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See detailPlasticity and regeneration of spinal cortex after experimental trauma and autograft of dorsal root ganglion neurons
Schoenen, J.; Delrée, P.; Martin, Didier ULg et al

Conference (1989, November)

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See detailPlasticity in the expression of the steroid receptor coactivator 1 in the Japanese quail brain: effect of sex, testosterone, stress and time of the day.
Charlier, Thierry ULg; Ball, G. F.; Balthazart, Jacques ULg

in Neuroscience (2006), 140(4), 1381-94

Analysis of nuclear receptor action on the eukaryotic genome highlights the importance of coactivators on gene transcription. The steroid receptor coactivator-1 in particular is the focus of an intense ... [more ▼]

Analysis of nuclear receptor action on the eukaryotic genome highlights the importance of coactivators on gene transcription. The steroid receptor coactivator-1 in particular is the focus of an intense research and physiological or behavioral studies have confirmed that it plays a major role in the modulation of steroid and thyroid receptors activity. However, little is known about the regulation of steroid receptor coactivator-1 expression the brain. The goal of this study was to determine the potential factors modulating steroid receptor coactivator-1 synthesis in Japanese quail by quantification of its mRNA with real time quantitative polymerase chain reaction and of the corresponding protein via Western blotting. Contrary to previously published results from our laboratory [Charlier TD, Lakaye B, Ball GF, Balthazart J (2002) The steroid receptor coactivator SRC-1 exhibits high expression in steroid-sensitive brain areas regulating reproductive behaviors in the quail brain. Neuroendocrinology 76:297-315], we found here that sexually mature females had a higher concentration of steroid receptor coactivator-1 in the preoptic area/hypothalamus compared with males. Steroid receptor coactivator-1 expression in the male preoptic area/hypothalamus was up-regulated by testosterone and tended to be decreased by stress. We also identified a significant correlation between the time of the day and the expression of the coactivator in the optic lobes, hippocampus, telencephalon and hindbrain but the pattern of changes in expression as a function of the time of the day varied from one brain area to another. Together, these data support the idea that steroid receptor coactivator-1 is not constitutively expressed but rather is finely regulated by steroids, stress and possibly other unidentified factors. [less ▲]

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See detailPlasticity of cultured mesenchymal stem cells: switch from nestin-positive to excitable neuron-like phenotype.
Wislet-Gendebien, Sabine ULg; Hans, Grégory ULg; Leprince, Pierre ULg et al

in Stem Cells (2005), 23(3), 392-402

Bone marrow mesenchymal stem cells (MSCs) can differentiate into several types of mesenchymal cells, including osteocytes, chondrocytes, and adipocytes, but, under appropriate experimental conditions, can ... [more ▼]

Bone marrow mesenchymal stem cells (MSCs) can differentiate into several types of mesenchymal cells, including osteocytes, chondrocytes, and adipocytes, but, under appropriate experimental conditions, can also differentiate into nonmesenchymal cells--for instance, neural cells. These observations have raised interest in the possible use of MSCs in cell therapy strategies for various neurological disorders. In the study reported here, we addressed the question of in vitro differentiation of MSCs into functional neurons. First, we demonstrate that when they are co-cultured with cerebellar granule neurons, adult MSCs can express neuronal markers. Two factors are needed for the emergence of neuronal differentiation of the MSCs: the first one is nestin expression by MSCs (nestin is a marker for the responsive character of MSCs to extrinsic signals), and the second one is a direct cell-cell interaction between neural cells and MSCs that allows the integration of these extrinsic signals. Three different approaches suggest that neural phenotypes arise from MSCs by a differentiation rather than a cell fusion process, although this last phenomenon can also coexist. The expression of several genes--including sox, pax, notch, delta, frizzled, and erbB--was analyzed by quantitative reverse transcription polymerase chain reaction (RT-PCR) in order to further characterize the nestin-positive phenotype compared to the nestin-negative one. An overexpression of sox2, sox10, pax6, fzd, erbB2, and erbB4 is found in nestin-positive MSCs. Finally, electrophysiological analyses demonstrate that MSC-derived neuron-like cells can fire single-action potentials and respond to several neurotransmitters such as GABA, glycine, and glutamate. We conclude that nestin-positive MSCs can differentiate in vitro into excitable neuron-like cells. [less ▲]

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See detailPlasticity of Developing and Adult Dorsal Root Ganglion Neurons as Revealed in Vitro
Delree, P.; Ribbens, Clio ULg; Martin, Didier ULg et al

in Brain Research Bulletin (1993), 30(3-4), 231-7

We review recent data on the plasticity of dorsal root ganglion (DRG) neurons as revealed during cultivation in vitro. Some experiments on cultured developing DRG neurons and on adult DRG neurons in vivo ... [more ▼]

We review recent data on the plasticity of dorsal root ganglion (DRG) neurons as revealed during cultivation in vitro. Some experiments on cultured developing DRG neurons and on adult DRG neurons in vivo are also mentioned. Cultured developing and adult DRG neurons can be switched from an apolar to a multipolar phenotype by fetal calf serum or fibronectin. The effect is concentration dependent and occurs through an early modification of cell-substratum interaction. Adult DRG neurons synthesize and release within hours after injury TGF beta-1, which is a mitogen and a differentiation factor for Schwann cells. Finally, adult DRG neurons express in vitro neurotransmitters that are not expressed in vivo. This neurotransmitter plasticity can be modulated in vitro by some growth factors and in vivo by distal or proximal axotomy. [less ▲]

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See detailPlasticity of rat central inhibitory synapses through GABA metabolism
Engel, Dominique ULg; Pahner, I; Schulze, K et al

in Journal of Physiology (2001), 535(2), 473-82

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See detailPlasticity of the mitoproteome to nitrogen sources (nitrate and ammonium) in Chlamydomonas reinhardtii: the logic of Aox1 gene localization
Gérin, Stéphanie ULg; Mathy, Grégory ULg; Blomme, Arnaud ULg et al

in Biochimica et Biophysica Acta-Bioenergetics (2010), 1797

Nitrate and ammonium constitute primary inorganic nitrogen sources that can be incorporated into carbon skeletons in photosynthetic eukaryotes. In Chlamydomonas, previous studies and the present one ... [more ▼]

Nitrate and ammonium constitute primary inorganic nitrogen sources that can be incorporated into carbon skeletons in photosynthetic eukaryotes. In Chlamydomonas, previous studies and the present one showed that the mitochondrial AOX is up-regulated in nitrate-grown cells in comparison with ammonium-grown cells. In this work, we have performed a comparative proteomic analysis of the soluble mitochondrial proteome of Chlamydomonas cells growth either on nitrate or ammonium. Our results highlight important proteomics modifications mostly related to primary metabolism in cells grown on nitrate. We could note an up-regulation of some TCA cycle enzymes and a down-regulation of cytochrome c1 together with an up-regulation of l-arginine and purine catabolism enzymes and of ROS scavenging systems. Hence, in nitrate-grown cells, AOX may play a dual role: (1) lowering the ubiquinone pool reduction level and (2) permitting the export of mitochondrial reducing power under the form of malate for nitrate and nitrite reduction. This role of AOX in the mitochondrial plasticity makes logical the localization of Aox1 in a nitrate assimilation gene cluster. [less ▲]

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See detailPlasticization of biphasic ionomers by chemically identical, short, monofunctional oligomers
Plante, Michel; Bazuin, C Géraldine; Jérôme, Robert ULg

in Macromolecules (1995), 28(5), 1567-1574

Blends of carboxylated polystyrene ionomers containing 7 mol% of ionic units and carboxylate-terminated, monofunctional, monodisperse styrene oligomers of MW 800 were investigated by dynamic mechanical ... [more ▼]

Blends of carboxylated polystyrene ionomers containing 7 mol% of ionic units and carboxylate-terminated, monofunctional, monodisperse styrene oligomers of MW 800 were investigated by dynamic mechanical analysis and small angle X-ray scattering(SAXS). Both Cs and Ba carboxylate salts were studied,as well as blends of the Cs oligomer with homopolystyrene. The cluster phase is preferentially plasticized by the oligomers for both salts.; However, whereas the nonclustered phase of the Cs system is only a Little more plasticized than that of the Ba system, the cluster phase in the Cs system undergoes dramatic plasticization, the cluster transition disappearing at 5 wt % oligomer content. Simultaneously, the SAXS ''ionomer peak'' disappears. A peak reappears at 20 wt % oligomer content, suggesting the development of a new morphology, proposed to be micelles or ''inverted multiplets''. The difference between the two systems is attributed to the much stronger electrostatic interactions in the Ba system; this is analyzed in terms of elementary ion units. It is concluded that, whereas the nature of the nonpolar tail is relatively unimportant, the nature and strength of the electrostatic interactions involved can be of critical importance to the plasticization effects in blends of ionomers with short, monofunctional oligomers. [less ▲]

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See detail(Plasticized) polylactide/(organo-)clay nanocomposites by in situ intercalative polymerization
Paul, Marie-Amélie; Delcourt, Cécile; Alexandre, Michaël ULg et al

in Macromolecular Chemistry and Physics (2005), 206(4), 484-498

Both intercalated and exfoliated poly(L,L-lactide) (P(L,L-LA)/organomodified montmorillonite nanocomposites were synthesized by in situ ring-opening polymerization Of L,L-lactide, in bulk, directly in the ... [more ▼]

Both intercalated and exfoliated poly(L,L-lactide) (P(L,L-LA)/organomodified montmorillonite nanocomposites were synthesized by in situ ring-opening polymerization Of L,L-lactide, in bulk, directly in the presence of the nanofiller. Intercalation of polyester chains was found to appear even for natural unmodified montmorillonite-Na+, while exfoliation occurred when the aluminosilicate layers were modified by ammonium cations bearing primary hydroxyl groups. Clay delamination was effectively triggered by the grafting reaction of the growing PLA chains onto the hydroxyl groups. Aluminium triisopropoxide, triethylaluminium, and stannous octoate, as initiating or co-initiating species, were compared in terms of polymerization control. The influence of nanoclay content (from 1 to 10 wt.-% in inorganics) on morphology and thermal behavior was also studied. In parallel, a highly filled nanocomposite (called masterbatch), prepared by in situ polymerization, was dispersed into a (plasticized) preformed polylactide matrix in the molten state, to reach a better clay delamination than that obtained by direct melt blending. Finally, L-,L-lactide and alpha,w-dihydroxylated poly(ethylene glycol) (PEG 1000) were copolymerized in presence of clay in order to study the behavior of the resulting triblocks towards nanocomposite formation. [less ▲]

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See detailPlate Forme Multi Acteurs (PMA) : quel degré d’appropriation de l’approche par les acteurs dans les bas-fonds de « Sissiotan (Houéyogbé ) et de Kossou-Togba (Dogbo) »
Dossouhoui, François Vihôdé ULg; Kinha, Christophe

Conference (2010, December 07)

Le projet RAP est mis en œuvre selon un processus multi-acteurs (PMA). La PMA constitue un cadre de concertation de plusieurs acteurs : producteurs, transformateurs, commerçants, pisciculteurs, éleveurs ... [more ▼]

Le projet RAP est mis en œuvre selon un processus multi-acteurs (PMA). La PMA constitue un cadre de concertation de plusieurs acteurs : producteurs, transformateurs, commerçants, pisciculteurs, éleveurs, structures d’appui, Partenaires Techniques et financiers, etc. Les intérêts de ces acteurs sont très souvent divergents. Mais, ces acteurs sont appelés à apprendre, agir, et innover ensemble dans une approche systémique pour une utilisation optimale et une gestion durable des ressources naturelles de ces bas-fonds. Après deux années de mise en œuvre de cette approche, nous évaluions le niveau d’appropriation par les acteurs. Les conditions de mobilisation des ressources humaines et financières pour la concrétisation de cette innovation ont été évaluées de même que les actions qui ont été mises en œuvre dans le processus d’ancrage de ce partenariat. Les acquis, les faiblesses et les contraintes à l’appropriation ont fait l’objet d’une analyse critique. En somme, les PMA sont en construction et il existe de réelles motivations autour de cette approche. [less ▲]

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See detailPlate Forme Multi Acteurs (PMA) : quel degré d’appropriation de l’approche par les acteurs dans les bas-fonds de « Sissiotan (Houéyogbé ) et de Kossou-Togba (Dogbo) »
Dossouhoui, François Vihôdé ULg; Kinha, Christophe

Conference (2010, December 07)

Le projet RAP est mis en œuvre selon un processus multi-acteurs (PMA). La PMA constitue un cadre de concertation de plusieurs acteurs : producteurs, transformateurs, commerçants, pisciculteurs, éleveurs ... [more ▼]

Le projet RAP est mis en œuvre selon un processus multi-acteurs (PMA). La PMA constitue un cadre de concertation de plusieurs acteurs : producteurs, transformateurs, commerçants, pisciculteurs, éleveurs, structures d’appui, Partenaires Techniques et financiers, etc. Les intérêts de ces acteurs sont très souvent divergents. Mais, ces acteurs sont appelés à apprendre, agir, et innover ensemble dans une approche systémique pour une utilisation optimale et une gestion durable des ressources naturelles de ces bas-fonds. Après deux années de mise en œuvre de cette approche, nous évaluions le niveau d’appropriation par les acteurs. Les conditions de mobilisation des ressources humaines et financières pour la concrétisation de cette innovation ont été évaluées de même que les actions qui ont été mises en œuvre dans le processus d’ancrage de ce partenariat. Les acquis, les faiblesses et les contraintes à l’appropriation ont fait l’objet d’une analyse critique. En somme, les PMA sont en construction et il existe de réelles motivations autour de cette approche. [less ▲]

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See detailDas Plateau des Kammer- und Aortenpules
Fredericq, Léon ULg

in Zentralblatt für Physiologie (1893)

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See detailLa plateforme ExAMS, un "assessment management system" pour instrumenter la construction et la gestion qualité des évaluations des apprentissages
Gilles, Jean-Luc ULg; Detroz, Pascal ULg; Crahay, Vinciane ULg et al

in Blais, Jean-Guy (Ed.) Evaluation des apprentissages et technologie de l'information et de la communication - Tome 2 (2011)

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See detailPlateforme interactive utilisée comme outil diagnostique et de remédiation adapté aux grandes populations étudiantes suivant un cours de physique
Marique, Pierre-Xavier ULg; Hoebeke, Maryse ULg

Conference (2014, May 01)

La réforme des études de médecine introduite en 2012 en Communauté Française (Belgique) a fortement modifié les programmes de cours, entre autres celui de physique, pour lequel certaines notions sont ... [more ▼]

La réforme des études de médecine introduite en 2012 en Communauté Française (Belgique) a fortement modifié les programmes de cours, entre autres celui de physique, pour lequel certaines notions sont désormais considérées comme prérequises. Conscientes que celles-ci ne sont pas toujours acquises par les étudiants, les équipes pédagogiques de l'ULg ont élaboré des systèmes de remédiation. Un espace en ligne a notamment été développé, parallèlement au cours présentiel (cours ex-cathedra, répétitions et laboratoires), afin de permettre aux enseignants et aux étudiants d'évaluer les difficultés et lacunes de ces derniers et d’y remédier. Cet outil est conçu pour offrir une aide spécifique adaptée à chacun malgré le nombre important d’étudiants inscrits (800 en 2013). Ils peuvent y travailler, de manière progressive et autonome, les aspects théoriques (notes et tests formatifs) et pratiques (exercices, problèmes décomposés ou non). Des tests diagnostiques en début et fin de parcours permettent aux apprenants d’apprécier leur évolution. De plus, la plate-forme centralise différents outils interactifs (forums, calendrier, annonces, …) accompagnant l’étudiant dans l’organisation de son apprentissage. Les premières analyses de traces indiquent une corrélation entre travail en ligne et réussite. Une adaptation progressive de l’outil sera basée sur l’analyse des résultats et du ressenti de étudiants. [less ▲]

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