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See detailLocal modulation of steroid action: rapid control of enzymatic activity.
Charlier, Thierry D.; Cornil, Charlotte ULg; Patte-Mensah, Christine et al

in Frontiers in neuroscience (2015), 9

Estrogens can induce rapid, short-lived physiological and behavioral responses, in addition to their slow, but long-term, effects at the transcriptional level. To be functionally relevant, these effects ... [more ▼]

Estrogens can induce rapid, short-lived physiological and behavioral responses, in addition to their slow, but long-term, effects at the transcriptional level. To be functionally relevant, these effects should be associated with rapid modulations of estrogens concentrations. 17beta-estradiol is synthesized by the enzyme aromatase, using testosterone as a substrate, but can also be degraded into catechol-estrogens via hydroxylation by the same enzyme, leading to an increase or decrease in estrogens concentration, respectively. The first evidence that aromatase activity (AA) can be rapidly modulated came from experiments performed in Japanese quail hypothalamus homogenates. This rapid modulation is triggered by calcium-dependent phosphorylations and was confirmed in other tissues and species. The mechanisms controlling the phosphorylation status, the targeted amino acid residues and the reversibility seem to vary depending of the tissues and is discussed in this review. We currently do not know whether the phosphorylation of the same amino acid affects both aromatase and/or hydroxylase activities or whether these residues are different. These processes provide a new general mechanism by which local estrogen concentration can be rapidly altered in the brain and other tissues. [less ▲]

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See detailLocal Operational Geomagnetic Index K Calculation (K-LOGIC) from digital ground-based magnetic measurements
Stankov, Stanimir; Stegen, Koen; Warnant, René ULg

Report (2011)

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See detailLocal order of the high-pressure metallic phase of liquid selenium: a diffraction study
Raty, Jean-Yves ULg; Gaspard, Jean-Pierre ULg; Le Bihan, T. et al

in Journal of Physics : Condensed Matter (1999), 11(50), 10243-1024910249

Liquid selenium undergoes a phase transition towards a metallic phase when sufficient pressure is applied. We performed an x-ray diffraction experiment at the 1D30 beamline of the ESRF at the wavelength ... [more ▼]

Liquid selenium undergoes a phase transition towards a metallic phase when sufficient pressure is applied. We performed an x-ray diffraction experiment at the 1D30 beamline of the ESRF at the wavelength of 0.149 Aring to investigate the local order of the metallic liquid. The diffraction pattern of liquid Se has been recorded with the large-volume Paris-Edinburgh cell between (20degC, 3 GPa) and (1650degC, 4.1 GPa). The local order of the metallic liquid selenium is found to be close to that of liquid tellurium. In particular, the coordination number Z increases with temperature from 2.6 to 3.0 [less ▲]

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See detailLocal order, dynamics and stability of C and N doped phase change materials
Hippert, Françoise; Raty, Jean-Yves ULg; Noé, Pierre et al

Conference (2013, July 26)

Doping Chalcogenide Phase Change Materials, such as Ge2Sb2Te5 and GeTe used in non-volatile phase change memories, was shown to improve the stability of the amorphous phase and to strongly increase the ... [more ▼]

Doping Chalcogenide Phase Change Materials, such as Ge2Sb2Te5 and GeTe used in non-volatile phase change memories, was shown to improve the stability of the amorphous phase and to strongly increase the crystallization temperature. We combined total X-ray scattering experiments [1], Fourier Transform InfraRed (FTIR) spectroscopy and ab initio Molecular Dynamics simulations to address the stabilization of the amorphous phase of GeTe doped with Carbon or Nitrogen. The comparison between the simulation and exp erimental results allows in depth understanding of the role of dopants. They deeply modify the structure of the amorphous phase by introducing tetrahedral units centered on C or N, triangular environments and short C chains in C-doped GeTe, N-Ge3 pyramids and N2 molecules in N-doped GeTe. One major difference between N and C doping is the fact that C can form short bonds with Te, although in smaller proportion than C-Ge, while short N-Te bonds are absent in N-doped GeTe. The inclusion of C or N leads to an increase in high frequency vibrational modes, to a reduction of the density of floppy vibrational modes that drive the crystallization and to an increase of the rigidity. This stabilization mechanism could apply more generally to various GST materials as well as to other iono-covalent glasses. [1] G.E. Ghezzi, J.Y.Raty, S. Maitrejean, A. Roule, E. Elkaim and F. Hippert, Appl. Phys. Lett. 99 (2011) 151906 [less ▲]

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See detailLocal ordering and magnetism in Ga0.9Fe3.1N
Burghaus, Jens; Sougrati, Moulay T.; Moechel, Anne et al

in Journal of Solid State Chemistry (2011), 184(9), 2315-2321

Prior investigations of the ternary nitride series Ga1-xFe3+xN (0 <= x 1) have indicated a transition from ferromagnetic gamma'-Fe4N to antiferromagnetic ``GaFe3N''. The ternary nitride ``GaFe3N'' has ... [more ▼]

Prior investigations of the ternary nitride series Ga1-xFe3+xN (0 <= x 1) have indicated a transition from ferromagnetic gamma'-Fe4N to antiferromagnetic ``GaFe3N''. The ternary nitride ``GaFe3N'' has been magnetically and spectroscopically reinvestigated in order to explore the weakening of the ferromagnetic interactions through the gradual incorporation of gallium into gamma'-Fe4N. A hysteretic loop at RI reveals the presence of a minority phase of only 0.1-0.2 at\%, in accord with the sound two-step synthesis. The composition of the gallium-richest phase ``GaFe3N'' was clarified by Prompt Gamma-ray Activation Analysis and leads to the berthollide formula Ga0.91(1)Fe3.09(10)N1.05(7). Magnetic measurements indicate a transition around 8 K, further supported by Mossbauer spectral data. The weakening of the ferromagnetic coupling through an increasing gallium concentration is explained by a simple Stoner argument. In Ga0.9Fe3.1N the presence of iron on the gallium site affects the magnetism by the formation of 13-atom iron clusters. (C) 2011 Elsevier Inc. All rights reserved. [less ▲]

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See detailLocal orders in II-VI liquid compounds
Gaspard, Jean-Pierre ULg; Raty, Jean-Yves ULg; Ceolin, R. et al

in Journal of Non-Crystalline Solids (1996), 205-207

The structure of liquid CdTe, HgTe and ZnTe is studied by neutron scattering. Upon melting, drastically different behaviors are found: CdTe and ZnTe keep their fourfold coordination in the melt and remain ... [more ▼]

The structure of liquid CdTe, HgTe and ZnTe is studied by neutron scattering. Upon melting, drastically different behaviors are found: CdTe and ZnTe keep their fourfold coordination in the melt and remain semiconductors, whereas HgTe becomes sixfold coordinated and metallic. This dissimilarity is discussed in terms of the electronegativity difference and of the repulsive potential hardness. Entropic aspects are also discussed [less ▲]

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See detailLocal Pantheons in Motion: Synoecism and Patron Deities in Hellenistic Rhodes
Paul, Stéphanie ULg

in CHS Research Bulletin (2015), 3(2),

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See detailLOCAL PARAMETERS THAT INFLUENCE THE LOCAL GROWTH OF ABDOMINAL AORTIC ANEURYSMS
Martufi, Giampaolo; Liljeqvist, Moritz Lindquist; SAKALIHASAN, Natzi ULg et al

Poster (2016)

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See detailLocal perceptions and attitudes towards synanthrope long-tailed macaques (Macaca fascicularis) living in Padangtegal Monkey forest, Bali (Indonesia)
Brotcorne, Fany ULg; Paquay, Leila; Wandia, I.Nengah et al

in Folia Primatologica : International Journal of Primatology = Internationale Zeitschrift für Primatologie = Journal international de Primatologie (2013, October 03), 85(1), 48

The sympatric relationship between humans and other primates in interface zones is a contemporary widespread phenomenon. The expanding landscapes anthropization leads to an intensification of human-other ... [more ▼]

The sympatric relationship between humans and other primates in interface zones is a contemporary widespread phenomenon. The expanding landscapes anthropization leads to an intensification of human-other primate interactions ranging from conflict to co-operation scenarios. Our study investigated the commensal relationships between long-tailed macaques and humans at the tourist Padangtegal Monkey Forest. We present here results related to human-macaque interactions and local people’s perceptions and attitudes towards the latter. We used ethological methods to quantify the nature of the interactions and we conducted a questionnaire survey to identify the macaques’ status in local public opinion. 99 respondents (62 males and 37 females) were selected in a radius of 2km around the Monkey Forest. Perceptions and attitudes were explicitly measured on self-reports and were attributed to a 4 point score. Macaques interacted with humans for 1.1% of their activity budget and these interactions were mostly aggressive (0.6%), food-related (0.4%) or neutral (0.1%). 80% of the aggressive interactions were initiated by humans but the majority aimed at protecting crops and properties from macaques’ incursions. Overall, most of the respondents had positive perceptions and attitudes towards macaques, except neighbouring landowner farmers who suffered from crop damage. Despite nuisances caused by macaques, the majority of the interviewees reported to derive compensatory economic and cultural benefits from their relationships with macaques. The religious and economic contexts might explain the high tolerance level towards macaques that represents a source of hope for a sustainable coexistence, although some management strategies minimizing crop damage still need to be reinforced. [less ▲]

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See detailLocal perfusion of the tumor necrosis factor alpha blocker infliximab to the inner ear improves autoimmune neurosensory hearing loss.
Van Wijk, F.; Staecker, H.; Keithley, E. et al

in Audiology & Neuro-otology (2006), 11(6), 357-65

OBJECTIVE: To evaluate the effect of transtympanic administration of tumor necrosis factor alpha (TNF-alpha) blockers to patients suffering from autoimmune inner ear disease (AIED). STUDY DESIGN ... [more ▼]

OBJECTIVE: To evaluate the effect of transtympanic administration of tumor necrosis factor alpha (TNF-alpha) blockers to patients suffering from autoimmune inner ear disease (AIED). STUDY DESIGN: Nonrandomized, prospective pilot study. SETTING: Tertiary referral center. PATIENTS: 9 patients (4 men and 5 women; aged 51.22 +/- 13.11 years) presenting with autoimmune sensorineural hearing loss who responded to oral steroid treatment. Two groups of patients were treated. Group A consisted of 5 patients with AIED who could not be tapered off steroids. Group B consisted of 4 patients who were treated with intratympanic anti-TNF-alpha antibody therapy alone after a relapse of hearing loss following discontinuation of steroids. INTERVENTION: A Silverstein MicroWick local delivery system was placed in the round window niche and the patients were treated for 4 weeks with a weekly infusion of infliximab, a monoclonal antibody against TNF-alpha. MAIN OUTCOME MEASURE(S): Evaluation of hearing thresholds at 250-8000 Hz was performed before and after implantation of the Silverstein MicroWick and local delivery of the TNF-alpha blocker. RESULTS: Local administration of the TNF-alpha blocker allowed methylprednisolone to be tapered off without loss of hearing function in 4/5 steroid-dependent patients. Four additional patients were treated only with anti-TNF-alpha perfusion to the round window membrane without concomitant systemic administration of methylprednisolone. In 3 of these 4 patients, the pure tone average improved to 22.6 +/- 15.7 dB, resulting in hearing recovery comparable to treatment with systemic methylprednisolone. The 7 responding patients showed a significant reduction of recurrence of hearing loss to 0.028 +/- 0.072 episodes per month over the 4.3 +/- 2.4 months of the post-treatment period compared to 0.84 +/- 0.4 recurrences per week seen in the pretreatment period. CONCLUSIONS: The results of this pilot trial demonstrate that in patients with AIED, transtympanic delivery of the TNF-alpha blocker infliximab once weekly for 4 weeks allowed steroids to be tapered off, resulted in hearing improvement and reduced disease relapses. These preliminary efficacy and safety results appear encouraging enough to warrant further follow-up and studies for better determination of the potential clinical utility of local administration of infliximab for autoimmune hearing loss. [less ▲]

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See detailLocal Pinsker inequalities via Stein’s discrete density approach
Swan, Yvik ULg; Ley, Christophe

in IEEE Transactions on Information Theory (2013), 59(9), 5584-5591

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See detailLocal planning in Belgium: a myriad of policy styles?
Wayenberg, Ellen; Reuchamp, Min; Kravagna, Marine et al

in Brans, Marleen; Aubin, David (Eds.) Policy Analysis in Belgium (2017)

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See detailA local potent glucocorticosteroid decreases the induction of galactosylhydroxylysyl glucosyltransferase in suction blisters but has no effect on basement membrane structures.
Oikarinen, A.; Peltonen, L.; Hintikka, J. et al

in British Journal of Dermatology (1983), 108(2), 171-8

The effects of local glucocorticosteroid treatment on collagen biosynthesis and basement membrane components were studied in suction blisters in human abdominal skin. Pretreatment with clobetasol-17 ... [more ▼]

The effects of local glucocorticosteroid treatment on collagen biosynthesis and basement membrane components were studied in suction blisters in human abdominal skin. Pretreatment with clobetasol-17-propionate, applied three times a day for 4 days, did not affect the activity of galactosylhydroxylysyl glucosyltransferase (GGT) in fresh blisters but post-blistering treatment for 3 days with the steroid markedly inhibited the increase of this enzyme activity during the initial phases of re-epithelialization. The GGT activity was over 50% lower in steroid-treated blisters compared with control values. Protein concentrations and blister fluid volumes were also significantly decreased in healing 3-day blisters after steroid treatment. These results suggest that local glucocorticosteroid decreases either the synthesis of GGT or its release from the tissue into the blister fluid. The treatment did not affect the blister histology nor the early process of re-epithelialization. Immunohistochemically, type IV and V collagens and laminin of the basement membrane zone were similarly located in blisters of steroid-treated and placebo-treated skin, suggesting that local glucocorticosteroid does not affect the integrity of the basement membrane. [less ▲]

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See detailLocal probing of the vortex-antivortex dynamics in superconductor/ferromagnet hybrid structures
Silhanek, Alejandro ULg; Gladilin, V. N.; Van de Vondel, J. et al

in Superconductor Science and Technology (2011), 24(2),

In-plane ferromagnetic bars, densely packed in a linear array underneath a superconducting bridge, create two types of vortex chains of opposite polarity inside the superconductor. In this work we ... [more ▼]

In-plane ferromagnetic bars, densely packed in a linear array underneath a superconducting bridge, create two types of vortex chains of opposite polarity inside the superconductor. In this work we investigate both experimentally and theoretically the dynamics of these vortex chains as a function of an external magnetic field for two different arrangements of magnetic moments, namely parallel and antiparallel. The theoretical approach, based on the time-dependent Ginzburg-Landau formalism, confirms previously proposed empirical models implemented to describe the basic properties of these hybrid systems. In addition, local transport measurements allow us to probe the dynamics of individual vortex channels as a function of the applied magnetic field. These measurements evidence a drastic reduction of the dissipation in the channel populated with vortices having opposite polarity to the applied field. [less ▲]

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See detailLocal search heuristics for large-scale discrete structural optimization with expensive black-box evaluations
Bay, Maud ULg; Crama, Yves ULg; Rigo, Philippe ULg

Report (2009)

This paper considers large-scale structural optimization problems featuring discrete variables, as well as nonlinear implicit constraints which can only be evaluated through time-expensive computations. A ... [more ▼]

This paper considers large-scale structural optimization problems featuring discrete variables, as well as nonlinear implicit constraints which can only be evaluated through time-expensive computations. A prominent application consists in the preliminary structural design of large ships, where many of the variables take their values in discrete sets which model standard element dimensions to be selected from catalogs, and where the evaluation of the constraints involves a complex structural analysis performed by black-box software. The resulting large-scale nonlinear combinatorial problems are particularly hard, and even nding a discrete feasible solution may prove challenging for some instances. In this paper, we propose two heuristics that combine local search methods and a sequential optimization method based on approximations of the implicit constraints. The heuristics are applied to the structural optimization of several large ships. For these instances, the heuristics provide discrete feasible solutions whose value is close to the optimal value of the continuous relaxation obtained by disregarding the discrete nature of the variables. [less ▲]

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See detailLocal Second Gradient Models and Damage Mechanics: 1D Post-Localization Studies in Concrete Specimens
Kotronis, Panagiotis; Collin, Frédéric ULg; Bésuelle, Pierre et al

in Exadaktylos, G.; Vardoulakis, Ioannis (Eds.) Bifurcations, Instabilities, Degradation in Geomechanics (2007)

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See detailLocal second gradient models and damage mechanics: application to concrete
Kotronis, Panagiotis; Chambon, René; Mazars, Jacky et al

Conference (2005)

The non linear behaviour of concrete is often simulated using local constitutive models based on the continuous damage mechanics theory. This approach however is not adequate for post-localisation studies ... [more ▼]

The non linear behaviour of concrete is often simulated using local constitutive models based on the continuous damage mechanics theory. This approach however is not adequate for post-localisation studies with strain softening. It is well known that spurious mesh dependence appears in computations and cases of failure without energy dissipation. In order to improve computational performance second grade local models are chosen to include a meso scale in the continuous damage model. This approach differs from the nonlocal one in the sense that it is a local theory with higher order stresses depending only on the local cinematic history. 1D numerical computations with concrete specimens are presented. Using a random initialisation of the iterative solver of the equilibrium equation we search the existence of various solutions for the boundary value study and also to see if the second grade term regularise the problem giving results that are mesh insensitive and objective. [less ▲]

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See detailLocal stability results for the collective behaviors of infinite populations of pulse-coupled oscillators
Mauroy, Alexandre ULg; Sepulchre, Rodolphe ULg

in Proceedings of the IEEE Conference on Decision and Control (2011)

In this paper, we investigate the behavior of pulse-coupled integrate-and-fire oscillators. Because the stability analysis of finite populations is intricate, we investigate stability results in the ... [more ▼]

In this paper, we investigate the behavior of pulse-coupled integrate-and-fire oscillators. Because the stability analysis of finite populations is intricate, we investigate stability results in the approximation of infinite populations. In addition to recovering known stability results of finite populations, we also obtain new stability results for infinite populations. In particular, under a weak coupling assumption, we solve for the continuum model a conjecture still prevailing in the finite dimensional case. © 2011 IEEE. [less ▲]

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See detailLocal Stakeholders’ Perceptions About the Introduction of Performance-Based Financing in Benin: A Case Study in Two Health Districts
Paul, Elisabeth ULg; Sossouhounto, Nadine; Eclou, Dieudonné

in International Journal of Health Policy and Management (2014), 3

Background: Performance-Based Financing (PBF) has been advanced as a solution to contribute to improving the performance of health systems in developing countries. This is the case in Benin. This study ... [more ▼]

Background: Performance-Based Financing (PBF) has been advanced as a solution to contribute to improving the performance of health systems in developing countries. This is the case in Benin. This study aims to analyse how two PBF approaches, piloted in Benin, behave during implementation and what effects they produce, through investigating how local stakeholders perceive the introduction of PBF, how they adapt the different approaches during implementation, and the behavioural interactions induced by PBF. Methods: The research rests on a socio-anthropological approach and qualitative methods. The design is a case study in two health districts selected on purpose. The selection of health facilities was also done on purpose, until we reached saturation of information. Information was collected through observation and semi-directive interviews supported by an interview guide. Data was analysed through contents and discourse analysis. Results: The Ministry of Health (MoH) strongly supports PBF, but it is not well integrated with other ongoing reforms and processes. Field actors welcome PBF but still do not have a sense of ownership about it. The two PBF approaches differ notably as for the organs in charge of verification. Performance premiums are granted according to a limited number of quantitative indicators plus an extensive qualitative checklist. PBF matrices and verification missions come in addition to routine monitoring. Local stakeholders accommodate theoretical approaches. Globally, staff is satisfied with PBF and welcomes additional supervision and training. Health providers reckon that PBF forces them to depart from routine, to be more professional and to respect national norms. A major issue is the perceived unfairness in premium distribution. Even if health staff often refer to financial premiums, actually the latter are probably too weak — and ‘blurred’ — to have a lasting inciting effect. It rather seems that PBF motivates health workers through other elements of its ‘package’, especially formative supervisions. Conclusion: If the global picture is quite positive, several issues could jeopardise the success of PBF. It appears crucial to reduce the perceived unfairness in the system, notably through enhancing all facilities’ capacities to ensure they are in line with national norms, as well as to ensure financial and institutional sustainability of the system. [less ▲]

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