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Mixed origin of neovascularization of human endometrial grafts in immunodeficient mouse models Alvarez Gonzalez, Maria-Luz ; ; et al in Human Reproduction (2009), 24(9), 2217-24 BACKGROUND: In vivo mouse models have been developed to study the physiology of normal and pathologic endometrium. Although angiogenesis is known to play an important role in endometrial physiology and ... [more ▼] BACKGROUND: In vivo mouse models have been developed to study the physiology of normal and pathologic endometrium. Although angiogenesis is known to play an important role in endometrial physiology and pathology, the origin of neovasculature in xenografts remains controversial. The aim of this study was to assess the origin of the neovasculature of endometrial grafts in different mouse models. METHODS: Human proliferative endometrium (n = 19 women) was grafted s.c. in two immunodeficient mouse strains: nude (n = 8) and severely compromised immunodeficient (SCID; n = 20). Mice were also treated with estradiol, progesterone or levonorgestrel. Fluorescence in-situ hybridization using a centromeric human chromosome X probe, immunohistochemistry (von Willebrand factor and collagen IV) and lectin perfusion were performed to identify the origin of the vessels. RESULTS: More than 90% of vessels within xenografts were of human origin 4 weeks after implantation. Some vessels (9.67 +/- 2.01%) were successively stained by human or mouse specific markers, suggesting the presence of chimeric vessels exhibiting a succession of human and murine portions. No difference in staining was observed between the two strains of mouse or different hormone treatments. Furthermore, erythrocytes were found inside human vessels, confirming their functionality. CONCLUSION: This article shows that human endometrial grafts retain their own vessels, which connect to the murine vasculature coming from the host tissue and become functional. [less ▲] Detailed reference viewed: 275 (17 ULg)Mixed Phenotype Murine Leukemias Defresne, Marie-Paule ; ; et al in Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K (1993), 7(8), 1253-60 Cell lines were derived from eight individual leukemias induced by X-rays in NFS mice. First typed as null cells (surface immunoglobulin negative, Thy-1 negative), they turned out to have a mixed ... [more ▼] Cell lines were derived from eight individual leukemias induced by X-rays in NFS mice. First typed as null cells (surface immunoglobulin negative, Thy-1 negative), they turned out to have a mixed phenotype with myeloid cytochemical markers, pre-B surface antigens and molecular markers of pro-B lymphocytes. They represent murine models for mixed phenotype (pro-pre-B-myeloid) leukemias. [less ▲] Detailed reference viewed: 6 (0 ULg)Mixed Reality Prototypes to Support Early Creative Design Safin, Stéphane ; Delfosse, Vincent ; Leclercq, Pierre in Dubois, E.; Gray, P.; Nigay, L. (Eds.) The Engineering of Mixed Reality Systems (2010) Many complex IT projects are still primarily focusing on today's technological challenges. The adaptation of the core technologies to potential applications often occurs in a second stage where the end ... [more ▼] Many complex IT projects are still primarily focusing on today's technological challenges. The adaptation of the core technologies to potential applications often occurs in a second stage where the end-users are involved. We describe a different approach, involving the users at the very beginning of the development. The domain we address is the creative design, mainly architecture. Rooted in a multidisciplinary approach as well as a deep understanding of architecture and design, our method aims at proposing adapted mixed reality solution to support two crucial activities : sketch-based preliminary design and distant synchronous collaboration in design. This chapter provides a summary of our work on a mixed-reality device based on a drawing table (the Virtual Desktop) designed specifically to address real-life/trade-focused issues. We explain our methodology, describe the two supported activities and the related users’s needs, we detail the technological solution we have developed and we present the main results of the multiple evaluation sessions. We then conclude on the usefulness of the profession-centered methodology and on the pertinence of the mixed reality to support creative design activities. [less ▲] Detailed reference viewed: 82 (17 ULg)Mixed self-assembly of poly(ethylene oxide)-b-poly(epsilon-caprolactone) copolymers and sodium dodecyl sulfate in aqueous solution ; Leyh, Bernard ; et al in Langmuir (2004), 20(21), 9019-9028 Interaction of amphiphilic poly(ethylene oxide)-b-poly(epsilon-caprolactone) copolymers with anionic sodium dodecyl sulfate (SDS) has been investigated in aqueous solution. Formation of mixed micelles has ... [more ▼] Interaction of amphiphilic poly(ethylene oxide)-b-poly(epsilon-caprolactone) copolymers with anionic sodium dodecyl sulfate (SDS) has been investigated in aqueous solution. Formation of mixed micelles has been confirmed by surface tension measurements, whereas the influence of the surfactant on the copolymer self-assembling has been studied by measurement of the 1H NMR self-diffusion coefficients and by small-angle neutron scattering. As a rule, the surfactant decreases the heterogeneity of the micellar structures formed by the copolymer in water. Moreover, increasing the content of SDS results in the increasingly more important extension of the poly(ethylene oxide) (PEO) corona chains and the copolymer micelle deaggregation. The stability of the micelles against SDS increases with the length of the hydrophobic block. Preliminary two-dimensional NMR measurements with nuclear Overhauser enhancement have confirmed the spatial vicinity between SDS and the constitutive blocks of the copolymer. [less ▲] Detailed reference viewed: 18 (4 ULg)A mixed solid-shell element for the analysis of laminated composites ; ; Habraken, Anne et al in International Journal for numerical methods in engineering (2012), 89(7), 805-828 Detailed reference viewed: 63 (13 ULg)Mixed symmetric baryon multiplets in large $N_c$ QCD: two and three flavours ; Stancu, Floarea in Bled Workshops in Physics (2010), 11(1), 37-43 We propose a new method to study mixed symmetric multiplets of baryons in the context of the $1/N_c$ expansion approach. The simplicity of the method allows to better understand the role of various ... [more ▼] We propose a new method to study mixed symmetric multiplets of baryons in the context of the $1/N_c$ expansion approach. The simplicity of the method allows to better understand the role of various operators acting on spin and flavour degrees of freedom. The method is tested on two and three flavours. It is shown that the spin and flavour operators proportional to the quadratic invariants of SU$_S$(2) and SU$_F$(3) respectively are dominant in the mass formula. [less ▲] Detailed reference viewed: 15 (5 ULg)Mixed Zone 3: "What is Africa to me now? The continent and its literary diasporas" Ledent, Bénédicte ; Tunca, Daria Article for general public (2013) Présentation bilingue des écrivains Jackie Kay, Caryl Phillips et Chika Unigwe, ainsi que du photographe Johny Pitts, suivie d'extraits vidéo de leurs interventions dans le cadre du colloque "What is ... [more ▼] Présentation bilingue des écrivains Jackie Kay, Caryl Phillips et Chika Unigwe, ainsi que du photographe Johny Pitts, suivie d'extraits vidéo de leurs interventions dans le cadre du colloque "What is Africa to me now? The continent and its literature diasporas". [less ▲] Detailed reference viewed: 69 (9 ULg)A mixed-integer heuristic for the structural optimization of a cruise ship Bay, Maud ; Crama, Yves ; et al in COMPIT 2007 , Cortona, Italy (2007, April 23) A heuristic approach is proposed to solve the structural optimization problem of a cruise ship. The challenge of optimization is to define the scantling of the structure of a ship in order to minimize the ... [more ▼] A heuristic approach is proposed to solve the structural optimization problem of a cruise ship. The challenge of optimization is to define the scantling of the structure of a ship in order to minimize the weight or the production cost. The variables are the dimensions and positions of the constitutive elements of the structure: they are discrete by nature. The objective functions are nonlinear functions. The structure is submitted to geometric constraints and to structural constraints. The geometric constraints are linear functions and the structural constraints are implicit functions requiring a high computation cost. The problem belongs to the class of mixed-integer nonlinear problems (MINLP). A local heuristic of the type “dive and fix” is combined with a solver based on approximation methods. The solver is used as a black-box tool to perform the structural analysis and solve the nonlinear optimization problems (NLP) defined by the heuristic. The heuristic is designed to always provide a discrete feasible solution. Experiments on a real-size structure demonstrate that the optimal value of the mixed-integer problem is of the same magnitude as the optimal value of the optimization problem for which all the variables can take continuous values. [less ▲] Detailed reference viewed: 119 (16 ULg)Mixed-integer sets from two rows of two adjacent simplex bases ; Louveaux, Quentin ; in Mathematical Programming (2010), 124(1-2), 455-480 In 2007 we studied a mixed-integer set arising from two rows of a simplex tableau. We showed that facets of such a set can be obtained from lattice point free triangles and quadrilaterals associated with ... [more ▼] In 2007 we studied a mixed-integer set arising from two rows of a simplex tableau. We showed that facets of such a set can be obtained from lattice point free triangles and quadrilaterals associated with either three or four variables. In this paper we generalize our ﬁndings and show that, when upper bounds on the non-basic variables are also considered, further classes of facets arise that cannot be obtained from triangles and quadrilaterals. Speciﬁcally, when exactly one upper bound on a non-basic variable is intro- duced, stronger inequalities that can be derived from pentagons involving up to six variables also appear. [less ▲] Detailed reference viewed: 120 (18 ULg)Mixing and aeration in an airlift fermenter adapted for fed-batch operation Groslambert, Sylvie ; ; Crine, Michel Poster (1990) Detailed reference viewed: 19 (3 ULg)Mixing in magnetic OB stars Morel, Thierry in Bulletin de la Société Royale des Sciences de Liège (2011), 80 Detailed reference viewed: 5 (4 ULg)Mixing in two magnetic OB stars discovered by the MiMeS collaboration Morel, Thierry in IAU Symposium 272: Active OB Stars: Structure, Evolution, Mass Loss and Critical Limits (2011) Detailed reference viewed: 4 (3 ULg)Mixing proximal regularization, penalization and parallel decomposition in convex programming Tossings, Patricia in Oettli, W.; Pallaschke, D. (Eds.) Advances in Optimization (W. Oettli - D. Pallaschke Editors), Proceedings FRG, Lambrecht (1991) Let A and B be two mutually complementary subspaces of a real Hilbert space H, T being a maximal monotone operator on H. The method of partial inverses has been introduced by J. Spingarn in 1983 for ... [more ▼] Let A and B be two mutually complementary subspaces of a real Hilbert space H, T being a maximal monotone operator on H. The method of partial inverses has been introduced by J. Spingarn in 1983 for solving problems in which the object is to find x in A and y in B such that y in Tx. We present a perturbed version of this method and its most important application: a perturbed method of parallel decomposition in convex programming. [less ▲] Detailed reference viewed: 6 (1 ULg)La mixité filles/garçons est-elle gage d’égalité ? Baye, Ariane Conference (2013, October 22) Detailed reference viewed: 8 (0 ULg)Mixmaster universe in fourth-order gravity theories ; ; De Rop, Yves et al in Physical Review. D : Particles and Fields (1993), 48 We analyze the behavior of the Bianchi type-IX cosmological model in the full fourth-order theory of gravity in four space-time dimensions on approach to the singularity both analytically and numerically ... [more ▼] We analyze the behavior of the Bianchi type-IX cosmological model in the full fourth-order theory of gravity in four space-time dimensions on approach to the singularity both analytically and numerically. By directly analyzing the full fourth-order field equations we prove explicitly that the Belinski-Khalatnikov-Lifshitz (BKL) analytic solution (and the accompanying bounce law) is also a solution to the more general case that we consider. But it appears to be nongeneric, because a perturbation analysis shows that power-law Kasner asymptotes are unstable on approach to the singularity. On the other hand, we find that the model possesses a stable isotropic monotonic power-law asymptotic solution and accordingly we show that there is a general solution which is nonchaotic near the space-time singularity. Numerical experiments confirm the existence of such a behavior. The inclusion of matter fields does not alter the evolution in the neighborhood of the singularity. The role of space-time dimensionality on the chaotic evolution of the mixmaster universe in these theories is also spelled out. In particular, we show that it is impossible to build a mixmaster universe in space-time dimensions higher than four in the full fourth-order gravity theory based on the BKL approximation scheme. [less ▲] Detailed reference viewed: 21 (0 ULg)Mixture model for inferring susceptibility to mastitis in dairy cattle: a procedure for likelihood-based inference ; ; et al in Genetics, Selection, Evolution (2004), 36(1, JAN-FEB), 3-27 A Gaussian mixture model with a finite number of components and correlated random effects is described. The ultimate objective is to model somatic cell count information in dairy cattle and to develop ... [more ▼] A Gaussian mixture model with a finite number of components and correlated random effects is described. The ultimate objective is to model somatic cell count information in dairy cattle and to develop criteria for genetic selection against mastitis, an important udder disease. Parameter estimation is by maximum likelihood or by an extension of restricted maximum likelihood. A Monte Carlo expectation- maximization algorithm is used for this purpose. The expectation step is carried out using Gibbs sampling, whereas the maximization step is deterministic. Ranking rules based on the conditional probability of membership in a putative group of uninfected animals, given the somatic cell information, are discussed. Several extensions of the model are suggested. [less ▲] Detailed reference viewed: 9 (0 ULg)A mixture model to assess the effect of a hormonal stimulation on the development of follicles in prepubertal heifers Lambert, Philippe in Journal of the Royal Statistical Society : Series C (Applied Statistics) (2002), 4 The goal of this study is to assess the effect of follicle stimulating hormone (FSH) on the growth of follicles in prepubertal heifers. Adams and co-workers have shown that follicles develop in waves as ... [more ▼] The goal of this study is to assess the effect of follicle stimulating hormone (FSH) on the growth of follicles in prepubertal heifers. Adams and co-workers have shown that follicles develop in waves as in post-pubertal heifers: after a few days, a dominant follicle arises on one of the two ovaries whereas the other subordinate follicles regress.The dominant follicle remains detectable when the next wave occurs. The number and the diameters of these follicles have been measured for 14 days.The same experiment was repeated after a 3-day FSH stimulation. Several large follicles now arise simultaneously on both ovaries together with small follicles which cannot be detected any more when the next wave occurs. Unfortunately, follicles were not individually tracked. Therefore a three-component mixture model was used to describe the potential simultaneous observation of dominant, decaying dominant and subordinate follicles before the FSH stimulation; the same type of model was considered for large, decaying large and small follicles after the hormonal stimulation. Moreover, for technical reasons, only follicles larger than 2 mm are observable. Measurements were thus left truncated.The models fitted are used to quantify the effects of the stimulation and to determine the ideal time point at which follicles should be punctured under ultrasonography to harvest ovocytes that will be fertilized and cultured in vitro. [less ▲] Detailed reference viewed: 8 (1 ULg)Mixtures of Bagged Markov Tree Ensembles Schnitzler, François ; Geurts, Pierre ; Wehenkel, Louis in Cano Utrera, Andrès; Gómez-Olmedo, Manuel; Nielsen, Thomas (Eds.) Proceedings of the 6th European Workshop on Probabilistic Graphical Models (2012, September) Markov trees, a probabilistic graphical model for density estimation, can be expanded in the form of a weighted average of Markov Trees. Learning these mixtures or ensembles from observations can be ... [more ▼] Markov trees, a probabilistic graphical model for density estimation, can be expanded in the form of a weighted average of Markov Trees. Learning these mixtures or ensembles from observations can be performed to reduce the bias or the variance of the estimated model. We propose a new combination of both, where the upper level seeks to reduce bias while the lower level seeks to reduce variance. This algorithm is evaluated empirically on datasets generated from a mixture of Markov trees and from other synthetic densities. [less ▲] Detailed reference viewed: 84 (6 ULg)A MLPA-oligochromatographic multiplex assay for identification of the toxin genotype and the hypervirulent ribotype O27 of Clostridium difficile Durenne, Bastien ; ; et al in Clinical Microbiology & Infection (2009, May), 15(s4), Detailed reference viewed: 175 (22 ULg)MMP-19 Deficiency Promotes Tenascin-C Accumulation and Allergen-induced Airway Inflammation. Guéders, Maud ; ; Quesada Calvo, Florence et al in American Journal of Respiratory Cell and Molecular Biology (2010), 43(3), 286-95 Matrix metalloproteinases (MMPs) recently appeared as key regulators of inflammation, allowing recruitment and clearance of inflammatory cells and modifying the biological activity of many peptidic ... [more ▼] Matrix metalloproteinases (MMPs) recently appeared as key regulators of inflammation, allowing recruitment and clearance of inflammatory cells and modifying the biological activity of many peptidic mediators by cleavage. MMP-19 is a newly described MMP and preferentially cleaves matrix proteins such as collagens and tenascin-C. The role of MMP-19 in asthma has not been described to date. The purpose of the present study was to assess MMP-19 expression in a murine asthma model and to address biological effects of MMP-19 deficiency in mice. Allergenexposed wild-type (WT) mice displayed an increased expression of MMP-19 mRNA and an increased number of MMP-19-positive cells in the lungs detected by immunohistochemistry. After allergen challenge of MMP-19 knockout (MMP-19-/-) mice, an exacerbated eosinophilic inflammation was detected in bronchoalveolar lavage fluid and bronchial tissue along with an increased airway responsiveness to methacholine. A shift towards increased Th2-driven inflammation in MMP-19-/- mice was demonstrated by 1) increased numbers of cells expressing the IL-33 receptor T1/ST2 in lung parenchyma, 2) increased IgG1 levels in serum and 3) higher levels of IL-13 and CCL11 in lung extracts. Tenascin-C was found accumulated in peribronchial areas of MMP-19-/- after allergen challenges as assessed by Western blot and immunohistochemistry analysis. We conclude that MMP-19 is a new mediator in asthma, preventing tenascin-C accumulation and directly or indirectly controlling Th2-driven airway eosinophilia and airway hyperreactivity. Our data suggest that MMP-19 might act on Th2 inflammation homeostasis through preventing tenascin protein accumulation. [less ▲] Detailed reference viewed: 89 (22 ULg) |
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