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See detailPotential Clinical and Economic Impact of Nonadherence with Osteoporosis Medications.
Hiligsmann, Mickaël ULg; Rabenda, Véronique ULg; Gathon, Henry-Jean ULg et al

in Calcified Tissue International (2010), 86

This study aims to estimate the potential clinical and economic implications of therapeutic adherence to bisphosphonate therapy. A validated Markov microsimulation model was used to estimate the impact of ... [more ▼]

This study aims to estimate the potential clinical and economic implications of therapeutic adherence to bisphosphonate therapy. A validated Markov microsimulation model was used to estimate the impact of varying adherence to bisphosphonate therapy on outcomes (the number of fractures and the quality-adjusted life-years [QALYs]), health-care costs, and the cost-effectiveness of therapy compared with no treatment. Adherence was divided into persistence and compliance, and multiple scenarios were considered for both concepts. Analyses were performed for women aged 65 years with a bone mineral density T-score of -2.5. Health outcomes and the cost-effectiveness of therapy improved significantly with increasing compliance and/or persistence. In the case of real-world persistence and with a medical possession ratio (MPR; i.e., the number of doses taken divided by the number of doses prescribed) of 100%, the QALY gain and the number of fractures prevented represented only 48 and 42% of the values estimated assuming full persistence, respectively. These proportions fell to 27 and 23% with an MPR value of 80%. The costs per QALY gained, for branded bisphosphonates (and generic alendronate), were estimated at <euro>19,069 (<euro>4,871), <euro>32,278 (<euro>11,985), and <euro>64,052 (<euro>30,181) for MPR values of 100, 80, and 60%, respectively, assuming real-world persistence. These values were <euro>16,997 (<euro>2,215), <euro>24,401 (<euro>6,179), and <euro>51,750 (<euro>20,569), respectively, assuming full persistence. In conclusion, poor compliance and failure to persist with osteoporosis medications results not only in deteriorating health outcomes, but also in a decreased cost-effectiveness of drug therapy. Adherence therefore remains an important challenge for health-care professionals treating osteoporosis. [less ▲]

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See detailPotential contribution of prenatal estrogens to the sexual differentiation of mate preferences in mice.
Brock, Olivier; Bakker, Julie ULg

in Hormones and Behavior (2011), 59(1), 83-9

The neural mechanisms controlling sexual behavior are sexually differentiated by perinatal actions of gonadal hormones. We recently observed using female mice deficient in alpha-fetoprotein (AFP-KO) and ... [more ▼]

The neural mechanisms controlling sexual behavior are sexually differentiated by perinatal actions of gonadal hormones. We recently observed using female mice deficient in alpha-fetoprotein (AFP-KO) and which lack the protective actions of AFP against maternal estrogens, that exposure to prenatal estrogens completely defeminized their potential to show lordosis behavior in adulthood. Therefore, we determined here whether mate preferences were also affected in female AFP-KO mice. We observed a robust preference for an estrous female over an intact male in female AFP-KO mice, which were ovariectomized in adulthood and subsequently treated with estradiol and progesterone, whereas similarly treated WT females preferred the intact male over the estrous female. Gonadally intact WT males preferred the estrous female over the male, but only when visual cues were blocked by placing stimulus animals behind opaque partitions. Furthermore, when given the choice between an intact male and a castrated male, WT females preferred the intact male, whereas AFP-KO females showed no preference. Finally when given the choice between an estrous female and an ovariectomized female, WT males preferred the estrous female whereas AFP-KO females preferred the ovariectomized female or showed no preference depending on whether they could see the stimulus animals or not. Taken together, when AFP-KO females are tested under estrous conditions, they do not show any male-directed preferences, indicating a reduced sexual motivation to seek out the male in these females. However, they do not completely resemble males in their mate preferences suggesting that the male-typical pattern of mate preferences is not solely organized by prenatal estrogens. [less ▲]

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See detailPotential cost-effectiveness of denosumab for the treatment of postmenopausal osteoporotic women.
Hiligsmann, Mickaël ULg; Reginster, Jean-Yves ULg

in BONE (2010), 47

Denosumab has recently been shown to be safe and to significantly reduce the risk of vertebral, hip and non-vertebral fractures in the "Fracture REduction Evaluation of Denosumab in Osteoporosis every ... [more ▼]

Denosumab has recently been shown to be safe and to significantly reduce the risk of vertebral, hip and non-vertebral fractures in the "Fracture REduction Evaluation of Denosumab in Osteoporosis every 6Months" (FREEDOM) Trial. Besides the clinical profile of a new drug, it becomes increasingly important to assess whether the drug represents good value for money. This study aims to examine the potential cost-effectiveness of denosumab in the treatment of postmenopausal osteoporotic women. An updated version of a validated Markov microsimulation model was used to estimate the cost (euro2009) per quality-adjusted life-year (QALY) gained of a 3-year denosumab treatment compared with no treatment. The model was populated with cost and epidemiological data for Belgium from a health-care perspective and the base-case population was defined from the FREEDOM Trial. The effect of denosumab after treatment cessation was conservatively assumed to decline linearly over 1year. Uncertainty was investigated using one-way and probabilistic sensitivity analyses. In particular, additional analyses were performed in populations (over 60years) where osteoporosis medications are currently reimbursed in many European countries, i.e. with bone mineral density (BMD) T-score</=-2.5 or prevalent vertebral fracture. In the base-case analysis, the cost per QALY gained of denosumab compared with no treatment was estimated at euro28,441. This value decreased to euro15,532 and to euro11,603 for women with a BMD T-score of -2.5 or prevalent vertebral fracture, respectively. Additional analyses showed that the cost-effectiveness of denosumab fall below commonly accepted threshold of euro30,000per QALY gained for women with a BMD T-score </=-2.5 or prevalent vertebral fracture, over the entire age range examined (60-80years). The results were robust under a wide range of plausible assumptions. In conclusion, this study suggests, on the basis of currently available data, that denosumab is cost-effective compared with no treatment for postmenopausal Belgian women with low bone mass and who are similar to patients included in the FREEDOM Trial. In addition, denosumab was found to be cost-effective in population currently reimbursed in Europe with T-score</=-2.5 or prevalent vertebral fracture, aged 60years and above. Additional data are needed on the relative cost-effectiveness compared with other anti-osteoporotic agents and on the long-term safety of denosumab. [less ▲]

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See detailPotential doubling time determination in a multicentre clinical study.
COUCKE, Philippe ULg

in Abstract book (1996)

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See detailPotential early indicators of anthropogenically derived nutrients : a multiscale stable isotope analysis
Vermeulen, Simon ULg; Sturaro, Nicolas ULg; Gobert, Sylvie ULg et al

in Marine Ecology. Progress Series (2011), 422

Increasing human pressure along Mediterranean coastlines raises the need to define sensitive bioindicators that provide an early response to nutrient enrichment. We performed multiscale carbon and ... [more ▼]

Increasing human pressure along Mediterranean coastlines raises the need to define sensitive bioindicators that provide an early response to nutrient enrichment. We performed multiscale carbon and nitrogen stable isotope analyses on the limpet Patella caerulea, the snail Monodonta turbinata, epilithic biofilms, and the macroalga Rissoella verruculosa inhabiting the rocky midlittoral zone. Samples were seasonally collected in 2006 from 5 sites exposed to a range of anthropogenic discharges in the Revellata Bay area and in Marseille harbour (France). All bioindicators exhibited strongly elevated δ15N values at impacted sites compared to pristine ones, which revealed the biological availability of anthropogenically derived nutrients. Only epilithic biofilms tended to show both the occurrence of nutrient pulses during the tourist season and a δ13C response at impacted sites. In contrast to macroalgae, which exhibited a somewhat equivocal signal, gastropods and especially M. turbinata provided the best time-integrated picture of the graduated exposure of the 5 sites to anthropogenic impact. Results also showed first evidence of large isotopic variability at a scale of tens of metres, close to that found at the kilometre scale. The intra- and interspecific isotopic variability in gastropods may be explained by the patchiness of resources and specific morphological and behavioural features, but these factors do not greatly hamper their potential as early bioindicators of wastewater disturbances. [less ▲]

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See detailPotential effects of blood contaminants on immune responses in harbour seals (Phoca vitulina)
Dupont, Aurélie ULg; Weijs, Liesbeth; Siebert, Ursula et al

Poster (2011, August 23)

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See detailPOTENTIAL EFFECTS OF BLOOD CONTAMINANTS ON IMMUNE RESPONSES IN HARBOUR SEALS (PHOCA VITULINA)
Dupont, Aurélie ULg; Weijs, Liesbeth; Siebert, Ursula et al

in Organohalogen Compounds (2011), 73

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See detailPotential effects of NSAID on myocellular enzyme leakage and delayed onset muscle soreness induced by isokinetic eccentric exercise
Croisier, Jean-Louis ULg; Camus, Gérard; Crielaard, Jean-Michel ULg

in Actes du XIXe Congrès National de la Société Française de Médecine du Sport (1999, October)

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See detailPotential energy surfaces and dissociation mechanisms of molecular ions
Lorquet, Jean-Claude ULg; Dehareng, Dominique ULg; Sannen, Christian et al

in Journal de Chimie Physique (1980), 77

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See detailPotential Energy Surfaces and Theory of Unimolecular Dissociation.
Lorquet, Jean-Claude ULg; Leyh, Bernard ULg

in Almoster Ferreira, M. A. (Ed.) Ionic Processes in the Gas Phase. (1984)

Reaction mechanisms can be determined from ab initio calculations of potential energy surfaces. Their complicated nature explains the frequent success of statistical theories, but non-statistical ... [more ▼]

Reaction mechanisms can be determined from ab initio calculations of potential energy surfaces. Their complicated nature explains the frequent success of statistical theories, but non-statistical behaviour is also accounted for. A certain correlation between structure and reactivity can be established, subject to many qualifications. Information on the nuclear motion on the potential energy surfaces of an ionized molecule can be extracted from a photoelectron spectrum by a Fourier transform operation. [less ▲]

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See detailPotential estimation of fatty acid content in cow milk by mid-infrared spectrometry
Soyeurt, Hélène ULg; Dardenne, Pierre; Lognay, Georges ULg et al

Conference (2006, June)

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See detailPotential Estimation of Fatty Acid Content in Cow Milk by Mid-Infrared Spectrometry
Soyeurt, Hélène ULg; Dardenne, Pierre; Lognay, Georges ULg et al

in Prooceedings of the 35th ICAR session (2006)

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See detailPotential estimation of major mineral contents in cow milk using mid-infrared spectrometry.
Soyeurt, Hélène ULg; Bruwier, Damien; Romnee, Jean-Michel et al

in Journal of Dairy Science (2009), 92(6), 2444-2454

Milk and dairy products are a major source of minerals, particularly calcium, involved in several metabolic functions in humans. Currently, several dairy products are enriched with calcium to prevent ... [more ▼]

Milk and dairy products are a major source of minerals, particularly calcium, involved in several metabolic functions in humans. Currently, several dairy products are enriched with calcium to prevent osteoporosis. The development of an inexpensive and fast quantitative analysis for minerals is required to offer dairy farmers an opportunity to improve the added value of the produced milk. The aim of this study was to develop 5 equations to measure Ca, K, Mg, Na, and P contents directly in bovine milk using mid-infrared (MIR) spectrometry. A total of 1,543 milk samples were collected between March 2005 and May 2006 from 478 cows during the Walloon milk recording and analyzed by MIR spectrometry. Using a principal component approach, 62 milk samples were selected by their spectral variability and separated in 2 calibration sets. Five outliers were detected and deleted. The mineral contents of the selected samples were measured by inductively coupled plasma atomic emission spectrometry. Using partial least squares combined with a repeatability file, 5 calibration equations were built to estimate the contents of Ca, K, Mg, Na, and P in milk. To assess the accuracy of the developed equations, a full cross-validation and an external validation were performed. The cross-validation coefficients of determination (R(2)cv) were 0.80, 0.70, and 0.79 for Ca, Na, and P, respectively (n = 57), and 0.23 and 0.50 for K and Mg, respectively (n = 31). Only Ca, Na, and P equations showed sufficient R(2)cv for a potential application. These equations were validated using 30 new milk samples. The validation coefficients of determination were 0.97, 0.14, and 0.88 for Ca, Na, and P, respectively, suggesting the potential to use the Ca and P calibration equations. The last 30 samples were added to the initial milk samples and the calibration equations were rebuilt. The R(2)cv for Ca, K, Mg, Na, and P were 0.87, 0.36, 0.65, 0.65, and 0.85, respectively, confirming the potential utilization of the Ca and P equations. Even if new samples should be added in the calibration set, the first results of this study showed the feasibility to quantify the calcium and phosphorus directly in bovine milk using MIR spectrometry. [less ▲]

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See detailPotential Estimation of Minerals Content in Cow Milk Using Mid-Infrared Spectrometry
Soyeurt, Hélène ULg; Bruwier, Damien; Gengler, Nicolas ULg et al

in ICAR Proceedings of the Biennial Sessions (2008, June 16)

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See detailPotential estimation of titratable acidity in cow milk using mid-infrared spectrometry
Colinet, Frédéric ULg; Soyeurt, Hélène ULg; Anceau, Christine ULg et al

in ICAR Technical Series (2010), 14

Milk coagulation has a direct effect on cheese yield. Several factors influence the milk coagulation kinetics. In addition to calcium and milk protein concentrations, titratable acidity influences all the ... [more ▼]

Milk coagulation has a direct effect on cheese yield. Several factors influence the milk coagulation kinetics. In addition to calcium and milk protein concentrations, titratable acidity influences all the phases of milk coagulation. The objective of this research was to study the feasibility of prediction of titratable acidity directly in bovine milk using mid-infrared spectrometry. In order to maximize the variability in the measurements of titratable acidity, milk samples were collected on basis of several criteria (e.g. breeds). The titratable acidity was recorded as Dornic degree. All samples were also analyzed by MIR spectrometry. Using partial least squares regressions and first derivative pretreatment of spectral data, a calibration equation was built to predict the Dornic degree in cow milk. First results were promising and showed the potentiality to this calibration. The calibration and cross-validation coefficients of determination were 92.25 and 89.88 %, respectively. Moreover, the ratio of standard error of prediction to standard deviation was 3.13 and permits us to consider the calibration equation as usable in most application such as scientific researches and the screening of the Walloon dairy herd particularly in order to improve the milk coagulation properties. [less ▲]

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See detailPotential estimation of titratable acidity in cow milk using mid-infrared spectrometry
Colinet, Frédéric ULg; Soyeurt, Hélène ULg; Anceau, Christine ULg et al

Conference (2010, June)

Milk coagulation has a direct effect on cheese yield. Several factors influence the milk coagulation kinetics. In addition to calcium and milk protein concentrations, titratable acidity influences all the ... [more ▼]

Milk coagulation has a direct effect on cheese yield. Several factors influence the milk coagulation kinetics. In addition to calcium and milk protein concentrations, titratable acidity influences all the phases of milk coagulation. The objective of this research was to study the feasibility of prediction of titratable acidity directly in bovine milk using mid-infrared spectrometry. In order to maximize the variability in the measurements of titratable acidity, milk samples were collected on basis of several criteria (e.g. breeds). The titratable acidity was recorded as Dornic degree. All samples were also analyzed by MIR spectrometry. Using partial least squares regressions and first derivative pretreatment of spectral data, a calibration equation was built to predict the Dornic degree in cow milk. First results were promising and showed the potentiality to this calibration. The calibration and cross-validation coefficients of determination were 92.25 and 89.88 %, respectively. Moreover, the ratio of standard error of prediction to standard deviation was 3.13 and permits us to consider the calibration equation as usable in most application such as scientific researches and the screening of the Walloon dairy herd particularly in order to improve the milk coagulation properties. [less ▲]

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See detailPotential for application of alkali roast acid leach technology for removal of phosphorus from iron ore
Ionkov, Krassimir ULg; Gaydardzhiev, Stoyan ULg; Bastin, David ULg et al

in Proceedings of 6-th International Congress on the Science and Technology of Ironmaking ICSTI (2012, October)

The present study deals with the effect of sodium hydroxide and sodium carbonate used as additives during oxidizing roasting of oolitic limonite iron concentrate and more precisely upon the change in its ... [more ▼]

The present study deals with the effect of sodium hydroxide and sodium carbonate used as additives during oxidizing roasting of oolitic limonite iron concentrate and more precisely upon the change in its magnetic susceptibility. Further, the efficiency of Alkali Roast Acid Leach (ARAL) technology for dephosphorisation of the concentrate is compared with the case when sodium hydroxide was added in alkali leach after roasting. The treatment without additives in roasting resulted in obtaining iron concentrate with 58 % iron and 0.21 % phosphorus, while the ARAL approach yielded concentrate with 63 % iron and 0.09 % phosphorus. The influence of combination of coke as reducing agent and sodium hydroxide in roasting at 900°C is also investigated and results displayed in 3D form. The combination of ARAL with reductive roasting, grinding of the clinker to 80 % - 0,075 mm, flotation of the non-reacted coke and magnetic separation before and after the acid leach resulted in iron concentrate with 66 % iron and 0.05 % phosphorus. The study has shown that the application of the ARAL approach with low addition of alkalis followed by 10 to 15 minute acid leaching at ambient temperature could substantially reduce phosphorus, thus offering the possibility for efficient treatment of high phosphorus iron ores. [less ▲]

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See detailPotential hill electron-acoustic solitons and double layers in plasmas with two electron species
Cattaert, Tom ULg; Verheest, F.; Hellberg, M. A.

in Physics of Plasmas (2005), 12(4), 10

In the description of (high-frequency) electron-acoustic solitons in a plasma consisting of positive ions, cool electrons, and hot electrons, the dynamics of the ions plays no essential role and can be ... [more ▼]

In the description of (high-frequency) electron-acoustic solitons in a plasma consisting of positive ions, cool electrons, and hot electrons, the dynamics of the ions plays no essential role and can be eliminated from the treatment, the ions merely providing a constant positive background. It is widely believed that in such a plasma only potential dip solitary waves can be generated. In a potential dip the cooler electrons are compressed and the hotter electrons rarefied, both being driven towards their sonic points, the cooler ones from above, the hotter ones from below. This transonic feature gives rise to the solitary wave. However, it is shown that the restriction to potential dip solitons is due to the neglect of the inertia of the hot electrons, implicitly or explicitly assumed by most-authors. If hot electron inertia is retained, there exists a parameter range where-potential hill solitary waves are formed, with both electron species being driven away from their sonic points This has important consequences for the reinterpretation of several astrophysical phenomena involving two-electron plasmas. (c) 2005 American Institute of Physics. [less ▲]

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See detailPotential Impact of Fertilization Practices on Human Dietary Intake of Dioxins in Belgium
Dumortier, Pierre ULg; Elskens, Marc; Focant, Jean-François ULg et al

in Science of the Total Environment (2012), 423

Detailed reference viewed: 35 (21 ULg)