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See detailA novel image-analysis toolbox enabling quantitative analysis of root system architecture
Lobet, Guillaume ULg; Pagès, L.; Draye, X.

in Plant Physiology (2011), 157(1), 29--39

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See detailA novel inactivating mutation of the LH/chorionic gonadotrophin receptor with impaired membrane trafficking leading to Leydig cell hypoplasia type 1.
Rivero-Muller, Adolfo; Potorac, Iulia ULg; Pintiaux, Axelle ULg et al

in European journal of endocrinology / European Federation of Endocrine Societies (2015), 172(6), 27-36

OBJECTIVE: The LH/chorionic gonadotrophin receptor (LHCGR) is a G protein-coupled receptor (GPCR) that plays a central role in male sexual differentiation, regulation of ovarian follicular maturation ... [more ▼]

OBJECTIVE: The LH/chorionic gonadotrophin receptor (LHCGR) is a G protein-coupled receptor (GPCR) that plays a central role in male sexual differentiation, regulation of ovarian follicular maturation, ovulation and maintenance of corpus luteum and pregnancy, as well as maintenance of testicular testosterone production. Mutations in the LHCGR gene are very rare. The aim of this work was to study the clinical and molecular characteristics of a rare familial LHCGR mutation. METHODS: Five affected members of a family, including a phenotypically female, but genotypically male (46,XY), patient with Leydig cell hypoplasia type 1 and four genotypically female siblings with reproductive abnormalities, were studied genetically. Cell trafficking studies as well as signalling studies of mutated receptor were performed. RESULTS: The five affected patients were all homozygous for a novel mutation in the LHCGR gene, a deletion of guanine in position 1850 (1850delG). This resulted in a frameshift affecting most of the C-terminal intracellular domain. In vitro studies demonstrated that the 1850delG receptor was completely incapable of transit to the cell membrane, becoming trapped within the endoplasmic reticulum. This could not be rescued by small-molecule agonist treatment or stimulated intracellularly by co-expression of a yoked human chorionic gonadotrophin. CONCLUSIONS: This novel LHCGR mutation leads to complete inactivation of the LHCGR receptor due to trafficking and signalling abnormalities, which improves our understanding of the impact of the affected structural domain on receptor trafficking and function. [less ▲]

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See detailNovel inhibitors of the sodium-calcium exchanger: benzene ring analogues of N-guanidino substituted amiloride derivatives
Rogister, F.; Laeckmann, D.; Plasman, P.-O. et al

in European Journal of Medicinal Chemistry (2001), 36

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See detailNovel insights into the management of atypical myopathy in grazing horses based on recent series of European outbreaks and advances in etiological investigations
Votion, Dominique ULg; Gerber, Vinzent

in Proceedings of The 12th Congress of The World Equine Veterinary (2011, November 02)

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See detailNovel Instrumentation for the Measurement of the Unsteady Pressure Distribution around a Wing Undergoing Stall Flutter Oscillations
Li, Jing; Dimitriadis, Grigorios ULg; Gu, Fengshu et al

in Autumn Conference of the Institute of Acoustics 2007: Advances in Noise and Vibration Engineering (2007, October)

In this work, a wind tunnel model of a wing undergoing stall flutter oscillations is studied. It is a rectangular wing with pitch and plunge degrees of freedom and low pitch stiffness. The objective of ... [more ▼]

In this work, a wind tunnel model of a wing undergoing stall flutter oscillations is studied. It is a rectangular wing with pitch and plunge degrees of freedom and low pitch stiffness. The objective of this study is to promote the understanding of the stall flutter phenomenon by measuring the unsteady pressure distribution around the wing as well as the wing displacement, during unforced motion in two degrees of freedom. Both steady and unsteady pressures must be measured with sufficient accuracy during two types of tests. In the static tests the wing is to be clamped in position and not allowed to move and the steady pressures are to be measured around the centre-span section at different angles of attack. Thus the stall angle of attack can be identified and the stall mechanism characterized. In the dynamic tests the wing will be allowed to move and the unsteady pressures will be measured and recorded during a number of cycles of the oscillation, at a number of free stream airspeeds. [less ▲]

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See detailNovel large ring 1,3 bridged 2-azetidinones as potential inhibitors of penicillin-binding proteins
Urbach, Allan; Dive, Georges ULg; Marchand-Brynaert, Jacqueline

in European Journal of Organic Chemistry (2009), 11

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See detailA novel lox/Cre-mediated multiple gene knockout procedue in the yeast Yarrowia lipolytica
Fickers, Patrick ULg; Le Dal, M.; Gaillardin, C. et al

Poster (2003, May 09)

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See detailNovel macromolecular architectures based on aliphatic polyesters: relevance of the "coordination-insertion" ring-opening polymerization
Mecerreyes, David; Jérôme, Robert ULg; Dubois, Philippe ULg

in Advances in Polymer Science (1999), 147

Recent developments in the macromolecular engineering of aliphatic polyesters have been overviewed. First, aluminum alkoxides mediated living ring opening polymerization (ROP) of cyclic (di)esters, i.e ... [more ▼]

Recent developments in the macromolecular engineering of aliphatic polyesters have been overviewed. First, aluminum alkoxides mediated living ring opening polymerization (ROP) of cyclic (di)esters, i.e., lactones, lactides, glycolide, is introduced. An insight into this so-called "coordination-insertion" mechanism and the ability of this living polymerization process to prepare well-defined homopolymers, telechelic polymers, random and block copolymers is then discussed. In the second part, the combination of the living ROP of (di)lac-tones with other well-controlled polymerization mechanisms such as anionic, cationic, free radical, and metathesis polyadditions of unsaturated comonomers, as well as polyconden-sations, is reported with special emphasis on the design of new and well-tailored macromolecular architectures. As a result of the above synthetic breakthrough, a variety of novel materials have been developed with versatile applications in very different fields such as biomedical and microelectronics. [less ▲]

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See detailNovel magneto-electric multiferroics from first-principles calculations
Varignon, Julien ULg; Bristowe, Nicholas ULg; Bousquet, Eric ULg et al

in Comptes Rendus Physique (2015), 16

Interest in first-principles calculations within the multiferroic community has been rapidly on the rise over the last decade. Initially considered as a powerful support to explain experimentally observed ... [more ▼]

Interest in first-principles calculations within the multiferroic community has been rapidly on the rise over the last decade. Initially considered as a powerful support to explain experimentally observed behaviours, the trend has evolved and, nowadays, density functional theory calculations have become also an essential predicting tool for identifying original rules to achieve multiferroism and design new magneto-electric compounds. This chapter aims at highlighting the key advances in the field of multiferroics, to which first-principles methods have contributed significantly. The essential theoretical developments that made this research possible are also briefly presented. [less ▲]

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See detailNovel markers reveal focal abnormalities of smooth muscles in human gastrointestinal motility disorders
Wedel, Theo; van Eys, G.; Waltregny, David ULg et al

Conference (2004)

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See detailA novel mathematical model to simulate and predict tissue regeneration
Geris, Liesbet ULg; Vander Sloten, Jos; Van Oosterwyck, Hans

in Middleton, J.; Jones, M. L.; Shrive, N. (Eds.) Proceedings of the 7th international symposium on Computer Methods in Biomechanics and Biomedical Engineering (2006)

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See detailNovel mechanisms for neuroendocrine regulation of aggression.
Soma, Kiran K; Scotti, Melissa-Ann L; Newman, Amy E M et al

in Frontiers in Neuroendocrinology (2008), 29(4), 476-89

In 1849, Berthold demonstrated that testicular secretions are necessary for aggressive behavior in roosters. Since then, research on the neuroendocrinology of aggression has been dominated by the paradigm ... [more ▼]

In 1849, Berthold demonstrated that testicular secretions are necessary for aggressive behavior in roosters. Since then, research on the neuroendocrinology of aggression has been dominated by the paradigm that the brain receives gonadal hormones, primarily testosterone, which modulate relevant neural circuits. While this paradigm has been extremely useful, recent studies reveal important alternatives. For example, most vertebrate species are seasonal breeders, and many species show aggression outside of the breeding season, when gonads are regressed and circulating testosterone levels are typically low. Studies in birds and mammals suggest that an adrenal androgen precursor-dehydroepiandrosterone (DHEA)-may be important for the expression of aggression when gonadal testosterone synthesis is low. Circulating DHEA can be metabolized into active sex steroids within the brain. Another possibility is that the brain can autonomously synthesize sex steroids de novo from cholesterol, thereby uncoupling brain steroid levels from circulating steroid levels. These alternative neuroendocrine mechanisms to provide sex steroids to specific neural circuits may have evolved to avoid the "costs" of high circulating testosterone during particular seasons. Physiological indicators of season (e.g., melatonin) may allow animals to switch from one neuroendocrine mechanism to another across the year. Such mechanisms may be important for the control of aggression in many vertebrate species, including humans. [less ▲]

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See detailA novel messenger ribonucleic acid homologous to human MAGE-D is strongly expressed in rat Sertoli cells and weakly in Leydig cells and is regulated by follitropin, lutropin, and prolactin.
Hennuy, Benoît ULg; Reiter, E.; Cornet, Anne ULg et al

in Endocrinology (2000), 141(10), 3821-31

We have cloned a novel complementary DNA whose expression was decreased in rat Sertoli cell cultures after treatment with FSH. This complementary DNA encodes a protein of 570 amino acids and shares 92 ... [more ▼]

We have cloned a novel complementary DNA whose expression was decreased in rat Sertoli cell cultures after treatment with FSH. This complementary DNA encodes a protein of 570 amino acids and shares 92% homology with the human MAGE-D protein. In contrast to other MAGE genes (A, B, or C), we have shown that MAGE-D expression was ubiquitous in healthy rat tissues. In the seminiferous tubules, the MAGE-D was expressed in Sertoli cells but not in germ cells as demonstrated by RT-PCR and in situ hybridization, whereas for the other MAGE genes, expression has been shown to be restricted to germ cells. Interestingly, MAGE-D was also detected for the first time in the female gonad by Northern blotting. In MLTC-1 cells (mouse Leydig tumor cell line-1), LH and PRL stimulated MAGE-D expression. Using hypophysectomized rats, it was confirmed that FSH decreased MAGE-D expression, whereas LH and PRL increased MAGE-D messenger RNA level in the whole testis most probably through a direct action on Leydig cells. As MAGE-D is present in both the seminiferous compartment and interstitium and hormonally regulated in each, it is possible that it has specific functions in each compartment during the development and the maintenance of the testis. [less ▲]

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See detailNovel method for high-throughput colony PCR screening in nanoliter-reactors.
Walser, Marcel; Pellaux, Rene; Meyer, Andreas et al

in Nucleic acids research (2009), 37(8), 57

We introduce a technology for the rapid identification and sequencing of conserved DNA elements employing a novel suspension array based on nanoliter (nl)-reactors made from alginate. The reactors have a ... [more ▼]

We introduce a technology for the rapid identification and sequencing of conserved DNA elements employing a novel suspension array based on nanoliter (nl)-reactors made from alginate. The reactors have a volume of 35 nl and serve as reaction compartments during monoseptic growth of microbial library clones, colony lysis, thermocycling and screening for sequence motifs via semi-quantitative fluorescence analyses. nl-Reactors were kept in suspension during all high-throughput steps which allowed performing the protocol in a highly space-effective fashion and at negligible expenses of consumables and reagents. As a first application, 11 high-quality microsatellites for polymorphism studies in cassava were isolated and sequenced out of a library of 20,000 clones in 2 days. The technology is widely scalable and we envision that throughputs for nl-reactor based screenings can be increased up to 100,000 and more samples per day thereby efficiently complementing protocols based on established deep-sequencing technologies. [less ▲]

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See detailA novel method for the quantitative assessment of the ionosphere effect on high accuracy GNSS applications which require ambiguity resolution
Lejeune, Sandrine; Warnant, René ULg

in Journal of Atmospheric & Solar-Terrestrial Physics (2008), 70

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See detailNovel micro-ct based characterization tool for surface roughness measurements of porous structures
Pyka, Grzegorz; Kerckhofs, Greet ULg; Braem, Annabel et al

in Abstract book SkyScan User Meeting 2010 (2010)

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See detailNovel micro-CT based local strain mapping tool to characterize the failure modes of bone tissue engineering scaffolds
Kerckhofs, Greet ULg; Van Bael, Simon; Moesen, Maarten et al

in Abstract book SkyScan User Meeting 2009 (2009)

Detailed reference viewed: 15 (4 ULg)
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See detailNovel micro-CT based local strain mapping tool to characterize the failure modes of bone tissue engineering scaffolds
Kerckhofs, Greet ULg; Van Bael, Simon; Moesen, Maarten et al

Conference (2009)

Detailed reference viewed: 14 (1 ULg)