailPolyolefin matrixes with permanent antibacterial activity : preparation, antibacterial activity, and action mode of the active species
Lenoir, Sandrine ULg; Pagnoulle, Christophe; Galleni, Moreno ULg et al

in Biomacromolecules (2006), 7(8), 2291-2296

Poly[2-(tert-butylamino)ethyl methacrylate] (PTBAEMA) belongs to a novel class of water-insoluble biocides. Dispersion of a poly(ethylene-co-butylene)-b-poly[2-(tert-butylamino)ethyl methacrylate] diblock ... [more ▼]

Poly[2-(tert-butylamino)ethyl methacrylate] (PTBAEMA) belongs to a novel class of water-insoluble biocides. Dispersion of a poly(ethylene-co-butylene)-b-poly[2-(tert-butylamino)ethyl methacrylate] diblock copolymer (PEB-b-PTBAEMA) within low-density polyethylene (LDPE) imparts antimicrobial properties to the polyolefin as assessed by the viable cell counting method against Escherichia coli (E. coli). This diblock copolymer has been synthesized by atom transfer radical polymerization (ATRP) with a poly(ethylene-co-butylene) (PEB) oligomer end-capped by an activated bromide as a macroinitiator for the polymerization of 2-(tert-butylamino)ethyl methacrylate (TBAEMA). Morphological changes of E. coli bacteria in contact with modified LDPE have been observed by transmission and scanning electron microscopy and indicate that the diblock copolymer is bactericide rather than bacteriostatic. Finally, the action mode of the PEB-b-PTBAEMA copolymer more likely relies on the displacement of the Ca2+ and/or Mg2+ ions of the outer membrane of the bacteria, which is disorganized and finally disrupted. [less ▲]

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See detailPolyolefin matrixes with permanent antibacterial activity: preparation, antibacterial activity, and action mode of the active species
Lenoir, Sandrine; Pagnoulle, Christophe; Galleni, Moreno ULg et al

Poster (2008, May 22)

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See detailPolyolefin-based composites by polymerization-filling technique
Dubois, Philippe ULg; Alexandre, Michaël ULg; Hindryckx, François et al

in Journal of Macromolecular Science - Reviews in Macromolecular Chemistry and Physics (1998), 38(3), 511-565

Dispersions of inorganic fillers within polymers are commonly designated as polymer-based composites. The properties of these materials are isotropic or anisotropic, depending on the geometry of the ... [more ▼]

Dispersions of inorganic fillers within polymers are commonly designated as polymer-based composites. The properties of these materials are isotropic or anisotropic, depending on the geometry of the filler particles and the effect of the processing conditions on their orientation. Fillers are used to improve some physicomechanical properties of the polymer, the material processability, or decrease the final cost. As a typical example, highly filled composites in which the filler concentration approaches the maximum packing fraction are known for their use in the shaping of ceramic articles. [less ▲]

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See detailPolyomavirus in Renal Transplantation: A Hot Problem
Bonvoisin, Catherine ULg; Weekers, Laurent ULg; Xhignesse, Patricia ULg et al

in Transplantation (2008), 85(7S), 42-48

Polyomavirus BK has emerged as an important complication after kidney transplantation. Although, BK nephropathy develops in only1%to5%of renal transplant recipients, its prognosis when present is very ... [more ▼]

Polyomavirus BK has emerged as an important complication after kidney transplantation. Although, BK nephropathy develops in only1%to5%of renal transplant recipients, its prognosis when present is very poor. The most accepted risk factor is the level of immunosuppressive treatment, but the serostatus of donor and recipient and the absence of human leukocyte antigen C7 in donor and/or recipient influence the BK virus (BKV) reactivation. The gold standard in diagnosing BKV nephropathy (BKVN) continues to be biopsy with use of immunohistochemistry for large T antigens. Urinary decoy cells and blood BKV DNA polymerase chain reaction are used in the screening, but their positive predictive values are poor. However, their use as predictors of the evolution of BKVN is more valuable. The reduction of immunosuppressive therapy currently represents the first-line treatment for BKVN. Cidofovir and leflunomide can be used when BKVN continues to progress. In the event of graft loss, retransplantation is possible with a low risk of recurrence when the infection is no longer active. [less ▲]

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See detailPolypeptide inducing HIV-neutralising antibodies
Brasseur, Robert ULg; Charloteaux, Benoît ULg; Chevalier, Michel et al

Patent (2002)

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See detailPolypes coliques et acromégalie
Beckers, Albert ULg

in Acromégalie : Les conséquences de l'hypersomatotropisme (2001)

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See detailPolyphase karst system in Cretaceous chalk and calcarenite of the Belgian-Dutch border
Willems, Luc ULg; Rodet, Joël; Fournier, Matthieu et al

in Zeitschrift für Geomorphologie (2007), 51(3), 361-376

Along the Belgian-Dutch border, underground and surface quarries dug in Cretaceous calcarenite and chalk intersect many karst features as well as deep large nodes of weathered rock. Their observation ... [more ▼]

Along the Belgian-Dutch border, underground and surface quarries dug in Cretaceous calcarenite and chalk intersect many karst features as well as deep large nodes of weathered rock. Their observation allows the reconstruction of the genesis of an original karst system resulting from the merging of initially independent endokarsts and exokarsts. Deep weathering has developed within the Cretaceous formations, creating nodes of weathered chalk and closed cavities. These phenomena are expanded over time and can form interconnected voids. Near the surface, solution pipes are generated under the coarsest deposits of a fluvial terrace capping the Cretaceous formations. These pipes develop vertically and may be related to the progressive lowering of the water table in connection with the incision of the Meuse valley. Some of these phenomena cut up the older endokarsts and organize complex systems of out-flow within the chalk. [less ▲]

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