Silences et double discours. Réflexions sur les contraintes du politique

Article for general public (2007)

Silencing subdomains of v-ErbA interact cooperatively with corepressors: involvement of helices 5/6

in Molecular Endocrinology (Baltimore, Md.) (2000), 14(2), 201-11

Members of the thyroid hormone receptor (TR) family act on vertebrate development and homeostasis by activating or repressing transcription of specific target genes in a ligand-dependent way. Repression ... [more ▼]

Members of the thyroid hormone receptor (TR) family act on vertebrate development and homeostasis by activating or repressing transcription of specific target genes in a ligand-dependent way. Repression by TR in the absence of ligand is mediated by an active silencing mechanism. The oncogene v-ErbA is a variant form of TR unable to bind hormone and thus acts as a constitutive repressor. Functional studies and mutation analysis revealed that the TR/v-ErbA silencing domain is composed of three silencing subdomains (SSD1-3) which, although nonfunctional individually, synergize such that silencing activity is restored when they are combined in a heteromeric complex. Here we demonstrate, using protein interaction assays in vitro and in vivo, that the inactive v-ErbA point mutant L489R within helix 5/6 in SSD2 fails to interact with the two corepressors N-CoR (nuclear receptor corepressor) or SMRT (silencing mediator of retinoic acid and thyroid hormone receptor). Furthermore, mutants in SSD1 and SSD3 exhibit a reduced corepressor recruitment corresponding to their weak residual silencing activity. In mammalian two-hybrid assays, only the combination of all three silencing subdomains, SSD1-3, leads to a cooperative binding to the corepressors N-CoR or SMRT comparable to that of the full-length v-ErbA repression domain. In conclusion, full silencing activity requires corepressor interaction with all three silencing subdomains, SSD1-3. Among these, SSD2 is a new target for N-CoR and SMRT and is essential for corepressor binding and function. [less ▲]

Silenzi, solitudini, segreti : Altre metamorfosi dannunziane

Book published by Bonanno (2011)

Silhouette Understanding System for Laser-radar Range Imagery

Conference (1985, November)

SILICA NANOPARTICLE Gd(III)- DOTA CONJUGATE AS CONTRAST AGENTS FOR MAGNETIC RESONANCE IMAGING

Poster (2004)

Silicon carbide fibers and particles reinforced aluminium alloys produced by stir casting

in Proceedings of The 4th European Conference on Composite Materials - Developments in The Science and Technology of Composite Materials (1990)

This study is concerned with the solidification processing of aluminium alloys reinforced by short fibers and particles of SiC. The reinforcements have been introduced and dispersed into aluminium alloys ... [more ▼]

This study is concerned with the solidification processing of aluminium alloys reinforced by short fibers and particles of SiC. The reinforcements have been introduced and dispersed into aluminium alloys melts by the vortex method. The commercial alloys (2024, 319) containing elements such as Cu or Mg chosen to provide adequate wetting have been used and compared. The samples have been examined both in the as-cast or as-rolled and heat treated conditions (T6). Examinations of the mechanical properties by statistical analyses show that both SiC chopped fibers and particles increase significantly the mechanical properties of the alloys especially at high temperature. [less ▲]

Silicon image sensor technology for in vivo detection of surfactant-induced corneocyte swelling and drying.

in Dermatology : International Journal for Clinical & Investigative Dermatology (2005), 210(3), 184-8

BACKGROUND: Several instrumental methods can indirectly assess some specific aspects of cutaneous irritation at the level of the stratum corneum (SC). OBJECTIVE: There is a need for developing more ... [more ▼]

BACKGROUND: Several instrumental methods can indirectly assess some specific aspects of cutaneous irritation at the level of the stratum corneum (SC). OBJECTIVE: There is a need for developing more sensitive approaches in this field. METHODS: We assessed a recently introduced innovative tool (SkinChip) based on capacitive pixel-sensing technology in its potential to detect early discrete manifestations of skin irritation. The sensor generates a detailed non-optical picture corresponding to a capacitance map of the skin surface reaching 50 microm pixel resolution. Some topographical details can be easily disclosed and the SC hydration as well. Two surfactant solutions were tested on volunteers. These solutions were applied under test patches for 2 days on the volar forearms. Clinical and SkinChip assessments were performed 3 h after removing the patch. RESULTS: The generated images allowed a precise observation of skin irritation which appeared as a two-step process. Early changes consisted of darker pixels corresponding to overhydrated swollen corneocytes at the irritated sites. Two days later, the same area appeared as white pixels, indicating the loss of corneocyte hydration. CONCLUSION: The SkinChip device appears to be a very sensitive tool for detecting the early steps of surfactant-induced skin irritation affecting the SC. [less ▲]

Silicone-based drug reservoirs manufacturing process - Critical quality attributes evaluation using NIR and Raman spectroscopy

Poster (2011, October)

The silk road

in Earth Observation by Satellite (2002)

Silo flow-pattern diagnosis using the tracer method

in Journal of Food Engineering (2009), 91(1), 118-125

The storage silo of a sugar refinery was designed by its manufacturer for a plug-flow pattern of sugar ingots in order to ensure effective drying of the sugar introduced at the top of the silo. Because of ... [more ▼]

The storage silo of a sugar refinery was designed by its manufacturer for a plug-flow pattern of sugar ingots in order to ensure effective drying of the sugar introduced at the top of the silo. Because of the excessive moisture content of the extracted ingots, the quality of flow within the silo was called into question. The silo flow-pattern was thus studied by introducing sugar lumps as a tracer at the top of the silo filled with ingots. The tracer weight percentage was measured at the outlet. Results show that the silo flow-pattern is not of the plug-flow type in its whole volume: after formation of a crater, only the central volume flows, while the outer residual volume remains motionless. The tracer test also enabled the detection of preferential flow patterns. The tracer method was found to be quite useful as a diagnosis method for such a device in normal functioning. (C) 2008 Elsevier Ltd. All rights reserved. [less ▲]