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See detailPotentialités quantitatives et qualité d'image de la camera TEMP/TDM Siemens Symbia T6
Seret, Alain ULg; Nguyen, Daniel ULg; HUSTINX, Roland ULg et al

in Médecine Nucléaire : Imagerie Fonctionnelle et Métabolique (2011, May 07), 35

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See detailPotentialities and issues of luminescence dating applied to building archaeology
Blain, Sophie ULg; Bouvier, Armel; Guibert, Pierre et al

Scientific conference (2010, October 09)

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See detailPotentialities of using ASTER & SRTM DEM for road planning in Central African sustainable forest logging context. A case study in East Gabon
Philippart, Julien ULg; Handerek, Daphné ULg; Lejeune, Philippe ULg et al

Poster (2011, June 02)

Slope is the main constraint for sustainable forest road planning in Central Africa. Remote sensing now provides free and downloadable Data Elevation Model (DEM) covering most of appeared lands. In this ... [more ▼]

Slope is the main constraint for sustainable forest road planning in Central Africa. Remote sensing now provides free and downloadable Data Elevation Model (DEM) covering most of appeared lands. In this study, we evaluate potentialities and limitations of Shuttle Radar Topography Mission (SRTM) DEMs, derived from radar interferometry and Advanced Spaceborn Thermal Emission and Reflection Radiometer (ASTER) DEMs, themselves derived from digital photogrammetry for slope evaluation. Assessment is presented for hilly (Milole) and flat (Okondja) areas. Three elevation maps were derived from initial ASTER 30-m and SRTM 90-m DEMs : a SRTM 30-m resampled from SRTM 90-m and two ASTER 30-m where absurd values (artifacts) were corrected with SRTM 90-m and resampled SRTM 30-m respectively. We qualitatively and quantitatively assess the accuracy of all elevation maps compared to 992 (698) slope measures on field along transects of 10.5 (7.5) km in Milolé (Okondja). We estimated root mean square error (RMSE) for slope estimation at 7.8 (10.7), 8.1 (10.1), 11.7 (11.2), 10.1 (11.2) and, 9.3° (11.0°) for SRTM 90-m, SRTM 30-m, ASTER 30-m, ASTER 30-m CORR 90 and ASTER 30-m CORR 30 respectively in Milolé (Okondja). We also use a classification error matrix to assess Global Accuracy (GA) and User’s Accuracy (UA) of elevation maps by classifying ground slopes in two categories: lower or equal and higher than maximum slope limitation of 12% (30%) for primary (secondary) roads. All DEMs show a greater GA in hilly area (Milolé) than in flat area (Okondja) and SRTM derived DEMs show a higher UA for secondary roads constraint. UA for the lower or equal category varies between 55.5 and 75.2% (63.9 and 91.7%) for primary (secondary) roads. The use of corrected aster DEMs increases initial ASTER UA from 0.1 to 18.8% depending on category and slope limitation. Despite a relatively high RMSE for slope grade, all of the DEMs tested were found to be consistent for consideration of maximum slope constraint aiming at sustainable road planning for forest logging in Central Africa. [less ▲]

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See detailPotentiality of clay raw materials from northern Morocco in ceramic industry: Tetouan and Meknes areas
El Ouahabi, Meriam ULg; Daoudi, Lahcen; De Vleeschouwer, François et al

in Journal of Minerals and Materials Characterization and Engineering (2014)

This study aims at evaluating the potential suitability of Tetouan and Meknes (central Morocco) clay material as raw materials in various ceramic applications by investigating their textural, chemical ... [more ▼]

This study aims at evaluating the potential suitability of Tetouan and Meknes (central Morocco) clay material as raw materials in various ceramic applications by investigating their textural, chemical, thermal and firing characteristics. Textural properties were identified by specific surface area, cation exchange capacity (CEC) and bulk density (ρs). Chemical and thermal properties were assessed using XRF and TG/DTA techniques, respectively. Firing characteristics at temperatures from 800°C to 1100°C were determined by linear firing shrinkage, loss on weight and water absorption capacity. The Meknes clays are characterised by medium cation exchange capacity (CEC) and specific surface area (SSA) values due to their moderate smectite content. The Tetouan clays have medium to low CEC and medium SSA values. The main oxides in the clayey samples are SiO2 (35 – 54.3 wt.%), Al2O3 (20.6 – 43.9 wt.%), and Fe2O3 (9.7 – 22.4 wt.%). The amount of CaO in Meknes clays ranges from 8 to 12 wt.%, whereas CaO is only present in some Tetouan clay (TE4, TE7, TN4 and TN5). A significant densification of ceramic behaviour could be noticed for most of Tetouan clays at firing temperatures above 1000°C. Meknes clays show earlier densification from 800 °C. The chemical, textural and ceramic properties of Tetouan and Meknes clays indicate their suitability as raw materials for the production of structural ceramics. The high amount of Fe2O3 in all clays makes them inappropriate in fine ceramics. [less ▲]

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See detailThe potentiality of PDMAEMA-based polycation for cardiovascular applications
Flebus, Luca ULg; Lombart, François ULg; Martinez, Lucia et al

Conference (2014, June 18)

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See detailPotentiality of using microbial biosensors for the detection of substrate heterogeneities and the assessment of microbial viability in industrial bioreactors: a complete set of experiments in chemostat and scale-down reactors, and elaboration of a mini scale-down platform
Brognaux, Alison ULg; Neubauer, Peter; Twizere, Jean-Claude ULg et al

in Communications in Agricultural and Applied Biological Sciences (2012), 77(1), 3-7

Substrate limitation responsive biosensors have been used in order to detect spatial substrate heterogeneities, , inside industrial bioreactors (whole-cell biosensor). Three green fluorescent protein (GFP ... [more ▼]

Substrate limitation responsive biosensors have been used in order to detect spatial substrate heterogeneities, , inside industrial bioreactors (whole-cell biosensor). Three green fluorescent protein (GFP) transcriptional reporters have been chosen in E.coli, i.e. uspA::gfp, csiE::gfp and yciG::gfp. The promoter uspA is induced in response to a variety of stresses whereas the two other promoters, csiE and yciG, are supposed to be more specific in front of a substrate limitation. The responsiveness of these biosensors has been assessed in chemostat reactor. Secondly, the same biosensors have been tested in well-mixed laboratory reactors and in scale-down reactors able to reproduce industrial conditions. Finally, a mini scale-down platform has been proposed as a high throughput tool to investigate rapidly the usefulness of a given microbial biosensor. Local heterogeneities in mini-bioreactor have caused a decrease of GFP expression, as in scale-down reactor. The presence of GFP in supernatants was noticed and this leakage seems to be correlated with the membrane permeability. [less ▲]

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See detailPotentiation instead of habituation characterizes visual evoked potentials in migraine patients between attacks
Schoenen, Jean ULg; Wang, W.; Albert, A. et al

in European Journal of Neurology (1995), 2

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See detailPotentiation of cyclophosphamide chemotherapy using the anti-angiogenic drug thalidomide: Importance of optimal scheduling to exploit the ‘normalization’ window of the tumor vasculature
SEGERS, Jérôme; DI FAZIO, Vincent; ANSIAUX, Réginald et al

in Cancer Letters (2006), 244(1), 12935

The aim of this work was to study how administration schedule affects potentiation of cyclophosphamide, an alkylating agent, by thalidomide, an anti-angiogenic agent. Tumor oxygenation after thalidomide ... [more ▼]

The aim of this work was to study how administration schedule affects potentiation of cyclophosphamide, an alkylating agent, by thalidomide, an anti-angiogenic agent. Tumor oxygenation after thalidomide administration was determined over time by EPR oximetry. Such measurements provide a surrogate marker for determining the timing of ‘normalization’ of tumor vasculature. Re-growth delays were measured using different combinations and schedules of treatments. Additionally, the uptake of the metabolite of cyclophosphamide (hydroxycyclophosphamide or OH-CP) into tumors was determined by high performance liquid chromatography/tandem mass spectrometry (HPLC/MS/MS). A significant increase in pO2 was observed after 2 and 3 days of treatment before eventually declining on day 4. Thalidomide potentiated the effect of cyclophosphamide only when cyclophosphamide was administered after 2 days of treatment with thalidomide (no significant benefit using other schedules). In this time frame, the HPLC/MS/MS measurements showed that the quantity of OH-CP penetrating into the tumor was about twice in mice treated by thalidomide compared to controls. In conclusion, the present study demonstrates that the benefit of combined therapy using an anti-angiogenic agent with a cytotoxic agent requires knowledge of the time window during which the vessels initially become normalized. [less ▲]

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See detailPotentiation of cytotoxicity and radiosensitization of (E)-2'-deoxy-2' (fluoromethylene) cytidine by pentoxifylline in vitro.
LI, Y-X; Sun, L-Q; Paschoud, N et al

in International Journal of Cancer = Journal International du Cancer (1999), 80

(E)-28-deoxy-28-(fluoromethylene) cytidine (FMdC), a novel inhibitor of ribonucleotide-diphosphate reductase, has been shown to have anti-tumor activity against solid tumors and sensitize tumor cells to ... [more ▼]

(E)-28-deoxy-28-(fluoromethylene) cytidine (FMdC), a novel inhibitor of ribonucleotide-diphosphate reductase, has been shown to have anti-tumor activity against solid tumors and sensitize tumor cells to ionizing radiation. Pentoxifylline (PTX) can potentiate the cell killing induced by DNAdamaging agents through abrogation of DNA-damagedependent G2 checkpoint. We investigated the cytotoxic, radiosensitizing and cell-cycle effects of FMdC and PTX in a human colon-cancer cell line WiDr. PTX at 0.25–1.0 mM enhanced the cytotoxicity of FMdC and lowered the IC50 of FMdC from 79 6 0.1 to 31.2 6 2.1 nM, as determined by MTT assay. Using clonogenic assay, pre-irradiation exposure of exponentially growing WiDr cells to 30 nM FMdC for 48 hr or post-irradiation to 0.5 to 1.0 mM PTX alone resulted in an increase in radiation-induced cytotoxicity. Moreover, there was a significant change of the radiosensitization if both drugs were combined as compared with the effect of either drug alone. Cell-cycle analysis showed that treatment with nanomolar FMdC resulted in S-phase accumulation and that such an S-phase arrest can be abrogated by PTX. Treatment with FMdC prior to radiation increased post-irradiation-induced G2 arrest, and such G2 accumulation was also abrogated by PTX. These results suggest that pharmacological abrogation of S and G2 checkpoints by PTX may provide an effective strategy for enhancing the cytotoxic and radiosensitizing effects of FMdC. Int. J. Cancer 80:155–160, 1999. [less ▲]

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See detailPotentiation of dopamine agonists-induced oral stereotypies by GABA-A agonists in mice : differentiation of dopamine uptake inhibitors
Tirelli, Ezio ULg; Witkin, J. M.

in Journal of Pharmacology and Experimental Therapeutics (The) (1998), 284

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See detailPotentiation of Histamine Release from Human Leucocytes by Paf
Louis, Renaud ULg; Bury, Thierry ULg; Corhay, Jean-Louis ULg et al

in Agents and Actions (1994), 41(1-2), 5-10

Studies on the effects of PAF on histamine release from human leucocytes have yielded conflicting results. We therefore investigated the effects of PAF on leucocytic histamine release (HR) focusing on ... [more ▼]

Studies on the effects of PAF on histamine release from human leucocytes have yielded conflicting results. We therefore investigated the effects of PAF on leucocytic histamine release (HR) focusing on direct as well as on modulating effects. Peripheral blood leucocytes of normal and atopic subjects were incubated with PAF, anti-IgE and FMP for 30 min at 37 degrees C, and histamine was measured fluorometrically. Unlike anti-IgE (1/2000) and FMP (10(-5) M) which caused histamine release (HR) of 34 +/- 7% and 31 +/- 8%, respectively, PAF by itself (10(-11)-10(-5) M) failed to induce any significant HR from human leucocytes (< 3%) in normal (n = 14) and atopic subjects (n = 6). Nevertheless, in normals as well as atopics, PAF, but not lyso-PAF, enhanced anti-IgE (1/2000) and FMP (10(-5) M)-induced HR in a concentration-related manner. Maximal potentiation of histamine release caused by FMP and anti-IgE was achieved with PAF (10(-7)) (mean +/- SEM: 26 +/- 5%, n = 5, p < 0.01) and PAF (10(-5)) (mean +/- SEM: 20 +/- 7%, n = 7, p < 0.05), respectively. This potentiation was suppressed by WEB2086 (10(-5) M), a specific PAF antagonist. The time course of the enhancing effect produced by PAF was dependent on the type of secretagogue. The enhancement was nearly maximal when PAF and FMP were added simultaneously to the leucocytes, whereas a preincubation of 20 min with PAF was required to get maximal enhancement with anti-IgE. The enhancing activity of PAF on HR induced by both anti-IgE and FMP was reversed by washing the cells after preincubation. While PAF enhancement of FMP-induced HR persisted on mononuclear cell fraction containing basophils, that of anti-IgE-induced HR was considerably reduced under these conditions.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailPotentiation of right ventricular function at a reduced workload: a potential pitfall in assessing right ventricular function by exercise radionuclide ventriculography.
Wahl, R. L.; McMeekin, J. D.; Legrand, Victor ULg et al

in American journal of physiologic imaging (1987), 2(2), 61-6

Right ventricular ejection fraction (RVEF) determinations at rest (R) and exercise (E) are a means of demonstrating exercise-induced RV dysfunction. Not all patients are able to maintain peak (P) cardiac ... [more ▼]

Right ventricular ejection fraction (RVEF) determinations at rest (R) and exercise (E) are a means of demonstrating exercise-induced RV dysfunction. Not all patients are able to maintain peak (P) cardiac workloads during a gated RVEF study or, if a first-pass study is performed, for multiple acquisitions. Reductions from P cardiac workloads have been shown to potentiate LV function; however, the effect on RVEF has not been studied. Supine exercise radionuclide ventriculography was performed on 26 patients: nine normal subjects and 17 patients with coronary artery disease (CAD) (greater than 50% stenosis of one or more coronary artery). Gated RVEF's were obtained from sequential left anterior oblique views obtained at R, P, and at a workload reduced approximately 40% from P work levels postpeak (PP). In normals, RVEFs were at R, P, and PP 27, 38 and 44. In CAD patient RVEFs were 31, 35 and 39, at R, P, and PP, respectively. The conclusions are that RVEF improves from rest to PP exercise levels in normal subjects and in CAD patients and from P to PP levels in normal subjects. This improvement must be considered in interpreting exercise RV studies to aid in the detection of patients with CAD. [less ▲]

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See detailPotentiation of the Pro-Inflammatory Effects of Bradykinin by Inhibition of Angiotensin-Converting Enzyme and Aminopeptidase P in Rat Paws
Damas, Jacques ULg; Liégeois, Jean-François ULg; Simmons, W. H.

in Naunyn-Schmiedeberg's Archives of Pharmacology (1996), 354(5), 670-6

The influence of some peptidase inhibitors on oedema and plasma extravasation induced by bradykinin and carrageenan in rat paw was evaluate. Bradykinin-induced oedema in normal rats was increased by o ... [more ▼]

The influence of some peptidase inhibitors on oedema and plasma extravasation induced by bradykinin and carrageenan in rat paw was evaluate. Bradykinin-induced oedema in normal rats was increased by o-phenanthroline (3.10(-2) M), by captopril (10(-6) M to 10(-4) M), by lisinopril (10(-6) M to 10(-4), or by lisinopril (10(-5) M) in combination with apstatin (8.10(-5) M or 1.4 10(-4) M). It was not modified by phosphoramidon (10(-6) M to 10(-5) M) and by diprotin A (10(-3) M). It was increased by mergepta at high concentrations (2.10(-4) M). Mergepta did not increase the potentiating effect of captopril. Carrageenan-oedema in normal rats was increased by captopril (10(-5) M), lisinopril (10(-5) M) and apstatin (1.4 10(-4) M. It was not modified by mergepta (10(-4) M), phosphoramidon (10 (-5) M) and diprotin A (109-3) M). Des-Arg1-bradykinin and Des-Arg9-bradykinin have low oedema-promoting effects. Captopril (10(-5) M) increased the effects of bradykinin but not those of carrageenan in kininogen-deficit Brown Norway rats. Angiotensin-converting enzyme and aminopeptidase P appear to be main kinin-inactivating enzymes in rat paws. Carboxypeptidase N, neutral endopeptidase 24.11 and dipeptidyl(amino)peptidase IV do not play a significant role in this inactivation. [less ▲]

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See detailPotentiation of tumor necrosis factor-induced NF-kappa B activation by deacetylase inhibitors is associated with a delayed cytoplasmic reappearance of I kappa B alpha
Adam, Emmanuelle; Quivy, Vincent; Bex, Françoise et al

in Molecular and Cellular Biology (2003), 23(17), 6200-6209

Previous studies have implicated acetylases and deacetylases in regulating the transcriptional activity of NF-kappaB. Here, we show that inhibitors of deacetylases such as trichostatin A (TSA) and sodium ... [more ▼]

Previous studies have implicated acetylases and deacetylases in regulating the transcriptional activity of NF-kappaB. Here, we show that inhibitors of deacetylases such as trichostatin A (TSA) and sodium butyrate (NaBut) potentiated TNF-induced expression of several natural NF-kappaB-driven promoters. This transcriptional synergism observed between TNF and TSA (or NaBut) required intact kappaB sites in all promoters tested and was biologically relevant as demonstrated by RNase protection on two instances of endogenous NF-kappaB-regulated gene transcription. Importantly, TSA prolonged both TNF-induced DNA-binding activity and the presence of NF-kappaKB in the nucleus. We showed that the p65 subunit of NF-kappaB was acetylated in vivo. However, this acetylation was weak, suggesting that other mechanisms could be implicated in the potentiated binding and transactivation activities of NF-kappaB after TNF plus TSA versus TNF treatment. Western blot and immunofluorescence confocal microscopy experiments revealed a delay in the cytoplasmic reappearance of the IkappaBalpha inhibitor that correlated temporally with the prolonged intranuclear binding and presence of NF-kappaB. This delay was due neither to a defect in IkappaBalpha mRNA production nor to a nuclear retention of IkappaBalpha but was rather due to a persistent proteasome-mediated degradation of IkappaBalpha. A prolongation of IkappaB kinase activity could explain, at least partially, the delayed IkappaBalpha cytoplasmic reappearance observed in presence of TNF plus TSA. [less ▲]

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See detailPotentiation of tumor necrosis factor-induced NF-kappa B activation by deacetylase inhibitors is associated with a delayed cytoplasmic reappearance of I kappa B alpha (vol 23, pg 6200, 2003)
Adam, Emmanuelle; Quivy, Vincent; Bex, Françoise et al

in Molecular and Cellular Biology (2004), 24(15), 6890

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See detailPotentiel d'utilisation de la spectrometrie moyen infrarouge pour prédire le rendement fromager du lait et étudier sa variabilité génétique
Colinet, Frédéric ULg; Troch, Thibault ULg; Abbas, O. et al

in 20èmes Rencontres Recherches Ruminants, Paris, les 4 et 5 Décembre 2013 (2013, December)

Fournir une indication rapide, fiable et bon marché du rendement fromager pour un lait donné, sans devoir appliquer des formules (empiriques ou théoriques) à partir des concentrations préalablement ... [more ▼]

Fournir une indication rapide, fiable et bon marché du rendement fromager pour un lait donné, sans devoir appliquer des formules (empiriques ou théoriques) à partir des concentrations préalablement déterminées pour différents constituants du lait, serait un outil utile et économiquement intéressant tant pour les éleveurs que pour l’industrie laitière. En vue d’étudier la variabilité génétique du rendement fromager à l’échelle du cheptel bovin wallon, des méthodes chimiométriques ont été utilisées afin de développer des équations de prédictions basées sur des spectres moyen infrarouge (MIR) pour les rendements fromagers déterminés en laboratoire et exprimés en frais (RdFF) ou en sec (RdFS). Ceux-ci ont été déterminés sur 258 échantillons de lait analysés en spectrométrie MIR. Les équations de prédiction à partir du spectre MIR du lait ont été développées en utilisant la régression des moindres carrés partiels (PLS) avec une validation croisée interne appliquée sur la dérivée première des spectres MIR. Les coefficients de détermination de validation croisée (R²cv) des équations étaient de 0,81 pour les prédictions du RdFF et de 0,82 pour les celles du RdFS. Les rapports des performances sur les variabilités (RPD) étaient égaux à 2,3. Ces résultats peuvent permettre d’envisager une bonne utilité pratique pour leur prédiction respective, notamment dans le cadre de recherches génétiques. Ces équations ont été appliquées sur la base de données spectrales générée dans le cadre du contrôle laitier wallon. Les composantes de la variance ont été estimées séparément pour le RdFF et le RdFS basées sur un modèle animal « contrôles élémentaires » utilisant des régressions aléatoires. Le jeu de données utilisé comportait 51 537 prédictions pour 7 870 vaches primipares Holstein. Les héritabilités journalières moyennes variaient entre 0,31 (au 5ème jour de lactation (JDL)) et 0,59 (au 279ème JDL) pour le RdFF et entre 0,31 (au 5ème JDL) et 0,57 (au 299ème JDL) pour le RdFS. Ces héritabilités journalières modérées à élevées ont indiqué le potentiel de sélection génétique pour ces deux caractères. [less ▲]

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See detailPotentiel d'utilisation de la spectrometrie moyen infrarouge pour prédire le rendement fromager du lait et étudier sa variabilité génétique
Colinet, Frédéric ULg; Troch, Thibault ULg; Abbas, O. et al

Conference (2013, December 04)

Providing a quick, reliable and cheap indication of the expected cheese yield for a milk sample by avoiding (empirical or theoretical) formulas based on previously determined milk constituents would be an ... [more ▼]

Providing a quick, reliable and cheap indication of the expected cheese yield for a milk sample by avoiding (empirical or theoretical) formulas based on previously determined milk constituents would be an economically valuable tool useful for farmers and the dairy industry. In order to study the genetic variability of cheese yield on a large scale, mid-infrared (MIR) chemometric methods were used to predict fresh or dry Individual Laboratory Cheese Yield (RdFF and RdFS, respectively). RdFF and RdFS were determined on a total of 258 milks samples also analyzed by a MIR spectrometer. Equations to predict RdFF and RdFS from milk MIR spectra were developed using partial least square regression (PLS) after first derivative pre-traitment applied to the spectra. The cross-validation coefficients of determination (R²cv) of the two equations were equal to 0.81 for the prediction of RdFF and 0.82 for the prediction RdFS. The ratios of performance to deviation (RPD) of the two equations were both equal to 2.3. Therefore, these results suggest a practical utility of these two equations, i.e. for genetic research. Both equations were applied on the spectral database generated during the Walloon routine milk recording. The variances components were estimated using univariate random regressions animal test-day model. The dataset included 51 537 predicted records from 7 870 Holstein first-parity cows. Estimated daily heritabilities ranged from 0.31 (at 5th day in milk (DIM)) to 0.59 (at 279th DIM) for RdFF and from 0.31 (at 5th DIM) to 0.57 (at 299th DIM) for RdFS. Those moderate to high daily heritabilities indicated potential of selection for both traits. [less ▲]

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