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See detailPlacental growth hormone (GH), GH-binding protein, and insulin-like growth factor axis in normal, growth-retarded, and diabetic pregnancies: Correlations with fetal growth
McIntyre, H. D.; Serek, R.; Crane, D. I. et al

in Journal of Clinical Endocrinology and Metabolism (2000), 85(3), 1143-1150

We previously described significant changes in GH-binding protein (GHBP) in pathological human pregnancy. There was a substantial elevation of GHBP in cases of noninsulin-dependent diabetes mellitus and a ... [more ▼]

We previously described significant changes in GH-binding protein (GHBP) in pathological human pregnancy. There was a substantial elevation of GHBP in cases of noninsulin-dependent diabetes mellitus and a reduction in insulin-dependent diabetes mellitus. GHBP has the potential to modulate the proportion of free placental GH (PGH) and hence the impact on the maternal GH/insulin-like growth factor I (IGF-I) axis, fetal growth, and maternal glycemic status. The present study was undertaken to investigate the relationship among glycemia, GHBP, and PGH during pregnancy and to assess the impact of GHBP on the concentration of free PGH. We have extended the analysis of specimens to include measurements of GHBP, PGH, IGF-I, IGF-II, IGF-binding protein-1 (IGFBP-1), IGFSP-2, and IGFBP-3 and have related these to maternal characteristics, fetal growth, and glycemia. The simultaneous measurement of GHBP and PGH has for the first time allowed calculation of the free component of PGH and correlation of the free component to indexes of fetal growth and other endocrine markers. PGH, free PGH, IGF-I, and IGF-II were substantially decreased in IUGR at 28-30 weeks gestation (K28) and 36-38 weeks gestation (K36). The mean concentration (+/-SEM) of total PGH increased significantly from K28 to K36 (30.0 +/- 2.2 to 50.7 +/- 6.2 ng/mL; n = 40), as did the concentration of free PGH (23.4 +/- 2.3 to 43.7 +/- 6.0 ng/mL; n = 38). The mean percentage of free PGH was significantly less in IUGR than in normal subjects (67% vs. 79%; P < 0.01). Macrosomia was associated with an increase in these parameters that did not reach statistical significance. Multiple regression analysis revealed that PGH/IGF-I and IGFBP-5 account for 40% of the variance in birth weight. IGFBP-3 showed a significant correlation with IGF-I, IGF-II, and free and total PGK at K28 and K36. Noninsulin-dependent diabetes mellitus patients had a lower mean percentage of free PGH (65%; P < 0.01), and insulin-dependent diabetics had a higher mean percentage of free PGH (87%; P < 0.01) than normal subjects. Mean postprandial glucose at K28 correlated positively with PGH and free PGH (consistent with the hyperglycemic action of GH). GHBP correlated negatively with both postprandial and fasting glucose. Although GHBP correlated negatively with PGH (r = -0.52; P <.001), free PGH and total PGH correlated very closely (r = 0.98). The results are consistent with an inhibitory function for GHBP in vivo and support a critical role for placental GH and IGF-I in driving normal fetal growth. [less ▲]

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See detailPlacental growth hormone and IGF-I in a pregnant woman with Pit-1 deficiency
Verhaeghe, J.; Bougoussa, M.; Van Herck, E. et al

in Clinical Endocrinology (2000), 53(5), 645-647

The respective contributions of pituitary and placental GH to circulating IGF-I in pregnant women have not been well established. We measured the serum concentrations of placental growth hormone (PGH) and ... [more ▼]

The respective contributions of pituitary and placental GH to circulating IGF-I in pregnant women have not been well established. We measured the serum concentrations of placental growth hormone (PGH) and IGF-I in a woman with pit-1 deficiency before, during and after pregnancy, resulting in the birth of a healthy child (not pit-1 deficient). Both PGH and IGF-I concentrations were below the assay detection limit before and after pregnancy. During pregnancy, PGH and IGF-I levels increased steadily; the concentrations of PGH and IGF-I in late pregnancy were comparable with levels previously measured in normal pregnancies. PGH and IGF-I concentrations were strongly correlated throughout pregnancy (r = 0.90; P = 0.002). PGH was undetectable in cord serum, whilst the IGF-I concentration was within the normal range. The findings of this case study corroborate the notion that PGH is the prime regulator of maternal serum IGF-I during pregnancy. [less ▲]

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See detailPlacental growth hormone secretion is not influenced in vivo by octreotide therapy
Caron, P.; Igout, A.; Hennen, Georges ULg et al

in 10th international Congress of Endocrinology - Abstract book (1996)

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See detailPLACENTAL GROWTH-HORMONE - SIGNIFICANCE RELATIVE TO PITUITARY GROWTH-HORMONES AND PLACENTAL-LACTOGEN HORMONE
Hennen, Georges ULg; Frankenne, Francis ULg; Scippo, Marie-Louise ULg et al

in Reproduction Nutrition Development (1988), 28(6B), 1699-1706

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See detailPlacental proteins in ruminants: biochemical, physiological and zootechnical aspects
Melo de Sousa, Noelita ULg; Figueiredo, J. R.; Beckers, Jean-François ULg

in Renaville, R.; Burny, A. (Eds.) Biotechnology in Animal Husbandry (2001)

During the last decade, investigations were carried out by several research groups in order to characterize proteins or glycoproteins synthesized in the ruminant placenta. Recently, as results of this ... [more ▼]

During the last decade, investigations were carried out by several research groups in order to characterize proteins or glycoproteins synthesized in the ruminant placenta. Recently, as results of this research, a large family of pregnancy-associated glycoproteins (PAGs) was discovered. Using molecular biology techniques, they were found to be members of the superfamily of the aspartic proteinases which also contains pepsinogen, chymosin, renin, beta-secretase, cathepsin D and E etc. Synthesized in the mono and/or binucleate cells of the trophoblast, some forms of PAG seem to lack of proteinase activity. It is likely they are synthesized together with molecules involved in the tissue remodeling of the placenta. Their release in large quantities into the maternal blood circulation results in measurable plasma concentrations. Thanks to international collaborative studies, we have shown that PAG levels are a good indicator of feto-placental well-being and that sharp decreases in PAG levels occur just before pregnancy failure in cows and in goats. In some countries, the PAG assay is available for veterinarians in the regional laboratories responsible for animal health including immunodiagnosis for brucellosis, IBR, BVD, CAEV, VISNA-MEDI etc. [less ▲]

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See detailPlacental proteins secreted in maternal circulation: useful indicators for both pregnancy diagnosis and embryonic mortality in bovine species
Moreira da Silva, F.; Melo de Sousa, Noelita ULg; Figueiredo, J. R. et al

in Revista Portuguesa de Zootecnia (2003), 10(1), 99-121

During the last decades, several research groups developed investigations in order to characterize proteins or glycoproteins synthesized by ruminant placenta. As result of these investigations, a large ... [more ▼]

During the last decades, several research groups developed investigations in order to characterize proteins or glycoproteins synthesized by ruminant placenta. As result of these investigations, a large family of pregnancy-associated glycoproteins was identified in bovine ovine and caprine placenta. By using molecular biology techniques, it was demonstrated that they are members of the aspartic proteinase superfamily, in which they co-exist with pepsinogens, renin, cathepsin D and E, etc. Due to their secretion in large amounts by the trophoblastic binucleated cells, bovine PAGs are detectable in maternal circulation soon after implantation. In the present work, in addition to the physiological and biochemical characterization of bovine PAGs, it will be showed how the measurement of PAG concentrations in maternal blood is useful for both pregnancy confirmation and follow-up of the fetus-placental well-being. Available information related to other placental proteins will be also discussed. [less ▲]

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See detailPlacing the academic library at the center of veterinary PhD students' training
Brouwir, Christine ULg; Vandenput, Sandrina ULg; Maas, Michel et al

in Journal of the European Association for Health Information and Libraries (2008, August), 4(3), 18-20

For several years academic librairies have been actively involved in information literacy instruction. However, the required competences are different for PhD students and in the case of the Veterinary ... [more ▼]

For several years academic librairies have been actively involved in information literacy instruction. However, the required competences are different for PhD students and in the case of the Veterinary Faculty of the University of Liège (Belgium), good Faculty-Librarian collaborations have been developed. Specific targeted courses and training sessions concerning information literacy have been officially incorporated in the PhD curriculum, with the main objective being to help PhD students to be autonomous and efficient in the elaboration of scientific publications, an essential stage of their scientific career. [less ▲]

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See detailLes Placodermes, Arthropodes et Lycophytes des Grès dévoniens de Dô Son (Haiphong, Viêt-Nam).
Janvier, Philippe; Tong-Dzuy, T.; Gerrienne, Philippe ULg

in Geobios (1989), 22

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See detailPLAG1, the main translocation target in pleomorphic adenoma of the salivary glands, is a positive regulator of IGF-II.
Voz, Marianne ULg; Agten, N. S.; Van de Ven, W. J. et al

in Cancer Research (2000), 60(1), 106-13

PLAG1, a novel developmentally regulated C2H2 zinc finger gene, is consistently rearranged and overexpressed in pleomorphic adenomas of the salivary glands with 8q12 translocations. In this report, we ... [more ▼]

PLAG1, a novel developmentally regulated C2H2 zinc finger gene, is consistently rearranged and overexpressed in pleomorphic adenomas of the salivary glands with 8q12 translocations. In this report, we show that PLAG1 is a nuclear protein that binds DNA in a specific manner. The consensus PLAG1 binding site is a bipartite element containing a core sequence, GRGGC, and a G-cluster, RGGK, separated by seven random nucleotides. DNA binding is mediated mainly via three of the seven zinc fingers, with fingers 6 and 7 interacting with the core and finger 3 with the G-cluster. In transient transactivation assays, PLAG1 specifically activates transcription from its consensus DNA binding site, indicating that PLAG1 is a genuine transcription factor. Potential PLAG1 binding sites were found in the promoter 3 of the human insulin-like growth factor II (IGF-II) gene. We show that PLAG1 binds IGF-II promoter 3 and stimulates its activity. Moreover, IGF-II transcripts derived from the P3 promoter are highly expressed in salivary gland adenomas overexpressing PLAG1. In contrast, they are not detectable in adenomas without abnormal PLAG1 expression nor in normal salivary gland tissue. This indicates a perfect correlation between PLAG1 and IGF-II expression. All of these results strongly suggest that IGF-II is one of the PLAG1 target genes, providing us with the first clue for understanding the role of PLAG1 in salivary gland tumor development. [less ▲]

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See detailPlagiat et citations: fascicule relatif à la rédaction du mémoire
Delville, Michel ULg; Simons, Germain ULg; Ramais, Thierry

Learning material (2008)

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See detailPlague and the human flea, Tanzania
Laudisoit, Anne ULg; Leirs, H.; Makundi, R. H. et al

in Emerging Infectious Diseases (2007), 13(5), 687-693

Domestic fleas were collected in 12 villages in the western Usambara Mountains in Tanzania. Of these, 7 are considered villages with high plague frequency, where human plague was recorded during at least ... [more ▼]

Domestic fleas were collected in 12 villages in the western Usambara Mountains in Tanzania. Of these, 7 are considered villages with high plague frequency, where human plague was recorded during at least 6 of the 17 plague seasons between 1986 and 2004. In the remaining 5 villages with low plague frequency, plague was either rare or unrecorded. Pulex irritans, known as the human flea, was the predominant flea species (72.4%) in houses. The density of P. irritans, but not of other domestic fleas, was significantly higher in villages with a higher plague frequency or incidence. Moreover, the P. irritans index was strongly positively correlated with plague frequency and with the logarithmically transformed plague incidence. These observations suggest that in Lushoto District human fleas may play a role in plague epidemiology. These findings are of immediate public health relevance because they provide an indicator that can be surveyed to assess the risk for plague. [less ▲]

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See detailPlaidoyer pour de grands absents : phrase, texte, discours
Dumortier, Jean-Louis ULg

in Puzzle (2006), 20

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See detailPlaidoyer pour l'enfant : Vers une culture de l'enfance
Delcourt, Jean-Claude ULg; Manciaux, M.; Mouvet, Bernadette ULg et al

Book published by De Boeck Université - 3ème éd. (2000)

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See detailPlaidoyer pour la biodiversité au crépuscule du deuxième millénaire.
Pierard, Sébastien ULg; Franchimont, Claudine ULg; Pierard, Gérald ULg

in Revue Verviétoise d'Histoire Naturelle (1998), 55

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See detailPlaidoyer pour la patrie et la culture nationale [traduction d’un texte latin de Balbinus]
Pietquin, Paul ULg

in Polet, Jean-Claude (Ed.) Patrimoine littéraire européen. 8 : Avènement de l'équilibre européen, 1616-1720 (1997)

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See detailPlaidoyer pour les enfants
Born, Michel ULg; Detraux, Jean-Jacques ULg; Manciaux, M. et al

Book published by Fonds Houtman (1999)

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See detailPlaidoyer pour un humanisme scientifique
Fredericq, Henri ULg

Speech (1949)

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See detailPlaidoyer pour une criminologie de terrain(s)
Dantinne, Michaël ULg

in Revue de Droit Pénal et de Criminologie (2009)

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See detailPlaidoyer pour une expertise entièrement contradictoire en matière pénale
Jacobs, Ann ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (1997)

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See detailPlaidoyer pour une professionnalisation des directeurs de prison en Belgique Un travail d’équipe au centre des politiques et des organisations pénitentiaires
Dubois, Christophe ULg

Scientific conference (2012, June 13)

Le fonctionnement des prisons peut être appréhendé à partir des trois dimensions organisationnelles que distingue Erhard Friedberg (2012) : les discours managériaux (relatifs aux Droits de l’Homme, au ... [more ▼]

Le fonctionnement des prisons peut être appréhendé à partir des trois dimensions organisationnelles que distingue Erhard Friedberg (2012) : les discours managériaux (relatifs aux Droits de l’Homme, au Nouveau Management Public, à la justice réparatrice, au développement durable, etc.), les structures formelles ou apparentes (lois pénitentiaires de 2005 et 2006, circulaires diverses, notes de service, règlements d’ordre intérieur, plans de management, instruments de gestion, etc.) et les structures parallèles ou profondes (qui résultent des interactions des acteurs entre eux et entre les deux autres dimensions organisationnelles)2. La gestion de ces établissements fréquemment secoués par des « imprévus » (émeutes, grèves, évasions, détérioration des bâtiments) repose sur des acteurs spécifiques : les directeurs de prison. Bien que peu étudiés, ils se situent au centre de l’institution pénitentiaire, véritables interfaces entre les discours et politiques étatiques et les pratiques locales. L’objectif de cet article consiste à décrire et analyser travail concret afin de saisir les spécificités d’un métier méconnu qui se joue en équipe (les staffs de direction) et d’analyser les chantiers de « modernisation » essentiellement (juridique et managériale) de l’administration pénitentiaire belge. [less ▲]

Detailed reference viewed: 49 (8 ULg)