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See detailThe LEECH Exoplanet Imaging Survey: Orbit and Component Masses of the Intermediate-age, Late-type Binary NO UMa
Schlieder, Joshua E.; Skemer, Andrew J.; Maire, Anne-Lise et al

in Astrophysical Journal (2016), 818

We present high-resolution Large Binocular Telescope LBTI/LMIRcam images of the spectroscopic and astrometric binary NO UMa obtained as part of the LBT Interferometer Exozodi Exoplanet Common Hunt ... [more ▼]

We present high-resolution Large Binocular Telescope LBTI/LMIRcam images of the spectroscopic and astrometric binary NO UMa obtained as part of the LBT Interferometer Exozodi Exoplanet Common Hunt exoplanet imaging survey. Our H-, K[SUB]s[/SUB]-, and L‧-band observations resolve the system at angular separations <0.″09. The components exhibit significant orbital motion over a span of ∼7 months. We combine our imaging data with archival images, published speckle interferometry measurements, and existing spectroscopic velocity data to solve the full orbital solution and estimate component masses. The masses of the K2.0 ± 0.5 primary and K6.5 ± 0.5 secondary are 0.83 ± 0.02 M[SUB]⊙[/SUB] and 0.64 ± 0.02 M[SUB]⊙[/SUB], respectively. We also derive a system distance of d = 25.87 ± 0.02 pc and revise the Galactic kinematics of NO UMa. Our revised Galactic kinematics confirm NO UMa as a nuclear member of the ∼500 Myr old Ursa Major moving group, and it is thus a mass and age benchmark. We compare the masses of the NO UMa binary components to those predicted by five sets of stellar evolution models at the age of the Ursa Major group. We find excellent agreement between our measured masses and model predictions with little systematic scatter between the models. NO UMa joins the short list of nearby, bright, late-type binaries having known ages and fully characterized orbits. Based on data obtained with the STELLA robotic telescope in Tenerife, an AIP facility jointly operated by AIP and IAC. [less ▲]

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See detailLEECH: A 100 Night Exoplanet Imaging Survey at the LBT
Skemer, Andrew; Apai, Daniel; Bailey, Vanessa et al

in Exploring the Formation and Evolution of Planetary Systems (2014, January 01)

In February 2013, the LEECH (LBTI Exozodi Exoplanet Common Hunt) survey began its 100-night campaign from the Large Binocular Telescope atop Mount Graham in Arizona. LEECH neatly complements other high ... [more ▼]

In February 2013, the LEECH (LBTI Exozodi Exoplanet Common Hunt) survey began its 100-night campaign from the Large Binocular Telescope atop Mount Graham in Arizona. LEECH neatly complements other high-contrast planet imaging efforts by observing stars in L' band (3.8 microns) as opposed to the shorter wavelength near-infrared bands (1-2.3 microns). This part of the spectrum offers deeper mass sensitivity for intermediate age (several hundred Myr-old) systems, since their Jovian-mass planets radiate predominantly in the mid-infrared. In this proceedings, we present the science goals for LEECH and a preliminary contrast curve from some early data. [less ▲]

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See detailLeeman Paul
Tomasovic, Dick ULg

in Moins, Philippe (Ed.) Image par image, le cinéma d’animation en communauté Wallonie-Bruxelles (2001)

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See detailLeer y escribir la literatura científica
Pochet, Bernard ULg; Durand, F.M.

Book published by Fundación universitaria para la investigación, desarrollo, ciencia y cultura San Antonio Abad del Cusco (FUNSAAC) (2016)

Esta obra (traducido por F. M. Durand del francés “Lire et écrire la littérature scientique” el 2012, incluye actualizaciones posteriores) no es una guía de empleo de internet o de diversas ... [more ▼]

Esta obra (traducido por F. M. Durand del francés “Lire et écrire la littérature scientique” el 2012, incluye actualizaciones posteriores) no es una guía de empleo de internet o de diversas herramientas documentales. Es une herramienta de formación científica con un enfoque resueltamente metodológico. Sirve de soporte a los cursos de metodología documental y de literatura científica de Gembloux Agro-Bio Tech (ULg). Puede ampliamente ser utilizado en todas las eseñanzaz y las formaciones que tocan a la literatura científica exactas y aplicadas. Basada en más de veinte años de experiencia y redactado en un estilo simple y directo, esta obra aborda los diferentes aspectos de la búsqueda de informaciones científicas y de la utilización de este información así como los de la producción de artículos publicados en revistas con comité de lectura. El lector por tanto es considerado como lector y usuario de la información científica, y como productor de esta información. Es este enfoque global de la comunicación científica que justifica la elección del título. [less ▲]

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See detailHet Leerdercorpus Nederlands in theorie en in de praktijk
Perrez, Julien ULg; Degand, Liesbeth

Conference (2009, August 24)

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See detailHet Leerdercorpus Nederlands
Degand, Liesbeth; Perrez, Julien ULg

Conference (2003)

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See detailHet Leerdercorpus Nederlands: Perspectieven op de tussentaal van Franstaligen
Degand, Liesbeth; Jansonius, Maarten; Perrez, Julien ULg

Conference (2004)

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See detailLeerdoelen en testformaat : De Europese Talencertificaten : Certificaat Nederlands
Hennen, Karl-Heinz; Vromans, Joseph ULg

Book published by Weiterbildungs-Testsysteme (1999)

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See detailDe leerkrachten en de pedagogisch-didaktische Vernieuwing
de Landsheere, Gilbert ULg

in Doceo (1972), 182

Het ware ongetwijfeld interessant hier ook enkele experimentele demonstraties over weerstanden tegen de vernieuwing te beschrijven. In dit korte bestek is dat echter niet mogelijk. Besluitend wil ik: een ... [more ▼]

Het ware ongetwijfeld interessant hier ook enkele experimentele demonstraties over weerstanden tegen de vernieuwing te beschrijven. In dit korte bestek is dat echter niet mogelijk. Besluitend wil ik: een onvoorwaardelijke waarschuwing laten horen. In onze veranderende samenleving, die zich resoluut en snel verwetenschappelijkt, trachten de opvoedingsdeskundigen soms met een onthutsende goede wil. de school in de vernieuwing in te schakelen. Slecht geïnformeerd, onvoldoende uitgerust met onderzoeksmethodes, slagen zij er niet altijd in een onderscheid te maken tussen de pedagogische mythe en de realiteit, tussen goedkope beweringen en wetenschap. Het getuigt van een ontzettende naïviteit te geloven dat de pedagogisch-didactische wetenschap op alle vragen kan antwoorden, alle problemen kan oplossen. Maar zo maar zonder meer aanvaarden dat de school verder kan evolueren naar haar echte rol in de maatschappij, zonder de beslissingen te doen steunen op strenge studies of de resultaten van de vernieuwingen te onderwerpen aan objectieve evaluaties, getuigt van een niet minder grote naïviteit. Ons land heeft een zeer dringende nood aan een net van onderzoekscentra van hoog niveau. Deze centra moeten zowel op gedetacheerde leerkrachten als academisch geschoolden, inspecteurs en administratieve mensen een beroep doen. Een school in ontwikkeling, deel uitmakend van een samenleving in wording, heeft klaarziende en getrainde geesten nodig. Avonturiers moeten uitgeschakeld worden. [less ▲]

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See detailDe Leeuw van Waterloo. Een trefpunt van verleden, heden en toekomst
Raxhon, Philippe ULg

in Tollebeek, Jo (Ed.) België, een parcours van hennering. Plaatsen van geschiedenis en expansie (2008)

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See detailLEF1-mediated MMP13 gene expression is repressed by SIRT1 in human chondrocytes.
Elayyan, Jinan; Lee, Eun-Jin; Gabay, Odile et al

in FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2017)

Reduced SIRT1 activity and levels during osteoarthritis (OA), promotes gradual loss of cartilage. Loss of cartilage matrix is accompanied by an increase in matrix metalloproteinase (MMP) 13, partially ... [more ▼]

Reduced SIRT1 activity and levels during osteoarthritis (OA), promotes gradual loss of cartilage. Loss of cartilage matrix is accompanied by an increase in matrix metalloproteinase (MMP) 13, partially because of enhanced LEF1 transcriptional activity. In this study, we assessed the role of SIRT1 in LEF1-mediated MMP13 gene expression in human OA chondrocytes. Results showed that MMP13 protein levels and enzymatic activity decreased significantly during SIRT1 overexpression or activation by resveratrol. Conversely, MMP13 gene expression was reduced in chondrocytes transfected with SIRT1 siRNA or treated with nicotinamide (NAM), a sirtuin inhibitor. Chondrocytes challenged with IL-1beta, a cytokine involved in OA pathogenesis, enhanced LEF1 protein levels, and gene expression, resulting in increased MMP13 gene expression; however, overexpression of SIRT1 during IL-1beta challenge impeded LEF1 levels and MMP13 gene expression. Previous reports showed that LEF1 binds to the MMP13 promoter and transactivates its expression, but we observed that SIRT1 repressed LEF1 protein and mRNA expression, ultimately reducing LEF1 transcriptional activity, as judged by luciferase assay. Finally, mouse articular cartilage from Sirt1-/- presented increased LEF1 and MMP13 protein levels, similar to human OA cartilage. Thus, demonstrating for the first time that SIRT1 represses MMP13 in human OA chondrocytes, which appears to be mediated, at least in part, through repression of the transcription factor LEF1, a known modulator of MMP13 gene expression.-Elayyan, J. Lee, E.-J., Gabay, O., Smith, C. A., Qiq, O., Reich, E., Mobasheri, A., Henrotin, Y., Kimber, S. J., Dvir-Ginzberg, M. LEF1-mediated MMP13 gene expression is repressed by SIRT1 in human chondrocytes. [less ▲]

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See detailLefort et Althusser : lecteurs de Machiavel
Mancuso, Eva ULg

Scientific conference (2014, February 20)

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See detailLeft atrial dysfunction as a correlate of heart failure symptoms in hypertrophic cardiomyopathy.
Rosca, Monica; Popescu, Bogdan A.; Beladan, Carmen C. et al

in Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography (2010), 23(10), 1090-8

BACKGROUND: Hypertrophic cardiomyopathy (HCM) represents a generalized myopathic process affecting both ventricular and atrial myocardium. We aimed to assess left atrial (LA) function by two-dimensional ... [more ▼]

BACKGROUND: Hypertrophic cardiomyopathy (HCM) represents a generalized myopathic process affecting both ventricular and atrial myocardium. We aimed to assess left atrial (LA) function by two-dimensional speckle tracking echocardiography and its relation with left ventricular (LV) function and clinical status in patients with HCM. METHODS: We prospectively enrolled 37 consecutive patients with HCM and 37 normal subjects with similar age and gender distribution. Longitudinal LV strain (epsilon) and LA epsilon and strain rate (Sr) parameters (systolic, early diastolic, and late diastolic during atrial contraction) were assessed. RESULTS: Peak LAepsilon and LA Sr parameters were significantly lower in patients compared with controls (P </= .001 for all). In patients, all LA function parameters correlated with LVepsilon (P < .003 for all). Indexed LA volume, LA function parameters, and mitral regurgitation degree were the main correlates of New York Heart Association class; late diastolic strain rate during atrial contraction was the only independent predictor of symptomatic status. CONCLUSION: In patients with HCM, LA function is significantly reduced and related to LV dysfunction. Moreover, LA booster pump function emerged as an independent correlate of heart failure symptoms in this setting. [less ▲]

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See detailLeft atrial function and remodelling in aortic stenosis.
O'Connor, K.; Magne, Julien ULg; Rosca, M. et al

in European Journal of Echocardiography (2011), 12(4), 299-305

AIMS: The present study sought to determine the relationship between left atrial (LA) volume (structural changes) and LA function as assessed by strain rate imaging in patients with aortic stenosis (AS ... [more ▼]

AIMS: The present study sought to determine the relationship between left atrial (LA) volume (structural changes) and LA function as assessed by strain rate imaging in patients with aortic stenosis (AS). <br />METHODS AND RESULTS: The study consisted of a total of 64 consecutive patients with severe AS (<1 cm²) and 20 healthy control subjects. The phasic LA volumes and function (tissue Doppler-derived strain) were assessed in all patients. As compared with healthy controls, all strain-derived parameters of LA function were reduced in patients with AS. Conversely, only indexed LA passive volume (increased) (7.6 ± 3.8 vs. 10.5 ± 5.1 ml/m², P= 0.02) and LA active fraction (decreased) (43 ± 6.7 vs. 31 ± 13.3%, P< 0.001) (volume-based parameters) were significantly different between AS and controls. In AS, LA volume-derived function parameters were poorly correlated with LA strain parameters. In fact, by multivariable analysis, no LA phasic strain parameters emerged as independently associated with LA phasic volume parameters. <br />CONCLUSIONS: In AS, changes in LA function did not parallel changes in LA size. Furthermore, the increase in LA volume does not necessarily reflect the presence of intrinsic LA dysfunction [less ▲]

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See detailLeft atrial function: pathophysiology, echocardiographic assessment, and clinical applications.
Rosca, M.; Lancellotti, Patrizio ULg; Popescu, B. A. et al

in Heart (2011), 97(23), 1982-9

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See detailLeft atrial thrombus in a newborn with dilated cardiomyopathy
Rigo, Vincent ULg; Rondia, Gilles; Rigo, Jacques ULg

in Edition Spéciale SBP, Vol 1 (2008, February 29)

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See detailA left atrial thrombus too big to embolize.
Lancellotti, Patrizio ULg; Radermecker, Marc ULg; Pierard, Luc ULg

in European Heart Journal (2007), 28(13), 1660

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See detailThe left atrium: an old 'barometer' which can reveal great secrets.
Lancellotti, Patrizio ULg; Henri, Christine

in European journal of heart failure (2014)

Detailed reference viewed: 15 (3 ULg)