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See detailNovel amphiphilic mikto-arm star-shaped copolymers for the preparation of PLA-based nanocarriers
Cajot, Sébastien ULg; Riva, Raphaël ULg; Billiet, Leen et al

in Macromolecular Symposia (2011), 309/310(1), 111-122

Three-arm (A2B) and four-arm (A2B2) star-shaped copolymers based on biocompatible and biodegradable hydrophobic poly(ε-caprolactone) (PCL) (A arms) and biocompatible and bioeliminable hydrophilic poly ... [more ▼]

Three-arm (A2B) and four-arm (A2B2) star-shaped copolymers based on biocompatible and biodegradable hydrophobic poly(ε-caprolactone) (PCL) (A arms) and biocompatible and bioeliminable hydrophilic poly(ethylene oxide) (PEO) (B arms) were synthesized by the coupling of an ω-azide terminated PEO chains with PCL chain bearing one (A2B) or two (A2B2) alkyne functions at the middle of the chain by the copper mediated azide-alkyne cycloaddition (CuAAC). The amphiphilic behavior of these different stars was confirmed by micellization experiments in water followed by dynamic light scattering and transmission electron microscopy analyses. The efficiency to stabilize PLA nanoparticles was investigated in function of the stars structure. [less ▲]

Detailed reference viewed: 62 (31 ULg)
See detailNovel and simple electrografting monomer method to exfoliate HOPG for lithium-ion batteries
Aqil, Abdelhafid ULg; Ouhib, Farid ULg; Jérôme, Christine ULg et al

Conference (2013, October 28)

Many methods have been developed in the last few decades to obtain high-quality graphene thin sheets. They are based on very different physicochemical processes. Here we demonstrate a novel one step and ... [more ▼]

Many methods have been developed in the last few decades to obtain high-quality graphene thin sheets. They are based on very different physicochemical processes. Here we demonstrate a novel one step and simple electrografting acrylate monomer method to exfoliate highly oriented pyrolytic graphite (HOPG) into thin nanoplatelets and even down to the single graphene sheet level. Among the high research activity in the area of surface modification, electrografting is a very powerful method which has received comparatively little attention. This is surprising because this technique has many attractive features for modification of conducting or semi-conducting surfaces. The main interest of the electrografting process is to solve the recurrent problem of the organic/substrates interface weakness. The electrografting warranties a robust polymer/substrates interface and offers the possibility to tailor the functionality of the grafted polymer film opening the door to a wide range of demanding technological applications. The graphene sheets obtained through electrografting process give a stable suspension in dimethyl formamide (DMF), and they can self-precipitate on the surface of substrates after adding water as an antisolvent due to their strong surface hydrophobicity. Interestingly, the continuous films obtained exhibit ultratransparency (∼98% transmittance), and the lateral size of the exfoliated graphene sheets observed by AFM ~1nm. Raman and TEM characterizations corroborate that the graphene sheets exfoliated by our electrochemical method preserve the intrinsic structure of grapheme and give preferentially monolayered graphene sheets. The electrochemical behaviour of the acrylate monomer grafted graphene sheets was evaluated in lithium-half cells with no addition of conductive additive or binder. The PAN grafted graphene dispersed in DMF was coated on Cu foil and dried in a vacuum oven at 55°C for 12h. After 200 cycles, the reversible capacity was still kept at 300mAh/g at the current density of 50mA/g. These results indicate that the prepared high quality graphene sheets possess good electrochemical performances for lithium storage. This work provides an efficient approach to obtain high-quality, cost-effective, and scalable production of “graphene ink”, which may pave a way toward future applications in lithium- ion batteries. [less ▲]

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See detailA novel and template-free method for the spontaneous formation of aluminosilicate macro-channels with mesoporous walls
Léonard, Alexandre ULg; Su, B.-L.

in Chemical Communications (2004), 10(14), 1674-1675

A simple and template-free synthesis pathway was developed leading to hierarchical meso-macroporous aluminosilicates made of an assembly of macro-channels with openings between 0.5 and 2.0 μm and ... [more ▼]

A simple and template-free synthesis pathway was developed leading to hierarchical meso-macroporous aluminosilicates made of an assembly of macro-channels with openings between 0.5 and 2.0 μm and mesoporous walls. [less ▲]

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See detailNovel antiangiogenic effects of the bisphosphonate compound zoledronic acid
Wood, J.; Bonjean, K.; Ruetz, S. et al

in Journal of Pharmacology and Experimental Therapeutics (2002), 302(3), 1055-1061

Bisphosphonate drugs inhibit osteoclastic bone resorption and are widely used to treat skeletal complications in patients with tumor-induced osteolysis. We now show that zoledronic acid, a new generation ... [more ▼]

Bisphosphonate drugs inhibit osteoclastic bone resorption and are widely used to treat skeletal complications in patients with tumor-induced osteolysis. We now show that zoledronic acid, a new generation bisphosphonate with a heterocyclic imidazole substituent, is also a potent inhibitor of angiogenesis. In vitro, zoledronic acid inhibits proliferation of human endothelial cells stimulated with fetal calf serum, basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (IC50 values 4.1, 4.2, and 6.9 muM, respectively), and modulates endothelial cell adhesion and migration. In cultured aortic rings and in the chicken egg chorioallantoic membrane assay, zoledronic acid reduces vessel sprouting. When administered systemically to mice, zoledronic acid potently inhibits the angiogenesis induced by subcutaneous implants impregnated with bFGF [ED50, 3 mug/kg (7.5 nmol/kg) s.c.]. These findings indicate that zoledronic acid has marked antiangiogenic properties that could augment its efficacy in the treatment of malignant bone disease and extend its potential clinical use to other diseases with an angiogenic component. [less ▲]

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See detailNovel antiangiogenic peptide agents and their therapeutic and diagnostic use
Weiner, Richard I.; Martial, Joseph ULg; Struman, Ingrid ULg et al

Patent (2008)

The current invention concerns novel antiangiogenic peptides which correspond to about 10 to about 150 consecutive amino acids of N-terminal sequences of human growth hormones, human placental lactogen ... [more ▼]

The current invention concerns novel antiangiogenic peptides which correspond to about 10 to about 150 consecutive amino acids of N-terminal sequences of human growth hormones, human placental lactogen, human growth hormone variant hGH-V, and prolactin, and their use in inhibiting angiogenesis and in the diagnosis of diseases of human pregnancy involving abnormalities of placental vascularization. [less ▲]

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See detailNovel applications of lactoperoxydase system against pathogens of cultivated plants
Jijakli, Haissam ULg; Bafort, Françoise ULg; perraudin, J.P

Conference (2010, June)

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See detailA novel approach for extracting time-delays from lightcurves of lensed quasar images
Burud, I.; Magain, Pierre ULg; Sohy, Sandrine ULg et al

in Astronomy and Astrophysics (2001), 380

We present a new method to estimate time delays from light curves of lensed quasars. The method is based on chi [SUP]2[/SUP] minimization between the data and a numerical model light curve. A linear ... [more ▼]

We present a new method to estimate time delays from light curves of lensed quasars. The method is based on chi [SUP]2[/SUP] minimization between the data and a numerical model light curve. A linear variation can be included in order to correct for slow long-term microlensing effects in one of the lensed images. An iterative version of the method can be applied in order to correct for higher-order microlensing effects. The method is tested on simulated light curves. When higher-order microlensing effects are present, the time delay is best constrained with the iterative method. Analysis of a published data set for the lensed double Q 0957+561 yields results in agreement with other published estimates. [less ▲]

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See detailA Novel Approach to Design Chitosan-Polyester Materials for Biomedical Applications
Akopova, Tatiana A.; Demina, Tatiana S.; Shchegolikhin, Alexander N. et al

in International Journal of Polymer Science (2012), 2012

Detailed reference viewed: 12 (3 ULg)
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See detailA novel approach to the study of familial influences on evoked cortical responses in migraine.
Schoenen, Jean ULg; Sandor, P. S.

in Cephalalgia : An International Journal of Headache (1999), 19 Suppl 24

Detailed reference viewed: 8 (1 ULg)
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See detailA novel aromatic-aliphatic copolyester of poly(ethylene-co-diethylene-terephthalate)-co-poly(L-lactic acid): Synthesis and characterization
Li, Jun; Jiang, Zhi-Qiang; Zhou, Jian et al

in Industrial & Engineering Chemistry Research (2010), 49(20), 9803-9810

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See detailNovel aspects of the pathogenesis of aneurysms of the abdominal aorta in humans.
Michel, Jérôme ULg; Martin-Ventura, J. L.; Egido, J. et al

in Cardiovascular Research (2011)

Aneurysm of the abdominal aorta (AAA) is a particular, specifically localized form of atherothrombosis, providing a unique human model of this disease. The pathogenesis of AAA is characterized by a ... [more ▼]

Aneurysm of the abdominal aorta (AAA) is a particular, specifically localized form of atherothrombosis, providing a unique human model of this disease. The pathogenesis of AAA is characterized by a breakdown of the extracellular matrix due to an excessive proteolytic activity, leading to potential arterial wall rupture. The roles of matrix metalloproteinases and plasmin generation in progression of AAA have been demonstrated both in animal models and in clinical studies. In the present review, we highlight recent studies addressing the role of the haemoglobin-rich, intraluminal thrombus and the adventitial response in the development of human AAA. The intraluminal thrombus exerts its pathogenic effect through platelet activation, fibrin formation, binding of plasminogen and its activators, and trapping of erythrocytes and neutrophils, leading to oxidative and proteolytic injury of the arterial wall. These events occur mainly at the intraluminal thrombus-circulating blood interface, and pathological mediators are conveyed outwards, where they promote matrix degradation of the arterial wall. In response, neo-angiogenesis, phagocytosis by mononuclear cells, and a shift from innate to adaptive immunity in the adventitia are observed. Abdominal aortic aneurysm thus represents an accessible spatiotemporal model of human atherothrombotic progression towards clinical events, the study of which should allow further understanding of its pathogenesis and the translation of pathogenic biological activities into diagnostic and therapeutic applications. [less ▲]

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See detailNovel association between vasoactive intestinal peptide and CRTH2 receptor in recruiting eosinophils: a possible biochemical mechanism for allergic eosinophilic inflammation of the airways.
EL SHAZLY, Amr ULg; Begon, Dominique ULg; KUSTERMANS, Gaëlle ULg et al

in Journal of Biological Chemistry (2013), 288(2), 1374-84

We explored the relation between vasoactive intestinal peptide (VIP), CRTH2, and eosinophil recruitment. It is shown that CRTH2 expression by eosinophils from allergic rhinitis (AR) patients and ... [more ▼]

We explored the relation between vasoactive intestinal peptide (VIP), CRTH2, and eosinophil recruitment. It is shown that CRTH2 expression by eosinophils from allergic rhinitis (AR) patients and eosinophils cell line (Eol-1 cells) was up-regulated by VIP treatment. This was functional and resulted into exaggerated migratory response of cells against PGD2. Nasal challenge of AR patients resulted into significant increase of VIP contents in nasal secretion (ELISA), and the immunohistochemical studies of allergic nasal tissues, showed significant expression of VIP in association with intense eosinophil recruitment. Biochemical assays showed that VIP-induced eosinophils chemotaxis from AR patients and Eol-1 cells, was mediated through CRTH2 receptor. Cells migration against VIP was sensitive to protein kinase C (PKC) and protein kinase A (PKA) inhibition, but not to tyrosine kinase or P38 MAP-kinase inhibition, or calcium chelation. Western blot demonstrated a novel CRTH2 mediated cytosol to membrane translocation of PKC-epsilon, PKC-delta and PKA-alpha, gamma and IIalpha reg in Eol-1 cells upon stimulation with VIP. Confocal images and FACS demonstrated a strong association and co-localization between VIP peptide and CRTH2 molecules. Further, VIP induced PGD2 secretion from eosinophils. Our results demonstrate the first evidence of association between VIP and CRTH2 in recruiting eosinophils. [less ▲]

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See detailNovel Bacterial Isolate from Permian Groundwater, Capable of Aggregating Potential Biofuel-Producing Microalga Nannochloropsis oceanica IMET1
Wang, H; Laughinghouse IV, Haywood ULg; Anderson, MA et al

in Applied and Environmental Microbiology (2012), 78(5), 1445-1453

Detailed reference viewed: 21 (1 ULg)
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See detailA Novel Bacteriocin With A Ygngv Motif From Vegetable-Associated Enterococcus Mundtii: Full Characterization And Interaction With Target Organisms
Bennik, Mhj.; Vanloo, B.; Brasseur, Robert ULg et al

in Biochimica et Biophysica Acta-Biomembranes (1998), 1373(1), 47-58

A novel broad-spectrum antimicrobial peptide produced by vegetable-associated Enterococcus mundtii was purified and characterized, and designated mundticin. To our knowledge, this is the first report on ... [more ▼]

A novel broad-spectrum antimicrobial peptide produced by vegetable-associated Enterococcus mundtii was purified and characterized, and designated mundticin. To our knowledge, this is the first report on bacteriocin production by this organism. The elucidation of the full primary amino acid sequence of mundticin (KYYGNGVSCNKKGCSVDWGKAIGIIGNNSAANLATGGAAGWSK) revealed that this antimicrobial peptide belongs to the class IIa bacteriocins of lactic acid bacteria which share a highly conserved N-terminal 'YGNGV' motif. Data obtained by computer modelling indicated an oblique orientation of the alpha-helical regions of mundticin and homologous class IIa bacteriocins at a hydrophobic-hydrophilic interface, which may play a role in the destabilization of phospholipid bilayers. The average mass of mundticin, as determined by electron spray mass spectrometry, was found to be 4287.21+/-0.59 Da. With respect to its biological activity, mundticin was shown to inhibit the growth of Listeria monocytogenes, Clostridium botulinum and a variety of lactic acid bacteria. Moreover, it was demonstrated to have a bactericidal effect on L. monocytogenes as a result of the dissipation of the membrane potential, and a loss of intracellular ATP in absence of ATP leakage. Its good solubility in water, and its stability over a wide pH and temperature range indicate the potential of this broad spectrum bacteriocin as a natural preservation agent for foods. [less ▲]

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See detailNovel biocompatible coatings strongly adhering onto stainless steel and carbon fibers, endowed with antibacterial properties
Ignatova, Miléna; Labaye, David-Emmanuel; Voccia, Samuel et al

Poster (2003, May 16)

Detailed reference viewed: 12 (1 ULg)
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See detailA novel biodegradable and biocompatible ceramer prepared by the sol-gel process
Tian, Dong; Dubois, Philippe ULg; Grandfils, Christian ULg et al

in Chemistry of Materials (1997), 9(4), 871-874

Detailed reference viewed: 38 (12 ULg)