Selective involvement of the right dorsal occipital stream for the spatial processing of sounds in early blind subjects; Vandewalle, Gilles ; et alin Journal of Cognitive Neuroscience (2010), 22(Suppl. 1), Selective localization of carbon black in immiscible polymer blends : a useful tool to design electrical conductive composites; Jérôme, Robert ; et alin Macromolecules (1994), 27(7), 1972-1974 Detailed reference viewed: 46 (1 ULg) A Selective Move Generator for the Game Axis and AlliesLupien St-Pierre, David ; ; in Computational Intelligence and Games (2010) We consider the move generation in a modern board game where the set of all the possible moves is too large to be generated. The idea is to provide a set of simple abstract tactics that would allow enough ... [more ▼] We consider the move generation in a modern board game where the set of all the possible moves is too large to be generated. The idea is to provide a set of simple abstract tactics that would allow enough combinations to provide strong opposition. The reduced search space is then traversed using the alpha beta search. We also propose a technique that allows us to remove the stochasticity from the search space. The model was tested in a game called Axis and Allies: a modern, turn-based, perfect information, non-deterministic, strategy board game. We first show that a tree search technique based on a restrained set of moves can beat the actual scripted AI engine --- E.Z. Fodder. We can conclude from the experiments that searching deeper generates complex maneuvers which in turn significantly increase the likelihood of victory. [less ▲] Detailed reference viewed: 11 (1 ULg) Selective osteopontin knockdown exerts anti-tumoral activity in a human glioblastoma model.Lamour, Virginie ; ; et alin International Journal of Cancer = Journal International du Cancer (2010), 126 Osteopontin (OPN), a member of the SIBLING (Small Integrin-Binding LIgand N-linked Glycoprotein) family, is overexpressed in human glioblastoma. Higher levels of OPN expression correlate with increased ... [more ▼] Osteopontin (OPN), a member of the SIBLING (Small Integrin-Binding LIgand N-linked Glycoprotein) family, is overexpressed in human glioblastoma. Higher levels of OPN expression correlate with increased tumor grade and enhanced migratory capacity of tumor cells. Based on these observations, we explored the possibility that knocking down OPN expression in glioblastoma cells could exert an anti-tumoral activity using an avian in vivo glioblastoma model that mimics closely human gliobastoma. Human U87-MG glioma cells transfected with specific anti-OPN small interfering RNAs (siRNAs) were grafted onto the chicken chorio-allantoic membrane (CAM). OPN-deficient U87-MG cells gave rise to tumors that were significantly smaller than tumors formed from untransfected cells (paired t-test, p<0.05). Accordingly, the amount of proliferating cells in OPN-deficient tumors showed a six-fold reduction when compared to control tumors. However, OPN inhibition did not affect significantly tumor-associated angiogenesis. In vitro, OPN-silenced U87-MG and U373-MG cells showed decreased motility and migration. This is the first demonstration that OPN inhibition blocks glioma tumor growth, making this invasion-related protein an attractive target for glioma therapy. (c) 2009 UICC. [less ▲] Detailed reference viewed: 50 (9 ULg) Selective pancreatic ATP-sensitive potassium channel openers for the treatement of glucose homeostasis disordersDe Tullio, Pascal ; ; Florence, Xavier et alin Drugs of the Future (2006), 31 Detailed reference viewed: 8 (1 ULg) Selective recognition of pyrimidine–pyrimidine DNA mismatches by distance-constrained macrocyclic bis-intercalators; Gabelica, Valérie ; et alin Nucleic Acids Research (2008), 36 Binding of three macrocyclic bis-intercalators, derivatives of acridine and naphthalene, and two acyclic model compounds to mismatch-containing and matched duplex oligodeoxynucleotides was analyzed by ... [more ▼] Binding of three macrocyclic bis-intercalators, derivatives of acridine and naphthalene, and two acyclic model compounds to mismatch-containing and matched duplex oligodeoxynucleotides was analyzed by thermal denaturation experiments, electrospray ionization mass spectrometry studies (ESI-MS) and fluorescent intercalator displacement (FID) titrations. The macrocyclic bis-intercalators bind to duplexes containing mismatched thymine bases with high selectivity over the fully matched ones, whereas the acyclic model compounds are much less selective and strongly bind to the matched DNA. Moreover, the results from thermal denaturation experiments are in very good agreement with the binding affinities obtained by ESI-MS and FID measurements. The FID results also demonstrate that the macrocyclic naphthalene derivative BisNP preferentially binds to pyrimidine– pyrimidine mismatches compared to all other possible base mismatches. This ligand also efficiently competes with a DNA enzyme (M.TaqI) for binding to a duplex with a TT-mismatch, as shown by competitive fluorescence titrations. Altogether, our results demonstrate that macrocyclic distance- constrained bis-intercalators are efficient and selective mismatch-binding ligands that can interfere with mismatch-binding enzymes. [less ▲] Detailed reference viewed: 49 (5 ULg) Selective reduction of C = C double bonds in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of microcystinsDeleuze, Christelle ; De Pauw, Edwin ; Quinton, Loïc ![]() in European Journal of Mass Spectrometry (Chichester, England) (2010), 16(1), 91-9 Cyanobacteria are photosynthetic bacteria encountered in various aquatic environments. Some of them are able to produce powerful toxins called cyanotoxins. Among cyanotoxins, microcystins (MCs) constitute ... [more ▼] Cyanobacteria are photosynthetic bacteria encountered in various aquatic environments. Some of them are able to produce powerful toxins called cyanotoxins. Among cyanotoxins, microcystins (MCs) constitute a group of closely related cyclic heptapeptides. Their sequences are made up of classical amino acids as well as post- translational modified ones. Interestingly, in vivo metabolism of microcystins seems to be greatly dependent on various minor structural differences and particularly those of the seventh amino acid, which can be either dehydroalanine (or a derivative), dehydroaminobutyric acid (or a derivative), serine or alanine. As a consequence, microcystins have been classified on the basis of the nature of this singular amino acid. A major difficulty in the classification of such toxins is that some of them share the same molecular masses and the same molecular formulas. Consequently, a simple mass measurement is not sufficient to determine the structure and the class of a toxin of interest. Heavy and expensive techniques are used to classify them, such as multi-dimensional nuclear magnetic resonance and amino acid analysis. In this work, a new matrix-assisted laser desorption/ionization time-of-flight method leading to an easy classification of MCs is proposed. The methodology relies on the reductive properties of the matrix 1,5-diaminonaphtalene (1,5-DAN) which appears to be able to selectively reduce the double carbon-carbon bond belonging to the seventh amino acid. Moreover, the yield of reduction seems to be influenced by the degree of substitution of this double bond, allowing a discrimination between dehydroalanine and dehydroaminobutyric acid. This selective reduction was confirmed by the study of three synthetic peptides by mass spectrometry and tandem mass spectrometry. According to these results, the use of reductive matrices seems to be promising in the study of microcystins and in their classification. More generally, 1,5-DAN allows the selective reduction of double carbon-carbon bonds. This property could also be employed in the characterization of others types of compound displaying double bonds (petrochemistry, metabolomics....). [less ▲] Detailed reference viewed: 70 (17 ULg) Selective thermal denaturation of Pisum sativum L. proteins using salt.; ; Blecker, Christophe ![]() Poster (2007, October 11) Detailed reference viewed: 4 (0 ULg) Selective transfer of persistent organic pollutants and their metabolites in grey seals during lactation; ; Habran, Sarah et alin Environment International (2012), 46 Detailed reference viewed: 47 (13 ULg) Selectivity enhancement for enantiomeric separations in capillary electrophoresis using dual cyclodextrin systemsFillet, Marianne ; ; Hubert, Philippe et alConference (1999) Detailed reference viewed: 1 (0 ULg) Selectivity enhancement for the CE enantioseparation of uncharged compounds using mixtures of cationic and anionic cyclodextrin derivatives; Fillet, Marianne ; Hubert, Philippe et alPoster (2002) Detailed reference viewed: 3 (0 ULg) Selectivity enhancement in chiral and achiral separations of basic drugs by ion-pairing in non-aqueous capillary electrophoresisCrommen, Jacques ; Servais, Anne-Catherine ; et alConference (2002) Detailed reference viewed: 1 (0 ULg) Selectivity improvement in the capillary electrophoretic enantioseparation of uncharged compounds by use of mixtures of charged and neutral cyclodextrinsFillet, Marianne ; Fotsing, Lucas ; Hubert, Philippe et alPoster (1998) Detailed reference viewed: 2 (0 ULg) Selectivity in small molecule binding to human telomeric RNA and DNA quadruplexes; ; et al in Chemical Communications (2009), (48), 7482-7484 Quadruplex RNAs are less well understood than their DNA counterparts, yet of potentially high biological relevance. The interactions of several quadruplex-binding ligands with telomeric RNA quadruplexes ... [more ▼] Quadruplex RNAs are less well understood than their DNA counterparts, yet of potentially high biological relevance. The interactions of several quadruplex-binding ligands with telomeric RNA quadruplexes are reported and compared with their binding to the analogous DNA quadruplexes. [less ▲] Detailed reference viewed: 42 (2 ULg) Selectivity lists of pesticides to beneficial arthropods for IPM programs in carrot--first results.; ; et al in Communications in agricultural and applied biological sciences (2005), 70(4), Detailed reference viewed: 32 (11 ULg) Selenium and blood antioxydant markers in two groups of suckling cows offered grass silage, maize silage and barely grown with fertilizer containing or not seleniumCabaraux, Jean-François ; Hornick, Jean-Luc ; Schoonheere, Nicolas et alin 9th Congress of the European Society of Veterinary and Comparative Nutrition (2005) Detailed reference viewed: 4 (0 ULg) Le sélénium dans la reproduction des oiseauxSchoonheere, Nicolas ; Istasse, Louis ![]() in Annales de Médecine Vétérinaire (2006), 150(4), 203-211 Selenium is a trace element of importance for antioxidant defence in birds. It is essential for the correct selenoprotein functions implicated in many physiological processes. So, glutathione peroxidase ... [more ▼] Selenium is a trace element of importance for antioxidant defence in birds. It is essential for the correct selenoprotein functions implicated in many physiological processes. So, glutathione peroxidase plays a central role in the antioxidant defence of the cells owing to its capacity to eliminate free radicals and to the sparing effect on other cell antioxidants. Embryo tissues and spermatozoa are particularly sensitive to oxidative attacks due to their high content in polyunsaturated fatty acids. They require thus an efficient antioxidant system during the reproduction period. A dietary selenium deficiency results in many reproduction disorders, such as, decreases of fertility and of hatchability of fertile eggs. On the other hand, excess of selenium is toxic. There is, however, a large difference between toxic dose and minimal requirements for adequate reproduction processes. Dietary selenium supplementation is thus considered as a major measure to improve reproduction parameters. [less ▲] Detailed reference viewed: 102 (6 ULg) Selenium enriched grass silage and winter barely for growing bulls: feedstuff composition and animal performance; Cabaraux, Jean-François ; et alin Proceedings of the British Society of Animal Science (2004) Detailed reference viewed: 13 (0 ULg) Selenium enriched winter barley for fattening bulls : animal performance and plasma metabolitesCabaraux, Jean-François ; ; et alin Proceedings of the British Society of Animal Science (2004) Detailed reference viewed: 30 (2 ULg) Selenium enriched winter barley in a diet for fattening bulls: effects on the selenium content in meat and organsCabaraux, Jean-François ; Hornick, Jean-Luc ; Schoonheere, Nicolas et alin Proceedings of the British Society of Animal Science (2006) Detailed reference viewed: 2 (0 ULg) |
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