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See detailOcanacatib antifracture efficacy and saftey in postmenopausal women with osteoporosis: results from the phase III long-term adonacatib fracture trial (LOFT)
McClung, MR; Langdahl, B; Papapoulos, S et al

in Osteoporosis International (2015), 26(1), 1

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See detailGli occhi e les mémoires du voir
Curreri, Luciano ULg

in Esercizi di memoria (2008)

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See detailOccipital nerve stimulation for drug-resistant chronic cluster headache: a prospective pilot study
Magis, Delphine ULg; Allena, Marta; Bolla, Monica et al

in Lancet Neurology (2007), 6(4), 314-321

Background Drug-resistant chronic duster headache (drCCH) is a devastating disorder for which various destructive procedures have been tried unsuccessfully. Occipital nerve stimulation (ONS) is a new ... [more ▼]

Background Drug-resistant chronic duster headache (drCCH) is a devastating disorder for which various destructive procedures have been tried unsuccessfully. Occipital nerve stimulation (ONS) is a new, safe strategy for intractable headaches. We undertook a prospective pilot trial of ONS in drCCH to assess clinical efficacy and pain perception. Methods Eight patients with drCCH had a suboccipital neurostimulator implanted on the side of the headache and were asked to record details of frequency, intensity, and symptomatic treatment for their attacks in a diary before and after Continuous ONS. To detect changes in cephalic and extracephalic pain processing we measured electrical and pressure pain thresholds and the nociceptive blink reflex. Findings Two patients were pain free after a follow-up of 16 and 22 months; one of them still had occasional autonomic attacks. Three patients had around a 90% reduction in attack frequency. Two patients, one of whom had had the implant for only 3 months, had improvement of around 40%. Mean follow-up was 15.1 months (SD 9.5, range 3-22). Intensity of attacks tends to decrease earlier than frequency during ONS and, on average, is improved by 50% in remaining attacks. All but one patient were able to substantially reduce their preventive drug treatment. Interruption of ONS by switching off the stimulator or because of an empty battery was followed within days by recurrence and increase of attacks in all improved patients. ONS did not significantly modify pain thresholds. The amplitude of the nociceptive blink reflex increased with longer durations of ONS. There were no serious adverse events. Interpretation ONS could be an efficient treatment for drCCH and could be safer than deep hypothalamic stimulation. The delay of 2 months or more between implantation and significant clinical improvement suggests that the procedure ads via slow neuromodulatory processes at the level of upper brain stem or diencephalic centres. [less ▲]

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See detailOccipital nerve stimulation for drug-resistant chronic cluster headache: long term follow-up up to 3 years
Gérardy, Pierre-Yves ULg; Magis, Delphine ULg; Allena, M. et al

in Cephalalgia : An International Journal of Headache (2009, January), 29(1),

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See detailOccipital nerve stimulation in refractory chronic cluster headache: a pilot study of efficacy and mechanisms in five patients
Magis, Delphine ULg; Allena, M.; Vandenheede, Michel et al

in Cephalalgia : An International Journal of Headache (2005, December), 25(12), 1197

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See detailOccipital nerve stimulation in refractory chronic cluster headache: a pilot study of efficacy and mechanisms in five patients.
MAGIS, Delphine ULg; Allena, Marta; Vandenheede, Michel et al

in Cephalalgia : An International Journal of Headache (2005, October), 25

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See detailOccipito-cervical fixation «vertex»: indications and operative techniques
Martin, Didier ULg

Conference (2002, October 10)

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See detailOcclusion dentaire : retentissement sur la force musculaire
Croisier, Jean-Louis ULg; Jalali, R.; Fernandez-Moreno, S. et al

in Archives of Physiology & Biochemistry (1998, September), 106(Suppl B), 154

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See detailOCCP Seminar on Dominant Positions and New Technologies
Petit, Nicolas ULg

Conference (2009, July 08)

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See detailOccult exposure to asbestos in steel workers revealed by bronchoalveolar lavage.
CORHAY, Jean-Louis ULg; Delavignette, Jean-Paul ULg; Bury, Thierry ULg et al

in Archives of Environmental Health (1990), 45(5), 278-82

To investigate the asbestos burden in a steelplant environment, we counted asbestos bodies (ABs) in the bronchoalveolar lavage fluid (BALF) of 65 steel workers who had retired during the previous 5 y ... [more ▼]

To investigate the asbestos burden in a steelplant environment, we counted asbestos bodies (ABs) in the bronchoalveolar lavage fluid (BALF) of 65 steel workers who had retired during the previous 5 y. They had worked for at least 15 y in the same area of the plant (coke oven or blast furnace) as maintenance or production workers. On the basis of occupational anamnesis, 28 had occasional past professional exposure to asbestos; the remaining 37 workers denied any contact with asbestos. A total of 54 white-collar workers who had no occupational exposure to asbestos were included in the study as controls. An increased prevalence and concentration of ABs was found in the BALF of steel workers. Electron microscopy and EDAX analysis of AB from steel workers revealed that the core fibers were mainly amphiboles. More ABs were found in the BALF of maintenance workers than in production workers. However, the BALF from steel workers who denied any contact with asbestos revealed an increased AB burden v. controls. This demonstrates that steel workers may be subject to an occult exposure to amphiboles in the steelplant environment. [less ▲]

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See detailOccult genital herpes presenting as an endometrial infection detected at delivery: a report of two cases
Aghazarian, Saro; Nikkels, Arjen ULg; Grodos, Jacques et al

in Journal of the European Academy of Dermatology & Venereology (1997), 9

Background: The prevalence and clinical implications of asymptomatic genital herpes remain elusive. Objective/aim: We report two cases of clinically asymptomatic intrautcrine herpes simplex virus II (HSV ... [more ▼]

Background: The prevalence and clinical implications of asymptomatic genital herpes remain elusive. Objective/aim: We report two cases of clinically asymptomatic intrautcrine herpes simplex virus II (HSV-II) infection in order to discuss their pathological significance and demonstrate the potential utility of specific DNA probes and antibodies. Methods: Standard histology, immunohistochemistry (IHC) and in situ hybridization (ISH) were applied to formalin-tixed. paraffin-em bedded lissue sections of curettage specimens from women presenting deciditalised fragments retention after normal delivery. Results: Hisiological analysis revealed a focal clearing of endometrial epithelial cell nuclei, suggesting a viral etiology. ISH and IHC with differetit DNA probes or antibodies confirmed the diagnosis of HSV-II infection at the time of specimen collection. Clinical signs of muco-cutaneous involvement in the mothers and of neonatal HSV infection were not observed. Conclusion: These findings suggest that intrauterinc HSV-II infection is not always associated with disease. The IHC and ISH methods can be helpful to a.ssess the diagnosis of HSV-II intrauterine infections in the presence of optically clear cndotTietrial nuclei. Whether or not such HSV-II occult infection may be associated with viral shedding and risk of sexual transtnission was not evaluated in the present study. © 1997 Elsevier Science B.V. [less ▲]

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See detailOccult Herpes Simplex Virus Colonization of Bullous Dermatitides
Nikkels, Arjen ULg; Delvenne, Philippe ULg; Herfs, Michael ULg et al

in American Journal of Clinical Dermatology (2008)

Background: Acantholytic disorders, including pemphigus vulgaris, chronic benign familial pemphigus (Hailey-Hailey disease), Darier disease, and Grover transient acantholytic dermatosis, as well as other ... [more ▼]

Background: Acantholytic disorders, including pemphigus vulgaris, chronic benign familial pemphigus (Hailey-Hailey disease), Darier disease, and Grover transient acantholytic dermatosis, as well as other vesiculobullous disorders, including bullous pemphigoid, epidermolysis bullosa, and atopic dermatitis, are prone to florid infections by herpes simplex virus (HSV)-I and -II, and, more rarely, by varicella-zoster virus (VZV). As these infections are difficult to recognize clinically and histologically, their frequency remains unknown. A possible occult viral colonization has never been documented in these disorders. The manner in which the primary bullous disorders are contaminated by herpesviridae remains unclear. Objective: To retrospectivally assess the possible presence of HSV and VZV in a series of biopsies of acantholytic disorders and bullous pemphigoid. Method: The typical a-herpesviridae-related cytopathic signs were searched for by conventional microscopy in skin biopsies of patients with pemphigus vulgaris (n = 19), bullous pemphigoid (n = 20), Darier disease (n = 18), Hailey-Hailey disease((Author: is this the same as superficial pemphigus, as mentioned in both Histology sections?)) (n = 3), and Grover transient acantholytic dermatosis (n = 3). Immunohistochemistry (IHC) targeted specific HSV-I, HSV-II, and VZV antigens. Polymerase chain reaction (PCR) was used for detecting HSV- and VZV-specific DNA sequences. Results: No cytopathic signs suggestive of HSV or VZV infection were detected. However, IHC revealed HSV antigens in Darier disease (1/18, HSV-I), Grover transient acantholytic dermatosis (1/3, HSV-I), pemphigus vulgaris (1/20((Author: 1/19 in the Immunohistochemistry section?)), HSV-I), and bullous pemphigoid (2/ 20, HSV-I and HSV-II). In these IHC-positive cases, PCR amplified specific HSV primers in Darier disease (1/ 18), pemphigus vulgaris (1/20((Author: 1/19 in the PCR section?))), and bullous pemphigoid (1/20). VZV antigens and nucleic acids were never identified. The HSV antigens were ((Author: nearly always, as in the Immunohistochemistry section?)) restricted to the upper part of the granular layer and thus differed from the usual HSV distribution during cutaneous infection. Negative and positive controls yielded consistently positive and negative results, respectively.((Author: OK?)) Conclusion: This report shows for the first time that clinically and histologically occult HSV colonization may occur in Darier disease, Grover transient acantholytic disease, pemphigus vulgaris, and bullous pemphigoid. Given the frequent use of immunosuppressive treatments for primary bullous disorders, greater awareness of HSV colonization and infection is recommended in these patients. [less ▲]

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See detailOccult Varicella
Nikkels, Arjen ULg; Pierard, Gérald ULg

in Pediatric Infectious Disease Journal (2009), 28(12), 1073-1075

Background: Localized varicella has been associated with UV-exposure and skin trauma. Varicella restricted to a pre-existent dermatitis is exceptional. Objectives: The clinical features, cytohistologic ... [more ▼]

Background: Localized varicella has been associated with UV-exposure and skin trauma. Varicella restricted to a pre-existent dermatitis is exceptional. Objectives: The clinical features, cytohistologic and immunohistochemical results, as well as serologic data of 6 patients with a sudden eruption of vesicular and eroded lesions restricted to a pre-existent dermatitis are presented. Results: All patients (mean age: 8,3 years, range: 3–22) showed crops of a few to numerous vesicular lesions clustered on the restricted sites of posttraumatic wound, perianal streptococcal dermatitis, dermatomycosis, allergic contact dermatitis, lichen sclerosus, and atopic foot dermatitis. All the Tzanck smears and 1 biopsy revealed multinucleated giant cells, consistent with herpes simplex virus (HSV) or varicella zoster virus (VZV) infection. Immunohistochemistry using specific anti-VZV antibodies (IE63 and gE) was positive on all the smears and the biopsy, whereas HSV-I and HSV-II immunolabeling was negative. VZV specific IgM , IgG EIAbased serology, and positive VZV-specific IgM complement fixation test suggested primary VZV infection. None had received varicella vaccine. None of the patients presented a history of varicella nor experienced breakthrough varicella. It was decided not to administer antiviral treatment, as the varicella lesions remained localized without any further skin extension and systemic signs. About 2 months later, EIA-serology revealed positive VZV-IgG and negative IgM levels in 5/5 patients. Conclusion: Some patients have varicella infection that remains hidden in a pre-existent infectious and/or inflammatory dermatitis without ever presenting full-blown chickenpox. The sudden occurrence of vesicular and/or ulcerated lesions on a pre-existent dermatitis should prompt searching for a viral infection. [less ▲]

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See detailOccultation by (136199) Eris
Jehin, Emmanuel ULg; Manfroid, Jean ULg; Gillon, Michaël ULg et al

in International Astronomical Union Circulars [=IAUCs] (2010), 9184

E. Jehin, J. Manfroid, M. Gillon, D. Hutsemekers, and P. Magain report that they observed an occultation of a star of magnitude I about 15.2 by the dwarf planet Eris (then at V about 18.7) on Nov. 6 using ... [more ▼]

E. Jehin, J. Manfroid, M. Gillon, D. Hutsemekers, and P. Magain report that they observed an occultation of a star of magnitude I about 15.2 by the dwarf planet Eris (then at V about 18.7) on Nov. 6 using the new telescope TRAPPIST at the European Southern Observatory (La Silla). A series of 3-s exposures of a field of size 3' x 3' (1".3/pixel) were secured in fast-readout mode (with a deadtime of 1.5 s), starting at 01h50m UT for one hour. Seven frames centered at 02h19m34s UT allowed them to derive the start of the occultation as 02h19m16s.75 +/- 0s.75 and the end as 02h19m47s.6 +/- 0s.2, for a total occultation time of 30.4 +/- 1.0 seconds. The predictions (see above) made by the Rio de Janeiro group (Assafin et al., Nov. 5) and by J. L. Ortiz estimated the time of the occultation around 02h18m UT for Chile, in good agreement with the observations. During the occultation, a point source is detected with a magnitude corresponding to that of Eris. A small flux increase was also seen at the middle of the occultation, which might result from refraction in Eris' atmosphere (Elliot and Olkin 1996, Ann. Rev. Earth Planet. Sci. 24, 89). Eris is by far the most-remote solar-system object observed to date via stellar occultation, with a geocentric distance of about 96 AU. TRAPPIST is a project driven by the University of Liege, in close collaboration with the Observatory of Geneva, supported by the Belgian Fund for Scientific Research and the Swiss National Science Foundation. [less ▲]

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See detailOccultation detection of a Neptune ring segment
Hubbard, W. B.; Brahic, A.; Bouchet, P. et al

in LPI Contributions (1985), 559

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See detailOccultation Detection of a Neptune Ring Segment
Hubbard, W. B.; Brahic, A.; Bouchet, P. et al

in Lunar and Planetary Institute Science Conference Abstracts (1985, March 01)

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See detailOccultation detection of a Neptune ring segment
Hubbard, W. B.; Brahic, A.; Bouchet, P. et al

in Journal of Geophysical Research. Supplement (1985, November 01), 90

A stellar occulation event of Neptune revealed a ring segment that was previously undetected. It appears that the object is not a complete ring, but rather a localized swarm of particles which follows a ... [more ▼]

A stellar occulation event of Neptune revealed a ring segment that was previously undetected. It appears that the object is not a complete ring, but rather a localized swarm of particles which follows a ring orbit over a limited range of longitudes. To avoid confusion with the standard use of the word ring it is suggested that the feature be called an arc. The distance of the arc zone is not precisely known because so far there has been no confirmed occultation by both an arc and the planet. [less ▲]

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See detailL’occulte au fond de tous. Idéologie et sens littéraire commun
Durand, Pascal ULg

in COnTEXTES : Revue de Sociologie de la Littérature (2007), 2

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