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See detailPulmonary Function Values and Growth in Belgian White and Blue Double-Muscled Cattle
Gustin, Pascal ULg; Bakima, M.; Art, Tatiana ULg et al

in Research in Veterinary Science (1988), 45(3), 405-410

Seventy-five double-muscled cattle of the Belgian white and blue breed, two days to 50 months old and weighing 45 to 680 kg, were investigated. Transpulmonary pressure changes, measured with an ... [more ▼]

Seventy-five double-muscled cattle of the Belgian white and blue breed, two days to 50 months old and weighing 45 to 680 kg, were investigated. Transpulmonary pressure changes, measured with an oesophageal balloon, variations of air flow and volume at the mouth were obtained during spontaneous breathing to calculate pulmonary function data. Oxygen and carbon dioxide tensions in arterial blood were also recorded. Growth related changes of the pulmonary function values were similar to those observed in other bovine breeds. Total pulmonary resistance, specific total pulmonary resistance, viscous work, power of breathing, specific viscous work, respiratory frequency and peak-to-peak change in transpulmonary pressure were greater in Belgian white and blue cattle than in Friesian cattle. In the former, tidal volume, specific tidal volume, lowest transpulmonary pressure during expiration, transpulmonary pressure at the functional residual capacity level, dynamic lung compliance and oxygen tension in arterial blood were smaller. Airflow, minute volume and carbon dioxide tension in arterial blood were similar in the Belgian white and blue and Friesian cattle. These results were related to the great sensitivity of double-muscled cattle of the Belgian white and blue breed to laryngitis and bronchopneumonia. [less ▲]

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See detailPulmonary Function Values in Friesian and Double-Muscled Calves During Acute Poikilocapnic Hypoxia
Rollin, Frédéric ULg; Amory, Hélène ULg; Desmecht, Daniel ULg et al

in Zentralblatt für Veterinarmedizin. Reihe A (1997), 44(2), 79-90

The effects of an acute non-isocapnic hypoxia on ventilation and pulmonary mechanics were investigated in 6 healthy unsedated Holstein-Friesian (HF) calves and in 7 double-muscled calves of the Belgian ... [more ▼]

The effects of an acute non-isocapnic hypoxia on ventilation and pulmonary mechanics were investigated in 6 healthy unsedated Holstein-Friesian (HF) calves and in 7 double-muscled calves of the Belgian White and Blue (BWB) breed known to develop more severe hypoxemia during exercise and respiratory diseases. Data were collected at 1 min intervals throughout the following protocol: breathing air (FIO2 = 21%), then breathing hypoxic gas mixture (FIO2 = 10%) for 5 min, and, finally, breathing air again for 5 min of recovery. Arterial blood was sampled at rest and at the 4th min of hypoxia for blood gas analysis. In HF and BWB calves, hypoxia induced a significant increase in tidal and minute volume, but did not change respiratory rate, dynamic lung compliance and total pulmonary resistance. However, with regard to their ventilation during normoxia at rest, BWB calves showed a comparatively greater rise in ventilation than HF calves during the first 4 min of hypoxia. On the contrary, by the 5th minute of hypoxia, ventilation of BWB calves declined to the normoxic level while HF calves largely sustained hyperventilation. This hypoxic ventilatory depression in BWB calves could be explained by the proportionately greater initial increase in ventilation. It was concluded that BWB calves supported this hypoxic challenge less easily than HF calves. [less ▲]

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See detailPulmonary function, airway cytology and bronchoalveolar lavage fluid drug concentration after aerosol administration of cefquinome to horses
Art, Tatiana ULg; Ramery, Eve ULg; Fraipont, Audrey ULg et al

in Equine Veterinary Education (2010), 22(9), 473-479

The administration of antibiotics by aerosol to horses suffering from respiratory infections may partially circumvent the limitations of antimicrobial therapy, e.g. large injection volumes, low ... [more ▼]

The administration of antibiotics by aerosol to horses suffering from respiratory infections may partially circumvent the limitations of antimicrobial therapy, e.g. large injection volumes, low bioavailability and risk of diarrhea. Only injectable formulations are available currently and usually contain other substances that could irritate the mucosa and induce coughing and bronchospasm. In addition, the quality of the aerosol, particularly in terms of the delivery of antibiotics to the deep parts of the lung, is unknown. Although used under field conditions, cefquinome delivered by aerosol has never been studied in horses. This study examined the safety of cefquinome injectable solution, administered by aerosol at a dose of 225 mg/inhalation to 7 healthy horses, by assessing (1) pulmonary function before and 15 min after a single inhalation, at the first day (Day 1) and the fifth day (Day 5) of a 5 day period treatment; and (2) the inflammatory status of the lung, i.e. percentage neutrophils and myeloperoxidase concentration, based on bronchoalveolar lavage (BAL) at D1 and D5. In addition, cefquinome concentrations were measured in bronchoalveolar lavage fluid after aerosol, intravenous (i.v.) and intramuscular (i.m.) administrations. A single aerosol of cefquinome injectable solution did not induce any immediate nor delayed pulmonary side effects in healthy horses and produced cefquinome concentrations in bronchoalveolar lavage (BAL) within 30 min that were higher than the minimal inhibitory concentration of the main equine respiratory pathogens. These results should stimulate further studies, especially in horses suffering from bronchial hyper-reactivity. Aerosol delivery of antibiotics may well have a role in equine therapeutics. [less ▲]

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See detailPulmonary hydrostatic microvascular pressure changes and lung fluid balance during histamine infusion in intact dogs
D'Orio, Vincenzo ULg; RODRIGUEZ, LM; WAHLEN, C et al

in Circulatory Shock (1987), 22

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See detailPulmonary Impedance and Right Ventricular-Vascular Coupling in Endotoxin Shock
D'Orio, Vincenzo ULg; Lambermont, Bernard ULg; Detry, Olivier ULg et al

in Cardiovascular Research (1998), 38(2), 375-82

OBJECTIVE: We tested the hypothesis that right heart failure during endotoxin shock may result from altered ventriculovascular coupling responsible for impeding power transfer to the pulmonary circulation ... [more ▼]

OBJECTIVE: We tested the hypothesis that right heart failure during endotoxin shock may result from altered ventriculovascular coupling responsible for impeding power transfer to the pulmonary circulation. METHODS: The changes in vascular pulmonary input impedance and right ventricular contractility produced by low-dose endotoxin infusion were studied in 6 intact anesthetized dogs. RESULTS: Endotoxin insult resulted in pulmonary hypertension (from 22 +/- 2 to 33 +/- 3 mmHg) associated with significant decreases in stroke volume (from 26.9 +/- 4 to 20.2 +/- 3 ml) and right ventricular ejection fraction (from 41 +/- 3 to 32 +/- 2%). The first minimum of input impedance spectrum and zero phase were shifted towards higher frequencies. Input resistance and characteristic resistance were dramatically increased. The latter change contributed to a significant increase in the pulsatile component of total right ventricular power output from 13 to 21%, indicating a reduction in the hydraulic right ventricle power output delivered into the main pulmonary artery. Overall changes in input pulmonary impedance were indicative of increased afterload facing the right ventricle leading to depressed performance. In contrast, right ventricular systolic elastance was simultaneously increased from 0.56 to 0.93 mmHg/ml indicating an increase in right heart contractility. CONCLUSION: These data suggest that pulmonary hypertension in the setting of experimental endotoxin shock is accompanied by deleterious changes in the pulmonary impedance spectrum, which are responsible for a mismatch of increased contractile state of the right ventricle to the varying hydraulic load ultimately leading to ventricular-vascular uncoupling. [less ▲]

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See detailPulmonary mechanics and inductance plethysmography as noninvasive tools to detect a bilateral diaphragmatic paralysis in a pony
Amory, Hélène ULg; Lomba, F; Lekeux, Pierre ULg et al

in Proceedings of the 3d Congress of the World Equine Veterinary Association (1993)

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See detailPulmonary Mechanics During Treadmill Exercise in Race Ponies
Art, Tatiana ULg; Lekeux, Pierre ULg

in Veterinary Research Communications (1988), 12(2-3), 245-258

Exercise-induced variations in their ventilatory mechanics were studied in 8 healthy ponies 4.2 +/- 1.4 years old and weighing 282 +/- 11 kg. Airflow (V), tidal volume (VT), esophageal pressure, mask ... [more ▼]

Exercise-induced variations in their ventilatory mechanics were studied in 8 healthy ponies 4.2 +/- 1.4 years old and weighing 282 +/- 11 kg. Airflow (V), tidal volume (VT), esophageal pressure, mask pressure and electrocardiogram were simultaneously recorded before, during and after a treadmill (incline 8.3 degrees) exercise which consisted of 2 min walking (1.5 m.sec-1), 3 min slow trotting (3.0 m.sec-1) and 3 min fast trotting (3.5 m.sec-1). The results of three consecutive daily measurements were averaged for each pony. Heart rate, minute volume (Ve), respiratory frequency (f) and peak inspiratory and expiratory V, mean inspiratory and expiratory V, and peak to peak changes in transpulmonary pressure (maxdPtp) increased linearly and significantly with increasing velocity (v) (R2 = 0.99). Tidal volume and the inspiratory time to total breathing time ratio showed a curvilinar relation with v (R2 = 0.99). Minute volume, maxdPtp, total pulmonary resistance (RL) and VT increased from rest to fast trot 6.7, 5.7, 1.5 and 1.6 times respectively. When the ponies stopped all these values decreased significantly. After 5 min recovery, the Ve was approximately doubled, VT and max dPtp unchanged and RL 30% smaller than their respective resting values. The exercise-induced increase in Ve was achieved by an increase in f at both low and high intensity of work. [less ▲]

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See detailPulmonary mechanics in full term and prematurely born neonates during the first two weeks of life
Battisti, Oreste ULg; Lecart, C.; Guissard, F. et al

Conference (1992)

Detailed reference viewed: 7 (2 ULg)
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See detailPulmonary perfusion redistribution in exercises horses
Votion, Dominique ULg; Harmegnies, N. F.; Duvivier, D. H. et al

in European Journal of Nuclear Medicine (2000), 41

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See detailPulmonary response to intravenous 5-hydroxytryptamine in the healthy calf
Desmecht, Daniel ULg; Rollin, Frédéric ULg; Amory, Hélène ULg et al

in Proceedings of the 8th Comparative Respiratory Society Meeting (1989)

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See detailPulmonary Response to Intravenous Administration of 5-Hydroxytryptamine after Type-2 Receptor Blockade in Healthy Calves
Linden, Annick ULg; Desmecht, Daniel ULg; Amory, Hélène ULg et al

in American Journal of Veterinary Research (1993), 54(1), 168-73

The purpose of this study was to investigate the mechanism by which 5-hydroxytryptamine (5-HT) modifies respiratory function, specifically, hyperventilation, diffuse bronchoconstriction, and pulmonary ... [more ▼]

The purpose of this study was to investigate the mechanism by which 5-hydroxytryptamine (5-HT) modifies respiratory function, specifically, hyperventilation, diffuse bronchoconstriction, and pulmonary arterial hypertension in cattle. We determined whether the IV response to 5-HT in calves was attributable to stimulation of 5-HT2 receptors. Six healthy unsedated young bull calves of the Friesian (n = 4) and of the Belgian White and Blue (n = 2) breeds were used. A specific 5-HT2 antagonist (metrenperone, 0.05 mg/kg of body weight) was administered IM 30 minutes before the cattle were given a 5-minute IV 5-HT infusion. Pulmonary function values were registered before, during, and after the 5-HT challenge infusion. Minute volume increased significantly, because of an increase in respiratory rate. Conversely, lung dynamic compliance, total pulmonary resistance, and pulmonary arterial pressure were not changed. We concluded that in cattle, 5-HT-induced ventilatory response is not mediated through activation of 5-HT2 receptors. However, the 5-HT2 receptors are involved in 5-HT-induced broncho- and pulmonary vasoconstriction. [less ▲]

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See detailPulmonary scintigraphy
Votion, Dominique ULg; Lekeux, Pierre ULg

in Dyson, S. J.; Pilsworth, R. C.; Twardock, A. R. (Eds.) et al Equine Scintigraphy (2003)

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See detailPulmonary scintigraphy
Votion, Dominique ULg; Lekeux, Pierre ULg

in McGorum, B. C.; Dixon, P. M.; Robinson, N. E. (Eds.) et al Equine Respiratory Medicine and Surgery (2007)

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See detailPulmonary surfactant from healthy Belgian white and blue and Holstein Friesian calves: Biochemical and biophysical comparison
Danlois, F.; Zaltash, S.; Johansson, J. et al

in Veterinary Journal (2002), 163

The biochemical composition and biophysical behaviour of pulmonary surfactant samples isolated from healthy Belgian White and Blue (BWB) and Holstein Friesian (HF) calves have been investigated and ... [more ▼]

The biochemical composition and biophysical behaviour of pulmonary surfactant samples isolated from healthy Belgian White and Blue (BWB) and Holstein Friesian (HF) calves have been investigated and compared. Interesting differences in composition have been demonstrated. In particular, a higher level of total hydrophobic surfactant-associated proteins (SP) (due to higher levels of SP-B and SP-C) is reported in HF calves compared to BWB calves. Higher levels of phosphatidylcholine (PC) and especially the disaturated form of PC were also found in HF as compared to BWB calves. No immediate effect on the surface tension properties evaluated by the pulsating bubble surfactometer was found between the surfactant samples of the two breeds under physiological conditions. However, since a high content of disaturated PC and the presence of the SP-B and SP-C are thought to be essential for the surface activity, we propose that the reported modifications could contribute to the apparently lower resistance of the BWB calves to respiratory troubles in comparison with HF calves. (C) 2002 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailPulmonary vascular response of healthy calves to intravenous and aerosol 5-hydroxytryptamine
Desmecht, Daniel ULg; Amory, Hélène ULg; Rollin, Frédéric ULg et al

in Archives Internationales de Physiologie et de Biochimie (1990)

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See detailPulmonary veno-occlusive disease in myeloproliferative disorder.
Willems, Evelyne ULg; Canivet, Jean-Luc ULg; Ghaye, Benoît ULg et al

in European Respiratory Journal (2009), 33(1), 213-216

The present study reports a case of biopsy-proven pulmonary veno-occlusive disease as a cause of severe pulmonary hypertension in a patient suffering from a chronic myeloproliferative disorder. The ... [more ▼]

The present study reports a case of biopsy-proven pulmonary veno-occlusive disease as a cause of severe pulmonary hypertension in a patient suffering from a chronic myeloproliferative disorder. The pulmonary disease evolved favourably under treatment with defibrotide, a pro-fibrinolytic medication used in hepatic veno-occlusive disease. [less ▲]

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See detailPulmonary Ventilation, Mechanics, Gas Exchange and Haemodynamics in Calves Following Intratracheal Inoculation of Pasteurella Haemolytica
Linden, Annick ULg; Desmecht, Daniel ULg; Amory, Hélène ULg et al

in Zentralblatt für Veterinarmedizin. Reihe A (1995), 42(8), 531-544

A Pasteurella haemolytica A1 broth was injected intratracheally in eight calves and measurements of pulmonary function values (PFV) were made once before and hourly post inoculation (p.i.). Changes in ... [more ▼]

A Pasteurella haemolytica A1 broth was injected intratracheally in eight calves and measurements of pulmonary function values (PFV) were made once before and hourly post inoculation (p.i.). Changes in PFVs, included increased respiratory rate and minute ventilation (up to 158% of baseline 2 h p.i.) and decreased tidal volume and lung dynamic compliance (up to 33% of baseline 3 h p.i.). Total pulmonary resistance was not affected. At and after 3 h p.i. there was a progressive impairement of gas exchange, as judged from arterial O2 tension which decreased up to 65% of baseline. In contrast, arterial CO2 tension was not affected. Pulmonary hypertension was observed during the 3 last h of the study and was attributable to an increased pulmonary vascular resistance. Severe neutropenia was observed at 3 h p.i. and post-mortem histological findings were consistent with an acute fibrinohemorragic bronchopneumonia. In conclusion, P. haemolytica airway challenge unequiovocally resulted in acute pneumonia, providing a reproducible pathophysiological model for investigations regarding new therapeutic strategies. [less ▲]

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See detailPulp chemical survey at Kasanshi plant (Zambia)
Bastin, David ULg; Jacques, Simon

Report (2010)

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See detailPulp temperature increase during photo-activated disinfection (PAD) of periodontal pockets: an in vitro study.
El Yazami, H.; Zeinoun, T.; Bou Saba, S. et al

in Lasers in medical science (2010)

The capacity of photo-sensitizers, used in combination with laser light to kill micro-organisms has been demonstrated in different studies. Photo-activated disinfection (PAD) has been introduced in ... [more ▼]

The capacity of photo-sensitizers, used in combination with laser light to kill micro-organisms has been demonstrated in different studies. Photo-activated disinfection (PAD) has been introduced in periodontology as an aid for disinfection of periodontal pockets. The aim of this study is to verify the harm for dental vitality of the use of PAD in periodontal pockets. Root canals of 24 freshly extracted human teeth where prepared using profiles up to a size of ISO #50 and filled with thermo-conductor paste. A silicon-based false gum was made in which a periodontal pocket was created and filled with photo-sensitizer phenothiazine chloride (phenothiazine-5-ium, 3.7-bis (dimethylamino)-, chloride). The external root surface was irradiated during 60 s with a 660-nm diode laser (output power: 20 mW; power density: 0.090 W/cm(2); Energy density: 5.46 J/cm(2)) using a periodontal tip with a diameter of 1 mm and a length of 7 mm. Temperatures were recorded inside the root canal using a thermocouple. Measurements were recorded every second, starting at 10 s before lasering, during the irradiation and were continued for 150 s after the end of irradiation, and six measurements were done per tooth. An average temperature increase of 0.48 +/- 0.11 degrees C was recorded. Our results demonstrated that pulp temperature increase was lower than 3 degrees C, which is considered to be harmless for pulp injury. Regarding pulp temperature increase, the use of PAD for disinfection of periodontal pockets can be considered as a safe procedure for dental vitality. [less ▲]

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